LOCUS       NM_004655               4260 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens axin 2 (AXIN2), transcript variant 1, mRNA.
ACCESSION   NM_004655
VERSION     NM_004655.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4260)
  AUTHORS   Alhazmi,N., Alaqla,A., Almuzzaini,B., Aldrees,M., Alnaqa,G.,
            Almasoud,F., Aldibasi,O. and Alshamlan,H.
  TITLE     What could be the role of genetic tests and machine learning of
            AXIN2 variant dominance in non-syndromic hypodontia? A case-control
            study in orthodontically treated patients
  JOURNAL   Prog Orthod 25 (1), 31 (2024)
   PUBMED   39183201
  REMARK    GeneRIF: What could be the role of genetic tests and machine
            learning of AXIN2 variant dominance in non-syndromic hypodontia? A
            case-control study in orthodontically treated patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4260)
  AUTHORS   Zheng,Y., Wang,Y., Qi,B., Gao,W., Liu,Y. and Li,T.
  TITLE     Axin2 depletion in macrophages alleviated senescence and increased
            immune response after myocardial infarction
  JOURNAL   Inflamm Res 73 (3), 407-414 (2024)
   PUBMED   38158447
  REMARK    GeneRIF: Axin2 depletion in macrophages alleviated senescence and
            increased immune response after myocardial infarction.
REFERENCE   3  (bases 1 to 4260)
  AUTHORS   Cao,W., Dai,S., Ruan,W., Long,T., Zeng,Z. and Lei,S.
  TITLE     Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ promotes
            proliferation and mobility of pancreatic cancer through AXIN2
  JOURNAL   J Cell Mol Med 27 (17), 2533-2546 (2023)
   PUBMED   37488774
  REMARK    GeneRIF: Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ
            promotes proliferation and mobility of pancreatic cancer through
            AXIN2.
REFERENCE   4  (bases 1 to 4260)
  AUTHORS   Zhai,J., Chen,H., Wong,C.C., Peng,Y., Gou,H., Zhang,J., Pan,Y.,
            Chen,D., Lin,Y., Wang,S., Kang,W., To,K.F., Chen,Z., Nie,Y.,
            He,H.H., Sung,J.J. and Yu,J.
  TITLE     ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote
            Colorectal Cancer and Is a Target for Boosting Immunotherapy
  JOURNAL   Gastroenterology 165 (2), 445-462 (2023)
   PUBMED   37169182
  REMARK    GeneRIF: ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to
            Promote Colorectal Cancer and Is a Target for Boosting
            Immunotherapy.
REFERENCE   5  (bases 1 to 4260)
  AUTHORS   Wang,L., Guo,M., Gao,L., Liu,K., Bai,J. and Liu,Z.
  TITLE     JNK2 Promotes Progression of Esophageal Squamous Cell Carcinoma via
            Inhibiting Axin2
  JOURNAL   Curr Pharm Des 29 (37), 2977-2987 (2023)
   PUBMED   37957865
  REMARK    GeneRIF: JNK2 Promotes Progression of Esophageal Squamous Cell
            Carcinoma via Inhibiting Axin2.
REFERENCE   6  (bases 1 to 4260)
  AUTHORS   von Kries,J.P., Winbeck,G., Asbrand,C., Schwarz-Romond,T.,
            Sochnikova,N., Dell'Oro,A., Behrens,J. and Birchmeier,W.
  TITLE     Hot spots in beta-catenin for interactions with LEF-1, conductin
            and APC
  JOURNAL   Nat Struct Biol 7 (9), 800-807 (2000)
   PUBMED   10966653
REFERENCE   7  (bases 1 to 4260)
  AUTHORS   Ikeda,S., Kishida,M., Matsuura,Y., Usui,H. and Kikuchi,A.
  TITLE     GSK-3beta-dependent phosphorylation of adenomatous polyposis coli
            gene product can be modulated by beta-catenin and protein
            phosphatase 2A complexed with Axin
  JOURNAL   Oncogene 19 (4), 537-545 (2000)
   PUBMED   10698523
REFERENCE   8  (bases 1 to 4260)
  AUTHORS   Kikuchi,A.
  TITLE     Modulation of Wnt signaling by Axin and Axil
  JOURNAL   Cytokine Growth Factor Rev 10 (3-4), 255-265 (1999)
   PUBMED   10647780
  REMARK    Review article
REFERENCE   9  (bases 1 to 4260)
  AUTHORS   Mai,M., Qian,C., Yokomizo,A., Smith,D.I. and Liu,W.
  TITLE     Cloning of the human homolog of conductin (AXIN2), a gene mapping
            to chromosome 17q23-q24
  JOURNAL   Genomics 55 (3), 341-344 (1999)
   PUBMED   10049590
REFERENCE   10 (bases 1 to 4260)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA754981.1, DA785881.1,
            BC101533.1, DA839648.1, CX759580.1, CX756263.1 and BE670767.1.
            
            On Jun 3, 2018 this sequence version replaced NM_004655.3.
            
            Summary: The Axin-related protein, Axin2, presumably plays an
            important role in the regulation of the stability of beta-catenin
            in the Wnt signaling pathway, like its rodent homologs, mouse
            conductin/rat axil. In mouse, conductin organizes a multiprotein
            complex of APC (adenomatous polyposis of the colon), beta-catenin,
            glycogen synthase kinase 3-beta, and conductin, which leads to the
            degradation of beta-catenin. Apparently, the deregulation of
            beta-catenin is an important event in the genesis of a number of
            malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region
            that shows frequent loss of heterozygosity in breast cancer,
            neuroblastoma, and other tumors. Mutations in this gene have been
            associated with colorectal cancer with defective mismatch repair.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR933657.1, SRR11853561.13223.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307078.10/ ENSP00000302625.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DA754981.1         1-26
            27-463              DA785881.1         1-437
            464-1679            BC101533.1         218-1433
            1680-1710           DA839648.1         132-162
            1711-2863           BC101533.1         1465-2617
            2864-3363           CX759580.1         218-717
            3364-3759           CX756263.1         337-732
            3760-4260           BE670767.1         8-508               c
FEATURES             Location/Qualifiers
     source          1..4260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.1"
     gene            1..4260
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /note="axin 2"
                     /db_xref="GeneID:8313"
                     /db_xref="HGNC:HGNC:904"
                     /db_xref="MIM:604025"
     exon            1..199
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            200..1130
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..2847
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     conductin; axin-like protein; axis inhibition protein 2"
                     /codon_start=1
                     /product="axin-2 isoform 1"
                     /protein_id="NP_004646.3"
                     /db_xref="CCDS:CCDS11662.1"
                     /db_xref="GeneID:8313"
                     /db_xref="HGNC:HGNC:904"
                     /db_xref="MIM:604025"
                     /translation="MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQ
                     VTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLERE
                     KCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDG
                     IKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSL
                     KVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKR
                     SDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQ
                     REMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLE
                     ERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTP
                     GCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTK
                     QTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMP
                     SEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWML
                     ESERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQD
                     PAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNP
                     SLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKK
                     GNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID"
     exon            1131..1271
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1374
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1515
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..2027
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2222
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2456
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2552
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2720
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..4260
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4237..4242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /note="hexamer: ATTAAA"
     polyA_site      4260
                     /gene="AXIN2"
                     /gene_synonym="AXIL; ODCRCS"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgtga ttggcgcggc gggatcactg gctccgcgag cctggcccgg gggagtcggc
       61 tggagccggc tgcgctttga taaggtcctg gcaactcagt aacagcccga gagccgggaa
      121 ataaaaataa cccctcagag cgatggattt cggggccgcc cggcggccga ggcgcccgcc
      181 gaaggccctg ctgtaaaaga gaggaggttc agatgagccc ctgctgactt gagagagaca
      241 gagagaccac gccgattgct gagaggaact ggaagaagaa aaattcccag actcagtggg
      301 aagagctccc tcaccatgag tagcgctatg ttggtgactt gcctcccgga ccccagcagc
      361 agcttccgtg aggatgcccc gcggccccca gtgccagggg aagaagggga gaccccaccg
      421 tgtcagccag gggtgggcaa gggccaggtc accaaaccca tgcctgtctc ttccaacacc
      481 aggcggaacg aagatgggtt gggggagccg gaggggcggg catctccgga ttcccctctg
      541 acccggtgga ccaagtcctt acactcctta ttgggcgatc aagacggtgc ttacctgttc
      601 cgaactttcc tggagaggga gaaatgcgtg gataccttag acttctggtt tgcctgcaat
      661 ggattcaggc agatgaacct gaaggatacc aaaactttac gagtagccaa agcgatctac
      721 aaaaggtaca ttgagaacaa cagcattgtc tccaagcagc tgaagcctgc caccaagacc
      781 tacataagag atggcatcaa gaagcagcag attgattcca tcatgtttga ccaggcgcag
      841 accgagatcc agtcggtgat ggaggaaaat gcctaccaga tgtttttgac ttctgatata
      901 tacctcgaat atgtgaggag tgggggagaa aacacagctt acatgagtaa tgggggactc
      961 gggagcctaa aggtcgtgtg tggctatctc cccaccttga atgaagaaga ggagtggact
     1021 tgtgccgact tcaagtgcaa actttcgcca accgtggttg gcttgtccag caaaactctg
     1081 agggccacgg cgagtgtgag gtccacggaa actgttgaca gtggatacag gtccttcaag
     1141 aggagcgatc ctgttaatcc ttatcacata ggttctggct atgtctttgc accagccacc
     1201 agcgccaacg acagtgagat atccagtgat gcgctgacgg atgattccat gtccatgacg
     1261 gacagcagtg tagatggaat tcctccttat cgtgtgggca gtaagaaaca gctccagaga
     1321 gaaatgcatc gcagtgtgaa ggccaatggc caagtgtctc tacctcattt cccgagaacc
     1381 caccgcctgc ccaaggagat gacccccgtg gaacccgcca cctttgcagc tgagctgatc
     1441 tcgaggctgg aaaagctgaa gctggagttg gagagccgcc acagcctgga ggagcgcctg
     1501 cagcagatcc gagaggatga agagagagag ggctccgagc tcacactcaa ttcgcgggag
     1561 ggggcgccca cgcagcaccc cctctcccta ctgccctccg gcagctacga ggaagacccg
     1621 cagacgatac tggacgatca cctgtccagg gtcctcaaga cccctggctg ccagtctcca
     1681 ggcgtaggcc gctatagccc ccgctcccgc tccccggacc accaccacca ccaccattcg
     1741 cagtaccact ccctgctccc gcccggtggc aagctgcctc ccgcggccgc ctcgccgggc
     1801 gcctgccccc tcctcggggg caaaggcttt gtgaccaagc agacgacgaa gcatgtccac
     1861 caccactaca tccaccacca tgccgtcccc aagaccaagg aggagatcga ggcggaggcc
     1921 acgcagcggg tgcactgctt ctgccctggg ggcagcgagt attactgcta ctcgaaatgc
     1981 aaaagccact ccaaggctcc ggaaaccatg cccagcgagc agtttggcgg cagcagaggc
     2041 agtaccttgc ccaaacgcaa tgggaaaggc acggagccgg gcctggccct gcccgccagg
     2101 gaaggagggg cccccggcgg agctggggcc ctgcagcttc cccgggagga aggagacagg
     2161 tcgcaggatg tctggcagtg gatgctggag agtgagcggc agagcaagcc caagccccat
     2221 agtgcccaaa gcacaaaaaa ggcctacccc ttggagtctg cccgctcgtc tccaggcgaa
     2281 cgagccagcc ggcaccatct gtgggggggc aacagcgggc acccccgcac caccccccgt
     2341 gcccacctgt tcacccagga ccctgcgatg cctcccctga ccccacccaa cacgctggct
     2401 cagctggagg aggcctgtcg caggctagct gaggtgtcga agcccccaaa gcagcggtgc
     2461 tgtgtggcca gtcagcagag ggacaggaat cattcggcca ctgttcagac gggagccaca
     2521 cccttctcca atccaagcct ggctccagaa gatcacaaag agccaaagaa actggcaggt
     2581 gtccacgcgc tccaggccag tgagttggtt gtcacttact ttttctgtgg ggaagaaatt
     2641 ccataccgga ggatgctgaa ggctcagagc ttgaccctgg gccactttaa agagcagctc
     2701 agcaaaaagg gaaattatag gtattacttc aaaaaagcaa gcgatgagtt tgcctgtgga
     2761 gcggtgtttg aggagatctg ggaggatgag acggtgctcc cgatgtatga aggccggatt
     2821 ctgggcaaag tggagcggat cgattgagcc ctggggtctg gctttggtga actgttggag
     2881 cccgaagctc ttgtgaactg tcttggctgt gagcaactgc gacaaaacat tttgaaggaa
     2941 aattaaacca atgaagaaga caaagtctaa ggaagaatcg gccagtgggc cttcgggagg
     3001 gcggggggag gttgattttc atgattcatg agctgggtac tgactgagat aagaaaagcc
     3061 tgaactattt attaaaaaca tgaccactct tggctattga agatgctgcc tgtatttgag
     3121 agactgccat acataatata tgacttccta gggatctgaa atccataaac taagagaaac
     3181 tgtgtatagc ttacctgaac aggaatcctt actgatattt atagaacagt tgatttcccc
     3241 catccccagt ttatggatat gctgctttaa acttggaagg gggagacagg aagttttaat
     3301 tgttctgact aaacttagga gttgagctag gagtgcgttc atggtttctt cactaacaga
     3361 ggaattatgc tttgcactac gtccctccaa gtgaagacag actgttttag acagactttt
     3421 taaaatggtg ccctaccatt gacacatgca gaaattggtg cgttttgttt ttttttttcc
     3481 tatgctgctc tgttttgtct taaaggtctt gagggttgac catgttgcgt catcatcaac
     3541 attttggggg ttgtgttgga tgggatgatc tgttgcagag ggagaggcag ggaaccctgc
     3601 tccttcgggc cccaggttga tcctgtgact gaggctcccc ctcatgtagc ctccccaggc
     3661 ccagggccct gaggcctgct agaatcactg ccgctgtgct ttcgtggaaa tgacagttcc
     3721 ttgttttttt tgtttctgtt tttgttttac attagtcatt ggaccacagc cattcaggaa
     3781 ctaccccctg ccccacaaag aaatgaacag ttgtagggag acccagcagc acctttcctc
     3841 cacacacctt cattttgatg ttcgggtttt tgtgttaagt taatctgtac attctgtttg
     3901 ccattgttac ttgtactata catctgtata tagtgtacgg caaaagagta ttaatccact
     3961 atctctagtg cttgacttta aatcagtaca gtacctgtac ctgcacggtc acccgctccg
     4021 tgtgtcgccc tatattgagg gctcaagctt tcccttgttt tttgaaaggg gtttatgtat
     4081 aaatatattt tatgcctttt tattacaagt cttgtactca atgacttttg tcatgacatt
     4141 ttgttctact tatactgtaa attatgcatt ataaagagtt catttaagga aaattacttg
     4201 gtacaataat tattgtaatt aagagatgta gcctttatta aaattttata tttttcaaaa
//
