LOCUS       NM_000707               5026 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens arginine vasopressin receptor 1B (AVPR1B), mRNA.
ACCESSION   NM_000707
VERSION     NM_000707.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5026)
  AUTHORS   Zhang,S., Li,N., Wang,J., Wang,L. and Yu,Z.
  TITLE     Correlation Between Sleep Electroencephalogram, Brain-Derived
            Neurotrophic Factor, AVPR1B Gene Polymorphism, and Suicidal
            Behavior in Patients with Depression
  JOURNAL   Appl Biochem Biotechnol 195 (5), 2767-2785 (2023)
   PUBMED   36367618
  REMARK    GeneRIF: Correlation Between Sleep Electroencephalogram,
            Brain-Derived Neurotrophic Factor, AVPR1B Gene Polymorphism, and
            Suicidal Behavior in Patients with Depression.
REFERENCE   2  (bases 1 to 5026)
  AUTHORS   Shima,T., Jesmin,S., Onishi,H., Yoshikawa,T. and Saitoh,R.
  TITLE     Physical activity associates empathy in Japanese young adults with
            specific gene variations of oxytocin receptor and vasopressin V1B
            receptor
  JOURNAL   Physiol Behav 255, 113930 (2022)
   PUBMED   35905808
  REMARK    GeneRIF: Physical activity associates empathy in Japanese young
            adults with specific gene variations of oxytocin receptor and
            vasopressin V1B receptor.
REFERENCE   3  (bases 1 to 5026)
  AUTHORS   Shichi,H., Fukuoka,H., Kanzawa,M., Yamamoto,M., Yamamoto,N.,
            Suzuki,M., Urai,S., Matsumoto,R., Kanie,K., Fujita,Y., Bando,H.,
            Iguchi,G., Inoshita,N., Yamada,S., Takahashi,Y. and Ogawa,W.
  TITLE     Responsiveness to DDAVP in Cushing's disease is associated with
            USP8 mutations through enhancing AVPR1B promoter activity
  JOURNAL   Pituitary 25 (3), 496-507 (2022)
   PUBMED   35451730
  REMARK    GeneRIF: Responsiveness to DDAVP in Cushing's disease is associated
            with USP8 mutations through enhancing AVPR1B promoter activity.
REFERENCE   4  (bases 1 to 5026)
  AUTHORS   Yeung,M.L., Teng,J.L.L., Jia,L., Zhang,C., Huang,C., Cai,J.P.,
            Zhou,R., Chan,K.H., Zhao,H., Zhu,L., Siu,K.L., Fung,S.Y., Yung,S.,
            Chan,T.M., To,K.K., Chan,J.F., Cai,Z., Lau,S.K.P., Chen,Z.,
            Jin,D.Y., Woo,P.C.Y. and Yuen,K.Y.
  TITLE     Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with
            proteins related to the renin-angiotensin system
  JOURNAL   Cell 184 (8), 2212-2228 (2021)
   PUBMED   33713620
  REMARK    Erratum:[Cell. 2023 Nov 22;186(24):5428-5432. doi:
            10.1016/j.cell.2023.10.008.. PMID: 37995658]
REFERENCE   5  (bases 1 to 5026)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   6  (bases 1 to 5026)
  AUTHORS   Thibonnier,M., Preston,J.A., Dulin,N., Wilkins,P.L.,
            Berti-Mattera,L.N. and Mattera,R.
  TITLE     The human V3 pituitary vasopressin receptor: ligand binding profile
            and density-dependent signaling pathways
  JOURNAL   Endocrinology 138 (10), 4109-4122 (1997)
   PUBMED   9322919
REFERENCE   7  (bases 1 to 5026)
  AUTHORS   de Keyzer,Y., Lenne,F., Auzan,C., Jegou,S., Rene,P., Vaudry,H.,
            Kuhn,J.M., Luton,J.P., Clauser,E. and Bertagna,X.
  TITLE     The pituitary V3 vasopressin receptor and the corticotroph
            phenotype in ectopic ACTH syndrome
  JOURNAL   J Clin Invest 97 (5), 1311-1318 (1996)
   PUBMED   8636444
REFERENCE   8  (bases 1 to 5026)
  AUTHORS   Rousseau-Merck,M.F., Rene,P., Derre,J., Bienvenu,T., Berger,R. and
            de Keyzer,Y.
  TITLE     Chromosomal localization of the human V3 pituitary vasopressin
            receptor gene (AVPR3) to 1q32
  JOURNAL   Genomics 30 (2), 405-406 (1995)
   PUBMED   8586456
REFERENCE   9  (bases 1 to 5026)
  AUTHORS   de Keyzer,Y., Auzan,C., Lenne,F., Beldjord,C., Thibonnier,M.,
            Bertagna,X. and Clauser,E.
  TITLE     Cloning and characterization of the human V3 pituitary vasopressin
            receptor
  JOURNAL   FEBS Lett 356 (2-3), 215-220 (1994)
   PUBMED   7805841
REFERENCE   10 (bases 1 to 5026)
  AUTHORS   Sugimoto,T., Saito,M., Mochizuki,S., Watanabe,Y., Hashimoto,S. and
            Kawashima,H.
  TITLE     Molecular cloning and functional expression of a cDNA encoding the
            human V1b vasopressin receptor
  JOURNAL   J Biol Chem 269 (43), 27088-27092 (1994)
   PUBMED   7929452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244035.3 and D31833.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000707.4.
            
            Summary: The protein encoded by this gene acts as receptor for
            arginine vasopressin. This receptor belongs to the subfamily of
            G-protein coupled receptors which includes AVPR1A, V2R and OXT
            receptors. Its activity is mediated by G proteins which stimulate a
            phosphatidylinositol-calcium second messenger system. The receptor
            is primarily located in the anterior pituitary, where it stimulates
            ACTH release. It is expressed at high levels in ACTH-secreting
            pituitary adenomas as well as in bronchial carcinoids responsible
            for the ectopic ACTH syndrome. A spliced antisense transcript of
            this gene has been reported but its function is not known.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L37112.1, D31833.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367126.5/ ENSP00000356094.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC244035.3         66400-66737         c
            339-2094            D31833.1           48-1803
            2095-5026           AC244035.3         56285-59216         c
FEATURES             Location/Qualifiers
     source          1..5026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..5026
                     /gene="AVPR1B"
                     /gene_synonym="AVPR3; V1bR; VPR3"
                     /note="arginine vasopressin receptor 1B"
                     /db_xref="GeneID:553"
                     /db_xref="HGNC:HGNC:896"
                     /db_xref="MIM:600264"
     exon            1..1438
                     /gene="AVPR1B"
                     /gene_synonym="AVPR3; V1bR; VPR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..1773
                     /gene="AVPR1B"
                     /gene_synonym="AVPR3; V1bR; VPR3"
                     /note="pituitary vasopressin receptor 3; antidiuretic
                     hormone receptor 1B; arginine vasopressin receptor 3; AVPR
                     V3; AVPR V1b; vasopressin V3 receptor; V1B receptor"
                     /codon_start=1
                     /product="vasopressin V1b receptor"
                     /protein_id="NP_000698.1"
                     /db_xref="CCDS:CCDS73015.1"
                     /db_xref="GeneID:553"
                     /db_xref="HGNC:HGNC:896"
                     /db_xref="MIM:600264"
                     /translation="MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATV
                     LVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQG
                     PDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLL
                     AAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTAC
                     YSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAK
                     IRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCN
                     PWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLS
                     LSLTLSGRPRPEESPRDLELADGEGTAETIIF"
     exon            1439..5026
                     /gene="AVPR1B"
                     /gene_synonym="AVPR3; V1bR; VPR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5001..5006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AVPR1B"
                     /gene_synonym="AVPR3; V1bR; VPR3"
                     /note="hexamer: AATAAA"
     polyA_site      5026
                     /gene="AVPR1B"
                     /gene_synonym="AVPR3; V1bR; VPR3"
                     /note="major polyA site"
ORIGIN      
        1 gctccagccg ctgctcacca ggcagagcga gcgggcttgg ctggggcttc ctgccctgag
       61 cgcgacaccg actgccccgg accgcgcctc caagcaggct gaagggcttc cgctcttggc
      121 ttccagaaaa gtttggagaa agagaatttg aggcggattg gagggtggta gcccctcccc
      181 agccttcttt ccctcccaga agcctcactc tgcacagcgt cccccattct tcccgtcctg
      241 attccccatc ttcctgaccc ctccttctcc ctctcctggg tcgatcccag tcacattttc
      301 tccttccgaa tctcatcctc cctcctcctc tctatcccag tcctctgaac gatttccgcc
      361 tatttgcaag ccttctccct gtcattctca acgcttctcc tttctctcca cctcccctgc
      421 cactccattt tatccatcaa acctctccac ttgcatccac accctccctt catccttccc
      481 tcccagcaaa ccttgctcat ggattctggg cctctgtggg atgccaaccc cacccctcgg
      541 ggcaccctct ctgcccccaa tgccacaaca ccctggctgg gccgggatga ggagctggcc
      601 aaggtggaga tcggagtcct ggccactgtc ctggtgctgg cgaccggggg caacctggct
      661 gtgctgctga ccctgggcca gctgggccgc aagcgctccc gcatgcacct gttcgtgctg
      721 cacttagccc tgacagacct ggccgtggcg ctcttccagg tgctgccaca gctgctgtgg
      781 gacatcacct accgcttcca gggccccgac ctcctgtgca gggccgtcaa gtacctgcag
      841 gtgctcagca tgtttgcctc cacctacatg ctgctggcca tgacgctgga ccgctacctg
      901 gctgtctgtc accccctgcg cagcctccag cagccaggcc agtccaccta cctgctcatc
      961 gctgctccct ggctgctggc cgccatcttc agcctccctc aagtcttcat tttttccctg
     1021 cgggaggtga tccagggctc aggggtgctg gactgctggg cagacttcgg cttcccttgg
     1081 gggccacggg cctacctcac ctggaccacc ctggctatct tcgttctgcc ggtgaccatg
     1141 ctcacggcct gctacagcct catctgccat gagatctgta aaaacctaaa agtcaagaca
     1201 caggcctggc gggtgggagg agggggctgg aggacttggg acaggccctc accttccacc
     1261 ttagctgcca ccactcgggg gctgccatct cgggtcagca gcatcaacac catctcacgg
     1321 gccaagatcc gaacagtgaa gatgaccttt gtcatcgtgc tggcctacat cgcttgctgg
     1381 gctcccttct tcagtgtcca gatgtggtcc gtgtgggaca agaatgcccc tgatgaagat
     1441 tccaccaatg tggctttcac catctctatg cttttgggca acctcaacag ctgctgcaac
     1501 ccctggatct acatgggctt caacagccac ctgttaccgc ggcccctgcg tcaccttgcc
     1561 tgctgtgggg gtccccagcc caggatgcgc cggcggctct ccgacggcag cctctcgagc
     1621 cgccacacca cgctgctgac ccgctccagc tgcccggcca ccctcagcct cagcctcagc
     1681 ctaaccctca gtgggaggcc caggcctgaa gagtcaccaa gggacttgga gctggcagat
     1741 ggggaaggca ccgctgagac catcatcttt taggaaagac tcgctggggt ctggtactgc
     1801 ccccaggact agtggaggtt ctctgcccac ctcgggcact ggaaatgaga gctgggaggg
     1861 taagggttgg agttagagga gccctgtcta aagcggagcg aaaaggccag aatgggtccc
     1921 ctaccctggt gtcacagctg cccctagtgt gagggctgcc tcataagctc ccaatctcag
     1981 acactggcag tcagggagaa tcaaactgcc tgtctccctg gtcctgccat attcataggg
     2041 tgtccatgca cacatggtgt cccagatcta ggcaggccta ggatggtgct gtctaggggt
     2101 ccacgggtgg caggaattca gaggctggcc ttgtgccctg gctacctgtc tccattctaa
     2161 cctgactggc acatctcagc ctaaccagga gaggggagaa gtgaaaaacc gtgaggagga
     2221 ctctatttgg atcctggatt tgttgttgtt gttgttgttg ttagagagaa aattgcttca
     2281 tgaagaaaag tgaatggata tgtagggatt accctgctgt gcccagctgt ctgttgaagg
     2341 gagatggtct catggagatg caggattcag tatagtacct ggtacctagc aggaactctg
     2401 caaatgccag tccctcttct cctcgtgcca ccccccatga cagcgtggat gacgggaaag
     2461 tgttgtatat tctctgtggt ctggtccact gtcagtgtgg gtgggaagaa agagggaggg
     2521 aaggagaaga tgaaaatggt catcataaaa ttaacagcaa gaataagcct caagggcagc
     2581 agggacttgt ggccctccct cctttcccca acccaccccc cagggaatcc agcctgctct
     2641 ttccccgggg gctacacaga ggagacctcc tttgagaaaa ggtgacatca tcatggctct
     2701 ggacaccctc caggctcttc agagcttcca ccatgaacca tatggatgct gtgatccagt
     2761 taggagcccg ggtttgaatc tcagctctgc cttcagtatc tgtgtgacct tgggtgagtc
     2821 actctccctt tccaggaccc agtctcctca cctgtgtaat aggtgagatg atctctaaac
     2881 tccaaccttc catgactctg caatactgga aatggtgtta cagagaaaca caaaggatat
     2941 tataaccaac agggtctaga agagttgttg catttttatg acaatggcat tgatatactc
     3001 tttgactcaa ttctggtgac ggtgggtccc accatggcca tactgtccac ttttgtcctc
     3061 atctgggatg ctgaatcctc ctccaaggct gggagaggct gcaggccaag gtagaccgag
     3121 gtagaggaag agcatggcac atgctcatta tctccagggg acttttatca tggcatagct
     3181 tccccaaccc aattctgatt ccaattgaag agagagcctt gctggtggaa aagacatcag
     3241 ctgaaacatc agcaaagctg catcctggtt ctgccaccac caatgacaca catcaataaa
     3301 atgctggcca gtccttgcta gcttggttct gagaatcaaa taggactgtg gatataaaag
     3361 tcatttgtaa agtcatgagc tctatactaa cgtaaggaat tactaatcta attaagagct
     3421 cctgagggaa gctctaggga acactttcag tctctacccc tgactcccag ggaagctttg
     3481 aggaatgact gtggctttgc ggatatactt ctttaagagg ccactcagct ctaagaagcc
     3541 tcctgaggct ttctaaaaag aaaagagcct tgctgaatgt tgtgagtgag caaagcgtcc
     3601 cagtccttca gtgctagaga actggagagt gagaccctaa tgggaccaag gctcaggcag
     3661 atgggaggac ccacagtctc cctctcactg agttctgttg cccatgtcag cccctgacat
     3721 ctaatacttc ttccctgtct atctgccctg gtgaagtggg cttagaagcc tcccatgcca
     3781 gccagagctg ttgaatctgc tccttcccct gcttacaaaa gcggcctccc cacccccttg
     3841 ccccatcttt agaccacagt ttctgaccct aatgcctaga gttggtaaat ctttgttctt
     3901 catgatgact gggaggtaga aggaacacca gctgtgtgcc ccaaagacct gggtttgcat
     3961 cttgatctca ccccttttct acctgtatca acttaagcaa gttatccaat ctcccccagc
     4021 aatgctttct tcatttatta aatagaaata gcaatgccca ctttgttggg agggatttgt
     4081 aagattgtag actagagata gagcactcaa cagatgttag agaggggaac aatggcctgg
     4141 ctccagattg catctggtag atgacctcca gggtcctgac ccaaaagagt ctacagttca
     4201 gagaggaaaa gaggagacag acctgggatc aaggctgact aaagcacttt cttgtctacc
     4261 ctttgccttc tatagatccc ctcttactac tatgatattt tctgttttgc attgcacaag
     4321 aataatttac ttggggtggt ggctttggag ccctcattgt tcctcccatg gaaaggctac
     4381 acttgatctt ttccagaaag ctggttctgt cctgtgatat ggacagtggg gagcgactgc
     4441 acactggctg agggcctcgg gaacccattc caggaagctc ctgaaggaaa tggtggatct
     4501 catcggatct atgagtgaaa gttctgcagg acctgtagga ggctcgcctg gacagtctgg
     4561 gccagtggaa gggccttgga tagggttcaa ggaggagggg ccctgtggaa gcaagaagga
     4621 ggctctgtgc tctctggggt gaatcccatt tctgacggct aaccccagga gaaactgaac
     4681 aatgccgtct ctggctgggc acttgtgtaa attgtttatg ccatcctgtg actgtgaatg
     4741 acagtacttt agtcccttaa aacctatgta caagcaggac atgaggggca gacgggacag
     4801 agaggaggac aggaggggtt catcggttga ctacggggat ttctcagaat cgttatgttg
     4861 tttggcacag gccagtactt tcccagataa tgtgtctgtg ttttgtatgt aaatagatca
     4921 cttatctact acagggctat agattcagcc caggctgtag cagttcattc ctgggtcaga
     4981 aacccaggtt gaaattcacc aataaaaaga tttaatatcc aggaaa
//
