LOCUS       NM_000706               6222 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens arginine vasopressin receptor 1A (AVPR1A), mRNA.
ACCESSION   NM_000706
VERSION     NM_000706.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6222)
  AUTHORS   Tanaka,H., Nishina,K., Shou,Q., Takahashi,H., Sakagami,M.,
            Matsuda,T., Inoue-Murayama,M. and Takagishi,H.
  TITLE     Association between arginine vasopressin receptor 1A (AVPR1A)
            polymorphism and inequity aversion
  JOURNAL   Proc Biol Sci 290 (2000), 20230378 (2023)
   PUBMED   37312550
  REMARK    GeneRIF: Association between arginine vasopressin receptor 1A
            (AVPR1A) polymorphism and inequity aversion.
REFERENCE   2  (bases 1 to 6222)
  AUTHORS   Heidman,L.M., Peinetti,N., Copello,V.A. and Burnstein,K.L.
  TITLE     Exploiting Dependence of Castration-Resistant Prostate Cancer on
            the Arginine Vasopressin Signaling Axis by Repurposing Vaptans
  JOURNAL   Mol Cancer Res 20 (8), 1295-1304 (2022)
   PUBMED   35503085
  REMARK    GeneRIF: Exploiting Dependence of Castration-Resistant Prostate
            Cancer on the Arginine Vasopressin Signaling Axis by Repurposing
            Vaptans.
REFERENCE   3  (bases 1 to 6222)
  AUTHORS   Vollebregt,O., Koyama,E., Zai,C.C., Shaikh,S.A., Lisoway,A.J.,
            Kennedy,J.L. and Beitchman,J.H.
  TITLE     Evidence for association of vasopressin receptor 1A promoter region
            repeat with childhood onset aggression
  JOURNAL   J Psychiatr Res 140, 522-528 (2021)
   PUBMED   34161896
  REMARK    GeneRIF: Evidence for association of vasopressin receptor 1A
            promoter region repeat with childhood onset aggression.
REFERENCE   4  (bases 1 to 6222)
  AUTHORS   Gao,X., Enten,G.A., DeSantis,A.J. and Majetschak,M.
  TITLE     Class A G protein-coupled receptors assemble into functional
            higher-order hetero-oligomers
  JOURNAL   FEBS Lett 595 (14), 1863-1875 (2021)
   PUBMED   34032285
  REMARK    GeneRIF: Class A G protein-coupled receptors assemble into
            functional higher-order hetero-oligomers.
REFERENCE   5  (bases 1 to 6222)
  AUTHORS   Rivera-Hechem,M.I., Rodriguez-Sickert,C., Guzman,R.A.,
            Ramirez-Parada,T., Benavides,F., Landaeta-Torres,V.,
            Aspe-Sanchez,M. and Repetto,G.M.
  TITLE     No association between genetic variants in MAOA, OXTR, and AVPR1a
            and cooperative strategies
  JOURNAL   PLoS One 15 (12), e0244189 (2020)
   PUBMED   33362272
  REMARK    GeneRIF: No association between genetic variants in MAOA, OXTR, and
            AVPR1a and cooperative strategies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6222)
  AUTHORS   Thibonnier,M., Graves,M.K., Wagner,M.S., Auzan,C., Clauser,E. and
            Willard,H.F.
  TITLE     Structure, sequence, expression, and chromosomal localization of
            the human V1a vasopressin receptor gene
  JOURNAL   Genomics 31 (3), 327-334 (1996)
   PUBMED   8838314
REFERENCE   7  (bases 1 to 6222)
  AUTHORS   Hirasawa,A., Shibata,K., Kotosai,K. and Tsujimoto,G.
  TITLE     Cloning, functional expression and tissue distribution of human
            cDNA for the vascular-type vasopressin receptor
  JOURNAL   Biochem Biophys Res Commun 203 (1), 72-79 (1994)
   PUBMED   8074728
REFERENCE   8  (bases 1 to 6222)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
REFERENCE   9  (bases 1 to 6222)
  AUTHORS   Thibonnier,M., Auzan,C., Madhun,Z., Wilkins,P., Berti-Mattera,L.
            and Clauser,E.
  TITLE     Molecular cloning, sequencing, and functional expression of a cDNA
            encoding the human V1a vasopressin receptor
  JOURNAL   J Biol Chem 269 (5), 3304-3310 (1994)
   PUBMED   8106369
REFERENCE   10 (bases 1 to 6222)
  AUTHORS   Young,W.S. 3rd, Kovacs,K. and Lolait,S.J.
  TITLE     The diurnal rhythm in vasopressin V1a receptor expression in the
            suprachiasmatic nucleus is not dependent on vasopressin
  JOURNAL   Endocrinology 133 (2), 585-590 (1993)
   PUBMED   8344200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135584.2, AF101725.1 and
            AA533159.1.
            
            On Aug 14, 2019 this sequence version replaced NM_000706.4.
            
            Summary: The protein encoded by this gene acts as receptor for
            arginine vasopressin. This receptor belongs to the subfamily of
            G-protein coupled receptors which includes AVPR1B, V2R and OXT
            receptors. Its activity is mediated by G proteins which stimulate a
            phosphatidylinositol-calcium second messenger system. The receptor
            mediates cell contraction and proliferation, platelet aggregation,
            release of coagulation factor and glycogenolysis. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.90892.1,
                                           SRR1803613.94958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence (PMID:
                                                8838314)
            MANE Ensembl match               :: ENST00000299178.4/
                                                ENSP00000299178.3
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AC135584.2         63578-63919         c
            343-1640            AF101725.1         1-1298
            1641-5874           AC135584.2         55825-60058         c
            5875-6222           AA533159.1         19-366              c
FEATURES             Location/Qualifiers
     source          1..6222
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.2"
     gene            1..6222
                     /gene="AVPR1A"
                     /gene_synonym="AVPR V1a; AVPR1; V1aR"
                     /note="arginine vasopressin receptor 1A"
                     /db_xref="GeneID:552"
                     /db_xref="HGNC:HGNC:895"
                     /db_xref="MIM:600821"
     exon            1..1335
                     /gene="AVPR1A"
                     /gene_synonym="AVPR V1a; AVPR1; V1aR"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..6222
                     /gene="AVPR1A"
                     /gene_synonym="AVPR V1a; AVPR1; V1aR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6175
                     /gene="AVPR1A"
                     /gene_synonym="AVPR V1a; AVPR1; V1aR"
                     /note="major polyA site"
     regulatory      6200..6205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AVPR1A"
                     /gene_synonym="AVPR V1a; AVPR1; V1aR"
                     /note="hexamer: TATAAA"
     polyA_site      6222
                     /gene="AVPR1A"
                     /gene_synonym="AVPR V1a; AVPR1; V1aR"
                     /note="major polyA site"
ORIGIN      
        1 aaccagcagt cttccggcaa tagggcggga gggagcgcgt cccaaggaaa caagcaccgc
       61 ataaatactt gagttgggaa cccagtgctt ccggaagctc ggagctcacc ttcccgacct
      121 cgccgaagtt gaaaaaaggc agagcaggga gaggggccag ctcaccctgc tgagagctgc
      181 tcagtgggca ggcgggacgc tgctccggga gacgcccact ggagggatcg cagagcccgg
      241 caagctgcga gcgcgccaaa gaccctgcgc ttcggacgag gagcccaagt cctccgagac
      301 ggggagggag cggcccgcga gggctggagc tccgaagagg gccgagtagg agctgcatgg
      361 acagcatgcg tctctccgcc ggtcccgacg cggggccctc gggcaactcc agcccatggt
      421 ggcctctggc caccggcgct ggcaacacaa gccgggaggc cgaagccctc ggggagggca
      481 acggcccacc gagggacgtg cgcaacgagg agctggccaa actggagatc gccgtgctgg
      541 cggtgacttt cgcggtggcc gtgctgggca acagcagcgt actgctggct ctgcaccgga
      601 cgccgcgcaa gacgtcccgc atgcacctct tcatccgaca cctcagcctg gccgacctgg
      661 ccgtggcatt cttccaggtg ctgccgcaaa tgtgctggga catcacctac cgcttccgcg
      721 gccccgactg gctgtgccgc gtggtgaagc acctgcaggt gttcggcatg tttgcgtcgg
      781 cctacatgct ggtagtcatg acagccgacc gctacatcgc ggtgtgccac ccgctcaaga
      841 ctctgcaaca gcccgcgcgc cgctcgcgcc tcatgatcgc ggccgcctgg gtgctgagct
      901 tcgtgctgag cacgccgcag tacttcgtct tctccatgat cgaggtgaac aatgtcacca
      961 aggcccgcga ctgctgggcc accttcatcc agccctgggg ttctcgtgcc tacgtgacct
     1021 ggatgacggg cggcatcttt gtggcgcccg tggtcatctt gggtacctgc tacggcttca
     1081 tctgctacaa catctggtgc aacgtccgcg ggaagacggc gtcgcgccag agcaagggtg
     1141 cagagcaagc gggtgtggcc ttccaaaagg ggttcctgct cgcaccctgt gtcagcagcg
     1201 tgaagtccat ttcccgggcc aagatccgca cggtgaagat gacttttgtg atcgtgacgg
     1261 cttacatcgt ctgctgggcg cctttcttca tcatccagat gtggtctgtc tgggatccca
     1321 tgtccgtctg gaccgaatcg gaaaacccta ccatcaccat cactgcatta ctgggttcct
     1381 tgaatagctg ctgtaatccc tggatataca tgttttttag tggccatctc cttcaagact
     1441 gtgttcaaag cttcccatgc tgccaaaaca tgaaggaaaa attcaacaaa gaagatactg
     1501 acagtatgag cagaagacag actttttatt ctaacaatcg aagcccaaca aacagtacgg
     1561 gtatgtggaa ggactcgcct aaatcttcca agtccatcaa attcattcct gtttcaactt
     1621 gagccttgca ttcatgcaac ttgattcttg tgattgactt tttggctcat tagctgaatt
     1681 gagctagaaa tcacaagaac aaatacactt tattaatata accataaatc aattcattgt
     1741 gtatgagact gtgtttctag ttgcattttc atattgctac caaaaactag acattatttt
     1801 gtatggaata ttaatggaaa catgctgtac taaaatatgc aggtctgatt cccagaaata
     1861 caacagaagt tatattttta aaggaaaaat cataaccacc ctagctttat attttgttgt
     1921 tagtttcttt tattttcatt tctaacataa gtaagacttg attggtttaa aagtcacata
     1981 aaatgcggca ctatttctga acaaagagag ctcatcatca gtcttaatat tcagagaaaa
     2041 cttcagagaa attatgtttt catccattaa aattaatttg tgcatcagaa aatgcagcct
     2101 taaacagtgt ccaggagatg ggatggtacc tcctaggagt acaagtgcct ggggtgtaat
     2161 gagctcctgc tcattgtggc cagtttagag ttctattaga agctatcaat caccttgcat
     2221 ttcaaaatgg taactttaca actggcagtg gcctcctttt ggttcctcac atattattgg
     2281 tcaagaaaag catgaaaact gagatgctga aggtgagagg aaatgttgac tggccaaaaa
     2341 tatctttttt cccccactgc gaggttgttt taaagtcaga tttgtataag gaaagccaaa
     2401 ttttattaaa agagtagaaa aggattgctt aaggtactct ggactttctc ttggacattg
     2461 taaacgtatt ttgatcagtg ttacaagggt atcctgtgct atgctggaca ttaacaagat
     2521 cattatcttc atgtttgggg aattcagatt cataatatga gtatcctaaa gagtgactca
     2581 ggatataaag tgtcccaaca tgtttaatta aaaatagctt tgtctttcca atctctcact
     2641 catctaacaa ttgcaaagca gagatgagac agggttggga catgggtgac agatggaaag
     2701 agaactgctc tgtgcccaga ctggcttcct tcattattaa atccacaact ttaggcaagt
     2761 ttcttaaaca catataaagc ctctgtttcc ttgacttacc gtggggttga taacacttac
     2821 ctcacagggt tgttgtaagg actaaatgaa atcaaatatg ttaaaagagc ttcagaaata
     2881 gtaaagtact atacacatgc tagcagttgc ttttattata gccttgggat ctccaaaatt
     2941 gcacagatgt tttccagttt atttttcatt aactagaatt ggttcatttc atggctggga
     3001 tataaaatcc taaaatttaa atatagatcg ctgattcatt ggacaacatt tccagtgact
     3061 gctcagcttg acttctcctg cctgactaaa gttttccaat ttaaagacag aacttgcttt
     3121 tctttgaatg caggtagatc aaagccaccc acaagcatca attttttcca tttttaaacg
     3181 gagaccaatt acactacttt gctgttatta catttttcat taatggaact cagtgatttt
     3241 tttcctagct attttgtctg gctgcttctt cttcttagag atcatgcaat gatttgagga
     3301 tacatcataa atattttgca tccttaagag gaagtaatag ttgctttttt tttttttgaa
     3361 acagagtctt gctcttttgc caggctggag tgcagtggcg tgatctcggc tcactgcaac
     3421 ctccgcttcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactata
     3481 tgcatgtgcc accacaccca gctaattttt atatttttag tagagatggg gtttcaccat
     3541 gttggccagc atggttttaa tagtattatt gagtttcttt ttttaccttt gtagataaga
     3601 aaatgagaac tggatagcac tgtgagaacc cggaagcgat aacttcactc ctcttcattc
     3661 ttctgccttt tgaaattctc agcccttagg ctccttgtat tgataggcct aaaaacatgt
     3721 ttccaaatgc tttatagaga ttataaacct agggactccc taggttttca aattcttctt
     3781 tctaaaaata acaaatatgt ctcttaaagg gtactgtcca atataagcca taactaaatt
     3841 aattaattca ttatttgagt tagagtagca tctcagtaac ccagcactcg aagactgtca
     3901 gtccttttaa caactctttg atagttcaaa aactaaagct ttttggtttg gaactaagat
     3961 gaacccattt ttttctaaat ccatttccaa agtaagaacc tcagaaccta tagatcttgc
     4021 ttcaaaatgt tgatatgtac ccccaagcaa aacaattcaa tttgaatgtt atttctgaga
     4081 acagctcaca aaaaaaagtg catatcaccc tacccagttg tattttctcc ttttaaatgt
     4141 attgggagat gagacagtag aaaatgggct ggggaaacat gagatctggg tgctagttct
     4201 gcactaggca aatacatggt cttattctct gcggtttagg ctgagaagtt tcatctgtct
     4261 ggttgctaaa ttttctcaat gttatgtacc cagaaatgga cgccacatat ctcaaaacaa
     4321 tatttcagat tggaaggaat ctacctgcct gtctgtttca gaagaagaga aactgaaaaa
     4381 gtattccggg aagggaagtt ttccttttct tgactaaaga gaagacctga gatattatgc
     4441 caaataacag cttacagtca agaaaaaaat gtgttgcagc accttatttt atttttcaca
     4501 gttaacagtg ggaagatcct gcaagtacac aattttaatg cctctatatg ggtattagga
     4561 atgtgatata taaaaaatgt ccagtaggga gaaactaatc agttgggcat ttgatgaata
     4621 ttaactgatg atggtaaata aacaatttag agtgcattat taagtgctta atgggttaat
     4681 tttggagcat gtattctaaa gtgtaaaact acttggcttt tattttgaaa tttcatttgg
     4741 aacacaattg tgaaggaaat cagtgaaatt cttgggttaa ttatatactt gttttacata
     4801 tagaatttct atcatcatca aacaagtctt atgccatgat ttcgggaagg gtatggtttt
     4861 agagaaaaaa atactaagca gtcttaatga tacacaggac cctgccaagc ttattacagt
     4921 ttctagaatg gacaactact aatgattaag aaacaacttt catctgttat tacacaagaa
     4981 acccgattag gttaaagttt gatgttttca gactctaaag cctatgtttt tgtaacttaa
     5041 ttggactttc agagtgttaa attatggctt cagagtttgg ctctacctaa aatttagtta
     5101 gatgccaacc agggagaaat taaacctaat ccttcacccc aaatatcaga ggttagacaa
     5161 acccatgtta attggagcct tatggttatt catattggag gcaatagctt tatttagagg
     5221 aagcccagga cagggccgtc tgggatgcta gttctggaaa tgcagaagca gccactgtat
     5281 ccctgcccac cccctccatc cagccctttt ggtactactc agtattgttg acaacatttg
     5341 gaatcataag taacatagga cagtaagtat tagagaatga ttctccgtta gaattggacc
     5401 tcagccgatt tgagccaaaa tttaggaact attcagaaga cagtttcttt cttttgagtg
     5461 cttaagacag tgtaaatggt tcgaatcaca cacattttaa gattccattg tatacataag
     5521 cattttaaga atattgtttt aacataatta ttaggcatac taagttatca tgaatgaaaa
     5581 tgtacatgtg acctgtagta tgttatatat tattatggct aaatgttaaa tgccattttt
     5641 ttgcttttta gttttatgta tttttgtatg tatataccca catttttaca ttgatttatg
     5701 ttctaaataa taattaaaac aaagtattat aaaatgaatg aaatattttt gtgttccatg
     5761 gtcaaattat taataaattc aggaaagaaa atctgatgat aaatctgata taaataccag
     5821 aataattatt attaatataa aataatattt tcacatatga aggtatgtct tcatactaca
     5881 ggatttctga cttgaatata ttctataatg ctttaattca ttaccataac aaatgtacta
     5941 agaattaatg ttgcatcttt agtattccat tttttggaac tgtttttcaa atgttctata
     6001 tcctctagct tattatgcta tctaaaataa tttcagtgtg ttttttcctg gggcaactga
     6061 atgattcttg ttttgaatga gtgataaaat gttttgtgat agtatctaat atttggtcct
     6121 ttacagaaaa aatggcttgt ggtactatat tgaaaaaact attgtatttc ctcaatttta
     6181 ctgtgtgttg tcttgtttct ataaacaaaa ataagttttg ga
//
