LOCUS       NM_021732               1375 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens arginine vasopressin induced 1 (AVPI1), mRNA.
ACCESSION   NM_021732
VERSION     NM_021732.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1375)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1375)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1375)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   4  (bases 1 to 1375)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1375)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   6  (bases 1 to 1375)
  AUTHORS   Thomas,C.P., Loftus,R.W. and Liu,K.Z.
  TITLE     AVP-induced VIT32 gene expression in collecting duct cells occurs
            via trans-activation of a CRE in the 5'-flanking region of the
            VIT32 gene
  JOURNAL   Am J Physiol Renal Physiol 287 (3), F460-F468 (2004)
   PUBMED   15140762
REFERENCE   7  (bases 1 to 1375)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   8  (bases 1 to 1375)
  AUTHORS   Nicod,M., Michlig,S., Flahaut,M., Salinas,M., Fowler Jaeger,N.,
            Horisberger,J.D., Rossier,B.C. and Firsov,D.
  TITLE     A novel vasopressin-induced transcript promotes MAP kinase
            activation and ENaC downregulation
  JOURNAL   EMBO J 21 (19), 5109-5117 (2002)
   PUBMED   12356727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355315.18.
            
            On Nov 23, 2018 this sequence version replaced NM_021732.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF131791.1, SRR3476690.110378.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267753 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370626.4/ ENSP00000359660.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AL355315.18        115541-116016       c
            477-773             AL355315.18        108394-108690       c
            774-1375            AL355315.18        106199-106800       c
FEATURES             Location/Qualifiers
     source          1..1375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..1375
                     /gene="AVPI1"
                     /gene_synonym="PP5395; VIP32; VIT32"
                     /note="arginine vasopressin induced 1"
                     /db_xref="GeneID:60370"
                     /db_xref="HGNC:HGNC:30898"
                     /db_xref="MIM:618537"
     exon            1..476
                     /gene="AVPI1"
                     /gene_synonym="PP5395; VIP32; VIT32"
                     /inference="alignment:Splign:2.1.0"
     exon            477..773
                     /gene="AVPI1"
                     /gene_synonym="PP5395; VIP32; VIT32"
                     /inference="alignment:Splign:2.1.0"
     CDS             487..930
                     /gene="AVPI1"
                     /gene_synonym="PP5395; VIP32; VIT32"
                     /note="vasopressin-induced transcript; AVP-induced protein
                     1"
                     /codon_start=1
                     /product="arginine vasopressin-induced protein 1"
                     /protein_id="NP_068378.2"
                     /db_xref="CCDS:CCDS7470.1"
                     /db_xref="GeneID:60370"
                     /db_xref="HGNC:HGNC:30898"
                     /db_xref="MIM:618537"
                     /translation="MGTPASVVSEPPPWQAPIEARGRKQASANIFQDAELLQIQALFQ
                     RSGDQLAEERAQIIWECAGDHRVAEALKRLRRKRPPRQKPLGHSLHHCSRLRILEPHS
                     ALANPQSATETASSEQYLHSRKKSARIRRNWRKSGPTSYLHQIRH"
     exon            774..1375
                     /gene="AVPI1"
                     /gene_synonym="PP5395; VIP32; VIT32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1356..1361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AVPI1"
                     /gene_synonym="PP5395; VIP32; VIT32"
                     /note="hexamer: AATAAA"
     polyA_site      1375
                     /gene="AVPI1"
                     /gene_synonym="PP5395; VIP32; VIT32"
                     /note="major polyA site"
ORIGIN      
        1 atacctggct agggccgagg attggctgtt ccggggctag ggagcgcttt ctcccgggaa
       61 ccgcggctgt gacccaagtg gcccggacca gtttggggct gcgtgcggcc tgcctcaagc
      121 aaccaggtac gtaggtcggc ggcccagctc ggcgctgcgg tgggagccgg agggcgacag
      181 tcagagccgg ggtgccagcg ggacgcgacc gccagatcca cttaggaccc cgtcgttctg
      241 cgaagcggcc acgtctgagt cccggggcct cctcgtgctg cagatgtcgc cttaggacct
      301 cggccaggat accctctgcc atgctcttgt gctgcccgtg atcaccgact ggcccttgta
      361 agcaccttcg cagagctgcg cctgcccttt ctgaaggctg tggaagaggt tggagtgggc
      421 gcatcttagc ttgccccatc cccatttgag gtctgtcgga gctgcccttc agtgtgagca
      481 tccacaatgg gtaccccagc ctcggtggtc agtgagccac ccccttggca ggccccgatt
      541 gaggcccggg gccgcaagca ggcctcggcc aacatcttcc aggacgccga gctgctgcag
      601 atccaagccc tgtttcaacg cagcggggac cagctggccg aggaacgggc acagatcatc
      661 tgggaatgtg caggggacca ccgtgtggct gaggccctca agaggctgcg caggaagagg
      721 cccccaaggc agaaacccct gggccactcg ctacaccact gcagccgcct cagaatcctg
      781 gagccccact ctgcactggc caacccacag agtgccacag agacagcctc cagtgagcag
      841 tatctgcact ctaggaagaa aagtgccagg atccgccgga actggaggaa gtcaggcccc
      901 acaagctacc tccaccagat cagacactga tccagggaaa gagccaggaa tggcagtgtc
      961 ttccctcttg ccaaaaggcc tggggaggtg aaggaagaga gactttaggc aagcagccca
     1021 aaggggtaaa tgaaagcaag aggctgctgc cactgacctg ctccattcag aacaagactg
     1081 gatgcttctg ttgagctctc cattatgtgg gacccattcc tcaccaaaat gaggagagac
     1141 agtgactgtt cctgccacag tccttcccag tctaacacta ttcctgggct gcatgatatt
     1201 cccctgggag caaagtgaca ggcacttaga tgcagcattt caccactcat gctactaatc
     1261 atctacctgc tactactgta aaccatggtt ccagcagcct gttccacacc cccacaccat
     1321 caggatagca cagggaaact gtagtttaag tggcaaataa aaacatttgc atcaa
//
