LOCUS       NM_000490                619 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens arginine vasopressin (AVP), mRNA.
ACCESSION   NM_000490
VERSION     NM_000490.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 619)
  AUTHORS   Bie,P.
  TITLE     Plasma concentrations of peptide hormones: Unrealistic levels of
            vasopressin (AVP), oxytocin (OXT), and brain natriuretic peptide
            (BNP)
  JOURNAL   Acta Physiol (Oxf) 240 (9), e14200 (2024)
   PUBMED   39034759
  REMARK    GeneRIF: Plasma concentrations of peptide hormones: Unrealistic
            levels of vasopressin (AVP), oxytocin (OXT), and brain natriuretic
            peptide (BNP).
            Review article
REFERENCE   2  (bases 1 to 619)
  AUTHORS   Wu,Z., Jiang,H., Yin,Q., Zhang,Z. and Chen,X.
  TITLE     Arginine vasopressin induces ferroptosis to promote heart failure
            via activation of the V1aR/CaN/NFATC3 pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (3), 474-481 (2024)
   PUBMED   38247327
  REMARK    GeneRIF: Arginine vasopressin induces ferroptosis to promote heart
            failure via activation of the V1aR/CaN/NFATC3 pathway.
REFERENCE   3  (bases 1 to 619)
  AUTHORS   El-Raufe El-Masry,S.A., Mahmoud,R.A., Hassan,N.E., Aly,M.M.,
            Abdallah,H.R., Hamdy,S., Megahed,S. and Elalfy,D.Y.
  TITLE     Zonulin and copeptin relation to some metabolic markers in
            school-aged obese children
  JOURNAL   BMC Pediatr 24 (1), 140 (2024)
   PUBMED   38402172
  REMARK    GeneRIF: Zonulin and copeptin relation to some metabolic markers in
            school-aged obese children.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 619)
  AUTHORS   Fahndrich,S., Herr,C., Teuteberg,S., Alter,P., Sohler,S.,
            Soriano,D., Classen,J., Adams,J., Weinhold,V., Watz,H., Waschki,B.,
            Zeller,T., Eichenlaub,M., Trudzinski,F.C., Michels,J.D., Omlor,A.,
            Seiler,F., Moneke,I., Biertz,F., Stolz,D., Welte,T., Kauczor,H.U.,
            Kahnert,K., Jorres,R.A., Vogelmeier,C.F. and Bals,R.
  CONSRTM   German COSYCONET Cohort
  TITLE     Midregional proatrial naturetic peptide (MRproANP) and copeptin
            (COPAVP) as predictors of all-cause mortality in recently diagnosed
            mild to moderate COPD-results from COSYCONET
  JOURNAL   Respir Res 25 (1), 56 (2024)
   PUBMED   38267944
  REMARK    GeneRIF: Midregional proatrial naturetic peptide (MRproANP) and
            copeptin (COPAVP) as predictors of all-cause mortality in recently
            diagnosed mild to moderate COPD-results from COSYCONET.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 619)
  AUTHORS   Szczepanska-Sadowska,E.
  TITLE     Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the
            Heart: Experimental and Clinical Evidence of Altered Interactions
            in Obesity and Diabetes Mellitus
  JOURNAL   Int J Mol Sci 25 (2), 1310 (2024)
   PUBMED   38279313
  REMARK    GeneRIF: Interplay of Angiotensin Peptides, Vasopressin, and
            Insulin in the Heart: Experimental and Clinical Evidence of Altered
            Interactions in Obesity and Diabetes Mellitus.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 619)
  AUTHORS   Bahnsen,U., Oosting,P., Swaab,D.F., Nahke,P., Richter,D. and
            Schmale,H.
  TITLE     A missense mutation in the vasopressin-neurophysin precursor gene
            cosegregates with human autosomal dominant neurohypophyseal
            diabetes insipidus
  JOURNAL   EMBO J 11 (1), 19-23 (1992)
   PUBMED   1740104
REFERENCE   7  (bases 1 to 619)
  AUTHORS   Ito,M., Mori,Y., Oiso,Y. and Saito,H.
  TITLE     A single base substitution in the coding region for neurophysin II
            associated with familial central diabetes insipidus
  JOURNAL   J Clin Invest 87 (2), 725-728 (1991)
   PUBMED   1840604
REFERENCE   8  (bases 1 to 619)
  AUTHORS   Summar,M.L., Phillips,J.A. 3rd, Battey,J., Castiglione,C.M.,
            Kidd,K.K., Maness,K.J., Weiffenbach,B. and Gravius,T.C.
  TITLE     Linkage relationships of human arginine vasopressin-neurophysin-II
            and oxytocin-neurophysin-I to prodynorphin and other loci on
            chromosome 20
  JOURNAL   Mol Endocrinol 4 (6), 947-950 (1990)
   PUBMED   1978246
REFERENCE   9  (bases 1 to 619)
  AUTHORS   Repaske,D.R., Phillips,J.A. 3rd, Kirby,L.T., Tze,W.J.,
            D'Ercole,A.J. and Battey,J.
  TITLE     Molecular analysis of autosomal dominant neurohypophyseal diabetes
            insipidus
  JOURNAL   J Clin Endocrinol Metab 70 (3), 752-757 (1990)
   PUBMED   1968469
REFERENCE   10 (bases 1 to 619)
  AUTHORS   Ganz,M.B., Boyarsky,G., Sterzel,R.B. and Boron,W.F.
  TITLE     Arginine vasopressin enhances pHi regulation in the presence of
            HCO3- by stimulating three acid-base transport systems
  JOURNAL   Nature 337 (6208), 648-651 (1989)
   PUBMED   2521920
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG715518.1 and BC126196.1.
            
            On May 17, 2019 this sequence version replaced NM_000490.4.
            
            Summary: This gene encodes a member of the vasopressin/oxytocin
            family and preproprotein that is proteolytically processed to
            generate multiple protein products. These products include the
            neuropeptide hormone arginine vasopressin, and two other peptides,
            neurophysin 2 and copeptin. Arginine vasopressin is a posterior
            pituitary hormone that is synthesized in the supraoptic nucleus and
            paraventricular nucleus of the hypothalamus. Along with its carrier
            protein, neurophysin 2, it is packaged into neurosecretory vesicles
            and transported axonally to the nerve endings in the
            neurohypophysis where it is either stored or secreted into the
            bloodstream. The precursor is thought to be activated while it is
            being transported along the axon to the posterior pituitary.
            Arginine vasopressin acts as a growth factor by enhancing pH
            regulation through acid-base transport systems. It has a direct
            antidiuretic action on the kidney, and also causes vasoconstriction
            of the peripheral vessels. This hormone can contract smooth muscle
            during parturition and lactation. It is also involved in cognition,
            tolerance, adaptation and complex sexual and maternal behaviour, as
            well as in the regulation of water excretion and cardiovascular
            functions. Mutations in this gene cause autosomal dominant
            neurohypophyseal diabetes insipidus (ADNDI). This gene is present
            in a gene cluster with the related gene oxytocin on chromosome 20.
            [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018062.1, BG715518.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1970526,
                                           SAMEA2142680 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380293.3/ ENSP00000369647.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BG715518.1         6-28
            24-619              BC126196.1         1-596
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..619
                     /gene="AVP"
                     /gene_synonym="ADH; ARVP; AVP-NPII; AVRP; VP"
                     /note="arginine vasopressin"
                     /db_xref="GeneID:551"
                     /db_xref="HGNC:HGNC:894"
                     /db_xref="MIM:192340"
     exon            1..170
                     /gene="AVP"
                     /gene_synonym="ADH; ARVP; AVP-NPII; AVRP; VP"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..545
                     /gene="AVP"
                     /gene_synonym="ADH; ARVP; AVP-NPII; AVRP; VP"
                     /note="vasopressin-neurophysin II-copeptin;
                     neurohypophyseal; antidiuretic hormone;
                     vasopressin-neurophysin 2-copeptin; prepro-AVP-NP II;
                     prepro-arginine-vasopressin-neurophysin II"
                     /codon_start=1
                     /product="vasopressin-neurophysin 2-copeptin
                     preproprotein"
                     /protein_id="NP_000481.2"
                     /db_xref="CCDS:CCDS13045.1"
                     /db_xref="GeneID:551"
                     /db_xref="HGNC:HGNC:894"
                     /db_xref="MIM:192340"
                     /translation="MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPC
                     GPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFG
                     VCCNDESCVTEPECREGFHRRARASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQ
                     PDAY"
     exon            171..372
                     /gene="AVP"
                     /gene_synonym="ADH; ARVP; AVP-NPII; AVRP; VP"
                     /inference="alignment:Splign:2.1.0"
     exon            373..619
                     /gene="AVP"
                     /gene_synonym="ADH; ARVP; AVP-NPII; AVRP; VP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      600..605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AVP"
                     /gene_synonym="ADH; ARVP; AVP-NPII; AVRP; VP"
                     /note="hexamer: AATAAA"
     polyA_site      619
                     /gene="AVP"
                     /gene_synonym="ADH; ARVP; AVP-NPII; AVRP; VP"
                     /note="major polyA site"
ORIGIN      
        1 acagagccac caagcagtgc tgcatacggg gtccacctgt gtgcaccagg atgcctgaca
       61 ccatgctgcc cgcctgcttc ctcggcctac tggccttctc ctccgcgtgc tacttccaga
      121 actgcccgag gggcggcaag agggccatgt ccgacctgga gctgagacag tgcctcccct
      181 gcggccccgg gggcaaaggc cgctgcttcg ggcccagcat ctgctgcgcg gacgagctgg
      241 gctgcttcgt gggcacggct gaggcgctgc gctgccagga ggagaactac ctgccgtcgc
      301 cctgccagtc cggccagaag gcgtgcggga gcgggggccg ctgcgccgcc ttcggcgttt
      361 gctgcaacga cgagagctgc gtgaccgagc ccgagtgccg cgagggcttt caccgccgcg
      421 cccgcgccag cgaccggagc aacgccacgc agctggacgg gccggccggg gccttgctgc
      481 tgcggctggt gcagctggcc ggggcgcccg agcccttcga gcccgcccag cccgacgcct
      541 actgagcccc gcgctcgccc caccggcgcg ctcttcgcgc ccgcccctgc agcacggaca
      601 ataaacctcc gccaatgca
//
