LOCUS       NM_015060               6987 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens AVL9 cell migration associated (AVL9), transcript
            variant 1, mRNA.
ACCESSION   NM_015060 XM_376589 XM_379801
VERSION     NM_015060.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6987)
  AUTHORS   Wei,D., Sun,L. and Feng,W.
  TITLE     hsa_circ_0058357 acts as a ceRNA to promote non-small cell lung
            cancer progression via the hsa-miR-24-3p/AVL9 axis
  JOURNAL   Mol Med Rep 23 (6) (2021)
   PUBMED   33880595
  REMARK    GeneRIF: hsa_circ_0058357 acts as a ceRNA to promote nonsmall cell
            lung cancer progression via the hsamiR243p/AVL9 axis.
REFERENCE   2  (bases 1 to 6987)
  AUTHORS   Liang,J., Sun,T., Wang,G. and Zhang,H.
  TITLE     Clinical significance and functions of miR-203a-3p/AVL9 axis in
            human non-small-cell lung cancer
  JOURNAL   Per Med 17 (4), 271-282 (2020)
   PUBMED   32678693
  REMARK    GeneRIF: Clinical significance and functions of miR-203a-3p/AVL9
            axis in human non-small-cell lung cancer.
REFERENCE   3  (bases 1 to 6987)
  AUTHORS   Linford,A., Yoshimura,S., Nunes Bastos,R., Langemeyer,L.,
            Gerondopoulos,A., Rigden,D.J. and Barr,F.A.
  TITLE     Rab14 and its exchange factor FAM116 link endocytic recycling and
            adherens junction stability in migrating cells
  JOURNAL   Dev Cell 22 (5), 952-966 (2012)
   PUBMED   22595670
REFERENCE   4  (bases 1 to 6987)
  AUTHORS   Harsay,E. and Schekman,R.
  TITLE     Avl9p, a member of a novel protein superfamily, functions in the
            late secretory pathway
  JOURNAL   Mol Biol Cell 18 (4), 1203-1219 (2007)
   PUBMED   17229886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB477229.1, AK090619.1, CN312870.1 and AC018633.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015060.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090619.1, SRR1163657.367014.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318709.9/ ENSP00000315568.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               DB477229.1         64-165
            103-1780            AK090619.1         28-1705
            1781-1962           CN312870.1         368-549
            1963-2428           AK090619.1         1888-2353
            2429-6987           AC018633.2         47755-52313
FEATURES             Location/Qualifiers
     source          1..6987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..6987
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /note="AVL9 cell migration associated"
                     /db_xref="GeneID:23080"
                     /db_xref="HGNC:HGNC:28994"
                     /db_xref="MIM:612927"
     exon            1..314
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2168
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /note="isoform 1 is encoded by transcript variant 1; late
                     secretory pathway protein AVL9 homolog; AVL9 homolog (S.
                     cerevisiase)"
                     /codon_start=1
                     /product="late secretory pathway protein AVL9 homolog
                     isoform 1"
                     /protein_id="NP_055875.1"
                     /db_xref="CCDS:CCDS34613.1"
                     /db_xref="GeneID:23080"
                     /db_xref="HGNC:HGNC:28994"
                     /db_xref="MIM:612927"
                     /translation="MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDG
                     HDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATVFGISCYRQIEAKAL
                     KVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHM
                     NSSLGGASLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGAL
                     MTVLSLFPGMIEHGLSDCSQYRPRKSMSEDGGLQESNPCADDFVSASTADVSHTNLGT
                     IRKVMAGNHGEDAAMKTEEPLFQVEDSSKGQEPNDTNQYLKPPSRPSPDSSESDWETL
                     DPSVLEDPNLKEREQLGSDQTNLFPKDSVPSESLPITVQPQANTGQVVLIPGLISGLE
                     EDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLSDAIVE
                     VEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQ
                     FAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPNHPF
                     QGQYSVSDMKLRFSHSVQNSERGKKIGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTA
                     MSSWLSTFTTSTSQSLTEPPDEKP"
     exon            315..435
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            436..521
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            522..593
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            594..683
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            684..750
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            751..791
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            792..830
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            831..900
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1436
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1571
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1791
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1909
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1963
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2052
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..6987
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2406..2411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /note="hexamer: ATTAAA"
     polyA_site      2435
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /note="major polyA site"
     regulatory      6947..6952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /note="hexamer: AATAAA"
     polyA_site      6972
                     /gene="AVL9"
                     /gene_synonym="KIAA0241"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcaggtg acagcccgga agctgcggaa gcggatgagg gaagggcggc cgtggccctg
       61 ggggcggcgg gagctgcttt gcctccaccg atctccctgt gcggccctca tgtgctgtgc
      121 tcgctgacac ccgaagtccg cggctttccg cacacggtgg ggtcgtcaga cccgctgccc
      181 ttggcggtcg aagtcgtcgt gcgggcccgc ggcggccgcc catggagaag gccaggagag
      241 gcggggatgg cgtcccccgg gggcccgtac tgcacatcgt ggtggtcgga tttcaccaca
      301 agaagggctg ccaggttgaa ttctcttacc cgcccctgat tccaggagat ggacatgaca
      361 gccacacttt acctgaagaa tggaagtatt tgcccttcct tgccttacca gatggcgcac
      421 acaactacca ggaagatact gtgttttttc acttgccacc cagaaatgga aatggagcca
      481 cagtatttgg tatctcttgc tatcgacaaa ttgaagccaa ggcactgaaa gtaaggcaag
      541 cagatatcac cagagagact gttcagaaaa gtgtctgtgt tctaagcaag ctgcctctgt
      601 atggtttact tcaagcaaaa cttcaactca ttacacatgc atattttgaa gagaaggatt
      661 tttcccaaat ttctattcta aaggagcttt atgaacatat gaatagttcc ttgggaggtg
      721 cttcattaga aggatcccaa gtatatcttg gtctgtcacc tcgagatctt gtccttcatt
      781 ttcgacacaa ggtcttaatc ctatttaagc taattcttct tgaaaaaaag gttctttttt
      841 atatttctcc agtgaataaa ttggtgggtg cactgatgac tgtgttatcc ctttttccag
      901 gcatgattga acatggtctc agtgactgtt ctcagtatag accccggaaa agtatgtctg
      961 aagatggtgg gcttcaggaa agtaacccat gtgcagatga ttttgtttct gcatccactg
     1021 ctgatgtttc acataccaac ttgggaacta tcaggaaagt catggcagga aaccatggag
     1081 aagatgctgc catgaagact gaggagcctt tgttccaagt ggaagacagc agcaaagggc
     1141 aggaacccaa tgataccaat caatatttga aacctccatc tcgcccatct ccagattctt
     1201 cagaaagtga ctgggaaact ttggatccta gtgtcttaga ggaccccaac ttgaaagaaa
     1261 gggaacagct gggatcagac cagacaaatt tgtttccaaa ggactctgtc ccctcagaga
     1321 gtcttccaat tactgtacaa cctcaagcta atacgggaca ggtagtcctg ataccagggc
     1381 tcatttcggg tttggaagag gatcagtatg gcatgcccct ggccatcttc acaaagggat
     1441 atctgtgttt gccttacatg gcattgcagc agcatcatct tctctccgat gtcaccgttc
     1501 gggggtttgt tgctggagct actaacatcc tttttcgaca acagaaacac ctcagtgatg
     1561 ccattgtgga agtagaagaa gctctgatcc agatccatga tccagaactc aggaagctgc
     1621 ttaacccaac cactgcagac ctaaggttcg cagactacct agtgaggcac gtgactgaga
     1681 atcgggatga cgtcttccta gatggcacgg gctgggaggg aggtgacgaa tggatccggg
     1741 cccagtttgc ggtctacatt catgccctgc tggctgccac actgcaatta gacaatgaaa
     1801 agatattatc ggactatggg acaacttttg ttacagcatg gaagaatact cacaactaca
     1861 gggtgtggaa cagcaacaag catccagcac ttgcagaaat aaatccaaac catccatttc
     1921 aaggccaata ctcagtatca gacatgaagt taaggttctc acattctgtt cagaatagtg
     1981 aacgtggcaa aaaaattgga aacgtcatgg tcacaactag ccggaatgtt gtacaaacag
     2041 gaaaagctgt tggccagtca gttggaggag ctttttccag tgcaaagaca gctatgtctt
     2101 catggctttc cactttcacc acttccacct cccaaagtct cactgagcca ccagatgaga
     2161 agccttgagc aaggcgtcag aggctgctat tgctttctga ggtttaagtg tcccctgtct
     2221 gtctgctgct cccaggctgt tactagccac agatccacag caggggacca tatgtcgaac
     2281 tgtttacatg gatgttgctc taagtgaatg tttcgggatg ccgaaatgat gaaatcacag
     2341 ccatagcagg gatggctttc caggttgggg tttcaattga ctacttttat ttcagtctga
     2401 gcctgattaa aacatacagt gaaccttcta atgaattttg agttctgata ttgtacattg
     2461 gtttacttta gaagagtttt tacttatgta aattttgttc tgttttggtg tttgaatatc
     2521 tagatggtca ctgtaattta tacttgctaa aattaattta tattaccatt ttctctaaag
     2581 ttggccttaa aacgtgctta taaagtgaag gggtcataca gttgggcctt cattattttg
     2641 ctgaattatg tgatgatttt tttgctttct acccacaaaa catttattaa ttcacttcct
     2701 cccagaaaca tgaaagttag aggtggtagt tctgaggatt gggtgttttg ttttacgttt
     2761 ttagtttgtt ctttccacat ccttaaaaac ttggtttcag acatcaagga gtatcactgt
     2821 gctttcctcc tctttataac tgtgcaggtg ggtgtgcaga gaaatagcag agtgatggtt
     2881 cgatgatact gaagcagttt aacatgaatg tgtctgtagg gcaatacttt caaagaagac
     2941 ctatgtgttt atttttcaac cgcagtcatg ttgcagtctt acaagcactt tttttttatt
     3001 ccagagtttg tgccatctgt ttctcttttt ttttttgggg gggggggggg ggcggggtct
     3061 cactctatcg cccaggctgg agtgcagtgg tgccatctcg gctcactgca acctccatct
     3121 cccgggttca agcaattctt gtacctcagc ctcccaagta gctgggatta tggacatgcg
     3181 ccaccatgcc cagctaatta ttgtattttt agtagagacg gggttttgcc atgttggcca
     3241 ggctggtctt gatctcctgg cctcaagtga tctgcccgcc tcagcctctc aaagtgctgg
     3301 gactacaggc atgagccact gcgcctggcc tgtttctttt ttaaacagtt ttctattggg
     3361 tgtttgcaga cctacagctt ttctcgtagt cttattcata aagcttttca aagcacttag
     3421 tcttctactt ccctaactga aagtcctcct ataatcaatc cctaccccct tctagaagta
     3481 tcttaaaaga aaagcaaggt gattgtaagt attaaataga aatctcatct tagtttatat
     3541 tcagcaaagt aagaggcaag agaagaaaac tgcagccttg acatctgtca tctgagaaag
     3601 gatatctggt ttcatgttag gcacatacat gcatgtgtgt gccatctact gatgatttgt
     3661 acacagctgg acctcgtgtg tttgccatgc tcagctctca tttgcttttc aaggatacct
     3721 gggatggctg ttctcagaga gtacttacgg ggaacagact gccttttagt aacaagggat
     3781 acttgggaaa tacattgtga gtatgatcta tcccagattg ctggggaaat aaaggagggc
     3841 cctgattata tttggtttat tcctcactaa atgtttaaga agtaaatgct cccaaggcat
     3901 ttgaaatgaa catagaaaca taatctaaat gtctctaaat tttccacttt gtgttttcta
     3961 aacacaaatt gtattactca tttgagcata actcaagaat tcagcgatga taaattgaag
     4021 ggctgaatgt gagaactcca ttaattccac ttcttccaag aaagttaacc tcaggaaatg
     4081 ctgtttgaag agaagaaagt agtaccaaac aaaaacctta aacagtactt gaatcttttt
     4141 tgcgctgaga ctataaagaa ttcattctaa catcttgttt cataagggcc acatcattcg
     4201 ttggagcatg atagtgtgat ttgtgtacaa ttgttacctc tcagctgctg aagttcacac
     4261 ttcaaggatc taggagctct gtgaggggtc gtccagcaag atgctgattt gtctttcagt
     4321 tggtatggtt tctgtgatcg gggtaaactc ccgtctccca ctattcaaaa gcagcccaac
     4381 tcatgctttg gaatccactg aaataaaaat agttacatga agtttaactt tgctttaata
     4441 tcacttgttc ctcattgaat atacactttg atcggacttt ctattaacat ttctagctaa
     4501 gagtttgact cttagtggtc actttactga ctttccaaca taaaacaagt atctcagaag
     4561 atacaacttt catcatagaa atggtcaaaa gaccatagct atatttcctt caggttctgg
     4621 gaggtggagt ttttcaagga acactggctg ttgtattgtt ggcaggggcc ccaaggcagc
     4681 tcgcacaatc aaaggcagga agcctcaccc ctggtcctgt gacccccccc ccccacacac
     4741 acacatactt caggcttgga ttctaggctc caagtggcca gcatagaagc agcagcctct
     4801 ctccaaaccc tggctctgtg agccatagga accagcacta ggtcatcttc tgacatagcc
     4861 ctggtgaagg tgtgtgtgtg ttggtggcca cacttgctaa ggcttttgtg tctaagaatt
     4921 gagtatttgt acctaggtgt gagggaacca gggtcagcca gcctttttca gatggcgcca
     4981 ggcacacaca ctacatcaat ggcttgctgg tggcttcacc actatccagg tgacttaaaa
     5041 gagtgtttgg aaaatgtccc tggtatactt caattcctac tagacattgt aatgacaatg
     5101 gtgtaggtaa ggaagagaga gttaaaacta ccagttgtgg aatagaaata gttgcatgtc
     5161 caaagaaggc ttagaatgat tgtgcatatg cagttggctc acataaccag catgaacagt
     5221 ctctccccaa atccattagt gattcactac cccccgccaa gcacagccct aaaacaattc
     5281 tcgtccactt tcctgttaag aaacacagca gcaatatact ttggcagcaa accagagcat
     5341 atgatgtaac ttgctcaacc ttatcttcct ttccaaattc tatactaagc atctgatgtt
     5401 ttttagaata atttcctttg gaaagccaac gagaaaacaa attaggaaga gagagaagtg
     5461 agaaattgtt gcatggctga ggaacaagat gcttaaaatc tgaatggaag tattttgaga
     5521 gcagtatttc atgtgctaag ggttataaga attcttttag aaagggatta gaattttact
     5581 ctgctagtta caagttttaa agtcacgcta cggcattatc accctggcag gtaggttttg
     5641 ttattgtttt acattttgtg aaaaaaagtt ttgtagaagt tacagctagt ggtcttttcc
     5701 ctccagagcc agtgatgagt gtgggagcac ttcagctctg taaggggcca gcgttctgac
     5761 ctttaaccac atgaactaac ctgcgtcagc agttgcagaa agtagcctgt taggacagca
     5821 gctgctaagc gttgcctggt attttagtgg ggagaaggct gggactcttc atggcatcaa
     5881 cacttgcatg ctctgaatct ttgatcagag atgaggtgcc atttttggca tttccacccc
     5941 gtctcgtggt agcctttaaa agtggtagaa gatgctgccc taattccccg aggatgattg
     6001 tcattccatg cagcataatg tgccgtgagg agttttctca ttccagttct ttggacttcg
     6061 taacattgga attgtttttc cataatttcc ggcattccat aaatatttgt caaggacaaa
     6121 gaaaaggaat gtggatgttt attcttttca tatgaatgac tttgtacaca tgacttcctg
     6181 ctttcattat gaaggagggg aaactagttc ccttgtatgg taactccaaa gttaaaaaat
     6241 tgtgcatgtc tgaggggttg aatatatttt gtaaaactct aaatacattt gtatttctgt
     6301 gctgttctaa agtttacctt tttacttata tgaaagataa ctatatattt aaatcatgta
     6361 agtggaacac agtgtagggg gtttttccaa tcttattttt catcaggttc tcacacccac
     6421 gtagtatgct gctcaaattt tttcgtgtgt gcaaatgtga acatttgaac atttcagtta
     6481 ggtactgagc cagaaaaggt aattgaagtt ttcagaaagc ttctgtgctt agaaaatatt
     6541 ttgttgtttt cttaaaatat tagtattttg tagctggaag aataagatca aggcttacat
     6601 gtttcaggcc acttggtcac tggttcctga atttagaaaa cattggatta atgagttggt
     6661 gaaggcattt agtggttaca aaaacagttt aaatatttat gattaaaggc ttttcacaaa
     6721 cctttttaaa gaaaatttag ctgagaaaac ttaaaaagtt ttctaaggaa gtttaactgt
     6781 ggcacatgtt ttgatcagaa aggtagttct ctttgctctg gtagttttaa agtttgtact
     6841 agttctttat ttctgttgtt tttttaaatt gttaaaatta taaatcacgt ctaatcatac
     6901 tgaattgtaa aacttgaatt gtatctttat tttaagcata aatgagaata aaatgatcct
     6961 gttcaccctg cctacagttg gacttga
//
