LOCUS       NM_015570               7469 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens activator of transcription and developmental regulator
            AUTS2 (AUTS2), transcript variant 1, mRNA.
ACCESSION   NM_015570
VERSION     NM_015570.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7469)
  AUTHORS   Geng,Z., Tai,Y.T., Wang,Q. and Gao,Z.
  TITLE     AUTS2 disruption causes neuronal differentiation defects in human
            cerebral organoids through hyperactivation of the WNT/beta-catenin
            pathway
  JOURNAL   Sci Rep 14 (1), 19522 (2024)
   PUBMED   39174599
  REMARK    GeneRIF: AUTS2 disruption causes neuronal differentiation defects
            in human cerebral organoids through hyperactivation of the
            WNT/beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7469)
  AUTHORS   Song,Y., Seward,C.H., Chen,C.Y., LeBlanc,A., Leddy,A.M. and
            Stubbs,L.
  TITLE     Isolated loss of the AUTS2 long isoform, brain-wide or targeted to
            Calbindin-lineage cells, generates a specific suite of brain,
            behavioral, and molecular pathologies
  JOURNAL   Genetics 226 (1) (2024)
   PUBMED   37816306
  REMARK    GeneRIF: Isolated loss of the AUTS2 long isoform, brain-wide or
            targeted to Calbindin-lineage cells, generates a specific suite of
            brain, behavioral, and molecular pathologies.
REFERENCE   3  (bases 1 to 7469)
  AUTHORS   Novotny,A., Plavec,J. and Kocman,V.
  TITLE     Structural polymorphism driven by a register shift in a CGAG-rich
            region found in the promoter of the neurodevelopmental regulator
            AUTS2 gene
  JOURNAL   Nucleic Acids Res 51 (6), 2602-2613 (2023)
   PUBMED   36864756
  REMARK    GeneRIF: Structural polymorphism driven by a register shift in a
            CGAG-rich region found in the promoter of the neurodevelopmental
            regulator AUTS2 gene.
REFERENCE   4  (bases 1 to 7469)
  AUTHORS   Fair,S.R., Schwind,W., Julian,D.L., Biel,A., Guo,G., Rutherford,R.,
            Ramadesikan,S., Westfall,J., Miller,K.E., Kararoudi,M.N.,
            Hickey,S.E., Mosher,T.M., McBride,K.L., Neinast,R., Fitch,J.,
            Lee,D.A., White,P., Wilson,R.K., Bedrosian,T.A., Koboldt,D.C. and
            Hester,M.E.
  TITLE     Cerebral organoids containing an AUTS2 missense variant model
            microcephaly
  JOURNAL   Brain 146 (1), 387-404 (2023)
   PUBMED   35802027
  REMARK    GeneRIF: Cerebral organoids containing an AUTS2 missense variant
            model microcephaly.
REFERENCE   5  (bases 1 to 7469)
  AUTHORS   Oksenberg,N. and Ahituv,N.
  TITLE     The role of AUTS2 in neurodevelopment and human evolution
  JOURNAL   Trends Genet 29 (10), 600-608 (2013)
   PUBMED   24008202
  REMARK    GeneRIF: AUTS2, its discovery, expression, association with autism
            and other neurological and non-neurological traits, implication in
            human evolution, function, regulation, and genetic pathways, are
            reviewed.
            Review article
REFERENCE   6  (bases 1 to 7469)
  AUTHORS   Elia,J., Gai,X., Xie,H.M., Perin,J.C., Geiger,E., Glessner,J.T.,
            D'arcy,M., deBerardinis,R., Frackelton,E., Kim,C., Lantieri,F.,
            Muganga,B.M., Wang,L., Takeda,T., Rappaport,E.F., Grant,S.F.,
            Berrettini,W., Devoto,M., Shaikh,T.H., Hakonarson,H. and White,P.S.
  TITLE     Rare structural variants found in attention-deficit hyperactivity
            disorder are preferentially associated with neurodevelopmental
            genes
  JOURNAL   Mol Psychiatry 15 (6), 637-646 (2010)
   PUBMED   19546859
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Mol Psychiatry. 2010 Nov;15(11):1122]
REFERENCE   7  (bases 1 to 7469)
  AUTHORS   Gratacos,M., Costas,J., de Cid,R., Bayes,M., Gonzalez,J.R.,
            Baca-Garcia,E., de Diego,Y., Fernandez-Aranda,F.,
            Fernandez-Piqueras,J., Guitart,M., Martin-Santos,R., Martorell,L.,
            Menchon,J.M., Roca,M., Saiz-Ruiz,J., Sanjuan,J., Torrens,M.,
            Urretavizcaya,M., Valero,J., Vilella,E., Estivill,X. and
            Carracedo,A.
  CONSRTM   Psychiatric Genetics Network Group
  TITLE     Identification of new putative susceptibility genes for several
            psychiatric disorders by association analysis of regulatory and
            non-synonymous SNPs of 306 genes involved in neurotransmission and
            neurodevelopment
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 150B (6), 808-816 (2009)
   PUBMED   19086053
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7469)
  AUTHORS   Hamshere,M.L., Green,E.K., Jones,I.R., Jones,L., Moskvina,V.,
            Kirov,G., Grozeva,D., Nikolov,I., Vukcevic,D., Caesar,S.,
            Gordon-Smith,K., Fraser,C., Russell,E., Breen,G., St Clair,D.,
            Collier,D.A., Young,A.H., Ferrier,I.N., Farmer,A., McGuffin,P.,
            Holmans,P.A., Owen,M.J., O'Donovan,M.C. and Craddock,N.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genetic utility of broadly defined bipolar schizoaffective disorder
            as a diagnostic concept
  JOURNAL   Br J Psychiatry 195 (1), 23-29 (2009)
   PUBMED   19567891
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 7469)
  AUTHORS   Sultana,R., Yu,C.E., Yu,J., Munson,J., Chen,D., Hua,W., Estes,A.,
            Cortes,F., de la Barra,F., Yu,D., Haider,S.T., Trask,B.J.,
            Green,E.D., Raskind,W.H., Disteche,C.M., Wijsman,E., Dawson,G.,
            Storm,D.R., Schellenberg,G.D. and Villacres,E.C.
  TITLE     Identification of a novel gene on chromosome 7q11.2 interrupted by
            a translocation breakpoint in a pair of autistic twins
  JOURNAL   Genomics 80 (2), 129-134 (2002)
   PUBMED   12160723
REFERENCE   10 (bases 1 to 7469)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006012.2, BC064693.1,
            AF326917.1, AW972135.1, CA450113.1 and AC073873.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_015570.3.
            
            Summary: This gene has been implicated in neurodevelopment and as a
            candidate gene for numerous neurological disorders, including
            autism spectrum disorders, intellectual disability, and
            developmental delay. Mutations in this gene have also been
            associated with non-neurological disorders, such as acute
            lymphoblastic leukemia, aging of the skin, early-onset androgenetic
            alopecia, and certain cancers. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF326917.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342771.10/ ENSP00000344087.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               AC006012.2         90255-90698         c
            445-858             BC064693.1         9-422
            859-6612            AF326917.1         1-5754
            6613-7023           AW972135.1         164-574
            7024-7031           CA450113.1         18-25               c
            7032-7469           AC073873.7         72345-72782
FEATURES             Location/Qualifiers
     source          1..7469
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.22"
     gene            1..7469
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /note="activator of transcription and developmental
                     regulator AUTS2"
                     /db_xref="GeneID:26053"
                     /db_xref="HGNC:HGNC:14262"
                     /db_xref="MIM:607270"
     exon            1..1488
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     CDS             1180..4959
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     autism-related protein 1; autism susceptibility gene 2
                     protein; autism susceptibility candidate 2; AUTS2,
                     activator of transcription and developmental regulator"
                     /codon_start=1
                     /product="autism susceptibility gene 2 protein isoform 1"
                     /protein_id="NP_056385.1"
                     /db_xref="CCDS:CCDS5539.1"
                     /db_xref="GeneID:26053"
                     /db_xref="HGNC:HGNC:14262"
                     /db_xref="MIM:607270"
                     /translation="MDGPTRGHGLRKKRRSRSQRDRERRSRGGLGAGAAGGGGAGRTR
                     ALSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEAL
                     EKDVALKPQERVEKRQTPLTKKKREALTNGLSFHSKKSRLSHPHHYSSDRENDRNLCQ
                     HLGKRKKMPKALRQLKPGQNSCRDSDSESASGESKGFHRSSSRERLSDSSAPSSLGTG
                     YFCDSDSDQEEKASDASSEKLFNTVIVNKDPELGVGTLPEHDSQDAGPIVPKISGLER
                     SQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQP
                     PPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLS
                     AYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQP
                     PAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFLASQSA
                     DRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDK
                     YPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTV
                     PHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGL
                     KPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAH
                     LEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHR
                     TPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPS
                     PAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEG
                     HLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKGEPAYE
                     NPKKSSEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTG
                     IHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRD
                     PLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPRREHERG
                     GHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQ
                     NGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRERPPSHTLKDIEAR"
     exon            1489..1701
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1803
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1839
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1869
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1921
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2393
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2647
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2868
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2913
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3009
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3081
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3111
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3183
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3325
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3403
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3487
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3710
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..7469
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6815..6820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /note="hexamer: ATTAAA"
     polyA_site      6833
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /note="major polyA site"
     regulatory      7013..7018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
                     /note="hexamer: TATAAA"
     polyA_site      7031
                     /gene="AUTS2"
                     /gene_synonym="FBRSL2; MRD26"
ORIGIN      
        1 agtgcccggg ctcccgctgc agccgcccgg ggacacgccg tgcaccctcc ggctcggggc
       61 tttctcggcg gcggcggcgg cagcagcagc agcgttagcg gcggcggcga gagcagcgtt
      121 cccggctgcg cttctccctc aggcggggcg gcgagagaag cggcggcggc ggcggcggca
      181 caccggtgtc tctcccgctg gagatttctt tctgctttcc tcatcgactg actgactcac
      241 cccctccctt ttttgaggaa gggtgacctc ttctctggga ctggaaaaaa tatttttgtg
      301 aggagggggg cgggtggcag cgacagggtt tgcttcttct cttctttcat ctccctctcc
      361 tcccccctcg aagaccgaaa agcaaacccc acaactgctc cagcagcatc ctccttccct
      421 tcctccgcct cccttctcct ccgccgctcg cagtttcgcc ctctcttccg ctaatgattg
      481 cattattatg ctcccctctc tggggggtct cgcccctctt gggtcgctcc ggagccccgg
      541 cctcccctgg ctgcatttct taaaaatttg ggagcctggg agtgagtttt ctccgaggcg
      601 tgtgtgagag gcggcggggg tgttttcctg cgcgaggggc gggtgaagtt cattgccccc
      661 acttttcccg cgaccttttt cggacccgat tttggatcga gttgaggggg gcgcgggcgt
      721 tttcgggggg cggggggcgc ggcggagaat ggccgcgggg agggctcccc ggagcctccc
      781 agtctcttga tcaaagcatt ccgctattct gatttattgc ttgcttggtg agttattttt
      841 ttttcctcta aaggagacct gtgtgttcag ccattacttt gctcggcgct gctcccaggc
      901 atctccgacc ctcggtgctg tggggagccc cacacttggg ctcctcgcct ctcgccctcg
      961 ctccccgtcc ctcctcccct ctctccgccc cttccccctt ttctttctcc tctctttctt
     1021 cccctctctc ccttctttcg gccgccgtct cccccgcgcc ctcctcgggg cggagggaag
     1081 ccgtgaaggg ggagggaggg ctcggtgtca attttttttt gtgtggctgc ggccgtagcc
     1141 tgtggcgggc aagcggggag accccggcgc agcagaacca tggatggccc gacgcggggc
     1201 catggactcc gcaaaaagcg gcggtcgcgg tcgcagcgag accgggagag gcgctcccgg
     1261 ggcgggctgg gggccggcgc ggccggcggc ggcggggctg gccggacccg ggcgctctca
     1321 ctcgcctcgt cgtcgggctc cgacaaggaa gacaatggga agcccccgtc ctccgccccg
     1381 tcccggccca gacccccgcg gaggaagcgg agagagtcca cctcggcaga agaggacatc
     1441 attgatggat ttgccatgac cagctttgtc acttttgaag cgctggagaa agatgtagca
     1501 cttaagcctc aggaacgtgt ggagaaacgc cagacgcccc tgaccaagaa gaaacgagaa
     1561 gcacttacca atggcttgtc ctttcattca aagaagagca gactcagcca cccacaccac
     1621 tacagctcag atcgagaaaa tgaccgcaat ctctgccagc accttgggaa gagaaagaaa
     1681 atgccgaagg cactcagaca gctcaagcca ggacagaaca gctgcaggga cagtgacagt
     1741 gaaagtgcca gtggagaatc caagggcttc caccggagca gctctcggga aaggctcagt
     1801 gatagttcag ctccttccag cttgggaaca ggctacttct gtgacagtga cagtgaccag
     1861 gaagagaagg catcagatgc cagctctgaa aaactcttca acactgttat tgtaaacaaa
     1921 gatccggagt taggtgttgg cacgctacca gaacatgaca gccaggatgc agggccgatt
     1981 gtccccaaga tatcgggtct agagagaagc caggagaaga gccaggactg ttgcaaagag
     2041 ccaatctttg agcctgtggt gcttaaagac ccctgccctc aggtcgcaca gccaataccc
     2101 cagccgcaga cggagcccca actccgagct ccttctccgg accctgactt ggtgcagcgc
     2161 acagaggccc cacctcaacc cccacctctg agtacacagc caccacaggg ccctcctgag
     2221 gcccagctcc agcctgcccc gcagcctcag gtgcagaggc cacccaggcc acagtccccc
     2281 acccagctgc tccatcagaa cctcccacct gtgcaggccc acccctctgc tcagagcctc
     2341 tcccagccat tgtcagccta caacagcagt agcttaagcc tcaacagttt aagcagcagc
     2401 agaagcagca ctccagcgaa gactcagccc gccccacctc acatctccca ccacccctct
     2461 gcctccccgt tccccctctc cctgcccaac cacagccccc tgcacagctt cacacccacc
     2521 ctccagcccc ccgcacactc acatcacccc aatatgtttg cccctcccac tgctctgcct
     2581 cctccaccac cactgacatc aggaagtctg caggtggccg gacacccggc cgggagcact
     2641 tactcagagc aagacatctt gcgacaggaa ctgaacactc gttttttggc ctctcagagt
     2701 gctgaccgcg gggcttccct gggccctccg ccctacctgc ggaccgagtt ccatcagcac
     2761 cagcaccagc accagcacac ccaccagcac acgcaccagc acaccttcac gccgttcccc
     2821 cacgccatcc cacccaccgc catcatgccg acgccagcac ctcccatgtt tgacaaatac
     2881 cctacaaaag ttgacccatt ctaccggcac agtctcttcc attcctatcc tcctgcagtg
     2941 tcgggcatcc cccctatgat cccacccact ggcccttttg gttcactaca aggagcattt
     3001 cagccgaaga catccaaccc tatcgatgtc gctgctcggc ctgggacagt cccacacact
     3061 ttactccaaa aggacccgag gttgacagat cctttcagac ctatgttaag gaaaccaggg
     3121 aagtggtgtg ctatgcatgt tcacatcgcc tggcagattt accaccacca acagaaagtc
     3181 aagaaacaga tgcagtcaga cccacataag ctggactttg gactgaaacc tgagttcctg
     3241 agccgccctc caggccccag tctttttgga gccatccacc acccccatga cctggcacgg
     3301 ccttcaactt tgttctctgc cgctggtgct gcacacccaa ctgggacccc ttttgggcca
     3361 cctcctcatc acagcaactt cctcaaccct gctgcccacc tagagccttt taatcggccg
     3421 tctacattca caggcctagc agcagttggt ggcaatgcct tcgggggact tggaaatcct
     3481 tccgttacac ccaactcaat gttcggccac aaggatggcc ccagtgtgca gaactttagc
     3541 aaccctcacg aaccctggaa ccggctgcac cgaacgcctc cgtcgttccc gacccctccg
     3601 ccctggctga agccagggga gctggagcgc agcgcgtccg ctgcagctca tgacagagat
     3661 agagatgtag ataaacgaga ctcatctgtt agtaaagatg acaaagaaag ggaaagcgtc
     3721 gagaagagac actccagcca cccttcacca gcacctgtcc tcccggtgaa tgccctggga
     3781 catacccgca gctccactga acagatccgg gctcatctga acactgaggc tcgggagaag
     3841 gacaaaccca aagagaggga gagagaccac tcggaatccc gcaaggacct ggccgccgac
     3901 gagcacaagg cgaaagaggg ccacctgccc gagaaggacg ggcacggcca cgaggggcgc
     3961 gccgcgggcg aagaggccaa gcagctggcc cgggtgccgt ctccctacgt gcggaccccg
     4021 gtggtggaga gtgccaggcc caacagcacc tcgagccggg aggccgagcc gcgcaagggt
     4081 gagccggcct acgagaaccc caagaagagc tccgaggtca aggtgaagga ggagcggaag
     4141 gaagaccatg acctgcctcc agaggccccg cagacccacc gggcctcgga gccgccgcct
     4201 cccaactcct cgtccagcgt gcacccgggg cccctggcct cgatgcccat gacggtgggg
     4261 gtgacgggca ttcaccccat gaacagcatc agcagcctgg acaggactcg catgatgacc
     4321 cccttcatgg gcatcagccc cctcccgggc ggagagcgct tcccgtaccc ttctttccac
     4381 tgggacccca tccgggaccc cttgagggat ccttaccgag aacttgacat tcaccggaga
     4441 gacccgctgg gcagggactt cctgctaagg aacgacccgc tccaccggct ctcgactccc
     4501 cggctgtacg aagccgaccg ctccttcagg gaccgggagc ctcacgacta cagccaccac
     4561 caccaccacc accaccaccc gctgtctgtg gaccctcggc gggagcacga gcggggaggc
     4621 cacctggacg agcgggagcg cttgcacatg ctcagagaag actacgagca cacgcggctc
     4681 cactccgtgc accccgcctc cctcgacgga cacctccccc accccagcct catcaccccg
     4741 ggactcccca gcatgcacta tccccgcatc agccccaccg cgggcaacca gaacggactc
     4801 ctcaacaaga cccctccgac agcagcgctg agcgcacctc ccccgctcat ctccacgctg
     4861 gggggccgcc cggtctctcc cagaaggacg actcctctgt ccgcagagat aagggagagg
     4921 cccccttccc acacgctgaa ggatatcgag gcccgataag ccgagaacag gagcaagaac
     4981 gaggaagaag aaaccctagg cagacaccag gccaggcttg agagacagaa ctcctgcatg
     5041 gctcacacag actggggggg aaagccccac cccttcccct tgtaaaaaat gtatagactc
     5101 agtgcacatt ttgaaatgtt ttgtatatta tatgttgaga tttttcagat cttttagccc
     5161 agtcatatgt tctcacgtct cctacttttt gtttctcgta taaaactttt tgatttgaac
     5221 caaaacagtg aagatgacaa cacacaccaa ttggatgata attgtagcgg gggcggtggg
     5281 ggggagaagt ccacgccatc catcatgcaa aattctttca gatgaggtgg gaaggccgtg
     5341 tacatagtta tgtaaaaaga gattgcttca tgagctaatg gttcatatat gcaaaagggt
     5401 aagatgaaag ctttactttg tacaaatgta aatagataaa gtaacataat acattaatac
     5461 ttcttaaaat gtgctatttg caaacttact taatatcagt gaacacagtc ggctaaagct
     5521 gtgttcccat atattgttat agacagctaa acccttcaac tatgcaatga atgttcgggc
     5581 ttttcacaaa agcccgccta actcaaagga gccttttcaa atccatttac agcatactta
     5641 aggtcatatt ttccctgaac aagcgcttac gtgatatgac tctgttttcc ttgcttgttt
     5701 tttttcaaac ggagaaacat cctgttttgc aaattggacc ccaggctgga acttagcatc
     5761 tgaagttgcc gcttgtgggc tctgggggaa agtgtagccc cggagaggta actgaggaca
     5821 tgagcaacca gtgccaggga gggtgggatt tgccagatgc caaaatcagg ggacgggtgg
     5881 tggtgtctgt cagacacaca caggtcgcca gtgacttcac acacacctca tgtgagaacc
     5941 atgccttttt tagtgtgtcc tatttcatac ctgtacacac ttcctcgttt tgtaatgaga
     6001 tttacttaca cccaaacaga tcctgaaaga aagcttcaag ttttctcaga tgatggatat
     6061 gttttcactg tattcaataa ctgacggatg taaggtgcac gtttcctgat gtgacgcact
     6121 gtattccagc tggtgatcaa gtctgggaac agccgtaaca ggtcaacctt gtggagccat
     6181 cgcgagttag agggtgaaag atggcagaaa aaaaagtctt gtgtgtgagt gtgttttttg
     6241 agtttgcatc aatcttaatg tctcttcata atacttttat aatacattaa gcctcttgtc
     6301 tacatatttg gagagaatat gactttacta gcagagaaat acaatatatc ttgtctactg
     6361 gactgtaaaa tatatgtatg aaataaaatt agttccattt ggtcttctag tatattaaag
     6421 tgctatctga cgttgttatc ctgtttttgc aaaaaaaaaa aaaaaaaaaa gttaactaca
     6481 gaccattgtt tctaataagc agagagatct attttagtag taaactgaag gtttagttgt
     6541 gagcttcaga ttttgtgaac tccagatgtt gtgcggtgtt tttttttttt tttaagacaa
     6601 caactaaaaa aaatgcaagg aatatgtaca ctggaactgt agtggtagct ttcagtattg
     6661 taaagagatt gttctatacg gacctttttg ctgtttatcc tgtatgtaat aaagtccttt
     6721 ctagatccta tgtgaaaaga aaagtgaagc aactgaatct tcagcatgtt ctcatcggcg
     6781 gagccttctt gtgtaatgta aactgtgcca tgttattaaa aaatgtgaac taagcttcca
     6841 gctgcttgtt tgtgtgaggt gaccatcatt accttaggga agaagccata cctgtacaag
     6901 accgggctct tgaaaagaaa cacctcgaac ccagcccgtg taagaacaga aggctcacct
     6961 gcagtggctg accaccctac ccaactcggt tagtgtctca ccaatttgtt actataaaca
     7021 tttgcacccc acacagtcgc ttgtggtttg ttttttgagg agggggggtt ctgttagttt
     7081 ttcgtatgtc caagatactg taaaaggtac ttctggattt tgtagacgtg tgtacagtgt
     7141 gggccacgtt agccagttgt ttgtgcctgg ctacttcaaa actcagcgaa agtgtttgct
     7201 tttccagcag tgatgagaat tctgacctag ggcctgtgac aacagttttt gcttgctcgt
     7261 tgtattgcat ttcaatctgt ggactcggtc agtcatatgt tacttaagac cttccagatt
     7321 tttttttcct gtcttagctt tttctctctt ttaattacgt ggtgtagtcc tcatcagttt
     7381 gcagtctccc tgtcctctaa aatctgtttt gtttttttcc atgatgttaa aaaaacaaaa
     7441 aaatgttaaa ttttcttata ccgacctga
//
