LOCUS       NM_001015878            1287 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens aurora kinase C (AURKC), transcript variant 1, mRNA.
ACCESSION   NM_001015878
VERSION     NM_001015878.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1287)
  AUTHORS   Redouane,S., Charoute,H., Harmak,H., Malki,A., Barakat,A. and
            Rouba,H.
  TITLE     Computational study of the potential impact of AURKC missense SNPs
            on AURKC-INCENP interaction and their correlation to
            macrozoospermia
  JOURNAL   J Biomol Struct Dyn 41 (19), 9503-9522 (2023)
   PUBMED   36326488
  REMARK    GeneRIF: Computational study of the potential impact of AURKC
            missense SNPs on AURKC-INCENP interaction and their correlation to
            macrozoospermia.
REFERENCE   2  (bases 1 to 1287)
  AUTHORS   de Castro,C.M.L., Pereira,C.O.B., Aprigio,J., Costa Lima,M.A.,
            Ribeiro,M.G. and Amorim,M.R.
  TITLE     Aurora kinase genetic polymorphisms: an association study in Down
            syndrome and spontaneous abortion
  JOURNAL   Hum Cell 35 (3), 849-855 (2022)
   PUBMED   35218477
  REMARK    GeneRIF: Aurora kinase genetic polymorphisms: an association study
            in Down syndrome and spontaneous abortion.
REFERENCE   3  (bases 1 to 1287)
  AUTHORS   Bejar,J.F., DiSanza,Z. and Quartuccio,S.M.
  TITLE     The oncogenic role of meiosis-specific Aurora kinase C in mitotic
            cells
  JOURNAL   Exp Cell Res 407 (2), 112803 (2021)
   PUBMED   34461108
  REMARK    GeneRIF: The oncogenic role of meiosis-specific Aurora kinase C in
            mitotic cells.
REFERENCE   4  (bases 1 to 1287)
  AUTHORS   Mesic,A., Rogar,M., Hudler,P., Bilalovic,N., Eminovic,I. and
            Komel,R.
  TITLE     Genetic variations in AURORA cell cycle kinases are associated with
            glioblastoma multiforme
  JOURNAL   Sci Rep 11 (1), 17444 (2021)
   PUBMED   34465813
  REMARK    GeneRIF: Genetic variations in AURORA cell cycle kinases are
            associated with glioblastoma multiforme.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1287)
  AUTHORS   Choi,S.H., Yoon,H.S., Yoo,S.A., Yun,S.H., Park,J.H., Han,E.H.,
            Chi,S.G. and Chung,Y.H.
  TITLE     Co-relation with novel phosphorylation sites of IkappaBalpha and
            necroptosis in breast cancer cells
  JOURNAL   BMC Cancer 21 (1), 596 (2021)
   PUBMED   34030642
  REMARK    GeneRIF: Co-relation with novel phosphorylation sites of
            IkappaBalpha and necroptosis in breast cancer cells.
            Erratum:[BMC Cancer. 2021 Nov 11;21(1):1198. doi:
            10.1186/s12885-021-08919-w.. PMID: 34763661]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1287)
  AUTHORS   Clark,A.G., Glanowski,S., Nielsen,R., Thomas,P.D., Kejariwal,A.,
            Todd,M.A., Tanenbaum,D.M., Civello,D., Lu,F., Murphy,B.,
            Ferriera,S., Wang,G., Zheng,X., White,T.J., Sninsky,J.J.,
            Adams,M.D. and Cargill,M.
  TITLE     Inferring nonneutral evolution from human-chimp-mouse orthologous
            gene trios
  JOURNAL   Science 302 (5652), 1960-1963 (2003)
   PUBMED   14671302
REFERENCE   7  (bases 1 to 1287)
  AUTHORS   Katayama,H., Brinkley,W.R. and Sen,S.
  TITLE     The Aurora kinases: role in cell transformation and tumorigenesis
  JOURNAL   Cancer Metastasis Rev 22 (4), 451-464 (2003)
   PUBMED   12884918
  REMARK    Review article
REFERENCE   8  (bases 1 to 1287)
  AUTHORS   Kimura,M., Matsuda,Y., Yoshioka,T. and Okano,Y.
  TITLE     Cell cycle-dependent expression and centrosome localization of a
            third human aurora/Ipl1-related protein kinase, AIK3
  JOURNAL   J Biol Chem 274 (11), 7334-7340 (1999)
   PUBMED   10066797
REFERENCE   9  (bases 1 to 1287)
  AUTHORS   Bernard,M., Sanseau,P., Henry,C., Couturier,A. and Prigent,C.
  TITLE     Cloning of STK13, a third human protein kinase related to
            Drosophila aurora and budding yeast Ipl1 that maps on chromosome
            19q13.3-ter
  JOURNAL   Genomics 53 (3), 406-409 (1998)
   PUBMED   9799611
REFERENCE   10 (bases 1 to 1287)
  AUTHORS   Tseng,T.C., Chen,S.H., Hsu,Y.P. and Tang,T.K.
  TITLE     Protein kinase profile of sperm and eggs: cloning and
            characterization of two novel testis-specific protein kinases
            (AIE1, AIE2) related to yeast and fly chromosome segregation
            regulators
  JOURNAL   DNA Cell Biol 17 (10), 823-833 (1998)
   PUBMED   9809744
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005261.2, AY661554.1 and
            AF054621.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001015878.1.
            
            Summary: This gene encodes a member of the Aurora subfamily of
            serine/threonine protein kinases. The encoded protein is a
            chromosomal passenger protein that forms complexes with Aurora-B
            and inner centromere proteins and may play a role in organizing
            microtubules in relation to centrosome/spindle function during
            mitosis. This gene is overexpressed in several cancer cell lines,
            suggesting an involvement in oncogenic signal transduction.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.261184.1,
                                           SRR5189667.161420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302804.12/ ENSP00000302898.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC005261.2         58799-58835
            38-81               AY661554.1         52-95
            82-550              AF054621.1         50-518
            551-1156            AY661554.1         373-978
            1157-1287           AF054621.1         1125-1255
FEATURES             Location/Qualifiers
     source          1..1287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..1287
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /note="aurora kinase C"
                     /db_xref="GeneID:6795"
                     /db_xref="HGNC:HGNC:11391"
                     /db_xref="MIM:603495"
     exon            1..284
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1156
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine kinase 13 (aurora/IPL1-like);
                     aurora/IPL1-related kinase 3; aurora 3; epididymis
                     secretory protein Li 90; aurora/IPL1/EG2 protein 2;
                     serine/threonine-protein kinase 13; ARK-3; aurora-related
                     kinase 3; serine/threonine-protein kinase aurora-C"
                     /codon_start=1
                     /product="aurora kinase C isoform 1"
                     /protein_id="NP_001015878.1"
                     /db_xref="CCDS:CCDS33128.1"
                     /db_xref="GeneID:6795"
                     /db_xref="HGNC:HGNC:11391"
                     /db_xref="MIM:603495"
                     /translation="MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFE
                     IGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN
                     ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDK
                     KVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDE
                     KVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRY
                     QPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS"
     exon            285..330
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /inference="alignment:Splign:2.1.0"
     exon            331..522
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /inference="alignment:Splign:2.1.0"
     exon            523..661
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /inference="alignment:Splign:2.1.0"
     exon            662..810
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /inference="alignment:Splign:2.1.0"
     exon            811..985
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1287
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1262..1267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /note="hexamer: AATAAA"
     polyA_site      1287
                     /gene="AURKC"
                     /gene_synonym="AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90;
                     SPGF5; STK13"
                     /note="major polyA site"
ORIGIN      
        1 gagcggttgg tgccgggtat aaaagaaggc cgcgcagcca cggctgctca cgacgccgcg
       61 gatcccgaag cctgtgtagc agtgagacat cagtgaggct gcaggacgag caggattgga
      121 agcgccccgg ccagaaagtg accccccacc cctttcagga ccctgtgaac gggaacagcc
      181 atccagaggg ttcaggaagg cgtccgcgcc ctcacctctt ctccccatga gctcccccag
      241 agctgtggtg cagctgggca aagctcaacc tgcaggcgaa gagttggcta cagcaaacca
      301 aacagcccag cagcccagca gcccagccat gcggcgcctc acagtcgatg actttgaaat
      361 cgggcgtccc ctgggcaagg ggaaatttgg gaatgtgtac ctggctcggc tcaaggaaag
      421 ccatttcatt gtggccctga aggttctctt caagtcgcag atagagaagg aaggactgga
      481 gcaccagctg cgccgggaaa ttgagatcca ggctcatcta caacacccca atatcctgcg
      541 cctgtataac tatttccatg atgcacgccg ggtgtacctg attctggaat atgctccaag
      601 gggtgagctc tacaaggagc tgcagaaaag cgagaaatta gatgaacagc gcacagccac
      661 gataatagag gagttggcag atgccctgac ctactgccat gacaagaaag tgattcacag
      721 agatattaag ccagagaacc tgctgctggg gttcaggggt gaggtgaaga ttgcagattt
      781 tggctggtct gtgcacaccc cctccctgag gaggaagaca atgtgtggga cactggacta
      841 cttgccgcca gaaatgattg aggggagaac atatgatgaa aaggtggatt tgtggtgcat
      901 tggagtgctc tgctatgagc tgctggtggg atatccaccc tttgagagcg cctcccacag
      961 tgagacttac agacgcatcc tcaaggtaga tgtgaggttt ccactatcaa tgcctctggg
     1021 ggcccgggac ttgatttcca ggcttctcag ataccagccc ttggagagac tgcccctggc
     1081 ccagatcctg aagcacccct gggttcaggc ccactcccga agggtgctgc ctccctgtgc
     1141 tcagatggct tcctgagccc tgtctgcctc tgttcccttt gtgtgtgttc agggagctct
     1201 cctggctctg ccacctcatt tgtctttatt tttttctctt ttaagatgta agatgctaat
     1261 taataaaagc tgaatcattt catacca
//
