LOCUS       NM_004217               1243 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens aurora kinase B (AURKB), transcript variant 1, mRNA.
ACCESSION   NM_004217
VERSION     NM_004217.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1243)
  AUTHORS   Zhang,T., Liu,S., Durojaye,O., Xiong,F., Fang,Z., Ullah,T., Fu,C.,
            Sun,B., Jiang,H., Xia,P., Wang,Z., Yao,X. and Liu,X.
  TITLE     Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic
            gene reactivation
  JOURNAL   Cell Rep 43 (9), 114739 (2024)
   PUBMED   39276350
  REMARK    GeneRIF: Dynamic phosphorylation of FOXA1 by Aurora B guides
            post-mitotic gene reactivation.
REFERENCE   2  (bases 1 to 1243)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1243)
  AUTHORS   Zhu,G., Luo,L., He,Y., Xiao,Y., Cai,Z., Tong,W., Deng,W., Xie,J.,
            Zhong,Y., Hu,Z. and Shan,R.
  TITLE     AURKB targets DHX9 to promote hepatocellular carcinoma progression
            via PI3K/AKT/mTOR pathway
  JOURNAL   Mol Carcinog 63 (9), 1814-1826 (2024)
   PUBMED   38874176
  REMARK    GeneRIF: AURKB targets DHX9 to promote hepatocellular carcinoma
            progression via PI3K/AKT/mTOR pathway.
REFERENCE   4  (bases 1 to 1243)
  AUTHORS   Li,L., Jiang,P., Hu,W., Zou,F., Li,M., Rao,T., Ruan,Y., Yu,W.,
            Ning,J. and Cheng,F.
  TITLE     AURKB promotes bladder cancer progression by deregulating the p53
            DNA damage response pathway via MAD2L2
  JOURNAL   J Transl Med 22 (1), 295 (2024)
   PUBMED   38515112
  REMARK    GeneRIF: AURKB promotes bladder cancer progression by deregulating
            the p53 DNA damage response pathway via MAD2L2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1243)
  AUTHORS   Sun,G., Ni,K., Shen,J., Liu,D. and Wang,H.
  TITLE     microRNA-486-5p Regulates DNA Damage Inhibition and Cisplatin
            Resistance in Lung Adenocarcinoma by Targeting AURKB
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (4), 13-23 (2024)
   PUBMED   38505869
  REMARK    GeneRIF: microRNA-486-5p Regulates DNA Damage Inhibition and
            Cisplatin Resistance in Lung Adenocarcinoma by Targeting AURKB.
REFERENCE   6  (bases 1 to 1243)
  AUTHORS   Katayama,H., Ota,T., Morita,K., Terada,Y., Suzuki,F., Katoh,O. and
            Tatsuka,M.
  TITLE     Human AIM-1: cDNA cloning and reduced expression during endomitosis
            in megakaryocyte-lineage cells
  JOURNAL   Gene 224 (1-2), 1-7 (1998)
   PUBMED   9931403
REFERENCE   7  (bases 1 to 1243)
  AUTHORS   Li,F., Ambrosini,G., Chu,E.Y., Plescia,J., Tognin,S.,
            Marchisio,P.C. and Altieri,D.C.
  TITLE     Control of apoptosis and mitotic spindle checkpoint by survivin
  JOURNAL   Nature 396 (6711), 580-584 (1998)
   PUBMED   9859993
REFERENCE   8  (bases 1 to 1243)
  AUTHORS   Tatsuka,M., Katayama,H., Ota,T., Tanaka,T., Odashima,S., Suzuki,F.
            and Terada,Y.
  TITLE     Multinuclearity and increased ploidy caused by overexpression of
            the aurora- and Ipl1-like midbody-associated protein mitotic kinase
            in human cancer cells
  JOURNAL   Cancer Res 58 (21), 4811-4816 (1998)
   PUBMED   9809983
REFERENCE   9  (bases 1 to 1243)
  AUTHORS   Shindo,M., Nakano,H., Kuroyanagi,H., Shirasawa,T., Mihara,M.,
            Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Yagita,H. and Okumura,K.
  TITLE     cDNA cloning, expression, subcellular localization, and chromosomal
            assignment of mammalian aurora homologues, aurora-related kinase
            (ARK) 1 and 2
  JOURNAL   Biochem Biophys Res Commun 244 (1), 285-292 (1998)
   PUBMED   9514916
REFERENCE   10 (bases 1 to 1243)
  AUTHORS   Kimura,M., Matsuda,Y., Yoshioka,T., Sumi,N. and Okano,Y.
  TITLE     Identification and characterization of STK12/Aik2: a human gene
            related to aurora of Drosophila and yeast IPL1
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 147-152 (1998)
   PUBMED   9858806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135178.13, BC000442.2 and
            BC009751.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004217.3.
            
            Summary: This gene encodes a member of the aurora kinase subfamily
            of serine/threonine kinases. The genes encoding the other two
            members of this subfamily are located on chromosomes 19 and 20.
            These kinases participate in the regulation of alignment and
            segregation of chromosomes during mitosis and meiosis through
            association with microtubules. A pseudogene of this gene is located
            on chromosome 8. Alternatively spliced transcript variants have
            been found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the predominant isoform (1). Variants 1 and
            4 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.562011.1,
                                           SRR5189652.192222.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585124.6/ ENSP00000463999.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC135178.13        174008-174017
            11-30               BC000442.2         1-20
            31-1243             BC009751.2         1-1213
FEATURES             Location/Qualifiers
     source          1..1243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1243
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /note="aurora kinase B"
                     /db_xref="GeneID:9212"
                     /db_xref="HGNC:HGNC:11390"
                     /db_xref="MIM:604970"
     exon            1..46
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     exon            47..119
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1106
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine kinase 12; aurora-B; aurora-1; aurora
                     kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase
                     2; aurora/IPL1-related kinase 2; serine/threonine-protein
                     kinase aurora-B; aurora- and Ipl1-like midbody-associated
                     protein 1; serine/threonine-protein kinase 5; protein
                     phosphatase 1, regulatory subunit 48;
                     serine/threonine-protein kinase 12; aurora- and Ipl1-like
                     midbody-associated protein 1 homolog"
                     /codon_start=1
                     /product="aurora kinase B isoform 1"
                     /protein_id="NP_004208.2"
                     /db_xref="CCDS:CCDS11134.1"
                     /db_xref="GeneID:9212"
                     /db_xref="HGNC:HGNC:11390"
                     /db_xref="MIM:604970"
                     /translation="MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSR
                     SNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFI
                     VALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRG
                     ELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIAD
                     FGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESA
                     SHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRV
                     LPPSALQSVA"
     exon            120..222
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     exon            223..277
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     exon            278..469
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     exon            470..608
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     exon            609..757
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     exon            758..932
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1243
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1217..1222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /note="hexamer: AATAAA"
     polyA_site      1243
                     /gene="AURKB"
                     /gene_synonym="AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB;
                     aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5"
                     /note="major polyA site"
ORIGIN      
        1 agttgtttgc gggcggccgg gagagtagca gtgccttgga ccccagctct cctccccctt
       61 tctctctaag gatggcccag aaggagaact cctacccctg gccctacggc cgacagacgg
      121 ctccatctgg cctgagcacc ctgccccagc gagtcctccg gaaagagcct gtcaccccat
      181 ctgcacttgt cctcatgagc cgctccaatg tccagcccac agctgcccct ggccagaagg
      241 tgatggagaa tagcagtggg acacccgaca tcttaacgcg gcacttcaca attgatgact
      301 ttgagattgg gcgtcctctg ggcaaaggca agtttggaaa cgtgtacttg gctcgggaga
      361 agaaaagcca tttcatcgtg gcgctcaagg tcctcttcaa gtcccagata gagaaggagg
      421 gcgtggagca tcagctgcgc agagagatcg aaatccaggc ccacctgcac catcccaaca
      481 tcctgcgtct ctacaactat ttttatgacc ggaggaggat ctacttgatt ctagagtatg
      541 ccccccgcgg ggagctctac aaggagctgc agaagagctg cacatttgac gagcagcgaa
      601 cagccacgat catggaggag ttggcagatg ctctaatgta ctgccatggg aagaaggtga
      661 ttcacagaga cataaagcca gaaaatctgc tcttagggct caagggagag ctgaagattg
      721 ctgacttcgg ctggtctgtg catgcgccct ccctgaggag gaagacaatg tgtggcaccc
      781 tggactacct gcccccagag atgattgagg ggcgcatgca caatgagaag gtggatctgt
      841 ggtgcattgg agtgctttgc tatgagctgc tggtggggaa cccacccttt gagagtgcat
      901 cacacaacga gacctatcgc cgcatcgtca aggtggacct aaagttcccc gcttccgtgc
      961 ccatgggagc ccaggacctc atctccaaac tgctcaggca taacccctcg gaacggctgc
     1021 ccctggccca ggtctcagcc cacccttggg tccgggccaa ctctcggagg gtgctgcctc
     1081 cctctgccct tcaatctgtc gcctgatggt ccctgtcatt cactcgggtg cgtgtgtttg
     1141 tatgtctgtg tatgtatagg ggaaagaagg gatccctaac tgttccctta tctgttttct
     1201 acctcctcct ttgtttaata aaggctgaag ctttttgtac tca
//
