LOCUS       NM_017900                753 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens aurora kinase A interacting protein 1 (AURKAIP1),
            transcript variant 1, mRNA.
ACCESSION   NM_017900
VERSION     NM_017900.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 753)
  AUTHORS   Tian,W., Tang,Y., Luo,Y., Xie,J., Zheng,S., Zou,Y., Huang,X.,
            Wu,L., Zhang,J., Sun,Y., Tang,H., Du,W., Li,X. and Xie,X.
  TITLE     AURKAIP1 actuates tumor progression through stabilizing DDX5 in
            triple negative breast cancer
  JOURNAL   Cell Death Dis 14 (12), 790 (2023)
   PUBMED   38040691
  REMARK    GeneRIF: AURKAIP1 actuates tumor progression through stabilizing
            DDX5 in triple negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 753)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 753)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 753)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 753)
  AUTHORS   Lee,S.Y., Kang,M.G., Park,J.S., Lee,G., Ting,A.Y. and Rhee,H.W.
  TITLE     APEX Fingerprinting Reveals the Subcellular Localization of
            Proteins of Interest
  JOURNAL   Cell Rep 15 (8), 1837-1847 (2016)
   PUBMED   27184847
REFERENCE   6  (bases 1 to 753)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 753)
  AUTHORS   Sun,T., Miao,X., Wang,J., Tan,W., Zhou,Y., Yu,C. and Lin,D.
  TITLE     Functional Phe31Ile polymorphism in Aurora A and risk of breast
            carcinoma
  JOURNAL   Carcinogenesis 25 (11), 2225-2230 (2004)
   PUBMED   15271856
  REMARK    GeneRIF: Phe31Ile polymorphism in Aurora A may be a genetic
            modifier for developing breast carcinoma.
REFERENCE   8  (bases 1 to 753)
  AUTHORS   Hirota,T., Kunitoku,N., Sasayama,T., Marumoto,T., Zhang,D.,
            Nitta,M., Hatakeyama,K. and Saya,H.
  TITLE     Aurora-A and an interacting activator, the LIM protein Ajuba, are
            required for mitotic commitment in human cells
  JOURNAL   Cell 114 (5), 585-598 (2003)
   PUBMED   13678582
REFERENCE   9  (bases 1 to 753)
  AUTHORS   Kiat,L.S., Hui,K.M. and Gopalan,G.
  TITLE     Aurora-A kinase interacting protein (AIP), a novel negative
            regulator of human Aurora-A kinase
  JOURNAL   J Biol Chem 277 (47), 45558-45565 (2002)
   PUBMED   12244051
  REMARK    GeneRIF: Results describe the identification of a novel negative
            regulator of Aurora-A, named AIP (Aurora-A kinase Interacting
            Protein).
REFERENCE   10 (bases 1 to 753)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG764236.1 and BC062333.1.
            
            On Jun 2, 2019 this sequence version replaced NM_017900.2.
            
            Transcript Variant: This variant (1) has a 5'UTR resulting from use
            of an alternate splice donor site.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.495123.1,
                                           SRR1163655.22666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150585 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338338.10/ ENSP00000340656.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BG764236.1         105-128
            25-753              BC062333.1         21-749
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..753
                     /gene="AURKAIP1"
                     /gene_synonym="AIP; AKIP; MRP-S38; mS38"
                     /note="aurora kinase A interacting protein 1"
                     /db_xref="GeneID:54998"
                     /db_xref="HGNC:HGNC:24114"
                     /db_xref="MIM:609183"
     exon            1..54
                     /gene="AURKAIP1"
                     /gene_synonym="AIP; AKIP; MRP-S38; mS38"
                     /inference="alignment:Splign:2.1.0"
     exon            55..140
                     /gene="AURKAIP1"
                     /gene_synonym="AIP; AKIP; MRP-S38; mS38"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..688
                     /gene="AURKAIP1"
                     /gene_synonym="AIP; AKIP; MRP-S38; mS38"
                     /note="aurora-A kinase interacting protein; aurora kinase
                     A-interacting protein; AURKA-interacting protein; 28S
                     ribosomal protein S38, mitochondrial; mitochondrial small
                     ribosomal subunit protein mS38"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS38"
                     /protein_id="NP_060370.1"
                     /db_xref="CCDS:CCDS25.1"
                     /db_xref="GeneID:54998"
                     /db_xref="HGNC:HGNC:24114"
                     /db_xref="MIM:609183"
                     /translation="MLLGRLTSQLLRAVPWAGGRPPWPVSGVLGSRVCGPLYSTSPAG
                     PGRAASLPRKGAQLELEEMLVPRKMSVSPLESWLTARCFLPRLDTGTAGTVAPPQSYQ
                     CPPSQIGEGAEQGDEGVADAPQIQCKNVLKIRRRKMNHHKYRKLVKKTRFLRRKVQEG
                     RLRRKQIKFEKDLRRIWLKAGLKEAPEGWQTPKIYLRGK"
     exon            141..586
                     /gene="AURKAIP1"
                     /gene_synonym="AIP; AKIP; MRP-S38; mS38"
                     /inference="alignment:Splign:2.1.0"
     exon            587..753
                     /gene="AURKAIP1"
                     /gene_synonym="AIP; AKIP; MRP-S38; mS38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      733..738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AURKAIP1"
                     /gene_synonym="AIP; AKIP; MRP-S38; mS38"
                     /note="hexamer: AATAAA"
     polyA_site      753
                     /gene="AURKAIP1"
                     /gene_synonym="AIP; AKIP; MRP-S38; mS38"
                     /note="major polyA site"
ORIGIN      
        1 ggaccggaag tgcccgaggg cggccgcaga acggtcaatt tgagccgcgt cgagctcccc
       61 tgggacctgt ggccgccgcc cacagaccat gctcctgggg cgcctgactt cccagctgtt
      121 gagggccgtt ccttgggcag gcggccgccc gccttggccc gtctctggag tgctgggcag
      181 ccgggtctgc gggccccttt acagcacatc gccggccggc ccaggtaggg cggcctctct
      241 ccctcgcaag ggggcccagc tggagctgga ggagatgctg gtccccagga agatgtccgt
      301 cagccccctg gagagctggc tcacggcccg ctgcttcctg cccagactgg ataccgggac
      361 cgcagggact gtggctccac cgcaatccta ccagtgtccg cccagccaga taggggaagg
      421 ggccgagcag ggggatgaag gcgtcgcgga tgcgcctcaa attcagtgca aaaacgtgct
      481 gaagatccgc cggcggaaga tgaaccacca caagtaccgg aagctggtga agaagacgcg
      541 gttcctgcgg aggaaggtcc aggagggacg cctgagacgc aagcagatca agttcgagaa
      601 agacctgagg cgcatctggc tgaaggcggg gctaaaggaa gcccccgaag gctggcagac
      661 ccccaagatc tacctgcggg gcaaatgagt ctggcgccgc ccttcccgcc cgttgctgct
      721 gtgatccgta gtaataaatt ctcagaggac tca
//
