LOCUS       NM_198437               2033 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens aurora kinase A (AURKA), transcript variant 6, mRNA.
ACCESSION   NM_198437
VERSION     NM_198437.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Borah,N.A., Mittal,R., Sucharita,S., Rath,S., Kaliki,S.,
            Patnaik,S., Tripathy,D. and Reddy,M.M.
  TITLE     Aurora Kinase A Is Overexpressed in Human Retinoblastoma and
            Correlates with Histopathologic High-Risk Factors: Implications for
            Targeted Therapy
  JOURNAL   Am J Pathol 194 (9), 1780-1798 (2024)
   PUBMED   38879085
  REMARK    GeneRIF: Aurora Kinase A Is Overexpressed in Human Retinoblastoma
            and Correlates with Histopathologic High-Risk Factors: Implications
            for Targeted Therapy.
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Ingebriktsen,L.M., Humlevik,R.O.C., Svanoe,A.A., Saele,A.K.M.,
            Winge,I., Toska,K., Kalvenes,M.B., Davidsen,B., Heie,A.,
            Knutsvik,G., Askeland,C., Stefansson,I.M., Hoivik,E.A., Akslen,L.A.
            and Wik,E.
  TITLE     Elevated expression of Aurora-A/AURKA in breast cancer associates
            with younger age and aggressive features
  JOURNAL   Breast Cancer Res 26 (1), 126 (2024)
   PUBMED   39198859
  REMARK    GeneRIF: Elevated expression of Aurora-A/AURKA in breast cancer
            associates with younger age and aggressive features.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Hu,Y., Wu,X., Tan,X. and Zhang,J.
  TITLE     Hsa_circRNA_007630 knockdown delays colon cancer progression by
            modulation of ferroptosis via miR-506-3p/AURKA axis
  JOURNAL   J Biochem Mol Toxicol 38 (8), e23771 (2024)
   PUBMED   39015057
  REMARK    GeneRIF: Hsa_circRNA_007630 knockdown delays colon cancer
            progression by modulation of ferroptosis via miR-506-3p/AURKA axis.
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Afghah,Z., Khan,N., Datta,G., Halcrow,P.W., Geiger,J.D. and Chen,X.
  TITLE     Involvement of Endolysosomes and Aurora Kinase A in the Regulation
            of Amyloid beta Protein Levels in Neurons
  JOURNAL   Int J Mol Sci 25 (11), 6200 (2024)
   PUBMED   38892390
  REMARK    GeneRIF: Involvement of Endolysosomes and Aurora Kinase A in the
            Regulation of Amyloid beta Protein Levels in Neurons.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Yang,P., He,S., Ye,L. and Weng,H.
  TITLE     Transcription Factor ETV4 Activates AURKA to Promote PD-L1
            Expression and Mediate Immune Escape in Lung Adenocarcinoma
  JOURNAL   Int Arch Allergy Immunol 185 (9), 910-920 (2024)
   PUBMED   38781935
  REMARK    GeneRIF: Transcription Factor ETV4 Activates AURKA to Promote PD-L1
            Expression and Mediate Immune Escape in Lung Adenocarcinoma.
REFERENCE   6  (bases 1 to 2033)
  AUTHORS   Zhou,H., Kuang,J., Zhong,L., Kuo,W.L., Gray,J.W., Sahin,A.,
            Brinkley,B.R. and Sen,S.
  TITLE     Tumour amplified kinase STK15/BTAK induces centrosome
            amplification, aneuploidy and transformation
  JOURNAL   Nat Genet 20 (2), 189-193 (1998)
   PUBMED   9771714
REFERENCE   7  (bases 1 to 2033)
  AUTHORS   Shindo,M., Nakano,H., Kuroyanagi,H., Shirasawa,T., Mihara,M.,
            Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Yagita,H. and Okumura,K.
  TITLE     cDNA cloning, expression, subcellular localization, and chromosomal
            assignment of mammalian aurora homologues, aurora-related kinase
            (ARK) 1 and 2
  JOURNAL   Biochem Biophys Res Commun 244 (1), 285-292 (1998)
   PUBMED   9514916
REFERENCE   8  (bases 1 to 2033)
  AUTHORS   Kimura,M., Kotani,S., Hattori,T., Sumi,N., Yoshioka,T., Todokoro,K.
            and Okano,Y.
  TITLE     Cell cycle-dependent expression and spindle pole localization of a
            novel human protein kinase, Aik, related to Aurora of Drosophila
            and yeast Ipl1
  JOURNAL   J Biol Chem 272 (21), 13766-13771 (1997)
   PUBMED   9153231
REFERENCE   9  (bases 1 to 2033)
  AUTHORS   Sen,S., Zhou,H. and White,R.A.
  TITLE     A putative serine/threonine kinase encoding gene BTAK on chromosome
            20q13 is amplified and overexpressed in human breast cancer cell
            lines
  JOURNAL   Oncogene 14 (18), 2195-2200 (1997)
   PUBMED   9174055
REFERENCE   10 (bases 1 to 2033)
  AUTHORS   Kimura,M., Matsuda,Y., Eki,T., Yoshioka,T., Okumura,K., Hanaoka,F.
            and Okano,Y.
  TITLE     Assignment of STK6 to human chromosome 20q13.2-->q13.3 and a
            pseudogene STK6P to 1q41-->q42
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 201-203 (1997)
   PUBMED   9605851
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP224535.1, BF029182.1,
            AF008551.1 and AF011468.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_198437.2.
            
            Summary: The protein encoded by this gene is a cell cycle-regulated
            kinase that appears to be involved in microtubule formation and/or
            stabilization at the spindle pole during chromosome segregation.
            The encoded protein is found at the centrosome in interphase cells
            and at the spindle poles in mitosis. This gene may play a role in
            tumor development and progression. A processed pseudogene of this
            gene has been found on chromosome 1, and an unprocessed pseudogene
            has been found on chromosome 10. Multiple transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (6) differs in the 5' UTR compared
            to variant 1. Variants 1-9 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006423.1, SRR11853561.18952.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395915.8/ ENSP00000379251.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BP224535.1         122-128
            8-221               BF029182.1         11-224
            222-793             AF008551.1         169-740
            794-2033            AF011468.1         997-2236
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.2"
     gene            1..2033
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /note="aurora kinase A"
                     /db_xref="GeneID:6790"
                     /db_xref="HGNC:HGNC:11393"
                     /db_xref="MIM:603072"
     exon            1..48
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     exon            49..95
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1265
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 6;
                     aurora/IPL1-like kinase; serine/threonine-protein kinase
                     6; serine/threonine protein kinase 15; aurora/IPL1-related
                     kinase 1; breast tumor-amplified kinase;
                     serine/threonine-protein kinase aurora-A; protein
                     phosphatase 1, regulatory subunit 47; aurora 2"
                     /codon_start=1
                     /product="aurora kinase A isoform 1"
                     /protein_id="NP_940839.1"
                     /db_xref="CCDS:CCDS13451.1"
                     /db_xref="GeneID:6790"
                     /db_xref="HGNC:HGNC:11393"
                     /db_xref="MIM:603072"
                     /translation="MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQA
                     QRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPL
                     PSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILA
                     LKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTV
                     YRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG
                     WSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTY
                     QETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSN
                     CQNKESASKQS"
     exon            96..372
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     exon            373..427
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     exon            428..619
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     exon            620..758
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     exon            759..907
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1082
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..2033
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2014..2019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /note="hexamer: AATAAA"
     polyA_site      2033
                     /gene="AURKA"
                     /gene_synonym="AIK; ARK1; AURA; BTAK; PPP1R47; STK15;
                     STK6; STK7"
                     /note="major polyA site"
ORIGIN      
        1 gaattctaac ggctgagctc ttggaagact tgggtccttg ggtcgcaggc atcatggacc
       61 gatctaaaga aaactgcatt tcaggacctg ttaaggctac agctccagtt ggaggtccaa
      121 aacgtgttct cgtgactcag caatttcctt gtcagaatcc attacctgta aatagtggcc
      181 aggctcagcg ggtcttgtgt ccttcaaatt cttcccagcg cattcctttg caagcacaaa
      241 agcttgtctc cagtcacaag ccggttcaga atcagaagca gaagcaattg caggcaacca
      301 gtgtacctca tcctgtctcc aggccactga ataacaccca aaagagcaag cagcccctgc
      361 catcggcacc tgaaaataat cctgaggagg aactggcatc aaaacagaaa aatgaagaat
      421 caaaaaagag gcagtgggct ttggaagact ttgaaattgg tcgccctctg ggtaaaggaa
      481 agtttggtaa tgtttatttg gcaagagaaa agcaaagcaa gtttattctg gctcttaaag
      541 tgttatttaa agctcagctg gagaaagccg gagtggagca tcagctcaga agagaagtag
      601 aaatacagtc ccaccttcgg catcctaata ttcttagact gtatggttat ttccatgatg
      661 ctaccagagt ctacctaatt ctggaatatg caccacttgg aacagtttat agagaacttc
      721 agaaactttc aaagtttgat gagcagagaa ctgctactta tataacagaa ttggcaaatg
      781 ccctgtctta ctgtcattcg aagagagtta ttcatagaga cattaagcca gagaacttac
      841 ttcttggatc agctggagag cttaaaattg cagattttgg gtggtcagta catgctccat
      901 cttccaggag gaccactctc tgtggcaccc tggactacct gccccctgaa atgattgaag
      961 gtcggatgca tgatgagaag gtggatctct ggagccttgg agttctttgc tatgaatttt
     1021 tagttgggaa gcctcctttt gaggcaaaca cataccaaga gacctacaaa agaatatcac
     1081 gggttgaatt cacattccct gactttgtaa cagagggagc cagggacctc atttcaagac
     1141 tgttgaagca taatcccagc cagaggccaa tgctcagaga agtacttgaa cacccctgga
     1201 tcacagcaaa ttcatcaaaa ccatcaaatt gccaaaacaa agaatcagct agcaaacagt
     1261 cttaggaatc gtgcaggggg agaaatcctt gagccagggc tgccatataa cctgacagga
     1321 acatgctact gaagtttatt ttaccattga ctgctgccct caatctagaa cgctacacaa
     1381 gaaatatttg ttttactcag caggtgtgcc ttaacctccc tattcagaaa gctccacatc
     1441 aataaacatg acactctgaa gtgaaagtag ccacgagaat tgtgctactt atactggttc
     1501 ataatctgga ggcaaggttc gactgcagcc gccccgtcag cctgtgctag gcatggtgtc
     1561 ttcacaggag gcaaatccag agcctggctg tggggaaagt gaccactctg ccctgacccc
     1621 gatcagttaa ggagctgtgc aataaccttc ctagtacctg agtgagtgtg taacttattg
     1681 ggttggcgaa gcctggtaaa gctgttggaa tgagtatgtg attcttttta agtatgaaaa
     1741 taaagatata tgtacagact tgtatttttt ctctggtggc attcctttag gaatgctgtg
     1801 tgtctgtccg gcaccccggt aggcctgatt gggtttctag tcctccttaa ccacttatct
     1861 cccatatgag agtgtgaaaa ataggaacac gtgctctacc tccatttagg gatttgcttg
     1921 ggatacagaa gaggccatgt gtctcagagc tgttaagggc ttattttttt aaaacattgg
     1981 agtcatagca tgtgtgtaaa ctttaaatat gcaaataaat aagtatctat gtc
//
