LOCUS       NM_024037               2161 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens aurora kinase A and ninein interacting protein
            (AUNIP), transcript variant 2, mRNA.
ACCESSION   NM_024037
VERSION     NM_024037.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Yang,Z., Liang,X., Fu,Y., Liu,Y., Zheng,L., Liu,F., Li,T., Yin,X.,
            Qiao,X. and Xu,X.
  TITLE     Identification of AUNIP as a candidate diagnostic and prognostic
            biomarker for oral squamous cell carcinoma
  JOURNAL   EBioMedicine 47, 44-57 (2019)
   PUBMED   31409573
  REMARK    GeneRIF: AUNIP could serve as a candidate diagnostic and prognostic
            biomarker for OSCC and suppression of AUNIP may be a potential
            approach to preventing and treating OSCC.
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Lou,J., Chen,H., Han,J., He,H., Huen,M.S.Y., Feng,X.H., Liu,T. and
            Huang,J.
  TITLE     AUNIP/C1orf135 directs DNA double-strand breaks towards the
            homologous recombination repair pathway
  JOURNAL   Nat Commun 8 (1), 985 (2017)
   PUBMED   29042561
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Lieu,A.S., Cheng,T.S., Chou,C.H., Wu,C.H., Hsu,C.Y., Huang,C.Y.,
            Chang,L.K., Loh,J.K., Chang,C.S., Hsu,C.M., Howng,S.L. and
            Hong,Y.R.
  TITLE     Functional characterization of AIBp, a novel Aurora-A binding
            protein in centrosome structure and spindle formation
  JOURNAL   Int J Oncol 37 (2), 429-436 (2010)
   PUBMED   20596670
  REMARK    GeneRIF: AIBp may not only be required for the dynamic movement of
            Aurora-A at the centrosomes and spindle apparatus during the cell
            cycle, but may also be important during brain tumorigenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BJ989876.1, BC000209.1, AL020996.6 and AI198661.1.
            
            On Jun 2, 2019 this sequence version replaced NM_024037.2.
            
            Transcript Variant: This variant (2) uses an alternate 3' terminal
            exon, compared to variant 1. It encodes isoform 2 which is shorter
            and has a distinct C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1283161.1, AK024326.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMN03568911
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374298.4/ ENSP00000363416.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BJ989876.1         11-55
            46-1342             BC000209.1         1-1297
            1343-1753           AL020996.6         4668-5078
            1754-2161           AI198661.1         17-424              c
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..2161
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
                     /note="aurora kinase A and ninein interacting protein"
                     /db_xref="GeneID:79000"
                     /db_xref="HGNC:HGNC:28363"
                     /db_xref="MIM:620397"
     exon            1..178
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1174
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
                     /note="isoform 2 is encoded by transcript variant 2;
                     aurora A-binding protein"
                     /codon_start=1
                     /product="aurora kinase A- and ninein-interacting protein
                     isoform 2"
                     /protein_id="NP_076942.1"
                     /db_xref="CCDS:CCDS266.1"
                     /db_xref="GeneID:79000"
                     /db_xref="HGNC:HGNC:28363"
                     /db_xref="MIM:620397"
                     /translation="MRRTGPEEEACGVWLDAAALKRRKVQTHLIKPGTKMLTLLPGER
                     KANIYFTQRRAPSTGIHQRSIASFFTLQPGKTNGSDQKSVSSHTESQINKESKKNATQ
                     LDHLIPGLAHDCMASPLATSTTADIQEAGLSPQSLQTSGHHRMKTPFSTELSLLQPDT
                     PDCAGDSHTPLAFSFTEDLESSCLLDRKEEKGDSARKWEWLHESKKNYQSMEKHTKLP
                     GDKCCQPLGKTKLERKVSAKENRQAPVLLQTYRESWNGENIESVKQSRSPVSVFSWDN
                     EKNDKDSWSQLFTEDSQGQRVIAHNTRAPFQDVTNNWNWDLGPFPNSPWAQCQEDGPT
                     QNLKPDLLFTQDSEGNQVIRHQF"
     exon            179..320
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
                     /inference="alignment:Splign:2.1.0"
     exon            321..2161
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
                     /note="hexamer: AATAAA"
     polyA_site      1342
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
                     /note="major polyA site"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
                     /note="hexamer: AATAAA"
     polyA_site      2161
                     /gene="AUNIP"
                     /gene_synonym="AIBP; C1orf135"
ORIGIN      
        1 gttggcgcga gatccgaacg tcggcggccg cggttctggc gttccctgag gcgccgggag
       61 cctgcgccgg cgtcctgccg gcttcgtctc ctcagcggcc atgaggcgga caggccccga
      121 ggaggaggcc tgcggcgtgt ggctggacgc ggcggcgctg aagaggcgga aagtgcagac
      181 acatttaatc aaaccaggca ccaaaatgct aacactcctt cctggagaaa gaaaggctaa
      241 tatttatttt actcaaagaa gagctccatc tacaggcatt caccagagaa gcattgcttc
      301 cttcttcacc ttgcagccag gaaagacaaa tggcagtgac cagaagagtg tttcatctca
      361 tacagaaagt cagatcaaca aagagtccaa gaaaaatgcg acccagctag accatttgat
      421 cccaggctta gcacacgatt gcatggcatc ccctttagcc acttcaacca ctgcagacat
      481 ccaggaagct ggactctctc ctcagtccct ccagacttct ggccaccaca gaatgaaaac
      541 cccattttca actgagctat ctttgctcca gcctgatact ccagactgtg ctggagatag
      601 tcatacccca ctggcttttt ccttcaccga ggacttggaa agttcttgtt tgctagaccg
      661 aaaggaagaa aaaggggatt ctgccaggaa atgggaatgg cttcatgagt ctaagaagaa
      721 ctatcagagt atggagaaac acaccaaact acctggggac aaatgctgtc agcccttagg
      781 caagactaaa ttggaaagaa aggtgtctgc caaagaaaac aggcaggccc ctgtcctcct
      841 tcaaacatac agggaatcct ggaatggaga aaacatagaa tcagtgaaac aaagccgtag
      901 tccagtttct gtgttttcct gggacaatga aaagaatgac aaggactcct ggagtcaact
      961 tttcactgaa gattctcaag gccagcgggt cattgcccac aacactagag ctccttttca
     1021 agatgtaacc aataactgga attgggactt agggccgttt cctaacagtc cttgggctca
     1081 gtgccaggag gatgggccaa ctcaaaatct gaagcctgat ttgctcttta cccaggactc
     1141 tgaaggtaat caagttatca gacaccaatt ctaaatgttt gaagctttgt ttctaaaagt
     1201 accttgaaat gatagagatg taggaaaata tagttgtggg tggagagagg agtgagtttg
     1261 tttaggtggg aaggtggcat gggatgaagt tgtcattact gagcatcttc tctgtgtaaa
     1321 taaagggcag taccattgtt aagacagtgg gattggcatc atggctttcc ctcaggaagg
     1381 tggtggctgg taaattccct gaatgagtct atgatgaaca ctgaggcagc acagtgggta
     1441 tttatctcta tgaaagtgcc ttttactcag cctgcacaga gccatctctt tgcccttcca
     1501 gatgtctgac tgggaccttg cttatggatg tgtttttttt tttttttttt tgagatggag
     1561 tctcgctctg ttgccaggct ggagtgcagt ggtgcgacct cagctcactg caccctctgt
     1621 ctcccggatt caagcgattc tcctgcctca gcctcccgaa tagcagggac tacaggcatg
     1681 cgccaccacg cccagctaat tttttttgga tttttagtag agacgaggtt tcaccatatt
     1741 agccaggatg gtctccatct cctgacctcc tgatccgccc acctcagcct cccaaagtgc
     1801 tgagattaca ggcataagcc accgcgccca gccagatgtg tgagctttta atctctggct
     1861 gatcttaacc cacatcagcc taagcttggg atgattactc ttgacccttt tttttcagtg
     1921 attagcaaat ctccccacaa cccaggtgtg gagagaagag aggtagaatg gtgctagttt
     1981 cctattttat ttttgtggta actgtacagc actttaaagt tatatactct atgtttaaat
     2041 atctccctta aaaagcctga gctgtacaac aatctggatg tgactctgtt acccttttcc
     2101 cacaagatag gagggaatcc cctttgtaaa actatgaatc caaataaatg tttacaaagt
     2161 g
//
