LOCUS       NM_001377405            7076 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ataxin 7 (ATXN7), transcript variant 4, mRNA.
ACCESSION   NM_001377405
VERSION     NM_001377405.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7076)
  AUTHORS   Zhou,C., Li,W., Liang,Z., Wu,X., Cheng,S., Peng,J., Zeng,K., Li,W.,
            Lan,P., Yang,X., Xiong,L., Zeng,Z., Zheng,X., Huang,L., Fan,W.,
            Liu,Z., Xing,Y., Kang,L. and Liu,H.
  TITLE     Mutant KRAS-activated circATXN7 fosters tumor immunoescape by
            sensitizing tumor-specific T cells to activation-induced cell death
  JOURNAL   Nat Commun 15 (1), 499 (2024)
   PUBMED   38216551
  REMARK    GeneRIF: Mutant KRAS-activated circATXN7 fosters tumor immunoescape
            by sensitizing tumor-specific T cells to activation-induced cell
            death.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7076)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 7076)
  AUTHORS   Zou,X., Yao,F., Li,F., Wu,S., Li,H., Sun,Z., Zhu,T., Wei,X., Li,D.
            and Sui,R.
  TITLE     Clinical characterization and the improved molecular diagnosis of
            autosomal dominant cone-rod dystrophy in patients with SCA7
  JOURNAL   Mol Vis 27, 221-232 (2021)
   PUBMED   34012225
  REMARK    GeneRIF: Clinical characterization and the improved molecular
            diagnosis of autosomal dominant cone-rod dystrophy in patients with
            SCA7.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7076)
  AUTHORS   Niss,F., Zaidi,W., Hallberg,E. and Strom,A.L.
  TITLE     Polyglutamine expanded Ataxin-7 induces DNA damage and alters FUS
            localization and function
  JOURNAL   Mol Cell Neurosci 110, 103584 (2021)
   PUBMED   33338633
  REMARK    GeneRIF: Polyglutamine expanded Ataxin-7 induces DNA damage and
            alters FUS localization and function.
REFERENCE   5  (bases 1 to 7076)
  AUTHORS   Einum,D.D., Clark,A.M., Townsend,J.J., Ptacek,L.J. and Fu,Y.H.
  TITLE     A novel central nervous system-enriched spinocerebellar ataxia type
            7 gene product
  JOURNAL   Arch Neurol 60 (1), 97-103 (2003)
   PUBMED   12533095
  REMARK    GeneRIF: identification of a novel ataxin-7 protein enriched in the
            central nervous system suggests that expression of multiple
            polyglutamine-containing proteins may play a role in the
            neurodegeneration patterns characteristic of SCA7
REFERENCE   6  (bases 1 to 7076)
  AUTHORS   David,G., Abbas,N., Stevanin,G., Durr,A., Yvert,G., Cancel,G.,
            Weber,C., Imbert,G., Saudou,F., Antoniou,E., Drabkin,H.,
            Gemmill,R., Giunti,P., Benomar,A., Wood,N., Ruberg,M., Agid,Y.,
            Mandel,J.L. and Brice,A.
  TITLE     Cloning of the SCA7 gene reveals a highly unstable CAG repeat
            expansion
  JOURNAL   Nat Genet 17 (1), 65-70 (1997)
   PUBMED   9288099
REFERENCE   7  (bases 1 to 7076)
  AUTHORS   Benomar,A., Krols,L., Stevanin,G., Cancel,G., LeGuern,E., David,G.,
            Ouhabi,H., Martin,J.J., Durr,A., Zaim,A. et al.
  TITLE     The gene for autosomal dominant cerebellar ataxia with pigmentary
            macular dystrophy maps to chromosome 3p12-p21.1
  JOURNAL   Nat Genet 10 (1), 84-88 (1995)
   PUBMED   7647798
REFERENCE   8  (bases 1 to 7076)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   9  (bases 1 to 7076)
  AUTHORS   La Spada,A.R.
  TITLE     Spinocerebellar Ataxia Type 7
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301433
REFERENCE   10 (bases 1 to 7076)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104162.2 and AC012557.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The autosomal dominant cerebellar ataxias (ADCA) are a
            heterogeneous group of neurodegenerative disorders characterized by
            progressive degeneration of the cerebellum, brain stem and spinal
            cord. Clinically, ADCA has been divided into three groups: ADCA
            types I-III. ADCAI is genetically heterogeneous, with five genetic
            loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6,
            being assigned to five different chromosomes. ADCAII, which always
            presents with retinal degeneration (SCA7), and ADCAIII often
            referred to as the 'pure' cerebellar syndrome (SCA5), are most
            likely homogeneous disorders. Several SCA genes have been cloned
            and shown to contain CAG repeats in their coding regions. ADCA is
            caused by the expansion of the CAG repeats, producing an elongated
            polyglutamine tract in the corresponding protein. The expanded
            repeats are variable in size and unstable, usually increasing in
            size when transmitted to successive generations. This locus has
            been mapped to chromosome 3, and it has been determined that the
            diseased allele associated with spinocerebellar ataxia-7 contains
            37-306 CAG repeats (near the N-terminus), compared to 4-35 in the
            normal allele. The encoded protein is a component of the
            SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free
            TAF-containing (TFTC) chromatin remodeling complexes, and it thus
            plays a role in transcriptional regulation. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038191.1291204.1, SRR14038194.72477.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968540, SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674280.1/ ENSP00000501377.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AC104162.2         37308-37599         c
            293-391             AC104162.2         2969-3067           c
            392-727             AC012557.23        69789-70124
            728-796             AC012557.23        70358-70426
            797-901             AC012557.23        109580-109684
            902-1154            AC012557.23        137116-137368
            1155-1414           AC012557.23        139387-139646
            1415-1497           AC012557.23        140140-140222
            1498-1763           AC012557.23        145260-145525
            1764-1962           AC012557.23        147377-147575
            1963-2084           AC012557.23        147939-148060
            2085-3063           AC012557.23        152706-153684
            3064-7076           AC012557.23        156651-160663
FEATURES             Location/Qualifiers
     source          1..7076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..7076
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /note="ataxin 7"
                     /db_xref="GeneID:6314"
                     /db_xref="HGNC:HGNC:10560"
                     /db_xref="MIM:607640"
     exon            1..292
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            293..391
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            392..727
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..3081
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /note="isoform a is encoded by transcript variant 4;
                     spinocerebellar ataxia type 7 protein; Autosomal dominant
                     cerebellar ataxia with retinal degeneration; SAGA
                     associated factor 73 kDa homolog"
                     /codon_start=1
                     /product="ataxin-7 isoform a"
                     /protein_id="NP_001364334.1"
                     /db_xref="CCDS:CCDS43102.1"
                     /db_xref="GeneID:6314"
                     /db_xref="HGNC:HGNC:10560"
                     /db_xref="MIM:607640"
                     /translation="MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQ
                     PQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVMLGQSWNLWVEAS
                     KLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQ
                     AFQSHYERRHSSSSKPPLAVPPTSVFSFFPSLSKSKGGSASGSNRSSSGGVLSASSSS
                     SKLLKSPKEKLQLRGNTRPMHPIQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGP
                     TCPATVSSLVKPGLNCPSIPKPTLPSPGQILNGKGLPAPPTLEKKPEDNSNNRKFLNK
                     RLSEREFDPDIHCGVIDLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNK
                     TREKELIRHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTP
                     SLPRPPGCPAQQGGSAPIDPPPVHESPHPPLPATEPASRLSSEEGEGDDKEESVEKLD
                     CHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEKHLNAQLWKKIPPV
                     PSTTSPISTRIPHRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTT
                     LNAQPAASGAMDPVCSMQSRQVSSSSSSPSTPSGLSSVPSSPMSRKPQKLKSSKSLRP
                     KESSGNSTNCQNASSSTSGGSGKKRKNSSPLLVHSSSSSSSSSSSSHSMESFRKNCVA
                     HSGPPYPSTVTSSHSIGLNCVTNKANAVNVRHDQSGRGPPTGSPAESIKRMSVMVNSS
                     DSTLSLGPFIHQSNELPVNSHGSFSHSHTPLDKLIGKKRKCSPSSSSINNSSSKPTKV
                     AKVPAVNNVHMKHTGTIPGAQGLMNSSLLHQPKARP"
     exon            728..796
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            797..901
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1154
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1414
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1497
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1763
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1962
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2084
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..3063
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..7076
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5857..5862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /note="hexamer: AGTAAA"
     polyA_site      5875
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /note="major polyA site"
     regulatory      7046..7051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /note="hexamer: AATAAA"
     regulatory      7051..7056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /note="hexamer: AATAAT"
     polyA_site      7066
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /note="major polyA site"
     polyA_site      7076
                     /gene="ATXN7"
                     /gene_synonym="ADCAII; OPCA3; SCA7; SGF73"
                     /note="major polyA site"
ORIGIN      
        1 acaatgcagc cgggtaaaca gccatggagg aggaggcggc ggcgcccgcg gccgcctgct
       61 ccgacgcctg agccgcgccg cgccgcgccg ccgccgccgc cgccgccgcc gcgggacccg
      121 cgctccccgc gctcccggta ctccccgggg gcggccgcgg ccggcgcgag ttggggcgag
      181 gcttggcggc cggcggcggc cccggctgca gcccgggctc ccgccgcccc ccttgcagcc
      241 cccgcccggc ccacgcccag aggccgcccc ggaggccgca gccagccgcc agatctgaac
      301 agaattaaga cgaacgagct ttcacaattg cagcagatga agatccattg gtaaattgat
      361 caggattttt ggcctaccct ccaaagaaaa ggagcggaaa gaatgtcgga gcgggccgcg
      421 gatgacgtca ggggggagcc gcgccgcgcg gcggcggcgg cgggcggagc agcggccgcg
      481 gccgcccggc agcagcagca gcagcagcag cagcagcagc cgccgcctcc gcagccccag
      541 cggcagcagc acccgccacc gccgccacgg cgcacacggc cggaggacgg cgggcccggc
      601 gccgcctcca cctcggccgc cgcaatggcg acggtcgggg agcgcaggcc tctgcccagt
      661 cctgaagtga tgctgggaca gtcgtggaat ctgtgggttg aggcttccaa acttcctggg
      721 aaggacggga cagaattgga cgaaagtttc aaggagtttg ggaaaaaccg cgaagtcatg
      781 gggctctgtc gggaagacat gccaatattt ggtttctgtc cagcccatga tgatttctac
      841 ttggtggtgt gtaacgactg taatcaggtt gtcaaaccgc aggcatttca atcacattat
      901 gaaagaagac atagctcatc cagcaagccg cctttggccg ttcctcccac ttcagtattt
      961 tccttcttcc cttctctgtc caaaagcaaa ggaggcagtg caagtggaag caaccgttct
     1021 tccagtggag gtgttcttag cgcatcctca tcaagttcca agttgttgaa atcacccaaa
     1081 gagaaactgc agctcagggg gaacaccagg ccaatgcatc ccattcagca aagtagagtt
     1141 ccccatggta gaatcatgac accctctgtg aaagtggaaa agattcatcc gaaaatggat
     1201 ggcacactac tgaaatctgc ggtggggcca acctgtcctg ctactgtgag ttccttagtc
     1261 aagcctggcc ttaactgccc ctcaatacca aagccaacct tgccttcacc tggacagatt
     1321 ctgaatggca aagggcttcc tgcaccgccc actctggaaa agaaacctga agacaattcc
     1381 aataatagga aatttttaaa taagagatta tcagaaagag agtttgatcc tgacatccac
     1441 tgtggggtta ttgatctcga caccaagaag ccctgcaccc ggtctttgac atgcaagaca
     1501 cattccttaa cccagcgcag ggctgtccag ggtagaagaa aacgatttga tgtgttatta
     1561 gccgagcaca aaaacaaaac cagggaaaag gaattgattc gccatccgga ctctcagcaa
     1621 ccaccgcagc ctctcaggga cccgcatccc gcccctccta gaacgtcaca ggagccgcac
     1681 caaaaccctc acggagtgat tccttccgaa tcaaagcctt ttgtagctag taaacctaaa
     1741 cctcacaccc ccagtcttcc aaggcctcca ggctgccctg ctcagcaagg tgggagtgcc
     1801 cccattgacc ctcctccagt ccatgaatct ccacaccctc ccctgcctgc cactgagcca
     1861 gcttctcggt tatccagtga ggagggcgaa ggcgatgaca aagaagagtc tgttgaaaaa
     1921 ctggactgtc attattcagg tcatcatcct cagccagcat ctttttgcac atttgggagc
     1981 cggcagatag gaagaggcta ttacgtgttt gactccaggt ggaatcgact tcgctgcgcc
     2041 ctcaacctca tggtggagaa gcatctgaat gcacagctat ggaagaaaat cccaccagtg
     2101 cccagtacca cctcacccat ctccacacgt attcctcacc ggacaaactc tgtgccgaca
     2161 tcacaatgtg gagtcagcta tctggcagca gccaccgtct ctacatcccc agtcctgctc
     2221 tcatctacct gcatctcccc aaatagcaaa tcggtaccag ctcatggaac cacactaaat
     2281 gcacagcctg ctgcttcagg ggcgatggat cctgtgtgca gtatgcaatc cagacaagtg
     2341 tcctcttcat cctcatcccc ttccacgccc tctggccttt cctcggttcc ttcctccccc
     2401 atgtccagga aacctcagaa attgaaatcc agcaaatctt tgaggcccaa ggagtcttct
     2461 ggtaacagca ctaactgtca aaatgccagt agcagtacca gtggcggctc aggaaagaaa
     2521 cgcaaaaaca gttccccact gttggttcac tcttcctcct cctcttcctc ctcctcctct
     2581 tcttctcatt ccatggagtc ttttaggaaa aactgtgtgg ctcactctgg gcctccctac
     2641 ccctcaacgg taacatcttc ccatagcatc ggcctcaact gtgtgacgaa taaagcaaat
     2701 gcggtgaacg tccggcatga ccagtcaggg aggggccccc ccaccgggag ccctgctgaa
     2761 tccatcaaga ggatgagtgt gatggtgaac agcagtgatt ctactctttc tcttgggcca
     2821 ttcattcacc agtccaatga actgcctgtc aactcccacg gcagtttttc ccactcacac
     2881 actcctctag acaaactcat aggaaagaaa agaaagtgct cacccagctc gagcagcatc
     2941 aacaacagca gcagcaaacc cacaaaggtt gccaaagtgc cagccgtgaa caatgtccac
     3001 atgaaacaca caggcaccat cccaggggca caaggactga tgaacagttc cctccttcat
     3061 cagccaaagg cacgtccctg acagctgaaa atagcacggg gaggaataat gcggacactt
     3121 ttgaggacaa gttacacctc cactcagcac tctggactcc acgatgcctt tgagtctgtt
     3181 ttcccaacct cctgtgggcc tcaagggtag aaacctgccg ggctgttgtt ttaacgagga
     3241 tttccctgaa gctatgtctc tagcagtgag tactcataaa ggacactgga tcaagttcag
     3301 ccaccgaatt gcttttatca gtgttaaagt ggtctgaact gcttgctacc aatctgtgag
     3361 aagtttttgt ttttgttttg ttttttaact tgcagtatat cacagagcca ctcttcaagt
     3421 agattggctg ggcaaaagaa tgttttggca agagcgttac tgtagacctt tctccctcct
     3481 tccttttact accatttttt tttaacactg tcatctgtag gtcactctcc agcagttagg
     3541 caccttaact ggagaccaga aaccttccag agaacacagg gctgcatccc gagcaaccct
     3601 ctgaagaagg gaattaggct ttagattttg atagcaatgt tccaggaatg aaatatagat
     3661 gttagcccaa gacaccatga caaaatagcc cagccttttg agagtaattt gggaaaagaa
     3721 gctgtcagaa gtttctaact tacaaactgg tttgaaattt ttgatgccca gacagcaagt
     3781 ataaatcatt ttggaggctt acttttcatg atacaaaagc aattctgtgt gatttttttt
     3841 tttaagaaga aagaaaatgc aagctagttt tgagaaagga aggccaaatt gggtcggggg
     3901 agggtgggag tgaggaagtt aaaatcacta tagggagaaa aaactttttt caagatttcc
     3961 aaagagatga aattttctta atccttttaa gttttcatag taaacagtat ggcagattgg
     4021 gttggttgtc ctacctggtc tatttttaaa agtcaccttt taaagtgaca ttattagata
     4081 cacttaaatg tttccaaggc actctctaca ttacccttgt ttttctcttt ggatactgtc
     4141 ctgggactaa gtgtagattt ctgcttcaag cacttctggc attgtgtgtt tttgtatgca
     4201 ctccccttca tgccacttca gatgtttatt tggatgtggt tggggacgag agcagacacc
     4261 aaggaaaggg agttggagag aatgtaagtc ctgacctgaa ggtcttttgt gatgcatgta
     4321 taggattgcc ctgacacaca ccctcctttc ttgggattat accagccatc ttcctgagag
     4381 ttttggagcc ctctaggata ttttttctag taccccaccc cccaccccta aagaaagacc
     4441 ttaatatgtt aaaacagcat tgcttggaga aggtgtcatt gaattccggg acgagccgga
     4501 gcctttaaat gggtgcttcc accactacag gctcctgaca cgagtaacag gcactgttgc
     4561 ttagaagaac acacgaagtt gccgaacaca gggtaaaatt tccaaggcgc tgatcgttgc
     4621 cctggccagg gcctgatgag agccagtcag tacattcttt ttttcctaca gttcttgggt
     4681 ttcaaacttc agtttcaggg aatttcaagt caacaacagg tagaatgaat aaacttggtt
     4741 accagcctaa taatgtgaat tgctacagaa ttattcttat tatgtaagaa aacaaaaact
     4801 ttatgcagat actttagcta taaattgatg taaaatactg atttttttaa aggaaggaga
     4861 gaacagtatc ttgttcaatt attatgcaat caatcagtaa atgtttttaa aatgatacta
     4921 caggagagct tagtaaggag agggcatgga tgggccagtt tggcatagtt gggagaaatc
     4981 agtctggttt ccatcccagt cggggaagag agaggtgaga gggaatcaga acgtacctag
     5041 ttgattcctt ggtgacaagt gcaatggggt atgggtagaa tttattttca gagccaagag
     5101 gacttgatgg ttataaataa agttgccttt agcaatggaa tttacagatc gatcatgttg
     5161 ttccgaaaga tgtgaatagg atccacaata acaagttgat tcagactaat gtagatattt
     5221 agattagcaa gtattgaaca tttgatttct tagactgagg ttttaaatga atttcattat
     5281 ttctcccggt aatacacaga gcatcgggat taggaaatta gccattttgg attctgtctg
     5341 ccacaaacag acctattcta aacagtgcta ttaaatttta gactgttgtt caaatatttt
     5401 attttctcct aaactacttt ttatggtgat gaataattaa gaccatttaa aacacgggag
     5461 tacaagtatt tttttgaatt aaattaactt gcaaaaacca aatttgcagt ggttgggttg
     5521 tttctagaca gactttggta tcaatttaaa accaagataa tttttatatt ctttccaata
     5581 gaatttcatg acaactcctg cagttttctt aacctacaaa aaaaaaaaaa aagtgctgca
     5641 atgatgaaca aagaattata caaaacctac ttttgtatct ttattttgga atttcttgtt
     5701 ctattataaa tatggaagta tccctatttc agaagacata ttttgttaaa aatgaattgt
     5761 acatatttaa atatgtattt ttgcacaggt ctttttttct gatatcctgt tttggtacaa
     5821 ttgagatcat ctagtattta tttattaatt aataaaagta aatacctttt tataatttga
     5881 agtggttcac tgccaagcca atagttctag aacctgcctc ctttacagtt ttaagggatg
     5941 cctctgttct gtgaaaagtc tttgtccctt ttagtgtctc gggagtggat tcatacagat
     6001 gaagtgggca ttgcttcttc ctggttgcct ggtttcccga tagactacat gtaactaagt
     6061 gacacactgc ttttcttttg ttagtatttt atgtgtggga gtatgtgact gcgtgtgtgt
     6121 gtgcctgtgc gtgtgtgtgt atactcagca catgtatgtt actatgtgat gtggtttaaa
     6181 actaatggaa aaaactgaaa gtgcctgaaa ctagttttaa gcttagacag aatctcttta
     6241 aaaagacttg aatgttcagt tgaacttttg gagtttgctt tttccaccta aatattgttt
     6301 ctaaaatttt aggggcggag ttgaaaacca ccaatgctgg taattttata aggtatttta
     6361 aaattaagac ctcttggttc atagtaattc aattggtgat ggattgcctg gtggcaccaa
     6421 gggttacaga tctttttgtc agccagcaac ttacacgatg tgtccgtttt gttattcact
     6481 catgaaatac aatttaaaat atttaaaata ttttgtattc caaaaatata atacaaagaa
     6541 gtacctctga gaacattgaa aaaaatgtat aatttgaaaa atgtaactta taagggcagc
     6601 tgtcttcctg caagagttct gttgccaagg aatttcttaa tgtcgctcat tctgtccagg
     6661 gggtttgggg cgattgggct ttgaaaaaat attcttaaaa gtttgtttag cagaaaataa
     6721 tcacttttac attttgtgca aaacatttta cattttcaga taatttaaat gagcactaca
     6781 tactgtcagt gtgaatgtag ggccttgaaa gcattttgct tttttttttt tttttttttt
     6841 tttgagcttg gttataaaag caatctcctg tgttaaaaac gtgtgaatag tttgataatt
     6901 tgtacacata atcaagagca tctcagctgg actttgtgtt ggctgctgta tagaacatga
     6961 acaaatgtca agggatagaa aattactttg gatatttaaa agagaagaaa tatatagtct
     7021 atttgttttg taacaagttt ctgtaaataa aataatttat actatttata agaaaa
//
