LOCUS       NM_000489              11165 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ATRX chromatin remodeler (ATRX), transcript variant 1,
            mRNA.
ACCESSION   NM_000489
VERSION     NM_000489.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11165)
  AUTHORS   Yasunaga,Y., Tanaka,M., Arita,J., Hasegawa,K. and Ushiku,T.
  TITLE     Loss of ATRX and DAXX in pancreatic neuroendocrine tumors:
            Association with recurrence risk, cellular phenotype, and
            heterogeneity
  JOURNAL   Hum Pathol 150, 51-57 (2024)
   PUBMED   38909708
  REMARK    GeneRIF: Loss of ATRX and DAXX in pancreatic neuroendocrine tumors:
            Association with recurrence risk, cellular phenotype, and
            heterogeneity.
REFERENCE   2  (bases 1 to 11165)
  AUTHORS   Sridalla,K., Woodhouse,M.V., Hu,J., Scheer,J., Ferlez,B. and
            Crickard,J.B.
  TITLE     The translocation activity of Rad54 reduces crossover outcomes
            during homologous recombination
  JOURNAL   Nucleic Acids Res 52 (12), 7031-7048 (2024)
   PUBMED   38828785
  REMARK    GeneRIF: The translocation activity of Rad54 reduces crossover
            outcomes during homologous recombination.
REFERENCE   3  (bases 1 to 11165)
  AUTHORS   Fuentes,M.E., Lu,X., Flores,N.M., Hausmann,S. and Mazur,P.K.
  TITLE     Combined deletion of MEN1, ATRX and PTEN triggers development of
            high-grade pancreatic neuroendocrine tumors in mice
  JOURNAL   Sci Rep 14 (1), 8510 (2024)
   PUBMED   38609433
  REMARK    GeneRIF: Combined deletion of MEN1, ATRX and PTEN triggers
            development of high-grade pancreatic neuroendocrine tumors in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11165)
  AUTHORS   Gibbons,R.J., Wada,T., Fisher,C.A., Malik,N., Mitson,M.J.,
            Steensma,D.P., Fryer,A., Goudie,D.R., Krantz,I.D. and
            Traeger-Synodinos,J.
  TITLE     Mutations in the chromatin-associated protein ATRX
  JOURNAL   Hum Mutat 29 (6), 796-802 (2008)
   PUBMED   18409179
  REMARK    GeneRIF: Mutations in ATRX have been shown to perturb gene
            expression and DNA methylation; this is a report of 127 mutations
            including 32 reported here for the first time.
REFERENCE   5  (bases 1 to 11165)
  AUTHORS   Villard,L., Bonino,M.C., Abidi,F., Ragusa,A., Belougne,J.,
            Lossi,A.M., Seaver,L., Bonnefont,J.P., Romano,C., Fichera,M.,
            Lacombe,D., Hanauer,A., Philip,N., Schwartz,C. and Fontes,M.
  TITLE     Evaluation of a mutation screening strategy for sporadic cases of
            ATR-X syndrome
  JOURNAL   J Med Genet 36 (3), 183-186 (1999)
   PUBMED   10204841
REFERENCE   6  (bases 1 to 11165)
  AUTHORS   Stayton,C.L., Dabovic,B., Gulisano,M., Gecz,J., Broccoli,V.,
            Giovanazzi,S., Bossolasco,M., Monaco,L., Rastan,S., Boncinelli,E.
            et al.
  TITLE     Cloning and characterization of a new human Xq13 gene, encoding a
            putative helicase
  JOURNAL   Hum Mol Genet 3 (11), 1957-1964 (1994)
   PUBMED   7874112
REFERENCE   7  (bases 1 to 11165)
  AUTHORS   Stevenson,R.E.
  TITLE     Alpha-Thalassemia X-Linked Intellectual Disability Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301622
REFERENCE   8  (bases 1 to 11165)
  AUTHORS   Gibbons,R.J., Suthers,G.K., Wilkie,A.O., Buckle,V.J. and Higgs,D.R.
  TITLE     X-linked alpha-thalassemia/mental retardation (ATR-X) syndrome:
            localization to Xq12-q21.31 by X inactivation and linkage analysis
  JOURNAL   Am J Hum Genet 51 (5), 1136-1149 (1992)
   PUBMED   1415255
REFERENCE   9  (bases 1 to 11165)
  AUTHORS   Mulley,J.C., Kerr,B., Stevenson,R. and Lubs,H.
  TITLE     Nomenclature guidelines for X-linked mental retardation
  JOURNAL   Am J Med Genet 43 (1-2), 383-391 (1992)
   PUBMED   1605216
  REMARK    Review article
REFERENCE   10 (bases 1 to 11165)
  AUTHORS   Ades,L.C., Kerr,B., Turner,G. and Wise,G.
  TITLE     Smith-Fineman-Myers syndrome in two brothers
  JOURNAL   Am J Med Genet 40 (4), 467-470 (1991)
   PUBMED   1684092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138743.6, AC233293.2 and
            AC233305.2.
            
            On Feb 14, 2020 this sequence version replaced NM_000489.5.
            
            Summary: The protein encoded by this gene contains an
            ATPase/helicase domain, and thus it belongs to the SWI/SNF family
            of chromatin remodeling proteins. This protein is found to undergo
            cell cycle-dependent phosphorylation, which regulates its nuclear
            matrix and chromatin association, and suggests its involvement in
            the gene regulation at interphase and chromosomal segregation in
            mitosis. Mutations in this gene are associated with X-linked
            syndromes exhibiting cognitive disabilities as well as
            alpha-thalassemia (ATRX) syndrome. These mutations have been shown
            to cause diverse changes in the pattern of DNA methylation, which
            may provide a link between chromatin remodeling, DNA methylation,
            and gene expression in developmental processes. Multiple
            alternatively spliced transcript variants encoding distinct
            isoforms have been reported. [provided by RefSeq, Jul 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72937.2, SRR1803612.85173.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373344.11/ ENSP00000362441.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AL138743.6         65602-65836         c
            236-348             AC233293.2         129139-129251       c
            349-404             AC233293.2         110582-110637       c
            405-457             AC233293.2         109591-109643       c
            458-585             AC233293.2         108585-108712       c
            586-699             AC233293.2         105832-105945       c
            700-809             AC233293.2         100826-100935       c
            810-877             AC233293.2         96947-97014         c
            878-3951            AC233293.2         93528-96601         c
            3952-4024           AC233293.2         88234-88306         c
            4025-4158           AC233293.2         76653-76786         c
            4159-4335           AC233293.2         75390-75566         c
            4336-4429           AC233293.2         68568-68661         c
            4430-4532           AC233293.2         66106-66208         c
            4533-4772           AC233293.2         64122-64361         c
            4773-4914           AC233305.2         153420-153561       c
            4915-5024           AC233305.2         152099-152208       c
            5025-5171           AC233305.2         151071-151217       c
            5172-5349           AC233305.2         150712-150889       c
            5350-5487           AC233305.2         137900-138037       c
            5488-5663           AC233305.2         136311-136486       c
            5664-5781           AC233305.2         134118-134235       c
            5782-5912           AC233305.2         117939-118069       c
            5913-6001           AC233305.2         117237-117325       c
            6002-6171           AC233305.2         116916-117085       c
            6172-6325           AC233305.2         111201-111354       c
            6326-6432           AC233305.2         107339-107445       c
            6433-6541           AC233305.2         91755-91863         c
            6542-6719           AC233305.2         76174-76351         c
            6720-6914           AC233305.2         74956-75150         c
            6915-7064           AC233305.2         40757-40906         c
            7065-7190           AC233305.2         39768-39893         c
            7191-7286           AC233305.2         38908-39003         c
            7287-7415           AC233305.2         38293-38421         c
            7416-11165          AC233305.2         22385-26134         c
FEATURES             Location/Qualifiers
     source          1..11165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..11165
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /note="ATRX chromatin remodeler"
                     /db_xref="GeneID:546"
                     /db_xref="HGNC:HGNC:886"
                     /db_xref="MIM:300032"
     exon            1..235
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..7694
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     X-linked nuclear protein; transcriptional regulator ATRX;
                     X-linked helicase II; ATP-dependent helicase ATRX"
                     /codon_start=1
                     /product="transcriptional regulator ATRX isoform 1"
                     /protein_id="NP_000480.3"
                     /db_xref="CCDS:CCDS14434.1"
                     /db_xref="GeneID:546"
                     /db_xref="HGNC:HGNC:886"
                     /db_xref="MIM:300032"
                     /translation="MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNT
                     DKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDET
                     VNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKR
                     GEDGLHGIVSCTACGQQVNHFQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDE
                     QCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICHPEPLLDL
                     VTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDS
                     CSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQL
                     KAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPC
                     ALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPAN
                     TSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNIS
                     SKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKL
                     EKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECN
                     ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKE
                     VSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSA
                     KSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS
                     KKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQA
                     SASTDGVDKLSGKEESFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKD
                     QSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPK
                     GIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG
                     REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNT
                     KEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSS
                     SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDD
                     DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQV
                     NSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSED
                     SEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSS
                     ENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQ
                     NALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQV
                     HRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHT
                     VLLCDKLDFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSELATVKRPQERSYM
                     LQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKN
                     EASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPI
                     QNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTSI
                     QCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKG
                     YFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKVW
                     NSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEH
                     SGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGE
                     GKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRV
                     IIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV
                     DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHI
                     VGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQT
                     PYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNL
                     SEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQ
                     QQQMTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPPMR
                     SKNPGPSQGKSM"
     exon            236..348
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            349..404
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            405..457
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            458..585
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            586..699
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            700..809
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            810..877
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            878..3951
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4024
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4158
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4335
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            4336..4429
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            4430..4532
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..4772
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..4914
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            4915..5024
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..5171
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            5172..5349
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            5350..5487
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            5488..5663
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            5664..5781
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            5782..5912
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            5913..6001
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            6002..6171
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            6172..6325
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            6326..6432
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            6433..6541
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            6542..6719
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            6720..6914
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            6915..7064
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            7065..7190
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            7191..7286
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            7287..7415
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     exon            7416..11165
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10313..10318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /note="hexamer: AATAAA"
     polyA_site      10332
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /note="major polyA site"
     polyA_site      10547
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /note="major polyA site"
     regulatory      11143..11148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
                     /note="hexamer: AATAAA"
     polyA_site      11165
                     /gene="ATRX"
                     /gene_synonym="JMS; MRX52; RAD54; RAD54L; XH2; XNP;
                     ZNF-HX"
ORIGIN      
        1 ctcggcccaa caaaatggcg gcggcagcgg tgtcgctttg tttccgcggc tcctgcggcg
       61 gtggcagtgg tagcggcctt tgagctgtgg ggaggttcca gcagcagcta cagtgacgac
      121 taagactcca gtgcatttct atcgtaaccg ggcgcggggg agcgcagatc ggcgcccagc
      181 aatcacagaa gccgacaagg cgttcaagcg aaaacatgac cgctgagccc atgagtgaaa
      241 gcaagttgaa tacattggtg cagaagcttc atgacttcct tgcacactca tcagaagaat
      301 ctgaagaaac aagttctcct ccacgacttg caatgaatca aaacacagat aaaatcagtg
      361 gttctggaag taactctgat atgatggaaa acagcaagga agagggaact agctcttcag
      421 aaaaatccaa gtcttcagga tcgtcacgat caaagaggaa accttcaatt gtaacaaagt
      481 atgtagaatc agatgatgaa aaacctttgg atgatgaaac tgtaaatgaa gatgcgtcta
      541 atgaaaattc agaaaatgat attactatgc agagcttgcc aaaaggtaca gtgattgtac
      601 agccagagcc agtgctgaat gaagacaaag atgattttaa agggcctgaa tttagaagca
      661 gaagtaaaat gaaaactgaa aatctcaaaa aacgcggaga agatgggctt catgggattg
      721 tgagctgcac tgcttgtgga caacaggtca atcattttca aaaagattcc atttatagac
      781 acccttcatt gcaagttctt atttgtaaga attgctttaa gtattacatg agtgatgata
      841 ttagccgtga ctcagatgga atggatgaac aatgtaggtg gtgtgcggaa ggtggaaact
      901 tgatttgttg tgacttttgc cataatgctt tctgcaagaa atgcattcta cgcaaccttg
      961 gtcgaaagga gttgtccaca ataatggatg aaaacaacca atggtattgc tacatttgtc
     1021 acccagagcc tttgttggac ttggtcactg catgtaacag cgtatttgag aatttagaac
     1081 agttgttgca gcaaaataag aagaagataa aagttgacag tgaaaagagt aataaagtat
     1141 atgaacatac atccagattt tctccaaaga agactagttc aaattgtaat ggagaagaaa
     1201 agaaattaga tgattcctgt tctggctctg taacctactc ttattccgca ctaattgtgc
     1261 ccaaagagat gattaagaag gcaaaaaaac tgattgagac cacagccaac atgaactcca
     1321 gttatgttaa atttttaaag caggcaacag ataattcaga aatcagttct gctacaaaat
     1381 tacgtcagct taaggctttt aagtctgtgt tggctgatat taagaaggct catcttgcat
     1441 tggaagaaga cttaaattcc gagtttcgag cgatggatgc tgtaaacaaa gagaaaaata
     1501 ccaaagagca taaagtcata gatgctaagt ttgaaacaaa agcacgaaaa ggagaaaaac
     1561 cttgtgcttt ggaaaagaag gatatttcaa agtcagaagc taaactttca agaaaacagg
     1621 tagatagtga gcacatgcat cagaatgttc caacagagga acaaagaaca aataaaagta
     1681 ccggtggtga acataagaaa tctgatagaa aagaagaacc tcaatatgaa cctgccaaca
     1741 cttctgaaga tttagacatg gatattgtgt ctgttccttc ctcagttcca gaagacattt
     1801 ttgagaatct tgagactgct atggaagttc agagttcagt tgatcatcaa ggggatggca
     1861 gcagtggaac tgaacaagaa gtggagagtt catctgtaaa attaaatatt tcttcaaaag
     1921 acaacagagg aggtattaaa tcaaaaacta cagctaaagt aacaaaagaa ttatatgtta
     1981 aactcactcc tgtttccctt tctaattccc caattaaagg tgctgattgt caggaagttc
     2041 cacaagataa agatggctat aaaagttgtg gtctgaaccc caagttagag aaatgtggac
     2101 ttggacagga aaacagtgat aatgagcatt tggttgaaaa tgaagtttca ttacttttag
     2161 aggaatctga tcttcgaaga tccccacgtg taaagactac acccttgagg cgaccgacag
     2221 aaactaaccc tgtaacatct aattcagatg aagaatgtaa tgaaacagtt aaggagaaac
     2281 aaaaactatc agttccagtg agaaaaaagg ataagcgtaa ttcttctgac agtgctatag
     2341 ataatcctaa gcctaataaa ttgccaaaat ctaagcaatc agagactgtg gatcaaaatt
     2401 cagattctga tgaaatgcta gcaatcctca aagaggtgag caggatgagt cacagttctt
     2461 cttcagatac tgatattaat gaaattcata caaaccataa gactttgtat gatttaaaga
     2521 ctcaggcggg gaaagatgat aaaggaaaaa ggaaacgaaa aagttctaca tctggctcag
     2581 attttgatac taaaaagggc aaatcagcta agagctctat aatttctaaa aagaaacgac
     2641 aaacccagtc tgagtcttct aattatgact cagaattaga aaaagagata aagagcatga
     2701 gtaaaattgg tgctgccaga accaccaaaa aaagaattcc aaatacaaaa gattttgact
     2761 cttctgaaga tgagaaacac agcaaaaaag gaatggataa tcaagggcac aaaaatttga
     2821 agacctcaca agaaggatca tctgatgatg ctgaaagaaa acaagagaga gagactttct
     2881 cttcagcaga aggcacagtt gataaagaca cgaccatcat ggaattaaga gatcgacttc
     2941 ctaagaagca gcaagcaagt gcttccactg atggtgtcga taagctttct gggaaagagg
     3001 agagttttac ttctttggaa gttagaaaag ttgctgaaac taaagaaaag agcaagcatc
     3061 tcaaaaccaa aacatgtaaa aaagtacagg atggcttatc tgatattgca gagaaattcc
     3121 taaagaaaga ccagagcgat gaaacttctg aagatgataa aaagcagagc aaaaagggaa
     3181 ctgaagaaaa aaagaaacct tcagacttta agaaaaaagt aattaaaatg gaacaacagt
     3241 atgaatcttc atctgatggc actgaaaagt tacctgagcg agaagaaatt tgtcattttc
     3301 ctaagggcat aaaacaaatt aagaatggaa caactgatgg agaaaagaaa agtaaaaaaa
     3361 taagagataa aacttctaaa aagaaggatg aattatctga ttatgctgag aagtcaacag
     3421 ggaaaggaga tagttgtgac tcttcagagg ataaaaagag taagaatgga gcatatggta
     3481 gagagaagaa aaggtgcaag ttgcttggaa agagttcaag gaagagacaa gattgttcat
     3541 catctgatac tgagaaatat tccatgaaag aagatggttg taactcttct gataagagac
     3601 tgaaaagaat agaattgagg gaaagaagaa atttaagttc aaagagaaat actaaggaaa
     3661 tacaaagtgg ctcatcatca tctgatgctg aggaaagttc tgaagataat aaaaagaaga
     3721 agcaaagaac ttcatctaaa aagaaggcag tcattgtcaa ggagaaaaag agaaactccc
     3781 taagaacaag cactaaaagg aagcaagctg acattacatc ctcatcttct tctgatatag
     3841 aagatgatga tcagaattct ataggtgagg gaagcagcga tgaacagaaa attaagcctg
     3901 tgactgaaaa tttagtgctg tcttcacata ctggattttg ccaatcttca ggagatgaag
     3961 ccttatctaa atcagtgcct gtcacagtgg atgatgatga tgacgacaat gatcctgaga
     4021 atagaattgc caagaagatg cttttagaag aaattaaagc caatctttcc tctgatgagg
     4081 atggatcttc agatgatgag ccagaagaag ggaaaaaaag aactggaaaa caaaatgaag
     4141 aaaacccagg agatgaggaa gcaaaaaatc aagtcaattc tgaatcagat tcagattctg
     4201 aagaatctaa gaagccaaga tacagacata ggcttttgcg gcacaaattg actgtgagtg
     4261 acggagaatc tggagaagaa aaaaagacaa agcctaaaga gcataaagaa gtcaaaggca
     4321 gaaacagaag aaaggtgagc agtgaagatt cagaagattc tgattttcag gaatcaggag
     4381 ttagtgaaga agttagtgaa tccgaagatg aacagcggcc cagaacaagg tctgcaaaga
     4441 aagcagagtt ggaagaaaat cagcggagct ataaacagaa aaagaaaagg cgacgtatta
     4501 aggttcaaga agattcatcc agtgaaaaca agagtaattc tgaggaagaa gaggaggaaa
     4561 aagaagagga ggaggaagag gaggaggagg aggaagagga ggaggaagat gaaaatgatg
     4621 attccaagtc tcctggaaaa ggcagaaaga aaattcggaa gattcttaaa gatgataaac
     4681 tgagaacaga aacacaaaat gctcttaagg aagaggaaga gagacgaaaa cgtattgctg
     4741 agagggagcg tgagcgagaa aaattgagag aggtgataga aattgaagat gcttcaccca
     4801 ccaagtgtcc aataacaacc aagttggttt tagatgaaga tgaagaaacc aaagaacctt
     4861 tagtgcaggt tcatagaaat atggttatca aattgaaacc ccatcaagta gatggtgttc
     4921 agtttatgtg ggattgctgc tgtgagtctg tgaaaaaaac aaagaaatct ccaggttcag
     4981 gatgcattct tgcccactgt atgggccttg gtaagacttt acaggtggta agttttcttc
     5041 atacagttct tttgtgtgac aaactggatt tcagcacggc gttagtggtt tgtcctctta
     5101 atactgcttt gaattggatg aatgaatttg agaagtggca agagggatta aaagatgatg
     5161 agaagcttga ggtttctgaa ttagcaactg tgaaacgtcc tcaggagaga agctacatgc
     5221 tgcagaggtg gcaagaagat ggtggtgtta tgatcatagg ctatgagatg tatagaaatc
     5281 ttgctcaagg aaggaatgtg aagagtcgga aacttaaaga aatatttaac aaagctttgg
     5341 ttgatccagg ccctgatttt gttgtttgtg atgaaggcca tattctaaaa aatgaagcat
     5401 ctgctgtttc taaagctatg aattctatac gatcaaggag gaggattatt ttaacaggaa
     5461 caccacttca aaataaccta attgagtatc attgtatggt taattttatc aaggaaaatt
     5521 tacttggatc cattaaggag ttcaggaata gatttataaa tccaattcaa aatggtcagt
     5581 gtgcagattc taccatggta gatgtcagag tgatgaaaaa acgtgctcac attctctatg
     5641 agatgttagc tggatgtgtt cagaggaaag attatacagc attaacaaaa ttcttgcctc
     5701 caaaacacga atatgtgtta gctgtgagaa tgacttctat tcagtgcaag ctctatcagt
     5761 actacttaga tcacttaaca ggtgtgggca ataatagtga aggtggaaga ggaaaggcag
     5821 gtgcaaagct tttccaagat tttcagatgt taagtagaat atggactcat ccttggtgtt
     5881 tgcagctaga ctacattagc aaagaaaata agggttattt tgatgaagac agtatggatg
     5941 aatttatagc ctcagattct gatgaaacct ccatgagttt aagctccgat gattatacaa
     6001 aaaagaagaa aaaagggaaa aaggggaaaa aagatagtag ctcaagtgga agtggcagtg
     6061 acaatgatgt tgaagtgatt aaggtctgga attcaagatc tcggggaggt ggtgaaggaa
     6121 atgtggatga aacaggaaac aatccttctg tttctttaaa actggaagaa agtaaagcta
     6181 cttcttcttc taatccaagc agcccagctc cagactggta caaagatttt gttacagatg
     6241 ctgatgctga ggttttagag cattctggga aaatggtact tctctttgaa attcttcgaa
     6301 tggcagagga aattggggat aaagtccttg ttttcagcca gtccctcata tctctggact
     6361 tgattgaaga ttttcttgaa ttagctagta gggagaagac agaagataaa gataaacccc
     6421 ttatttataa aggtgagggg aagtggcttc gaaacattga ctattaccgt ttagatggtt
     6481 ccactactgc acagtcaagg aagaagtggg ctgaagaatt taatgatgaa actaatgtga
     6541 gaggacgatt atttatcatt tctactaaag caggatctct aggaattaat ctggtagctg
     6601 ctaatcgagt aattatattc gacgcttctt ggaatccatc ttatgacatc cagagtatat
     6661 tcagagttta tcgctttgga caaactaagc ctgtttatgt atataggttc ttagctcagg
     6721 gaaccatgga agataagatt tatgatcggc aagtaactaa gcagtcactg tcttttcgag
     6781 ttgttgatca gcagcaggtg gagcgtcatt ttactatgaa tgagcttact gaactttata
     6841 cttttgagcc agacttatta gatgacccta attcagaaaa gaagaagaag agggatactc
     6901 ccatgctgcc aaaggatacc atacttgcag agctccttca gatacataaa gaacacattg
     6961 taggatacca tgaacatgat tctcttttgg accacaaaga agaagaagag ttgactgaag
     7021 aagaaagaaa agcagcttgg gctgagtatg aagcagagaa gaagggactg accatgcgtt
     7081 tcaacatacc aactgggacc aatttacccc ctgtcagttt caactctcaa actccttata
     7141 ttcctttcaa tttgggagcc ctgtcagcaa tgagtaatca acagctggag gacctcatta
     7201 atcaaggaag agaaaaagtt gtagaagcaa caaacagtgt gacagcagtg aggattcaac
     7261 ctcttgagga tataatttca gctgtatgga aggagaacat gaatctctca gaggcccaag
     7321 tacaggcgtt agcattaagt agacaagcca gccaggagct tgatgttaaa cgaagagaag
     7381 caatctacaa tgatgtattg acaaaacaac agatgttaat cagctgtgtt cagcgaatac
     7441 ttatgaacag aaggctccag cagcagtaca atcagcagca acagcaacaa atgacttatc
     7501 aacaagcaac actgggtcac ctcatgatgc caaagccccc aaatttgatc atgaatcctt
     7561 ctaactacca gcagattgat atgagaggaa tgtatcagcc agtggctggt ggtatgcagc
     7621 caccaccatt acagcgtgca ccacccccaa tgagaagcaa aaatccagga ccttcccaag
     7681 ggaaatcaat gtgattttgc actaaaagct taatggattg ttaaaatcat agaaagatct
     7741 tttatttttt taggaatcaa tgacttaaca gaactcaact gtataaatag tttggtcccc
     7801 ttaaatgcca atcttccata ttagttttac tttttttttt tttaaatagg gcataccatt
     7861 tcttcctgac atttgtcagt gatgttgcct agaatcttct tacacacgct gagtacagaa
     7921 gatatttcaa attgttttca gtgaaaacaa gtccttccat aatagtaaca actccacaga
     7981 tttcctctct aaatttttat gcctgctttt agcaaccata aaattgtcat aaaattaata
     8041 aatttaggaa agaataaaga tttatatatt cattctttac atataaaaac acacagctga
     8101 gttcttagag ttgattcctc aagttatgaa atacttttgt acttaatcca tttcttgatt
     8161 aaagtgattg aaatggtttt aatgttcttt tgactgaagt ctgaaactgg gctcctgctt
     8221 tattgtctct gtgactgaaa gttagaaact gagggttatc tttgacacag aattgtgtgc
     8281 aatattctta aatactactg ctctaaaagt tggagaagtc ttgcagttat cttagcattg
     8341 tataaacagc cttaagtata gcctaagaag agaattcctt tttcttcttt agtccttctg
     8401 ccatttttta ttttcagtta tatgtgctga aataattact ggtaaaattt cagggttgtg
     8461 gattatcttc cacacatgaa ttttctctct cctggcacga atataaagca catctcttaa
     8521 ctgcatggtg ccagtgctaa tgcttcatcc tgttgctggc agtgggatgt ggacttagaa
     8581 aatcaagttc tagcatttta gtaggttaac actgaagttg tggttgttag gttcacaccc
     8641 tgttttataa acaacatcaa aatggcagaa ccattgctga ctttaggttc acatgaggaa
     8701 tgtactttta acaattccca gtactatcag tattgtgaaa taattcctct gaaagataag
     8761 aatcactggc ttctatgcgc ttcttttctc tcatcatcat gttcttttac cccagtttcc
     8821 ttacattttt ttaaattgtt tcagagtttg tttttttttt agtttagatt gtgaggcaat
     8881 tattaaatca aaattaattc atccaatacc cctttactag aagttttact agaaaatgta
     8941 ttacatttta ttttttctta atccagttct gcaaaaatga cctataaatt tattcatgta
     9001 caattttggt tacttgaatt gttaaagaaa acattgtttt tgactatggg agtcaactca
     9061 acatggcaga accatttttg agatgatgat acaacaggta gtgaaacagc ttaagaattc
     9121 caaaaaaaaa aaaaaaaaaa aaaaaaagaa aactgggttt gggctttgct ttaggtatca
     9181 ctggattaga atgagtttaa cattagctaa aactgctttg agttgtttgg atgattaaga
     9241 gattgccatt tttatcttgg aagaactagt ggtaaaacat ccaagagcac taggattgtg
     9301 atacagaatt tgtgaggttt ggtggatcca cgcccctctc ccccactttc ccatgatgaa
     9361 atatcactaa taaatcctgt atatttagat attatgctag ccatgtaatc agatttattt
     9421 aattgggtgg ggcaggtgtg tatttacttt agaaaaaatg aaaaagacaa gatttatgag
     9481 aaatatttga aggcagtaca ctctggccaa ctgttaccag ttggtatttc tacaagttca
     9541 gaatatttta aacctgattt actagacctg ggaattttca acatggtcta attatttact
     9601 caaagacata gatgtgaaaa ttttaggcaa ccttctaaat ctttttcacc atggatgaaa
     9661 ctataactta aagaataata cttagaaggg ttaattggaa atcagagttt gaaataaaac
     9721 ttggaccact ttgtatacac tcttctcact tgacatttta gctatataat atgtactttg
     9781 agtataacat caagctttaa caaatattta aagacaaaaa aatcacgtca gtaaaatact
     9841 aaaaggctca tttttatatt tgttttagat gttttaaata gttgcaatgg attaaaaatg
     9901 atgatttaaa atgttgcttg taatacagtt ttgcctgcta aattctccac attttgtaac
     9961 ctgttttatt tctttgggtg taaagcgttt ttgcttagta ttgtgatatt gtatatgttt
    10021 tgtcccagtt gtatagtaat gtttcagtcc atcatccagc tttggctgct gaaatcatac
    10081 agctgtgaag acttgccttt gtttctgtta gactgctttt cagttctgta ttgagtatct
    10141 taagtactgt agaaaagatg tcacttcttc ctttaaggct gttttgtaat atatataagg
    10201 actggaattg tgtttttaaa gaaaagcatt caagtatgac aatatactat ctgtgttttc
    10261 accattcaaa gtgctgttta gtagttgaaa cttaaactat ttaatgtcat ttaataaagt
    10321 gaccaaaatg tgttgtgctc tttattgtat tttcacagct ttgaaaatct gtgcacatac
    10381 tgtttcatag aaaatgtata gcttttgttg tcctatataa tggtggttct tttgcacatt
    10441 tagttattta atattgagag gtcacgaagt ttggttattg aatctgttat atactaaatt
    10501 ctgtaaaggg agatctctca tctcaaaaag aatttacata ccaggaagtc catgtgtgtt
    10561 tgtgttagtt ttggatgtct ttgtgtaatc cagccccatt tcctgtttcc caacagctgt
    10621 aacactcatt ttaagtcaag cagggctacc aacccacact tgatagaaaa gctgcttacc
    10681 attcagaagc ttccttatta cctggcctcc aaatgagctg aatattttgt agccttccct
    10741 tagctatgtt cattttccct ccattatcat aaaatcagat cgatatttat gtgccccaaa
    10801 caaaacttta agagcagtta cattctgtcc cagtagccct tgtttccttt gagagtagca
    10861 tgttgtgagg ctatagagac ttattctacc agtaaaacag gtcaatcctt ttacatgttt
    10921 attatactaa aaattatgtt cagggtattt actactttat ttcaccagac tcagtctcaa
    10981 gtgacttggc tatctccaaa tcagatctac ccttagagaa taaacatttt tctaccgtta
    11041 ttttttttca agtctataat ctgagccagt cccaaaggag tgatcaagtt tcagaaatgc
    11101 tttcatcttc acaacatttt atatatacta ttatatgggg tgaataaagt tttaaatccg
    11161 aaata
//
