LOCUS       NM_207303               8746 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens attractin like 1 (ATRNL1), transcript variant 1, mRNA.
ACCESSION   NM_207303
VERSION     NM_207303.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8746)
  AUTHORS   Fang,M., Zhou,Y., Li,Z. and Li,X.
  TITLE     Transcriptional factor CCAAT enhancer binding protein beta inhibits
            epithelial-mesenchymal transition in cervical cancer via regulating
            attractin-like 1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (13), 1-7 (2023)
   PUBMED   38158696
  REMARK    GeneRIF: Transcriptional factor CCAAT enhancer binding protein beta
            inhibits epithelial-mesenchymal transition in cervical cancer via
            regulating attractin-like 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8746)
  AUTHORS   Luciano,M., Hansell,N.K., Lahti,J., Davies,G., Medland,S.E.,
            Raikkonen,K., Tenesa,A., Widen,E., McGhee,K.A., Palotie,A.,
            Liewald,D., Porteous,D.J., Starr,J.M., Montgomery,G.W.,
            Martin,N.G., Eriksson,J.G., Wright,M.J. and Deary,I.J.
  TITLE     Whole genome association scan for genetic polymorphisms influencing
            information processing speed
  JOURNAL   Biol Psychol 86 (3), 193-202 (2011)
   PUBMED   21130836
REFERENCE   3  (bases 1 to 8746)
  AUTHORS   Cota,C.D., Liu,R.R., Sumberac,T.M., Jung,S., Vencato,D.,
            Millet,Y.H. and Gunn,T.M.
  TITLE     Genetic and phenotypic studies of the dark-like mutant mouse
  JOURNAL   Genesis 46 (10), 562-573 (2008)
   PUBMED   18821597
  REMARK    GeneRIF: Transgenic overexpression of Attractin-like-1 (Atrnl1),
            which compensates for loss of ATRN, does not rescue dark-like
            mutant phenotypes.
REFERENCE   4  (bases 1 to 8746)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 8746)
  AUTHORS   Haqq,A.M., Rene,P., Kishi,T., Khong,K., Lee,C.E., Liu,H.,
            Friedman,J.M., Elmquist,J.K. and Cone,R.D.
  TITLE     Characterization of a novel binding partner of the melanocortin-4
            receptor: attractin-like protein
  JOURNAL   Biochem J 376 (Pt 3), 595-605 (2003)
   PUBMED   14531729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035157.1, AY442317.1 and AC022542.5.
            
            On Mar 25, 2014 this sequence version replaced NM_207303.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.231188.1,
                                           SRR1660809.112260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355044.8/ ENSP00000347152.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               BC035157.1         6-391
            387-4526            AY442317.1         1-4140
            4527-8746           AC022542.5         69715-73934
FEATURES             Location/Qualifiers
     source          1..8746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..8746
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /note="attractin like 1"
                     /db_xref="GeneID:26033"
                     /db_xref="HGNC:HGNC:29063"
                     /db_xref="MIM:612869"
     exon            1..679
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..4526
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; attractin-like protein 1"
                     /codon_start=1
                     /product="attractin-like protein 1 isoform 1 precursor"
                     /protein_id="NP_997186.1"
                     /db_xref="CCDS:CCDS7592.1"
                     /db_xref="GeneID:26033"
                     /db_xref="HGNC:HGNC:29063"
                     /db_xref="MIM:612869"
                     /translation="METGGRARTGTPQPAAPGVWRARPAGGGGGGASSWLLDGNSWLL
                     CYGFLYLALYAQVSQSKPCERTGSCFSGRCVNSTCLCDPGWVGDQCQHCQGRFKLTEP
                     SGYLTDGPINYKYKTKCTWLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLI
                     AVLSGLIVPEIRGNETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINSCPNNCSGH
                     GKCTTSVSVPSQVYCECDKYWKGEACDIPYCKANCGSPDHGYCDLTGEKLCVCNDSWQ
                     GPDCSLNVPSTESYWILPNVKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVL
                     NYNLESSIWNVGTPSRGPLQRYGHSLALYQENIFMYGGRIETNDGNVTDELWVFNIHS
                     QSWSTKTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHIS
                     SNTWLVPETKGAIVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNT
                     KTWTILKESGFARYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDE
                     WKILPKPNLHRDVNRFGHSAVVINGSMYIFGGFSSVLLNDILVYKPPNCKAFRDEELC
                     KNAGPGIKCVWNKNHCESWESGNTNNILRAKCPPKTAASDDRCYRYADCASCTANTNG
                     CQWCDDKKCISANSNCSMSVKNYTKCHVRNEQICNKLTSCKSCSLNLNCQWDQRQQEC
                     QALPAHLCGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDE
                     IQKYTQQKVSPWVGLRKINISYWGWEDMSPFTNTTLQWLPGEPNDSGFCAYLERAAVA
                     GLKANPCTSMANGLVCEKPVVSPNQNARPCKKPCSLRTSCSNCTSNGMECMWCSSTKR
                     CVDSNAYIISFPYGQCLEWQTATCSPQNCSGLRTCGQCLEQPGCGWCNDPSNTGRGHC
                     IEGSSRGPMKLIGMHHSEMVLDTNLCPKEKNYEWSFIQCPACQCNGHSTCINNNVCEQ
                     CKNLTTGKQCQDCMPGYYGDPTNGGQCTACTCSGHANICHLHTGKCFCTTKGIKGDQC
                     QLCDSENRYVGNPLRGTCYYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDI
                     SINASNNFNLNITWSVGSTAGTISGEETSIVSKNNIKEYRDSFSYEKFNFRSNPNITF
                     YVYVSNFSWPIKIQIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASR
                     RREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVL
                     TVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKASDSKDKTSGVRNRKHLSTRQGTC
                     V"
     exon            680..763
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..877
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1006
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1215
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1390
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1478
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1734
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1918
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2073
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2158
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2367
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2486
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2619
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2801
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..3015
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3204
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3423
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3561
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3655
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3708
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3803
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..3882
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4040
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4102
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4103..4181
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4182..4289
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4404
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..8746
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6296..6301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /note="hexamer: AATAAG"
     polyA_site      6318
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /note="major polyA site"
     regulatory      6508..6513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /note="hexamer: AATAAA"
     polyA_site      6526
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /note="major polyA site"
     regulatory      8710..8715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /note="hexamer: AATAAA"
     polyA_site      8746
                     /gene="ATRNL1"
                     /gene_synonym="ALP; bA338L11.1; bA454H24.1"
                     /note="major polyA site"
ORIGIN      
        1 agttggcgcg ggccgcgggc gaggcggggc cgcgcgcggg gtcccctcct cctgccggtc
       61 aggtcccctc aggagcgccg ggcgcagtct gcgcctcccg ctccccgcct ccggccgggt
      121 ccgggacgcc gcggctgtgg ggtcggcccg ctaaggacaa ggtcgggaga ctgggtggcg
      181 atgcccgagt gcgactggag gcagccgagc ggaggcgacg gcggttggga tctgtccctc
      241 ctgaccgggg agcgggactc ggacgggcgc cggtgaggag gaggagaagc ggcggcggag
      301 aggttttctg cggccggaat tcccttcaac agcatccctg tcggcgcccg cgagcgcagt
      361 ctcgccgggc aggggcgccg gggaagatgg agactggggg ccgggcccgc actggtaccc
      421 cgcagccagc ggccccgggg gtgtggaggg ctcggccggc gggcggcggc ggcgggggcg
      481 cctcctcctg gctgctggac gggaacagct ggctgctgtg ctatggcttc ctctacctgg
      541 cgctctacgc gcaggtgtcc cagtccaagc cgtgcgagag gaccggctcc tgcttctcgg
      601 gccgctgtgt caactccacc tgcctctgcg acccgggctg ggtgggggac cagtgccagc
      661 actgccaggg caggttcaag ttaacagaac cttctggata tttaacagat ggcccaatta
      721 actataaata taaaactaaa tgtacttggc tcattgaagg ctatccaaat gcagtgttaa
      781 gattaagatt caatcatttt gctacagaat gtagctggga tcatatgtat gtttatgatg
      841 gagattcaat atatgcacct ttaatagctg tacttagtgg tttgatagtc cctgaaataa
      901 ggggcaatga aactgtgcct gaagttgtta ctacatctgg ctatgcactg ttacattttt
      961 ttagtgatgc tgcgtataat ctaactggtt tcaacatttt ctattcaatc aattcttgtc
     1021 ctaacaattg ctctggtcat gggaagtgta caactagtgt ctctgttcca agtcaagtat
     1081 attgtgaatg tgataaatac tggaagggtg aagcttgtga tattccttac tgtaaagcca
     1141 attgcggcag tccagatcac ggttactgtg acctgactgg agaaaaatta tgtgtctgca
     1201 atgatagttg gcaaggtcct gattgttctt tgaatgttcc ctctactgag tcttactgga
     1261 ttctgccaaa cgttaaaccc ttcagtcctt ctgtaggtcg ggcttcacat aaagcagttt
     1321 tacacgggaa atttatgtgg gtgattggtg gatatacttt taactacagt tcttttcaaa
     1381 tggtcctaaa ttacaattta gaaagcagta tatggaatgt aggaactcca tcaaggggac
     1441 ctctccagag atatggacac tctcttgctt tatatcagga aaacatcttt atgtatggag
     1501 gcagaattga aacaaatgat ggcaatgtca cagatgaatt atgggttttt aacatacata
     1561 gtcagtcatg gagtacaaaa actcctactg ttcttggaca tggtcagcag tatgctgtgg
     1621 agggacattc agcacatatt atggagttgg atagtagaga tgttgtcatg atcataatat
     1681 ttggatattc tgcaatatat ggttatacaa gcagcataca ggaataccat atctcatcaa
     1741 acacttggct tgttccagaa actaaaggag ctattgtaca aggtggatat ggccatacta
     1801 gtgtgtatga tgaaataaca aagtccattt atgttcatgg agggtataaa gcattgccag
     1861 ggaacaaata tggattggtt gatgatcttt ataaatatga agttaacact aagacttgga
     1921 ctattttgaa agaaagtggg tttgccagat accttcattc agctgttctt atcaatggag
     1981 ctatgcttat ttttggagga aatacccata atgacacttc cttgagtaac ggtgcaaaat
     2041 gtttttctgc cgatttcctg gcatatgaca tagcttgtga tgaatggaaa atactaccaa
     2101 aaccaaatct tcatagagat gtcaacagat ttggacactc tgcagtagtc attaacgggt
     2161 ccatgtatat atttggggga ttttctagtg tactccttaa tgatatcctt gtatacaagc
     2221 ctccaaattg caaggctttc agagatgaag aactttgtaa aaatgctggt ccagggataa
     2281 aatgtgtttg gaataaaaat cactgtgaat cttgggaatc tgggaatact aataatattc
     2341 ttagagcaaa gtgccctcct aaaacagctg cttctgatga cagatgttac agatatgcag
     2401 attgtgccag ctgtactgcc aatacaaatg ggtgccaatg gtgtgatgac aagaaatgca
     2461 tttcggcaaa tagtaactgc agtatgtctg tcaagaacta caccaaatgt catgtgagaa
     2521 atgagcagat ttgtaacaaa cttaccagct gtaaaagctg ttcactaaac ttgaattgcc
     2581 agtgggatca gagacagcaa gaatgccagg ctttaccagc tcatctttgt ggagaaggat
     2641 ggagtcatat tggggatgct tgtcttagag tcaattccag tagagaaaac tatgacaatg
     2701 caaaacttta ttgctataat cttagtggaa atcttgcttc attaacaacc tcaaaagaag
     2761 tagaatttgt tctggatgaa atacagaagt atacacaaca gaaagtatca ccttgggtag
     2821 gcttgcgcaa gatcaatata tcctattggg gatgggaaga catgtctcct tttacaaaca
     2881 caacactaca gtggcttcct ggcgaaccca atgattctgg gttttgtgca tatctggaaa
     2941 gggctgcagt ggcaggctta aaagctaatc cttgtacatc tatggcaaat ggccttgtct
     3001 gtgaaaaacc tgttgttagt ccaaatcaaa atgcgaggcc gtgcaaaaag ccatgctctc
     3061 tgaggacatc atgttccaac tgtacaagca atggcatgga gtgtatgtgg tgcagcagta
     3121 cgaaacgatg tgttgactct aatgcctata tcatctcttt tccatatgga caatgtctag
     3181 agtggcaaac tgccacctgc tcccctcaaa attgttctgg attgagaacc tgtggacagt
     3241 gtttggaaca gcctggatgt ggctggtgca atgatcctag taatacagga agaggacatt
     3301 gcattgaagg ttcttcacgg ggaccaatga agcttattgg aatgcaccac agtgagatgg
     3361 ttcttgacac caatctttgc cccaaagaaa agaactatga gtggtccttt atccagtgtc
     3421 cagcttgcca gtgtaatgga catagcactt gcatcaataa taatgtgtgc gaacagtgta
     3481 aaaatctcac cacaggaaag cagtgtcaag attgtatgcc aggttattat ggagatccaa
     3541 ccaatggtgg acagtgcaca gcttgtacat gcagtggcca tgcaaatatc tgtcatctgc
     3601 acacaggaaa atgtttctgc acaactaaag gaataaaagg tgaccaatgc caattatgtg
     3661 actctgaaaa tcgctatgtt ggtaatccac ttagaggaac atgttattac agccttttga
     3721 ttgattatca atttaccttc agcttattac aggaagatga tcgccaccat actgccataa
     3781 actttatagc aaacccagaa cagtcgaaca aaaatctgga tatatcaatt aatgcatcaa
     3841 acaactttaa tctcaacatt acgtggtctg tcggttcaac agctggaaca atatctgggg
     3901 aagagacttc tatagtttcc aagaataata taaaggaata cagagatagt ttttcctatg
     3961 aaaaatttaa ctttagaagc aatcctaaca ttacattcta tgtgtacgtc agcaactttt
     4021 cctggcctat taaaatacag attgcattct cacaacacaa tacaatcatg gaccttgtgc
     4081 agttttttgt caccttcttc agttgtttcc tatccttatt gctggtggct gctgtggtat
     4141 ggaagatcaa acaaacttgt tgggcttctc gacggagaga gcaactgctt cgagaacgac
     4201 agcagatggc cagccgtccc tttgcttctg ttgatgtagc tctggaagtg ggagctgaac
     4261 aaacagagtt tctgcgaggg ccattagagg gggcacccaa gccaattgcc attgaaccat
     4321 gtgctgggaa cagagctgct gttctgactg tgtttctttg tctaccacga ggatcatcag
     4381 gtgcccctcc ccctgggcag tcaggccttg caattgccag tgccctaata gatatttcac
     4441 aacagaaagc ttcagatagt aaagataaga cttctggagt ccggaatcga aaacaccttt
     4501 caacacgtca aggaacttgt gtctgagaaa tggaaaccgc tcctgtatat tctgtactgt
     4561 tttacttcgg gcttctgtta aagctgttct atggccttgg attttatgga ggcagatctc
     4621 tgtatcatcc agagcctgag tacagtttcc ttccaaatgg acaatgaccc aggtggccaa
     4681 agaatgttca tgagttttat aaaagtattg atggtcacag gtgataaagt cagtttttac
     4741 cactatctta ggcttattat agctaacatt aaattactct ggaaaaagat gtatattgtt
     4801 tcttaatgaa gatgaaaaat atgtaattca tataaatcaa ctgtttatat cccaagactt
     4861 gaaagaaaga cattttttaa tgcctgaatg atgagaattg tacagttttt gcctcataag
     4921 caaacttgaa tcacctgtgt atgaacaggg aatgaacaca ttgcaatggc tttaaatgct
     4981 cttttatctc gttgtaaagg taaggcaaga ttttgatgta gtaggatgta ggtaatgtat
     5041 ttaaatattt catatgacca tatcgtgtcc aaactcagtc tgagaatgtg acagctttcc
     5101 gcctaactag aatgcagacc agaatgagtt caactcattc tgtgcaactt cacagggggt
     5161 ttattagaat gctcagtgta gaggacattc ctgtcatcca tgccaactac ctaactcgtt
     5221 atcagagctg atagagcatg gaaaagtctg tccagcgatc agttgttccc ctccttccaa
     5281 aaacagcctc caataccaca acctgaaaag agccgaaatg gttattttac agcatacaag
     5341 cttctgctcc agtatgataa tttttaattg cctaagaatc attggatcag acctaaatga
     5401 tccatctgca tttttataag aatggatctt tctttgccct tcctctccta gctgctagat
     5461 tttaactacc ttttacaaat gttacaaaat gtattttaga ggcgacatct ctcaagatga
     5521 cctgagttcc ttcctgccaa ctgttccacc tagaatacaa gtagagaaga gcactggctg
     5581 gcaagcatca acaggagtct tcttcccaac acgagcgcat ccatgtcctg agaaaaagtc
     5641 tgtggtttag aaaatatgtc catggttgcc cacagtcagc acactcttag tgactcaaaa
     5701 ttctgaatta tggcagaaag gaaaaataaa acatacttca cattagaaca cagaatcatt
     5761 tacatcctaa tactgaccac agttcactaa agctcagtag cattaacaga tatagtttgg
     5821 aattgcagtt tcctcacttc agggtgacaa gatatgtata acagtgacag aaatctccaa
     5881 agctgctgta tatgatatag ctttgttaaa tatgaaggtc ctttaaatac aattgatgtt
     5941 tagtactata tatgtacttt tcacattctt tggatttctg gaaggttatg acactttact
     6001 gtttacagct aatgcatagt tacttgcatg ccatggttgt acagtagcag actatgaccc
     6061 tattgtgata ttaagtgttt atttcataat gccatttata catagctgaa tttgatgagg
     6121 attgaatgtc atatataaga ggaatgatca tacaatatgt agttgcatct tatataagat
     6181 ttctaggttg catctaacca tgactatgtc attattttga taattaggca tttatgaatt
     6241 atagtatata ttcctcatgt tggcatgata attttgctat tttccatgca ttaaaaataa
     6301 gacaaattct tagagtaatt ttagtaattt tatctataat ctgtggggtt tttttggagg
     6361 gggaggccac tggttgtttc tacttccctg tgatattttc tctctcatta aaggaatgag
     6421 ctaagtttgt aaatatctcc taaaaacaat caagtaattt tattagcttc ttttggaccc
     6481 tctaaatatt gacttctctc atgaaaaaat aaattgatga aactaatgat tacaaagata
     6541 taatcatttt ttaaaaagtg attgcccaat gtatttctct aacaattgtc acaagagaaa
     6601 gcataacaat aaaaatacaa aaacatacag atttagatgt aaaatctata taagctatat
     6661 ttttagggag gctaagcaga tagtattact gtggaagaat tatcaagttt tattcacctc
     6721 aaatcccact gggttcttaa aacttgaaaa ttcaaattgt agagaattat gagacacaat
     6781 gtgatgttta gttaaagtca tgctatacct ttctgggcca catattgcta actctgtggc
     6841 taattatgca attaattctc aacgtatcaa agcttttcac tggcagtaaa ttctttgccc
     6901 tcaggtgaag tggattgaaa agacatcaag gatcaaggat aatcactttg aatctgttgg
     6961 tttttccccc tacattccag acactttaaa tttggatgct ttcatttttt ttaaatcaaa
     7021 ccacacaaat atgcagatac tttcccagaa tttcgcagtt aaatggctga tcctcttgaa
     7081 aactaacctt aatggaattc taaacatttc agtttagaat gactttgaaa aattccttag
     7141 atttttagga tgttttattc tgccaagtat gaaaaaaaaa tggttaaata caatggagtt
     7201 ttaaaaatta acctggggat tctatttgaa ctagaaaatt cctattggaa aagaatttgc
     7261 acatacttac agattcagct aataaatttt aagaggatta ggattctcat aattctttaa
     7321 atgaaaattt gttttagtga tacacagaga tgccgtatac tatagtgtta tgttcagtag
     7381 gaaaacttca aatagttcgt atttaaaaag gtaattgatc cttgctgtac ttcccaacat
     7441 ctcatcttct tttagctgca gtaagataga ggtgactgta tggctacagt tcatggtata
     7501 aggtcattta gggtgcacac tggcacacag gctggaaaac gggcactgga cccagctttc
     7561 aggtgtgtgg tgctgggtaa gtttcacctt tgaagcctca gccttccatc tgtaaagggc
     7621 ggtaatggtg cccacctttc gaggcattgc gaggctagat ggtaacacac agaaagctcc
     7681 cacagtggga ccttgatgca gcgtagctgg tattaacaac cgtggggaca ccaggccact
     7741 ctttttctac cagttgtttt atgaatccac ctattaattt tcatccatct tttggtcgta
     7801 ggtaaaggtc aatcaggttt ttcaaaaaga ctccctgaat aacttaagtt cctgtatttc
     7861 taagatatag ggatttctac aaaacgactt tgacatttag tcaataaaga cttaaactct
     7921 tcttaaatct atagttttag gagagttttt cttaaaatta ctgactgatg acattgagac
     7981 aagagcatca atgatcacct ttcacgtaca aactaggcaa gacagggtca gtgcttacat
     8041 tttgtggtta tacatgatac atcttttctc agtgaacata aaactatgat ttgaaaggtg
     8101 tcttatattt aaaaaagatt gtaaaatgaa aactgaccaa atgaactaat tctacccacc
     8161 tatggtcttt ttaaatgtcg agtttcaaaa cccatttgcc gtatactaga gtgagcttgg
     8221 aaacttacct gattacagga attgcttggg ttcaggcaga ttcccacttt cacctctaga
     8281 gatttagatt cagaaacact ggggtaggcc ctggagagca gtactcttaa caagctcctc
     8341 agtgcttctt accattaggc aaattaggga aacactgcat tgggtcaaag tgctgccttt
     8401 aatcgaccat tagagggagt tctctaaata acaaagttat tactctaatt caaaatgctt
     8461 taaagaattt tccaaggaat acaagccatc tggttggtgt tagttatagc agtgatttca
     8521 ttagagtgta catttaacat tttagtttta tcaaaatttt ttgaaattaa gaattagaac
     8581 cagagctcct atcagtatat atgtacacag gtgtgcatgc cagtgttcaa aagattgtgt
     8641 aaaagttcaa gcccgtttta gaaagccaac attttatgtt ataatatgct gttaatcagg
     8701 actttattaa ataaaaacat tggctcttcc aacccccact gccaaa
//
