LOCUS       NM_139321               8651 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens attractin (ATRN), transcript variant 1, mRNA.
ACCESSION   NM_139321
VERSION     NM_139321.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8651)
  AUTHORS   Shahrour MA, Ashhab M, Edvardson S, Gur M, Abu-Libdeh B and Elpeleg
            O.
  TITLE     Hypomyelinating leukodystrophy associated with a deleterious
            mutation in the ATRN gene
  JOURNAL   Neurogenetics 18 (3), 135-139 (2017)
   PUBMED   28493104
  REMARK    GeneRIF: ATRN encodes Attractin, which was previously shown to play
            a critical role in central myelination
REFERENCE   2  (bases 1 to 8651)
  AUTHORS   Cheng D, Ming Y, Li J, Chi Y, Li HG, Zou YJ and Xiong CL.
  TITLE     Expression of Attractin in male reproductive tract of human and
            mice and its correlation with male reproduction
  JOURNAL   J. Huazhong Univ. Sci. Technol. Med. Sci. 34 (5), 745-749 (2014)
   PUBMED   25318887
  REMARK    GeneRIF: Data indicate that Attractin was involved in male
            reproduction in both human and BALB/c mice, but it exerted a
            different expression profile in different species.
REFERENCE   3  (bases 1 to 8651)
  AUTHORS   Laudes M, Oberhauser F, Schulte DM, Schilbach K, Freude S,
            Bilkovski R, Schulz O, Faust M and Krone W.
  TITLE     Dipeptidyl-peptidase 4 and attractin expression is increased in
            circulating blood monocytes of obese human subjects
  JOURNAL   Exp. Clin. Endocrinol. Diabetes 118 (8), 473-477 (2010)
   PUBMED   20198559
  REMARK    GeneRIF: The levels of both dipeptidyl-peptidase 4 and attractin in
            circulating monocytes were significantly higher in obese subjects
            as compared with levels in lean controls or in subjects with type 2
            diabetes.
REFERENCE   4  (bases 1 to 8651)
  AUTHORS   Radhakrishnan Y, Hamil KG, Tan JA, Grossman G, Petrusz P, Hall SH
            and French FS.
  TITLE     Novel partners of SPAG11B isoform D in the human male reproductive
            tract
  JOURNAL   Biol. Reprod. 81 (4), 647-656 (2009)
   PUBMED   19535787
  REMARK    GeneRIF: associated with spermatozoa
REFERENCE   5  (bases 1 to 8651)
  AUTHORS   Nan H, Kraft P, Hunter DJ and Han J.
  TITLE     Genetic variants in pigmentation genes, pigmentary phenotypes, and
            risk of skin cancer in Caucasians
  JOURNAL   Int. J. Cancer 125 (4), 909-917 (2009)
   PUBMED   19384953
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 8651)
  AUTHORS   Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M,
            Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow
            KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE,
            Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C,
            Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee
            CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A,
            Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA,
            Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths
            MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S,
            Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K,
            Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A,
            Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM,
            Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray
            AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver
            K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ,
            Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE,
            Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C,
            Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L,
            Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis
            JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA,
            Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S and
            Rogers J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 8651)
  AUTHORS   Tang W, Gunn TM, McLaughlin DF, Barsh GS, Schlossman SF and
            Duke-Cohan JS.
  TITLE     Secreted and membrane attractin result from alternative splicing of
            the human ATRN gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (11), 6025-6030 (2000)
   PUBMED   10811918
  REMARK    GeneRIF: Provides the genomic basis for production of a soluble and
            membrane form of attractin by alternative splicing. In the process,
            by sequencing from positionally-determined BAC clones, confirms the
            localization of attractin to chromosome 20p13.
REFERENCE   8  (bases 1 to 8651)
  AUTHORS   Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ and Schlossman
            SF.
  TITLE     Attractin (DPPT-L), a member of the CUB family of cell adhesion and
            guidance proteins, is secreted by activated human T lymphocytes and
            modulates immune cell interactions
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (19), 11336-11341 (1998)
   PUBMED   9736737
REFERENCE   9  (bases 1 to 8651)
  AUTHORS   Duke-Cohan JS, Morimoto C, Rocker JA and Schlossman SF.
  TITLE     Serum high molecular weight dipeptidyl peptidase IV (CD26) is
            similar to a novel antigen DPPT-L released from activated T cells
  JOURNAL   J. Immunol. 156 (5), 1714-1721 (1996)
   PUBMED   8596018
REFERENCE   10 (bases 1 to 8651)
  AUTHORS   Mori M, Sakurai M and Araie M.
  TITLE     [Topical timolol and blood-aqueous barrier permeability to protein
            in human eyes]
  JOURNAL   Nippon Ganka Gakkai Zasshi 96 (11), 1418-1422 (1992)
   PUBMED   1476071
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB240822.1, BC101705.1,
            EC440053.1, AB011120.1, AL132773.14 and BE326239.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_139321.2.
            
            Summary: This gene encodes both membrane-bound and secreted protein
            isoforms. A membrane-bound isoform exhibits sequence similarity
            with the mouse mahogany protein, a receptor involved in controlling
            obesity. A secreted isoform is involved in the initial immune cell
            clustering during inflammatory responses that may regulate the
            chemotactic activity of chemokines. [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1), which is contained in the membrane.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.197821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262919.10/ ENSP00000262919.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               DB240822.1         1-158
            159-594             DB240822.1         160-595
            595-2981            BC101705.1         545-2931
            2982-2986           EC440053.1         1-5                 c
            2987-3019           BC101705.1         2937-2969
            3020-4813           AB011120.1         1-1794
            4814-8444           AL132773.14        99953-103583
            8445-8651           BE326239.1         8-214               c
FEATURES             Location/Qualifiers
     source          1..8651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..8651
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /note="attractin"
                     /db_xref="GeneID:8455"
                     /db_xref="HGNC:HGNC:885"
                     /db_xref="MIM:603130"
     exon            1..500
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..4380
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; attractin-2; mahogany protein; mahogany
                     homolog"
                     /codon_start=1
                     /product="attractin isoform 1 preproprotein"
                     /protein_id="NP_647537.1"
                     /db_xref="CCDS:CCDS13053.1"
                     /db_xref="GeneID:8455"
                     /db_xref="HGNC:HGNC:885"
                     /db_xref="MIM:603130"
                     /translation="MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLG
                     AGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAVSGSAAAEAKECD
                     RPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTW
                     LIEGQPNRIMRLRFNHFATECSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPE
                     VVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVECECSEN
                     WKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEY
                     SNLKLPRASHKAVVNGNIMWVVGGYMFNHSDYNMVLAYDLASREWLPLNRSVNNVVVR
                     YGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAH
                     IVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYD
                     HRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFFRYLHTAVIVSGTM
                     LVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNRFGHSAVLHNS
                     TMYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALAT
                     DEQEEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDCHWCNDHCVPRNHSCSEGQIS
                     IFRYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNS
                     CLKITTAKENYDNAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPW
                     VGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLN
                     GSVCERPANHSAKQCRTPCALRTACGDCTSGSSECMWCSNMKQCVDSNAYVASFPFGQ
                     CMEWYTMSTCPPENCSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQ
                     APTGNFYPQPLLNSSMCLEDSRYNWSFIHCPACQCNGHSKCINQSICEKCENLTTGKH
                     CETCISGFYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRY
                     QGNPLRGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFN
                     LNITWAASFSAGTQAGEEMPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFVYVSNFTW
                     PIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREM
                     QQMASRPFASVNVALETDEEPPDLIGGSIKTVPKPIALEPCFGNKAAVLSVFVRLPRG
                     LGGIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI"
     exon            501..584
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            585..698
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            699..827
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1033
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1202
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1293
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1537
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1721
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1876
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1961
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2182
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2304
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2443
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2634
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2854
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3040
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3274
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3412
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3506
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3559
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3654
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3733
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3891
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..3953
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3954..4032
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4140
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4255
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..8651
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8629..8634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /note="hexamer: AATAAA"
     polyA_site      8651
                     /gene="ATRN"
                     /gene_synonym="DPPT-L; MGCA"
                     /note="major polyA site"
ORIGIN      
        1 acagccccgc cccgcacggc caggcgaagc ggagccggcc gtgcggtgtg tgtgtatgtg
       61 ttcgcggggc gccgtctcag ccccgggaag atggtggctg cagcggcggc aactgaggca
      121 aggctgagga ggaggacggc ggcgacggca gcgctcgcgg gcaggagcgg cgggccgcac
      181 tgggactggg acgtgaccag ggctgggagg ccggggctgg gggccgggct gcgcctcccg
      241 cggctgctgt ctccaccgct gcggccacgg ctgctgctgc tgctgttgtt gctctcgccg
      301 ccgctgctgc tgctgctgct gccctgtgag gccgaggccg cggcggcggc ggcggcggtg
      361 tcgggctcag ccgcagccga ggccaaggaa tgtgaccggc cctgtgtcaa cggcggtcgc
      421 tgcaaccctg gcaccggcca gtgcgtctgc cccgccggct gggtgggcga gcaatgccag
      481 cactgcgggg gccgcttcag actaactgga tcttctgggt ttgtgacaga tggacctgga
      541 aattataaat acaaaacgaa gtgcacgtgg ctcattgaag gacagccaaa tagaataatg
      601 agacttcgtt tcaatcattt tgctacagag tgtagttggg accatttata tgtttatgat
      661 ggggactcaa tttatgcacc gctagttgct gcatttagtg gcctcattgt tcctgagaga
      721 gatggcaatg agactgtccc tgaggttgtt gccacatcag gttatgcctt gctgcatttt
      781 tttagtgatg ctgcttataa tttgactgga tttaatatta cttacagttt tgatatgtgt
      841 ccaaataact gctcaggccg aggagagtgt aagatcagta atagcagcga tactgttgaa
      901 tgtgaatgtt ctgaaaactg gaaaggtgaa gcatgtgaca ttcctcactg tacagacaac
      961 tgtggttttc ctcatcgagg catctgcaat tcaagtgatg tcagaggatg ctcctgcttc
     1021 tcagactggc agggtcctgg atgttcagtt cctgtaccag ctaaccagtc attttggact
     1081 cgagaggaat attctaactt aaagctcccc agagcatctc ataaagctgt ggtcaatgga
     1141 aacattatgt gggttgttgg aggatatatg ttcaaccact cagattataa catggttcta
     1201 gcgtatgacc ttgcttctag ggagtggctt ccactaaacc gttctgtgaa caatgtggtt
     1261 gttagatatg gtcattcttt ggcattatac aaggataaaa tttacatgta tggaggaaaa
     1321 attgattcaa ctgggaatgt gaccaatgag ttgagagttt ttcacattca taatgagtca
     1381 tgggtgttgt tgacccctaa ggcaaaggag cagtatgcag tggttgggca ctctgcacac
     1441 attgttacac tgaagaatgg ccgagtggtc atgctggtca tctttggtca ctgccctctc
     1501 tatggatata taagcaatgt gcaggaatat gatttggata agaacacatg gagtatatta
     1561 cacacccagg gtgcccttgt gcaagggggt tacggccata gcagtgttta cgaccatagg
     1621 accagggccc tatacgttca tggtggctac aaggctttca gtgccaataa gtaccggctt
     1681 gcagatgatc tctaccgata tgatgtggat acccagatgt ggaccattct taaggacagc
     1741 cgatttttcc gttacttgca cacagctgtg atagtgagtg gaaccatgct ggtgtttgga
     1801 ggaaacacac acaatgacac atctatgagc catggcgcca aatgcttctc ttcagatttc
     1861 atggcctatg acattgcctg tgaccgctgg tcagtgcttc ccagacctga tctccaccat
     1921 gatgtcaaca gatttggcca ttcagcagtc ttacacaaca gcaccatgta tgtgttcggt
     1981 ggtttcaata gtctcctcct cagcgacatc ctggtattca cctcggaaca gtgtgatgcg
     2041 catcggagtg aagccgcttg tttagcagca ggacctggta ttcggtgtgt gtggaacaca
     2101 gggtcgtctc agtgtatctc gtgggcgctg gcaactgatg aacaagaaga aaagttaaaa
     2161 tcagaatgtt tttccaaaag aactcttgac catgacagat gtgaccagca cacagattgt
     2221 tacagctgca cagccaacac caatgactgc cactggtgca atgaccattg tgtccccagg
     2281 aaccacagct gctcagaagg ccagatctcc atttttaggt atgagaattg ccccaaggat
     2341 aaccccatgt actactgtaa caagaagacc agctgcagga gctgtgccct ggaccagaac
     2401 tgccagtggg agccccggaa tcaggagtgc attgccctgc ccgaaaatat ctgtggcatt
     2461 ggctggcatt tggttggaaa ctcatgtttg aaaattacta ctgccaagga gaattatgac
     2521 aatgctaaat tgttctgtag gaaccacaat gcccttttgg cttctcttac aacccagaag
     2581 aaggtagaat ttgtccttaa gcagctgcga ataatgcagt catctcagag catgtccaag
     2641 ctcaccttaa ccccatgggt cggccttcgg aagatcaatg tgtcctactg gtgctgggaa
     2701 gatatgtccc catttacaaa tagtttacta cagtggatgc cgtctgagcc cagtgatgct
     2761 ggattctgtg gaattttatc agaacccagt actcggggac tgaaggctgc aacctgcatc
     2821 aacccactca atggtagtgt ctgtgaaagg cctgcaaacc acagtgctaa gcagtgccgg
     2881 acaccatgtg ccttgaggac agcatgtgga gattgcacca gcggcagctc tgagtgcatg
     2941 tggtgcagca acatgaagca gtgtgtggac tccaatgcct acgtggcctc cttccctttt
     3001 ggccagtgta tggaatggta tacgatgagc acctgccccc ctgaaaattg ttcaggctac
     3061 tgtacctgta gtcattgctt ggagcaacca ggctgtggct ggtgtactga tcccagcaat
     3121 actggcaaag ggaaatgcat agagggttcc tataaaggac cagtgaagat gccttcgcaa
     3181 gcccctacag gaaatttcta tccacagccc ctgctcaatt ccagcatgtg tctagaggac
     3241 agcagataca actggtcttt cattcactgt ccagcttgcc aatgcaacgg ccacagtaaa
     3301 tgcatcaatc agagcatctg tgagaagtgt gagaacctga ccacaggcaa gcactgcgag
     3361 acctgcatat ctggcttcta cggtgatccc accaatggag ggaaatgtca gccatgcaag
     3421 tgcaatgggc acgcgtctct gtgcaacacc aacacgggca agtgcttctg caccaccaag
     3481 ggcgtcaagg gggacgagtg ccagctatgt gaggtagaaa atcgatacca aggaaaccct
     3541 ctcagaggaa catgttatta tactcttctt attgactatc agttcacctt tagtctatcc
     3601 caggaagatg atcgctatta cacagctatc aattttgtgg ctactcctga cgaacaaaac
     3661 agggatttgg acatgttcat caatgcctcc aagaatttca acctcaacat cacctgggct
     3721 gccagtttct cagctggaac ccaggctgga gaagagatgc ctgttgtttc aaaaaccaac
     3781 attaaggagt acaaagatag tttctctaat gagaagtttg attttcgcaa ccacccaaat
     3841 atcactttct ttgtttatgt cagtaatttc acctggccca tcaaaattca gattgccttc
     3901 tctcagcaca gcaattttat ggacctggta cagttcttcg tgactttctt cagttgtttc
     3961 ctctctttgc tcctggtggc tgctgtggtt tggaagatca aacaaagttg ttgggcctcc
     4021 agacgtagag agcaacttct tcgagagatg caacagatgg ccagccgtcc ctttgcctct
     4081 gtaaatgtcg ccttggaaac agatgaggag cctcctgatc ttattggggg gagtataaag
     4141 actgttccca aacccattgc actggagccg tgttttggca acaaagccgc tgtcctctct
     4201 gtgtttgtga ggctccctcg aggcctgggt ggcatccctc ctcctgggca gtcaggtctt
     4261 gctgtggcca gcgccctggt ggacatttct cagcagatgc cgatagtgta caaggagaag
     4321 tcaggagccg tgagaaaccg gaagcagcag ccccctgcac agcctgggac ctgcatctga
     4381 tgctggggcc agggactctc ccacgcacga gctagtgagt ggcacaccag agccatctgc
     4441 agggaagggc gtggcgggga aatggctgtg cggtgcggga cggaagactg gaaaccctca
     4501 aagcatctga ctcacctgca tgatcacaag ctttctttga cggtttctcc catccgtgtt
     4561 ccagcatcta accttttact tttgcatagg aaatacttga tttaattaca ggtccaggga
     4621 tgagctgatg gttgctggag gaggccagtg tagagccagt gagagaacta ggaatgacac
     4681 tcaggttcac tgtggaaaac tgttcttggg actgtctcaa ctgtgcaaaa aacaaaagat
     4741 ggagtgttta caagtagaca ttcgtcatca gttgttcttg aacatggtct tttaaaaact
     4801 agtcagatga attgttttca tctgaagcct gctatctttt ttaaaagatg tgctatttat
     4861 tcttgcacga tttaggcaat tatctctctt ccagggagta cctttttttc tagttgagaa
     4921 ttaataatgg tccatctctt ttgatcatat caagctagga tagaaggggg gctattttaa
     4981 atgtcaaggt cagcagtgtt actttgaatg taaactggta taataggtag ttttctatag
     5041 taacttgatt aatttagtct taatccattt gaaactctct cttcctttct ctctgcctgt
     5101 ccctctcctt ctccatctca ccctccctct ctcacacata cacacacaaa cacatacaca
     5161 caacactaag tgcctagact ttaaatagat ctagcaattg gaaagttagt aagcctaagt
     5221 ttttacataa ttgcattcct acattcttgt aaaatttaaa tagctaccat tggcaatctg
     5281 ctttttttct aaaatctgat ttgcagccag gaaagaattt tctcacccaa ggaacatttg
     5341 atctagcagc agggatgaga ggaaagcaga aatgaatgaa ctgtgaaagc tcctgttttt
     5401 attatcaaaa aggacactgt caagaaggcg ccccctgccc ccacccccgt gtcaccctag
     5461 gcctgataag cgatcagagg aaaggactca ttcatgtcac gcttccttga gcagaaaaga
     5521 gcactgagag cacttgggac ccctggatca gagagcatct gtgtgtcctg cagcctcctc
     5581 tgaacttgtg gttcattctc aggctggggt ggactcagat gccaggaaag ggacagcctc
     5641 ccattgtcag gcagaagctg cccaaagcct ggagaaggac ttgtttgccc tctttccccc
     5701 aggaggggct cgacccaccc accctccctc tcagaccaag gtggtggctg tgaggagggc
     5761 agcaaatgct gacaaggatg aaaagcacat ggaaaaaaat ggatgaggag ggaaaactct
     5821 gccaaatgga aaatgaccaa atttaagagg gtgggacagt cccctgctcc tctcccagag
     5881 ggcactgctt ggaaattgtg ttttccccat ttatggtgct ctgtattctg gcattatgca
     5941 gcagcctccc agaagctctc ttctgcttca aaacctggga tctctggcat taccctattg
     6001 ggatggaccg ctggacagca atgctcgagt ttgtgaattt ggagagatac tcaaaagagc
     6061 taaaactgca gcattttacc tttaaatgca gtgcctagag agagagtatt gtctcttccc
     6121 caacactaac cccactccca tgaagaattg cctggaaaga tgttttcaag gaatttgaac
     6181 cataaaacac tatctgatgc acagaacacc tctactttga gactcacctc tcataaagct
     6241 tctttttcac attactgtta aagaccagac gttctagaaa agacccctcc tctcatgagc
     6301 tcccccatcc ctgctacaga acacagcacc catggcgcct gcagtggact ggccccttaa
     6361 ttcccacagg cccccccagc aaggccaaag ggaggcccct gggtattgtc ctcctacaag
     6421 gaagatcctc tttgtttgtt caaaggacca gttttcctag gccaaagaag tctcttcccc
     6481 atgttagtcc tatgccttga aatatcatgc accatgaccc acagccatct ggttatgtct
     6541 tatttttttc ctaaaagata atgtttattt ttaaaaagga aggaaggagc aagtgaagtt
     6601 tcattctgct ccagcggtgg ggaagccgct gaatccacct gcttctcctt tgcaaccgac
     6661 agcaaacagc tttctccggc ctcagggcag aaaaagggaa tggcagggag taagaggcgc
     6721 tgggctcgga gcctgtttcc aagaaggaat tggttgtcat ctggcagtgt tgcgcgtcac
     6781 aagagagcct gtatataaat taaaatagtc aagacaacac tgaccttgca cttgtacata
     6841 actatacagt agtgtccaga atgttcagac attcggagtg tacataaaac agaaaaaatc
     6901 ttcatgtatt tttattaaat ataacaatgt ctgagtttca cctaagatgt ttttgtgcca
     6961 tatgctggat atccaggttc tcgccaggcc ccgatacatg aataacaaac ccaagaaacg
     7021 catccccatt gtgtgatgtg ttcagatgca tctggcacca attaggtatt tcttaaaaca
     7081 ggactcatct gtcagagtgc acatgaaaaa tcaggcaggg aatcgaaacg acagtgctgg
     7141 aggagactca ggaagcagag gcgtccctgc cgctgccctt ggccctgcaa gcacatcatg
     7201 accctttctg gcagcctctt ggtgctctgg gtagtgaggg atgaccagtc ttgtcctgag
     7261 aaatgtttct cttagtcttt aagttcaaag actaacctgt agcaatcaga ctttccaaaa
     7321 gggggttctc cattttttgt agttttgtct aaatttttaa tgaccatttc ctggaatcag
     7381 tttattatac tgaaaactgg gggtgggagt agggagctag tttgttgata aatagttccc
     7441 atttccccat ggagaatttg acataccctg gactcctgtg tgcctcctgc catccctgca
     7501 cacagcctgg ggagaagcct gtgcctcccc gtgtggagag aaggcaaccc cagatcccct
     7561 gagctaaccc ggaggaaagg cagtcctgga cagaagactg tcagcagaag gaaagtactg
     7621 gactacccgt gggtaagtcc tgccattcaa gactggagac acctgggaaa taaaaagagc
     7681 agggcactgc tggtgggaag aggcatttta ccttccagtg caaatcctgc tcctttgatt
     7741 taatggggtg tactggggcc aggggctgat tcacttcctt gggagatggt ggtgttttca
     7801 tgaacatctt tgatccttcc atttcattta ttcatccatc cattcaacaa gtatttgcta
     7861 aacactaact taagctaatg ctagggtagt gactgagatg taaaaataga ttttagaatt
     7921 aaaacaaaat ccaagtcctc acacccctgt catcccagga gatctttcct tgtggtggtt
     7981 tctgtgagaa ttggccatcc tgaggacaca gccaggacgg cagaggcctc ctggcctcag
     8041 ggcatgccct gcctaccttc tgaaatgttt accccattga ccaaacttgg ctccagccat
     8101 tgcggtggtt tctagatagc caggcccacc aagagatatt gccccttgat gagagtcaaa
     8161 caccctgcct acaaggagat gttttgaaat ggagaggaaa attggcacct catcttttaa
     8221 aggcagtaat ggaattgatt ttcagtaact gaatttgtgc acaaaacatt ctaaacacta
     8281 gtgaagcctg tttcgttgaa ctaattctgg ctctggaaat gtttttgttt tatagttatt
     8341 tacgatttcg tttgtttgga ttcaagctta gtttgttaat atgtataatt tagcatctat
     8401 tacactcatg taaatatgga gtaagtattg taaactattt catcgcgggg attgtgggtg
     8461 ttatacatac atttaggact gcaatttttt ggtatttttt gtattgtaaa ataacagcta
     8521 atttaagcag gaacaagaga actaagggag gtctgtgcat tttaaacaca aatgtgaaga
     8581 acttgtatat aaacaaaagt aaatactata atacaaactt ccttctgaaa taaaagtaga
     8641 tctggtaaaa a
//
