LOCUS       NM_001170795            1227 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens all-trans retinoic acid induced differentiation factor
            (ATRAID), transcript variant 3, mRNA.
ACCESSION   NM_001170795
VERSION     NM_001170795.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1227)
  AUTHORS   Zhou,W., van Rooij,J.G.J., Ebeling,P.R., Verkerk,A.J.M.H. and
            Zillikens,M.C.
  TITLE     The Genetics of Atypical Femur Fractures-a Systematic Review
  JOURNAL   Curr Osteoporos Rep 19 (2), 123-130 (2021)
   PUBMED   33587247
  REMARK    GeneRIF: The Genetics of Atypical Femur Fractures-a Systematic
            Review.
REFERENCE   2  (bases 1 to 1227)
  AUTHORS   Surface,L.E., Burrow,D.T., Li,J., Park,J., Kumar,S., Lyu,C.,
            Song,N., Yu,Z., Rajagopal,A., Bae,Y., Lee,B.H., Mumm,S., Gu,C.C.,
            Baker,J.C., Mohseni,M., Sum,M., Huskey,M., Duan,S., Bijanki,V.N.,
            Civitelli,R., Gardner,M.J., McAndrew,C.M., Ricci,W.M.,
            Gurnett,C.A., Diemer,K., Wan,F., Costantino,C.L., Shannon,K.M.,
            Raje,N., Dodson,T.B., Haber,D.A., Carette,J.E., Varadarajan,M.,
            Brummelkamp,T.R., Birsoy,K., Sabatini,D.M., Haller,G. and
            Peterson,T.R.
  TITLE     ATRAID regulates the action of nitrogen-containing bisphosphonates
            on bone
  JOURNAL   Sci Transl Med 12 (544) (2020)
   PUBMED   32434850
REFERENCE   3  (bases 1 to 1227)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1227)
  AUTHORS   Tian,X., Wang,Q., Wu,J., Han,Q., Shen,L., Wei,C., Song,H., Li,M.,
            Fang,Y., Wang,X. and Sun,Q.
  TITLE     Interaction of Nel-like molecule 1 with apoptosis related protein 3
            with its influence on human dental pulp cells proliferation and
            differentiation into odontoblasts
  JOURNAL   Biochem Biophys Res Commun 518 (2), 246-252 (2019)
   PUBMED   31416616
  REMARK    GeneRIF: Nell-1 could reciprocally interact with APR3 and stimulate
            the differentiation and mineralization of human dental pulp cells.
REFERENCE   5  (bases 1 to 1227)
  AUTHORS   Yu,Z., Surface,L.E., Park,C.Y., Horlbeck,M.A., Wyant,G.A.,
            Abu-Remaileh,M., Peterson,T.R., Sabatini,D.M., Weissman,J.S. and
            O'Shea,E.K.
  TITLE     Identification of a transporter complex responsible for the
            cytosolic entry of nitrogen-containing bisphosphonates
  JOURNAL   Elife 7, e36620 (2018)
   PUBMED   29745899
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1227)
  AUTHORS   Shin,N., Ahn,N., Chang-Ileto,B., Park,J., Takei,K., Ahn,S.G.,
            Kim,S.A., Di Paolo,G. and Chang,S.
  TITLE     SNX9 regulates tubular invagination of the plasma membrane through
            interaction with actin cytoskeleton and dynamin 2
  JOURNAL   J Cell Sci 121 (Pt 8), 1252-1263 (2008)
   PUBMED   18388313
REFERENCE   7  (bases 1 to 1227)
  AUTHORS   Yang,G., Yu,F., Fu,H., Lu,F., Huang,B., Bai,L., Zhao,Z., Yao,L. and
            Lu,Z.
  TITLE     Identification of the distinct promoters for the two transcripts of
            apoptosis related protein 3 and their transcriptional regulation by
            NFAT and NFkappaB
  JOURNAL   Mol Cell Biochem 302 (1-2), 187-194 (2007)
   PUBMED   17387583
  REMARK    GeneRIF: These data suggested that APR3 might be functionally
            important in certain processes under which NFAT and/or NFkappaB
            are/is activated.
REFERENCE   8  (bases 1 to 1227)
  AUTHORS   Yu,F., Yang,G., Zhao,Z., Ji,L., Cao,Y., Bai,L., Lu,F., Fu,H.,
            Huang,B., Li,H., Zhang,J., Yao,L. and Lu,Z.
  TITLE     Apoptosis related protein 3, an ATRA-upregulated membrane protein
            arrests the cell cycle at G1/S phase by decreasing the expression
            of cyclin D1
  JOURNAL   Biochem Biophys Res Commun 358 (4), 1041-1046 (2007)
   PUBMED   17524364
REFERENCE   9  (bases 1 to 1227)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 1227)
  AUTHORS   Zhu,F., Yan,W., Zhao,Z.L., Chai,Y.B., Lu,F., Wang,Q., Peng,W.D.,
            Yang,A.G. and Wang,C.J.
  TITLE     Improved PCR-based subtractive hybridization strategy for cloning
            differentially expressed genes
  JOURNAL   Biotechniques 29 (2), 310-313 (2000)
   PUBMED   10948432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013403.9.
            
            On Jan 13, 2021 this sequence version replaced NM_001170795.3.
            
            Summary: This gene is thought to be involved in apoptosis, and may
            also be involved in hematopoietic development and differentiation.
            The use of alternative splice sites and promotors result in
            multiple transcript variants encoding different isoforms.[provided
            by RefSeq, Dec 2009].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002846.1, BM547374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000380171.9/
                                                ENSP00000369518.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               AC013403.9         152741-153167
            428-549             AC013403.9         153877-153998
            550-621             AC013403.9         156021-156092
            622-693             AC013403.9         156174-156245
            694-815             AC013403.9         156332-156453
            816-913             AC013403.9         157223-157320
            914-1227            AC013403.9         157544-157857
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1227
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /note="all-trans retinoic acid induced differentiation
                     factor"
                     /db_xref="GeneID:51374"
                     /db_xref="HGNC:HGNC:24090"
                     /db_xref="MIM:619682"
     exon            1..427
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1018
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; apoptosis related protein APR-3;
                     apoptosis-related protein 3"
                     /codon_start=1
                     /product="all-trans retinoic acid-induced differentiation
                     factor isoform c precursor"
                     /protein_id="NP_001164266.1"
                     /db_xref="CCDS:CCDS62877.1"
                     /db_xref="GeneID:51374"
                     /db_xref="HGNC:HGNC:24090"
                     /db_xref="MIM:619682"
                     /translation="MAPHDPGSLTTLVPWAAALLLALGVERALALPEICTQCPGSVQN
                     LSKVAFYCKTTRELMLHARCCLNQKGTILGLDLQNCSLEDPGPNFHQAHTTVIIDLQA
                     NPLKGDLANTFRGFTQLQTLILPQHVNCPGGINAWNTITSYIDNQICQGQKNLCNNTG
                     DPEMCPENGSCVPDGPGLLQCVCADGFHGYKCMRQGSFSLLMFFGILGATTLSVSILL
                     WATQRRKAKTS"
     exon            428..549
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /inference="alignment:Splign:2.1.0"
     exon            550..621
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /inference="alignment:Splign:2.1.0"
     exon            622..693
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /inference="alignment:Splign:2.1.0"
     exon            694..815
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /inference="alignment:Splign:2.1.0"
     exon            816..913
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1227
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1207..1212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /note="hexamer: AATAAA"
     polyA_site      1227
                     /gene="ATRAID"
                     /gene_synonym="APR--3; APR-3; APR3; C2orf28; HSPC013; p18;
                     PRO240"
                     /note="major polyA site"
ORIGIN      
        1 gagtttctgc gaagccgcga cctcggcgtc cggacgcggg gaacaccggg ctgagggagt
       61 ctgcagtcgg ctccgggaag ccgcgcggcg acgggggagg ccttcactaa aggggaaaag
      121 gaagaggggg tcggccagta tccccgaaag agggctaggg cgcatgaaga ccagcgcaga
      181 gctccacgag caggaaaagc ccccaagcag ccccagggcg actggaccgg gccgcttagg
      241 ccacgcccgg ggaagagggc ctgacgcgct gcggggcggg gccgcggggc cgggtcgcgc
      301 gagcagcgga gcaccaaggg aacggaaaat ggcgcctcac gacccgggta gtcttacgac
      361 cctggtgccc tgggctgccg ccctgctcct cgctctgggc gtggaaaggg ctctggcgct
      421 acccgagata tgcacccaat gtccagggag cgtgcaaaat ttgtcaaaag tggcctttta
      481 ttgtaaaacg acacgagagc taatgctgca tgcccgttgc tgcctgaatc agaagggcac
      541 catcttgggg ctggatctcc agaactgttc tctggaggac cctggtccaa actttcatca
      601 ggcacatacc actgtcatca tagacctgca agcaaacccc ctcaaaggtg acttggccaa
      661 caccttccgt ggctttactc agctccagac tctgatactg ccacaacatg tcaactgtcc
      721 tggaggaatt aatgcctgga atactatcac ctcttatata gacaaccaaa tctgtcaagg
      781 gcaaaagaac ctttgcaata acactgggga cccagaaatg tgtcctgaga atggatcttg
      841 tgtacctgat ggtccaggtc ttttgcagtg tgtttgtgct gatggtttcc atggatacaa
      901 gtgtatgcgc cagggctcgt tctcactgct tatgttcttc gggattctgg gagccaccac
      961 tctatccgtc tccattctgc tttgggcgac ccagcgccga aaagccaaga cttcatgaac
     1021 tacataggtc ttaccattga cctaagatca atctgaacta tcttagccca gtcagggagc
     1081 tctgcttcct agaaaggcat ctttcgccag tggattcgcc tcaaggttga ggccgccatt
     1141 ggaagatgaa aaattgcact cccttggtgt agacaaatac cagttcccat tggtgttgtt
     1201 gcctataata aacacttttt tcttttt
//
