LOCUS       NM_001184               8158 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ATR serine/threonine kinase (ATR), transcript variant
            1, mRNA.
ACCESSION   NM_001184 XM_940761
VERSION     NM_001184.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8158)
  AUTHORS   Garcia-Rodriguez,N., Dominguez-Garcia,I., Dominguez-Perez,M.D.C.
            and Huertas,P.
  TITLE     EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR
            activation and to maintain viability in BRCA1-deficient cells
  JOURNAL   Nucleic Acids Res 52 (11), 6376-6391 (2024)
   PUBMED   38721777
  REMARK    GeneRIF: EXO1 and DNA2-mediated ssDNA gap expansion is essential
            for ATR activation and to maintain viability in BRCA1-deficient
            cells.
REFERENCE   2  (bases 1 to 8158)
  AUTHORS   Kim,H., Cho,U., Hong,S.H., Park,H.S., Kim,I.H., An,H.J., Shim,B.Y.
            and Kang,J.H.
  TITLE     New insights into ATR inhibition in muscle invasive bladder cancer:
            The role of apolipoprotein B mRNA editing catalytic subunit 3B
  JOURNAL   Oncol Res 32 (6), 1021-1030 (2024)
   PUBMED   38827321
  REMARK    GeneRIF: New insights into ATR inhibition in muscle invasive
            bladder cancer: The role of apolipoprotein B mRNA editing catalytic
            subunit 3B.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8158)
  AUTHORS   Geng,A., Sun,J., Tang,H., Yu,Y., Wang,X., Zhang,J., Wang,X.,
            Sun,X., Zhou,X., Gao,N., Tan,R., Xu,Z., Jiang,Y. and Mao,Z.
  TITLE     SIRT2 promotes base excision repair by transcriptionally activating
            OGG1 in an ATM/ATR-dependent manner
  JOURNAL   Nucleic Acids Res 52 (9), 5107-5120 (2024)
   PUBMED   38554113
  REMARK    GeneRIF: SIRT2 promotes base excision repair by transcriptionally
            activating OGG1 in an ATM/ATR-dependent manner.
REFERENCE   4  (bases 1 to 8158)
  AUTHORS   Liu,M.Y., Lin,K.R., Chien,Y.L., Yang,B.Z., Tsui,L.Y., Chu,H.C. and
            Wu,C.P.
  TITLE     ATR phosphorylates DHX9 at serine 321 to suppress R-loop
            accumulation upon genotoxic stress
  JOURNAL   Nucleic Acids Res 52 (1), 204-222 (2024)
   PUBMED   37930853
  REMARK    GeneRIF: ATR phosphorylates DHX9 at serine 321 to suppress R-loop
            accumulation upon genotoxic stress.
REFERENCE   5  (bases 1 to 8158)
  AUTHORS   Kovacs,M.T., Vallette,M., Wiertsema,P., Dingli,F., Loew,D.,
            Nader,G.P.F., Piel,M. and Ceccaldi,R.
  TITLE     DNA damage induces nuclear envelope rupture through ATR-mediated
            phosphorylation of lamin A/C
  JOURNAL   Mol Cell 83 (20), 3659-3668 (2023)
   PUBMED   37832547
REFERENCE   6  (bases 1 to 8158)
  AUTHORS   Cliby,W.A., Roberts,C.J., Cimprich,K.A., Stringer,C.M., Lamb,J.R.,
            Schreiber,S.L. and Friend,S.H.
  TITLE     Overexpression of a kinase-inactive ATR protein causes sensitivity
            to DNA-damaging agents and defects in cell cycle checkpoints
  JOURNAL   EMBO J 17 (1), 159-169 (1998)
   PUBMED   9427750
REFERENCE   7  (bases 1 to 8158)
  AUTHORS   Bentley,N.J., Holtzman,D.A., Flaggs,G., Keegan,K.S., DeMaggio,A.,
            Ford,J.C., Hoekstra,M. and Carr,A.M.
  TITLE     The Schizosaccharomyces pombe rad3 checkpoint gene
  JOURNAL   EMBO J 15 (23), 6641-6651 (1996)
   PUBMED   8978690
REFERENCE   8  (bases 1 to 8158)
  AUTHORS   Keegan,K.S., Holtzman,D.A., Plug,A.W., Christenson,E.R.,
            Brainerd,E.E., Flaggs,G., Bentley,N.J., Taylor,E.M., Meyn,M.S.,
            Moss,S.B., Carr,A.M., Ashley,T. and Hoekstra,M.F.
  TITLE     The Atr and Atm protein kinases associate with different sites
            along meiotically pairing chromosomes
  JOURNAL   Genes Dev 10 (19), 2423-2437 (1996)
   PUBMED   8843195
REFERENCE   9  (bases 1 to 8158)
  AUTHORS   Cimprich,K.A., Shin,T.B., Keith,C.T. and Schreiber,S.L.
  TITLE     cDNA cloning and gene mapping of a candidate human cell cycle
            checkpoint protein
  JOURNAL   Proc Natl Acad Sci U S A 93 (7), 2850-2855 (1996)
   PUBMED   8610130
REFERENCE   10 (bases 1 to 8158)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U49844.1, U76308.1 and
            BE859077.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001184.3.
            
            Summary: The protein encoded by this gene is a serine/threonine
            kinase and DNA damage sensor, activating cell cycle checkpoint
            signaling upon DNA stress. The encoded protein can phosphorylate
            and activate several proteins involved in the inhibition of DNA
            replication and mitosis, and can promote DNA repair, recombination,
            and apoptosis. This protein is also important for fragile site
            stability and centrosome duplication. Defects in this gene are a
            cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U76308.1, Y09077.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350721.9/ ENSP00000343741.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4249              U49844.1           77-4325
            4250-7903           U76308.1           4300-7953
            7904-8158           BE859077.1         8-262               c
FEATURES             Location/Qualifiers
     source          1..8158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..8158
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /note="ATR serine/threonine kinase"
                     /db_xref="GeneID:545"
                     /db_xref="HGNC:HGNC:882"
                     /db_xref="MIM:601215"
     exon            1..88
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..7964
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; MEC1,
                     mitosis entry checkpoint 1, homolog; FRAP-related
                     protein-1; ataxia telangiectasia and Rad3-related protein"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ATR isoform 1"
                     /protein_id="NP_001175.2"
                     /db_xref="CCDS:CCDS3124.1"
                     /db_xref="GeneID:545"
                     /db_xref="HGNC:HGNC:882"
                     /db_xref="MIM:601215"
                     /translation="MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRI
                     LTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNW
                     IITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLH
                     RRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIA
                     IVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLEL
                     LKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVL
                     MRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYL
                     LGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEE
                     IKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCS
                     HQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKV
                     VKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRI
                     SDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQ
                     NSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDL
                     FCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFRED
                     ETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTH
                     AQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRAL
                     VAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMAL
                     NTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILI
                     NNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQ
                     QVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIE
                     DKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLD
                     HACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELK
                     KIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
                     YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQG
                     KDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETN
                     GPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASW
                     AGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEI
                     MAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSN
                     RNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQN
                     IQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAI
                     QLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQW
                     DLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERG
                     SYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPI
                     LALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVE
                     RAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANF
                     ESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGR
                     SLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNY
                     LAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMR
                     VNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKK
                     LVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASL
                     QKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRT
                     YAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLK
                     VFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGEN
                     ILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEV
                     TMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIE
                     QRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM"
     exon            89..180
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..321
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..1199
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1378
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1570
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1761
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1914
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2107
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2370
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2561
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2662
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2834
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3005
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3200
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3386
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3479
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3610
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3754
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3848
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..3974
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4181
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4182..4295
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4296..4411
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4412..4532
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..4670
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4671..4881
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..5060
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5061..5225
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5226..5317
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5318..5409
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5410..5587
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5588..5767
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5768..5927
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5928..6107
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6108..6250
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6251..6348
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6349..6581
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6582..6716
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6717..6926
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6927..7070
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7071..7221
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7222..7378
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7379..7532
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7533..7684
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7685..7790
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7791..8158
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8056..8061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /note="hexamer: CATAAA"
     polyA_site      8077
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /note="major polyA site"
     regulatory      8137..8142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
                     /note="hexamer: AATAAA"
     polyA_site      8158
                     /gene="ATR"
                     /gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
ORIGIN      
        1 gtggttgact agtgcctcgc agcctcagca tgggggaaca tggcctggag ctggcttcca
       61 tgatccccgc cctgcgggag ctgggcagtg ccacaccaga ggaatataat acagttgtac
      121 agaagccaag acaaattctg tgtcaattca ttgaccggat acttacagat gtaaatgttg
      181 ttgctgtaga acttgtaaag aaaactgact ctcagccaac ctccgtgatg ttgcttgatt
      241 tcatccagca tatcatgaaa tcctccccac ttatgtttgt aaatgtgagt ggaagccatg
      301 aggccaaagg cagttgtatt gaattcagta attggatcat aacgagactt ctgcggattg
      361 cagcaactcc ctcctgtcat ttgttacaca agaaaatctg tgaagtcatc tgttcattat
      421 tatttctttt taaaagcaag agtcctgcta tttttggggt actcacaaaa gaattattac
      481 aactttttga agacttggtt tacctccata gaagaaatgt gatgggtcat gctgtggaat
      541 ggccagtggt catgagccga tttttaagtc aattagatga acacatggga tatttacaat
      601 cagctccttt gcagttgatg agtatgcaaa atttagaatt tattgaagtc actttattaa
      661 tggttcttac tcgtattatt gcaattgtgt tttttagaag gcaagaactc ttactttggc
      721 agataggttg tgttctgcta gagtatggta gtccaaaaat taaatcccta gcaattagct
      781 ttttaacaga actttttcag cttggaggac taccagcaca accagctagc acttttttca
      841 gctcattttt ggaattatta aaacaccttg tagaaatgga tactgaccaa ttgaaactct
      901 atgaagagcc attatcaaag ctgataaaga cactatttcc ctttgaagca gaagcttata
      961 gaaatattga acctgtctat ttaaatatgc tgctggaaaa actctgtgtc atgtttgaag
     1021 acggtgtgct catgcggctt aagtctgatt tgctaaaagc agctttgtgc catttactgc
     1081 agtatttcct taaatttgtg ccagctgggt atgaatctgc tttacaagtc aggaaggtct
     1141 atgtgagaaa tatttgtaaa gctcttttgg atgtgcttgg aattgaggta gatgcagagt
     1201 acttgttggg cccactttat gcagctttga aaatggaaag tatggaaatc attgaggaga
     1261 ttcaatgcca aactcaacag gaaaacctca gcagtaatag tgatggaata tcacccaaaa
     1321 ggcgtcgtct cagctcgtct ctaaaccctt ctaaaagagc accaaaacag actgaggaaa
     1381 ttaaacatgt ggacatgaac caaaagagca tattatggag tgcactgaaa cagaaagctg
     1441 aatcccttca gatttccctt gaatacagtg gcctaaagaa tcctgttatt gagatgttag
     1501 aaggaattgc tgttgtctta caactgactg ctctgtgtac tgttcattgt tctcatcaaa
     1561 acatgaactg ccgtactttc aaggactgtc aacataaatc caagaagaaa ccttctgtag
     1621 tgataacttg gatgtcattg gatttttaca caaaagtgct taagagctgt agaagtttgt
     1681 tagaatctgt tcagaaactg gacctggagg caaccattga taaggtggtg aaaatttatg
     1741 atgctttgat ttatatgcaa gtaaacagtt catttgaaga tcatatcctg gaagatttat
     1801 gtggtatgct ctcacttcca tggatttatt cccattctga tgatggctgt ttaaagttga
     1861 ccacatttgc cgctaatctt ctaacattaa gctgtaggat ttcagatagc tattcaccac
     1921 aggcacaatc acgatgtgtg tttcttctga ctctgtttcc aagaagaata ttccttgagt
     1981 ggagaacagc agtttacaac tgggccctgc agagctccca tgaagtaatc cgggctagtt
     2041 gtgttagtgg attttttatc ttattgcagc agcagaattc ttgtaacaga gttcccaaga
     2101 ttcttataga taaagtcaaa gatgattctg acattgtcaa gaaagaattt gcttctatac
     2161 ttggtcaact tgtctgtact cttcacggca tgttttatct gacaagttct ttaacagaac
     2221 ctttctctga acacggacat gtggacctct tctgtaggaa cttgaaagcc acttctcaac
     2281 atgaatgttc atcttctcaa ctaaaagctt ctgtctgcaa gccattcctt ttcctactga
     2341 aaaaaaaaat acctagtcca gtaaaacttg ctttcataga taatctacat catctttgta
     2401 agcatcttga ttttagagaa gatgaaacag atgtaaaagc agttcttgga actttattaa
     2461 atttaatgga agatccagac aaagatgtta gagtggcttt tagtggaaat atcaagcaca
     2521 tattggaatc cttggactct gaagatggat ttataaagga gctttttgtc ttaagaatga
     2581 aggaagcata tacacatgcc caaatatcaa gaaataatga gctgaaggat accttgattc
     2641 ttacaacagg ggatattgga agggccgcaa aaggagattt ggtaccattt gcactcttac
     2701 acttattgca ttgtttgtta tccaagtcag catctgtctc tggagcagca tacacagaaa
     2761 ttagagctct ggttgcagct aaaagtgtta aactgcaaag ttttttcagc cagtataaga
     2821 aacccatctg tcagtttttg gtagaatccc ttcactctag tcagatgaca gcacttccga
     2881 atactccatg ccagaatgct gacgtgcgaa aacaagatgt ggctcaccag agagaaatgg
     2941 ctttaaatac gttgtctgaa attgccaacg ttttcgactt tcctgatctt aatcgttttc
     3001 ttactaggac attacaagtt ctactacctg atcttgctgc caaagcaagc cctgcagctt
     3061 ctgctctcat tcgaacttta ggaaaacaat taaatgtcaa tcgtagagag attttaataa
     3121 acaacttcaa atatattttt tctcatttgg tctgttcttg ttccaaagat gaattagaac
     3181 gtgcccttca ttatctgaag aatgaaacag aaattgaact ggggagcctg ttgagacaag
     3241 atttccaagg attgcataat gaattattgc tgcgtattgg agaacactat caacaggttt
     3301 ttaatggttt gtcaatactt gcctcatttg catccagtga tgatccatat cagggcccga
     3361 gagatatcat atcacctgaa ctgatggctg attatttaca acccaaattg ttgggcattt
     3421 tggctttttt taacatgcag ttactgagct ctagtgttgg cattgaagat aagaaaatgg
     3481 ccttgaacag tttgatgtct ttgatgaagt taatgggacc caaacatgtc agttctgtga
     3541 gggtgaagat gatgaccaca ctgagaactg gccttcgatt caaggatgat tttcctgaat
     3601 tgtgttgcag agcttgggac tgctttgttc gctgcctgga tcatgcttgt ctgggctccc
     3661 ttctcagtca tgtaatagta gctttgttac ctcttataca catccagcct aaagaaactg
     3721 cagctatctt ccactacctc ataattgaaa acagggatgc tgtgcaagat tttcttcatg
     3781 aaatatattt tttacctgat catccagaat taaaaaagat aaaagccgtt ctccaggaat
     3841 acagaaagga gacctctgag agcactgatc ttcagacaac tcttcagctc tctatgaagg
     3901 ccattcaaca tgaaaatgtc gatgttcgta ttcatgctct tacaagcttg aaggaaacct
     3961 tgtataaaaa tcaggaaaaa ctgataaagt atgcaacaga cagtgaaaca gtagaaccta
     4021 ttatctcaca gttggtgaca gtgcttttga aaggttgcca agatgcaaac tctcaagctc
     4081 ggttgctctg tggggaatgt ttaggggaat tgggggcgat agatccaggt cgattagatt
     4141 tctcaacaac tgaaactcaa ggaaaagatt ttacatttgt gactggagta gaagattcaa
     4201 gctttgccta tggattattg atggagctaa caagagctta ccttgcgtat gctgataata
     4261 gccgagctca agattcagct gcctatgcca ttcaggagtt gctttctatt tatgactgta
     4321 gagagatgga gaccaacggc ccaggtcacc aattgtggag gagatttcct gagcatgttc
     4381 gggaaatact agaacctcat ctaaatacca gatacaagag ttctcagaag tcaaccgatt
     4441 ggtctggagt aaagaagcca atttacttaa gtaaattggg tagtaacttt gcagaatggt
     4501 cagcatcttg ggcaggttat cttattacaa aggttcgaca tgatcttgcc agtaaaattt
     4561 tcacctgctg tagcattatg atgaagcatg atttcaaagt gaccatctat cttcttccac
     4621 atattctggt gtatgtctta ctgggttgta atcaagaaga tcagcaggag gtttatgcag
     4681 aaattatggc agttctaaag catgacgatc agcataccat aaatacccaa gacattgcat
     4741 ctgatctgtg tcaactcagt acacagactg tgttctccat gcttgaccat ctcacacagt
     4801 gggcaaggca caaatttcag gcactgaaag ctgagaaatg tccacacagc aaatcaaaca
     4861 gaaataaggt agactcaatg gtatctactg tggattatga agactatcag agtgtaaccc
     4921 gttttctaga cctcataccc caggatactc tggcagtagc ttcctttcgc tccaaagcat
     4981 acacacgagc tgtaatgcac tttgaatcat ttattacaga aaagaagcaa aatattcagg
     5041 aacatcttgg atttttacag aaattgtatg ctgctatgca tgaacctgat ggagtggccg
     5101 gagtcagtgc aattagaaag gcagaaccat ctctaaaaga acagatcctt gaacatgaaa
     5161 gccttggctt gctgagggat gccactgctt gttatgacag ggctattcag ctagaaccag
     5221 accagatcat tcattatcat ggtgtagtaa agtccatgtt aggtcttggt cagctgtcta
     5281 ctgttatcac tcaggtgaat ggagtgcatg ctaacaggtc cgagtggaca gatgaattaa
     5341 acacgtacag agtggaagca gcttggaaat tgtcacagtg ggatttggtg gaaaactatt
     5401 tggcagcaga tggaaaatct acaacatgga gtgtcagact gggacagcta ttattatcag
     5461 ccaaaaaaag agatatcaca gctttttatg actcactgaa actagtgaga gcagaacaaa
     5521 ttgtacctct ttcagctgca agctttgaaa gaggctccta ccaacgagga tatgaatata
     5581 ttgtgagatt gcacatgtta tgtgagttgg agcatagcat caaaccactt ttccagcatt
     5641 ctccaggtga cagttctcaa gaagattctc taaactgggt agctcgacta gaaatgaccc
     5701 agaattccta cagagccaag gagcctatcc tggctctccg gagggcttta ctaagcctca
     5761 acaaaagacc agattacaat gaaatggttg gagaatgctg gctgcagagt gccagggtag
     5821 ctagaaaggc tggtcaccac cagacagcct acaatgctct ccttaatgca ggggaatcac
     5881 gactcgctga actgtacgtg gaaagggcaa agtggctctg gtccaagggt gatgttcacc
     5941 aggcactaat tgttcttcaa aaaggtgttg aattatgttt tcctgaaaat gaaaccccac
     6001 ctgagggtaa gaacatgtta atccatggtc gagctatgct actagtgggc cgatttatgg
     6061 aagaaacagc taactttgaa agcaatgcaa ttatgaaaaa atataaggat gtgaccgcgt
     6121 gcctgccaga atgggaggat gggcattttt accttgccaa gtactatgac aaattgatgc
     6181 ccatggtcac agacaacaaa atggaaaagc aaggtgatct catccggtat atagttcttc
     6241 attttggcag atctctacaa tatggaaatc agttcatata tcagtcaatg ccacgaatgt
     6301 taactctatg gcttgattat ggtacaaagg catatgaatg ggaaaaagct ggccgctccg
     6361 atcgtgtaca aatgaggaat gatttgggta aaataaacaa ggttatcaca gagcatacaa
     6421 actatttagc tccatatcaa tttttgactg ctttttcaca attgatctct cgaatttgtc
     6481 attctcacga tgaagttttt gttgtcttga tggaaataat agccaaagta tttctagcct
     6541 atcctcaaca agcaatgtgg atgatgacag ctgtgtcaaa gtcatcttat cccatgcgtg
     6601 tgaacagatg caaggaaatc ctcaataaag ctattcatat gaaaaaatcc ttagagaagt
     6661 ttgttggaga tgcaactcgc ctaacagata agcttctaga attgtgcaat aaaccggttg
     6721 atggaagtag ttccacatta agcatgagca ctcattttaa aatgcttaaa aagctggtag
     6781 aagaagcaac atttagtgaa atcctcattc ctctacaatc agtcatgata cctacacttc
     6841 catcaattct gggtacccat gctaaccatg ctagccatga accatttcct ggacattggg
     6901 cctatattgc agggtttgat gatatggtgg aaattcttgc ttctcttcag aaaccaaaga
     6961 agatttcttt aaaaggctca gatggaaagt tctacatcat gatgtgtaag ccaaaagatg
     7021 acctgagaaa ggattgtaga ctaatggaat tcaattcctt gattaataag tgcttaagaa
     7081 aagatgcaga gtctcgtaga agagaacttc atattcgaac atatgcagtt attccactaa
     7141 atgatgaatg tgggattatt gaatgggtga acaacactgc tggtttgaga cctattctga
     7201 ccaaactata taaagaaaag ggagtgtata tgacaggaaa agaacttcgc cagtgtatgc
     7261 taccaaagtc agcagcttta tctgaaaaac tcaaagtatt ccgagaattt ctcctgccca
     7321 ggcatcctcc tatttttcat gagtggtttc tgagaacatt ccctgatcct acatcatggt
     7381 acagtagtag atcagcttac tgccgttcca ctgcagtaat gtcaatggtt ggttatattc
     7441 tggggcttgg agaccgtcat ggtgaaaata ttctctttga ttctttgact ggtgaatgcg
     7501 tacatgtaga tttcaattgt cttttcaata agggagaaac ctttgaagtt ccagaaattg
     7561 tgccatttcg cctgactcat aatatggtta atggaatggg tcctatggga acagagggtc
     7621 tttttcgaag agcatgtgaa gttacaatga ggctgatgcg tgatcagcga gagcctttaa
     7681 tgagtgtctt aaagactttt ctacatgatc ctcttgtgga atggagtaaa ccagtgaaag
     7741 ggcattccaa agcgccactg aatgaaactg gagaagttgt caatgaaaag gccaagaccc
     7801 atgttcttga cattgagcag cgactacaag gtgtaatcaa gactcgaaat agagtgacag
     7861 gactgccgtt atctattgaa ggacatgtgc attaccttat acaggaagct actgatgaaa
     7921 acttactatg ccagatgtat cttggttgga ctccatatat gtgaaatgaa attatgtaaa
     7981 agaatatgtt aataatctaa aagtaatgca tttggtatga atctgtggtt gtatctgttc
     8041 aattctaaag tacaacataa atttacgttc tcagcaactg ttatttctct ctgatcatta
     8101 attatatgta aaataatata cattcagtta ttaagaaata aactgctttc ttaataca
//
