LOCUS       NM_198531               4361 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ATPase phospholipid transporting 9B (putative)
            (ATP9B), transcript variant 1, mRNA.
ACCESSION   NM_198531 XM_351168
VERSION     NM_198531.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4361)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   2  (bases 1 to 4361)
  AUTHORS   Tashiro-Yamaji,J., Shimizu,T., Hayashi,M., Yamana,H., Tanigawa,N.,
            Uchiyama,K., Kubota,T. and Yoshida,R.
  TITLE     Specific binding of HLA-B44 to human macrophage MHC receptor 1 on
            monocytes
  JOURNAL   Gene 501 (2), 127-134 (2012)
   PUBMED   22525042
  REMARK    GeneRIF: These results revealed that human human macrophage MHC
            receptor 1 on monocytes is a novel receptor specific for HLA-B44.
REFERENCE   3  (bases 1 to 4361)
  AUTHORS   Takatsu,H., Baba,K., Shima,T., Umino,H., Kato,U., Umeda,M.,
            Nakayama,K. and Shin,H.W.
  TITLE     ATP9B, a P4-ATPase (a putative aminophospholipid translocase),
            localizes to the trans-Golgi network in a CDC50 protein-independent
            manner
  JOURNAL   J Biol Chem 286 (44), 38159-38167 (2011)
   PUBMED   21914794
  REMARK    Erratum:[J Biol Chem. 2015 Jan 9;290(2):886]
REFERENCE   4  (bases 1 to 4361)
  AUTHORS   Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
            Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
            Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
            Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
            Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
            Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
            Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
            Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
            Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
            Birren,B.W., Sakaki,Y. and Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 18
  JOURNAL   Nature 437 (7058), 551-555 (2005)
   PUBMED   16177791
  REMARK    Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
REFERENCE   5  (bases 1 to 4361)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
REFERENCE   6  (bases 1 to 4361)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4361)
  AUTHORS   Halleck,M.S., Pradhan,D., Blackman,C., Berkes,C., Williamson,P. and
            Schlegel,R.A.
  TITLE     Multiple members of a third subfamily of P-type ATPases identified
            by genomic sequences and ESTs
  JOURNAL   Genome Res 8 (4), 354-361 (1998)
   PUBMED   9548971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY028472.1, BC022535.1, AK093704.1, BX537860.1, BC037546.1,
            AL096735.1 and AW411030.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198531.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This transcript is supported by overlapping EST and
            cDNA clones. The available sequence data suggest that some
            alternate splicing occurs. This record is provided so that the
            longer gene length can be represented. It is possible that this
            exact combination does not occur in vivo. The encoded protein is
            supported by mouse data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.240124.1,
                                           SRR1803612.156541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426216.6/ ENSP00000398076.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 HY028472.1         120-122
            4-352               BC022535.1         4-352
            353-362             AK093704.1         167-176
            363-795             BC022535.1         363-795
            796-2920            BX537860.1         298-2422
            2921-3029           BC037546.1         394-502
            3030-4112           AL096735.1         321-1403
            4113-4361           AW411030.1         36-284              c
FEATURES             Location/Qualifiers
     source          1..4361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..4361
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /note="ATPase phospholipid transporting 9B (putative)"
                     /db_xref="GeneID:374868"
                     /db_xref="HGNC:HGNC:13541"
                     /db_xref="MIM:614446"
     exon            1..136
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..3461
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /EC_number="7.6.2.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable phospholipid-transporting ATPase IIB; ATPase type
                     IV, phospholipid transporting (P-type); macrophage MHC
                     receptor 1; ATPase, class II, type 9B"
                     /codon_start=1
                     /product="probable phospholipid-transporting ATPase IIB
                     isoform 1"
                     /protein_id="NP_940933.3"
                     /db_xref="CCDS:CCDS12014.1"
                     /db_xref="GeneID:374868"
                     /db_xref="HGNC:HGNC:13541"
                     /db_xref="MIM:614446"
                     /translation="MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLE
                     DESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCDGWKFLCTSCCGW
                     LINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNL
                     YFLVISCSQFVPALKIGYLYTYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSK
                     LTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWK
                     LKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENT
                     LWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNRLTKALFLALVALS
                     IVMVTLQGFVGPWYRNLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMMKDENIPGTVV
                     RTSTIPEELGRLVYLLTDKTGTLTQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQ
                     MQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSRIHEAVKAIVLCHNVTPVYESRAGVTE
                     ETEFAEADQDFSDENRTYQASSPDEVALVQWTESVGLTLVSRDLTSMQLKTPSGQVLS
                     FCILQLFPFTSESKRMGVIVRDESTAEITFYMKGADVAMSPIVQYNDWLEEECGNMAR
                     EGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGV
                     EDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSR
                     GEAHLELNAFRRKHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKAR
                     IVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIG
                     RLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATI
                     YTMFPVFSLVLDQDVKPEMAMLYPELYKDLTKGRSLSFKTFLIWVLISIYQGGILMYG
                     ALVLFESEFVHVVAISFTALILTELLMVALTVRTWHWLMVVAEFLSLGCYVSSLAFLN
                     EYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCLPLYVLKYLRRKLSPPSYCKLA
                     S"
     exon            137..310
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            311..461
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            462..575
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            576..684
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            685..743
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            744..795
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            796..890
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            891..971
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1047
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1124
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1285
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1428
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1541
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1790
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1952
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2045
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2129
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2300
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2399
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2489
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2634
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2699
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2855
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2920
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3029
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3087
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3291
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3324
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..4361
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4051
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /note="major polyA site"
     regulatory      4199..4204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /note="hexamer: AATAAA"
     polyA_site      4220
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /note="major polyA site"
     regulatory      4326..4331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /note="hexamer: AGTAAA"
     polyA_site      4361
                     /gene="ATP9B"
                     /gene_synonym="ATPASEP; ATPIIB; hMMR1; HUSSY-20; NEO1L"
                     /note="major polyA site"
ORIGIN      
        1 aaaggggcgg tcggaacatg gcggaccaga tcccgcttta cccggtgcgt agcgcagcgg
       61 cggccgcagc caaccgcaaa cgcgcggcct actacagcgc cgcggggccc aggccgggag
      121 ccgaccggca cagcaggtac cagctggagg atgagtctgc gcatttggat gaaatgccac
      181 taatgatgtc tgaagaaggc tttgagaatg aggaaagtga ttaccacacc ttaccacgag
      241 ccaggataat gcaaaggaaa agaggactgg agtggtttgt ctgtgatggc tggaagttcc
      301 tctgtaccag ttgctgtggt tggctgataa atatttgtcg aagaaagaaa gagctgaaag
      361 ctcgcacagt atggcttgga tgtcctgaaa agtgtgaaga aaaacatccc aggaattcta
      421 taaaaaatca aaaatacaat gtgtttacct ttatacctgg ggttttgtat gaacaattca
      481 agtttttctt gaatctctat tttctagtaa tatcctgctc acagtttgta ccagcattga
      541 aaataggcta tctctacacc tactgggctc ctctgggatt tgtcttggct gttactatga
      601 cacgggaagc aattgatgaa tttcggcgtt ttcagcgtga caaggaagtg aattcacaac
      661 tatatagcaa gcttacagta agaggtaaag tgcaagttaa gagttcagac atacaagttg
      721 gagacctcat catagtggaa aagaatcaaa gaattccatc ggacatggtg tttcttagga
      781 cttcagaaaa agcaggttcg tgttttattc gaactgatca actagatggt gaaactgact
      841 ggaagctgaa ggtggcagtg agctgcacgc aacagctgcc ggctctgggg gacctttttt
      901 ctatcagtgc ttatgtttat gctcagaaac cacaaatgga cattcacagt ttcgaaggca
      961 catttaccag ggaagacagt gacccgccca ttcatgaaag tctcagcata gaaaatacat
     1021 tgtgggcaag caccattgtt gcatcaggta ctgtaatagg tgttgtcatt tataccggaa
     1081 aagagactcg aagtgtaatg aacacatcca atccaaaaaa taaggttggt ttgttggacc
     1141 ttgaactcaa tcggctgacg aaagcgctat ttttggcttt agttgctctt tccattgtta
     1201 tggtaacctt acaaggattt gtgggtccat ggtaccgcaa tctttttcgg ttccttctcc
     1261 tcttttctta catcattccc ataagtttgc gtgtgaactt ggacatgggc aaagcggtgt
     1321 atggatggat gatgatgaaa gatgagaaca tccctggcac ggtcgttcgg accagcacta
     1381 tcccagagga acttgggcgc ctggtgtatt tattgacaga caaaacagga accctcaccc
     1441 agaatgaaat gatatttaag cggctgcacc tgggcaccgt gtcctatggc gccgacacga
     1501 tggatgagat ccagagccat gtcagggact cctactcaca gatgcagtct caagctggtg
     1561 gaaacaatac tggttcaact ccactaagaa aagcccaatc ttcagctccc aaagttagga
     1621 aaagtgtcag tagtcgaatc catgaagccg tgaaagccat cgtgctgtgt cacaacgtga
     1681 cccccgtgta tgagtctcgg gccggcgtta ctgaggagac tgagttcgca gaggctgacc
     1741 aagacttcag tgatgagaat cgcacctacc aggcttccag cccggatgag gtcgctctgg
     1801 tgcagtggac agagagtgtg ggcctcacgc tggtcagcag ggacctcacc tccatgcagc
     1861 tgaagacccc cagtggccag gtcctcagct tctgcattct gcagctgttt cccttcacct
     1921 ccgagagcaa gcggatgggc gtcatcgtca gggatgaatc cacggcagaa atcacattct
     1981 acatgaaggg cgctgacgtg gccatgtctc ctatcgtgca gtataatgac tggctggaag
     2041 aggagtgcgg aaacatggct cgcgaaggac tgcggaccct cgtggttgca aagaaggcgt
     2101 tgacagagga gcagtaccag gactttgaga gccgatacac tcaagccaag ctgagcatgc
     2161 acgacaggtc cctcaaggtg gccgcggtag tcgagagcct ggagagggag atggaactgc
     2221 tgtgcctcac cggcgtggag gaccagctgc aggcagacgt gcggcccacg ctggagatgc
     2281 tgcgcaacgc cgggatcaag atatggatgc taacaggcga taaactcgag acagctacct
     2341 gcattgccaa aagttcacat ctcgtgtcta gaacacaaga tattcatatt ttcagacagg
     2401 taaccagtcg gggagaggca catttggagc tgaatgcatt tcgaaggaag catgattgtg
     2461 cactagtcat atctggggac tctctggagg tttgtctaaa gtactacgag catgaatttg
     2521 tggagctggc ctgccagtgc cctgccgtgg tttgctgccg ctgctcaccc acccagaagg
     2581 cccgcattgt gacactgctg cagcagcaca cagggagacg cacctgcgcc atcggtgatg
     2641 gaggaaatga tgtcagcatg attcaggcag cagactgtgg gattgggatt gagggaaagg
     2701 agggtaaaca ggcctcgctg gcggccgact tctccatcac gcagttccgg cacataggca
     2761 ggctgctcat ggtgcacggg cggaacagct acaagaggtc ggcggcactc ggccagttcg
     2821 tcatgcacag gggccttatc atctccacca tgcaggctgt gttttcctca gtcttctact
     2881 tcgcatccgt ccctttgtat cagggcttcc tcatggtggg gtatgccacc atatacacca
     2941 tgttcccagt gttctcctta gtgctggacc aggacgtgaa gccagagatg gcgatgctct
     3001 acccggagct gtacaaggac ctcaccaagg gaagatcctt gtccttcaaa accttcctca
     3061 tctgggtttt aataagtatt taccaaggcg gcatcctcat gtatggggcc ctggtgctct
     3121 tcgagtctga gttcgtccac gtggtggcca tctccttcac cgcactgatc ctgaccgagc
     3181 tgctgatggt ggcgctgacc gtccgcacgt ggcactggct gatggtggtg gccgagttcc
     3241 tcagcttagg ctgctacgtg tcctcactcg cttttctcaa tgaatatttt ggtataggca
     3301 gagtgtcttt tggagctttc ttagatgttg cctttatcac caccgtgacc ttcctgtgga
     3361 aagtgtcggc gatcaccgtg gtcagctgcc tcccgctgta tgtcctcaag tacctgaggc
     3421 gcaagctctc tcctcccagc tactgcaagc tggcctccta aggggctgtg cacccccagc
     3481 gggctggccc cagcaccttc tgcccttccc agcaccttgt gcccttgcca gtgaacgcag
     3541 ggtttgccat tgctaccaag caagcaccac aagaaaggga gggtacgcca ggcgagccca
     3601 gggcacagat gctgagacag cctctccttc tcagtgcagg gacgtcaccc ctgccaggca
     3661 agcccagggc acagatgcca ggatggcttc tccctctcag tgcgaggctt cacccctgcc
     3721 aggcaagccc agggcataga tgctgagaca gcctctccct ctcagtgcag ggacgtcacc
     3781 cctgccaggc aagcccaggg cacagaggcc gggacggcct ctccctctca gtgtgaggct
     3841 tcacccatgc taggcaagcc cagggcacag atgccgggat ggcccctccc tctcagtgcg
     3901 ggaacgtcac ccctgccagg caagcccagg gcacagatgc tgcgatggcc tcttcctctt
     3961 aagtgtgggg cctcacccct gcttttcttt ctttttttgt attgtcaaaa ttgtatttcc
     4021 atattgaagc agcttgagtt tctactgaaa atgagcccga attatttcac tattactgta
     4081 aagggttcat cttactctgg cattctgaga attagactga aagtttaatt tctgcagttc
     4141 cctcatattc agattctttc tttgatgtta taacacaaag tcattcctac tcaaatgtaa
     4201 taaaattgag gctccacgga ggcccgtgtc cacatcagct gcagctccca ctcagacaga
     4261 cggcctgccc cacagcctgc cctttgctga agataccctc gctttatact tgcatttcgc
     4321 ttttcagtaa aaacagtcaa gttactgagt tctcacataa a
//
