LOCUS       NM_006045               7862 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ATPase phospholipid transporting 9A (putative)
            (ATP9A), mRNA.
ACCESSION   NM_006045 XM_030577
VERSION     NM_006045.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7862)
  AUTHORS   Yao,Y., Chen,C., Wang,J., Xuan,H., Chen,X., Li,Z., Yang,F.,
            Wang,B., Lin,S., Li,S., Tang,D., Gong,L. and Gao,W.
  TITLE     Circular RNA circATP9A promotes non-small cell lung cancer
            progression by interacting with HuR and by promoting extracellular
            vesicles-mediated macrophage M2 polarization
  JOURNAL   J Exp Clin Cancer Res 42 (1), 330 (2023)
   PUBMED   38049814
  REMARK    GeneRIF: Circular RNA circATP9A promotes non-small cell lung cancer
            progression by interacting with HuR and by promoting extracellular
            vesicles-mediated macrophage M2 polarization.
            Erratum:[J Exp Clin Cancer Res. 2023 Dec 19;42(1):345. doi:
            10.1186/s13046-023-02924-6.. PMID: 38111017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7862)
  AUTHORS   Wang,X., Li,Y., Xiao,Y., Huang,X., Wu,X., Zhao,Z., Yang,M.,
            Kong,L., Shi,D., Chen,X., Ouyang,Y., Chen,X., Lin,C., Li,J.,
            Song,L., Lin,Y. and Guan,J.
  TITLE     The phospholipid flippase ATP9A enhances macropinocytosis to
            promote nutrient starvation tolerance in hepatocellular carcinoma
  JOURNAL   J Pathol 260 (1), 17-31 (2023)
   PUBMED   36715683
  REMARK    GeneRIF: The phospholipid flippase ATP9A enhances macropinocytosis
            to promote nutrient starvation tolerance in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 7862)
  AUTHORS   Meng,T., Chen,X., He,Z., Huang,H., Lin,S., Liu,K., Bai,G., Liu,H.,
            Xu,M., Zhuang,H., Zhang,Y., Waqas,A., Liu,Q., Zhang,C., Sun,X.D.,
            Huang,H., Umair,M., Yan,Y. and Feng,D.
  TITLE     ATP9A deficiency causes ADHD and aberrant endosomal recycling via
            modulating RAB5 and RAB11 activity
  JOURNAL   Mol Psychiatry 28 (3), 1219-1231 (2023)
   PUBMED   36604604
REFERENCE   4  (bases 1 to 7862)
  AUTHORS   Vogt,G., Verheyen,S., Schwartzmann,S., Ehmke,N., Potratz,C.,
            Schwerin-Nagel,A., Plecko,B., Holtgrewe,M., Seelow,D.,
            Blatterer,J., Speicher,M.R., Kornak,U., Horn,D., Mundlos,S.,
            Fischer-Zirnsak,B. and Boschann,F.
  TITLE     Biallelic truncating variants in ATP9A cause a novel
            neurodevelopmental disorder involving postnatal microcephaly and
            failure to thrive
  JOURNAL   J Med Genet 59 (7), 662-668 (2022)
   PUBMED   34379057
  REMARK    GeneRIF: Biallelic truncating variants in ATP9A cause a novel
            neurodevelopmental disorder involving postnatal microcephaly and
            failure to thrive.
REFERENCE   5  (bases 1 to 7862)
  AUTHORS   Bai,L., Jain,B.K., You,Q., Duan,H.D., Takar,M., Graham,T.R. and
            Li,H.
  TITLE     Structural basis of the P4B ATPase lipid flippase activity
  JOURNAL   Nat Commun 12 (1), 5963 (2021)
   PUBMED   34645814
  REMARK    GeneRIF: Structural basis of the P4B ATPase lipid flippase
            activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7862)
  AUTHORS   Yu,D., Mathews,C.A., Scharf,J.M., Neale,B.M., Davis,L.K.,
            Gamazon,E.R., Derks,E.M., Evans,P., Edlund,C.K., Crane,J.,
            Fagerness,J.A., Osiecki,L., Gallagher,P., Gerber,G., Haddad,S.,
            Illmann,C., McGrath,L.M., Mayerfeld,C., Arepalli,S., Barlassina,C.,
            Barr,C.L., Bellodi,L., Benarroch,F., Berrio,G.B., Bienvenu,O.J.,
            Black,D.W., Bloch,M.H., Brentani,H., Bruun,R.D., Budman,C.L.,
            Camarena,B., Campbell,D.D., Cappi,C., Silgado,J.C., Cavallini,M.C.,
            Chavira,D.A., Chouinard,S., Cook,E.H., Cookson,M.R., Coric,V.,
            Cullen,B., Cusi,D., Delorme,R., Denys,D., Dion,Y., Eapen,V.,
            Egberts,K., Falkai,P., Fernandez,T., Fournier,E., Garrido,H.,
            Geller,D., Gilbert,D.L., Girard,S.L., Grabe,H.J., Grados,M.A.,
            Greenberg,B.D., Gross-Tsur,V., Grunblatt,E., Hardy,J., Heiman,G.A.,
            Hemmings,S.M., Herrera,L.D., Hezel,D.M., Hoekstra,P.J.,
            Jankovic,J., Kennedy,J.L., King,R.A., Konkashbaev,A.I.,
            Kremeyer,B., Kurlan,R., Lanzagorta,N., Leboyer,M., Leckman,J.F.,
            Lennertz,L., Liu,C., Lochner,C., Lowe,T.L., Lupoli,S.,
            Macciardi,F., Maier,W., Manunta,P., Marconi,M., McCracken,J.T.,
            Mesa Restrepo,S.C., Moessner,R., Moorjani,P., Morgan,J., Muller,H.,
            Murphy,D.L., Naarden,A.L., Nurmi,E., Ochoa,W.C., Ophoff,R.A.,
            Pakstis,A.J., Pato,M.T., Pato,C.N., Piacentini,J., Pittenger,C.,
            Pollak,Y., Rauch,S.L., Renner,T., Reus,V.I., Richter,M.A.,
            Riddle,M.A., Robertson,M.M., Romero,R., Rosario,M.C., Rosenberg,D.,
            Ruhrmann,S., Sabatti,C., Salvi,E., Sampaio,A.S., Samuels,J.,
            Sandor,P., Service,S.K., Sheppard,B., Singer,H.S., Smit,J.H.,
            Stein,D.J., Strengman,E., Tischfield,J.A., Turiel,M., Valencia
            Duarte,A.V., Vallada,H., Veenstra-VanderWeele,J., Walitza,S.,
            Wang,Y., Weale,M., Weiss,R., Wendland,J.R., Westenberg,H.G.,
            Shugart,Y.Y., Hounie,A.G., Miguel,E.C., Nicolini,H., Wagner,M.,
            Ruiz-Linares,A., Cath,D.C., McMahon,W., Posthuma,D., Oostra,B.A.,
            Nestadt,G., Rouleau,G.A., Purcell,S., Jenike,M.A., Heutink,P.,
            Hanna,G.L., Conti,D.V., Arnold,P.D., Freimer,N.B., Stewart,S.E.,
            Knowles,J.A., Cox,N.J. and Pauls,D.L.
  TITLE     Cross-disorder genome-wide analyses suggest a complex genetic
            relationship between Tourette's syndrome and OCD
  JOURNAL   Am J Psychiatry 172 (1), 82-93 (2015)
   PUBMED   25158072
REFERENCE   7  (bases 1 to 7862)
  AUTHORS   Takatsu,H., Baba,K., Shima,T., Umino,H., Kato,U., Umeda,M.,
            Nakayama,K. and Shin,H.W.
  TITLE     ATP9B, a P4-ATPase (a putative aminophospholipid translocase),
            localizes to the trans-Golgi network in a CDC50 protein-independent
            manner
  JOURNAL   J Biol Chem 286 (44), 38159-38167 (2011)
   PUBMED   21914794
  REMARK    Erratum:[J Biol Chem. 2015 Jan 9;290(2):886]
REFERENCE   8  (bases 1 to 7862)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   9  (bases 1 to 7862)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 7862)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY147052.1, AK299064.1, BC110592.1, BF089115.1 and AL035684.25.
            
            On May 17, 2019 this sequence version replaced NM_006045.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.196180.1,
                                           SRR1803614.38645.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338821.6/ ENSP00000342481.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                HY147052.1         23-72
            51-647              AK299064.1         1-597
            648-1064            BC110592.1         161-577
            1065-1114           BF089115.1         351-400
            1115-3294           AK299064.1         1065-3244
            3295-7862           AL035684.25        73404-77971
FEATURES             Location/Qualifiers
     source          1..7862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.2"
     gene            1..7862
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /note="ATPase phospholipid transporting 9A (putative)"
                     /db_xref="GeneID:10079"
                     /db_xref="HGNC:HGNC:13540"
                     /db_xref="MIM:609126"
     exon            1..89
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..3165
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /EC_number="7.6.2.1"
                     /note="ATPase type IV, phospholipid-transporting
                     (P-type),(putative); phospholipid-transporting ATPase IIA;
                     ATPase, class II, type 9A"
                     /codon_start=1
                     /product="probable phospholipid-transporting ATPase IIA"
                     /protein_id="NP_006036.1"
                     /db_xref="CCDS:CCDS33489.1"
                     /db_xref="GeneID:10079"
                     /db_xref="HGNC:HGNC:13540"
                     /db_xref="MIM:609126"
                     /translation="MTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWLG
                     HPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGAL
                     YTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVKVKSSNIQVGDL
                     IIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQ
                     IRSYVYAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGTVVASGTVVGVVLYT
                     GRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIR
                     FLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDK
                     TGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRR
                     TMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQW
                     TESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFY
                     MKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLS
                     VHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLE
                     TATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKY
                     YEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDC
                     GVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTM
                     QAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLL
                     KGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALT
                     IQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVITLVSCLPLYVL
                     KYLRRRFSPPSYSKLTS"
     exon            90..234
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            235..348
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            349..457
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            458..516
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            517..568
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            569..663
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            664..744
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            745..820
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            821..897
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1058
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1201
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1314
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1527
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1689
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1782
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1866
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2037
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2136
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2226
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2371
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2436
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2592
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2657
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2766
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2824
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..3028
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..7862
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7579..7584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /note="hexamer: AATAAA"
     polyA_site      7598
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /note="major polyA site"
     polyA_site      7651
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
     regulatory      7839..7844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
                     /note="hexamer: TATAAA"
     polyA_site      7862
                     /gene="ATP9A"
                     /gene_synonym="ATPIIA; NEDGBA"
ORIGIN      
        1 aaggcgggcg gcgccgccga catgacggac aacatcccgc tgcagccggt gcgccagaag
       61 aagcggatgg acagcaggcc ccgcgccggg tgctgcgagt ggctgagatg ctgcggtgga
      121 ggggaggcca ggccccgcac tgtctggctg gggcaccccg agaagagaga ccagaggtat
      181 cctcggaatg tcatcaacaa tcagaagtac aatttcttca cctttcttcc tggggtgctg
      241 ttcaaccagt tcaaatactt tttcaacctc tatttcttac ttcttgcctg ctctcagttt
      301 gttcccgaaa tgagacttgg tgcactctat acctactggg ttcccctggg cttcgtgctg
      361 gccgtcactg tcatccgtga ggcggtggag gagatccgat gctacgtgcg ggacaaggaa
      421 gtcaactccc aggtctacag ccggctcaca gcacgaggca cagtgaaggt gaagagttct
      481 aacatccaag ttggagacct tatcatcgtt gaaaagaacc agcgggtccc tgccgacatg
      541 atcttcctga ggacatcaga aaaaaacggg tcatgcttct tgcggacgga tcagctggat
      601 ggggagacgg actggaagct gcggcttccc gtggcctgca cgcagaggct ccccacggcc
      661 gccgaccttc ttcagattcg atcgtatgtg tacgcagaag agccaaatat tgacattcac
      721 aacttcgtgg gaacttttac ccgagaagac agcgaccccc cgatcagcga gagcctgagc
      781 atagagaaca cgctgtgggc tggcactgtg gtcgcatcag gtactgttgt gggtgttgtt
      841 ctttacactg gcagagaact ccggagtgtc atgaatacct caaatccccg aagtaagatc
      901 ggcctgttcg acttggaagt gaactgcctc accaagatcc tctttggtgc cctggtggtg
      961 gtctcgctgg tcatggttgc ccttcagcac tttgcaggcc gttggtacct gcagatcatc
     1021 cgcttcctcc tcttgttttc caacatcatc cccattagtt tgcgtgtgaa cctggacatg
     1081 ggcaagatcg tgtacagctg ggtgattcga agggactcga aaatccccgg gaccgtggtt
     1141 cgctccagca cgattcctga gcagctgggc aggatttcgt acttactcac agacaagaca
     1201 ggcactctta cccagaacga gatgattttc aaacggctcc atctcggaac agtagcctac
     1261 ggcctcgact caatggacga agtacaaagc cacattttca gcatttacac ccagcaatcc
     1321 caggacccac cggctcagaa gggcccaacg ctcaccacta aggtccggcg gaccatgagc
     1381 agccgcgtgc acgaagccgt gaaggccatc gcgctctgcc acaacgtgac tcccgtgtat
     1441 gagtccaacg gtgtgactga tcaggctgag gccgagaagc agtacgaaga ctcctgccgc
     1501 gtataccagg catccagccc cgatgaggtg gccctggtac agtggacgga aagtgtgggc
     1561 ttaaccctgg tgggccgaga ccagtcttcc atgcagctga ggacccctgg cgaccagatc
     1621 ctgaacttca ccatcctaca gatcttccct ttcacctatg aaagcaaacg tatgggcatc
     1681 atcgtgcggg atgaatcaac tggagaaatt acgttttaca tgaagggagc agatgtggtc
     1741 atggctggca ttgtgcagta caatgactgg ttggaggaag agtgtggcaa catggcccga
     1801 gaagggctgc gggtgctcgt ggtggcaaag aagtctcttg cagaggagca gtatcaggac
     1861 tttgaagccc gctacgtcca ggccaagctg agtgtgcacg accgctccct caaagtggcc
     1921 acggtgatcg agagcctgga gatggagatg gaactgctgt gcctgacggg cgtggaggac
     1981 cagctgcagg cagatgtgcg gcccacgctg gagaccctga ggaatgctgg catcaaggtt
     2041 tggatgctga caggggacaa gctggagaca gctacgtgca cagcgaagaa tgcacatctg
     2101 gtgaccagaa accaagacat ccacgttttt cggctggtga ccaaccgcgg ggaggctcac
     2161 ctcgagctga acgccttccg caggaagcat gattgtgccc tggtcatctc gggagactcc
     2221 ctggaggttt gcctcaagta ctatgagtac gagttcatgg agctggcctg ccagtgcccg
     2281 gccgtagtct gctgccgatg tgcccccacc cagaaggccc agatcgtgcg cctgcttcag
     2341 gagcgcacgg gcaagctcac ctgtgcagta ggggacggag gcaatgacgt cagcatgatt
     2401 caggaatctg actgcggcgt gggagtggaa ggaaaggaag gaaaacaggc ttcgttggct
     2461 gcagacttct ccatcactca atttaagcat cttggccggt tgcttatggt gcatggccgg
     2521 aacagctaca agcggtcagc cgccctcagc cagttcgtga ttcacaggag cctctgtatc
     2581 agcaccatgc aggctgtctt ttcctccgtg ttttactttg cctccgtccc tctctatcaa
     2641 ggattcctca tcattgggta ctccacaatt tacaccatgt ttcctgtgtt ttctctggtc
     2701 ctggacaaag atgtcaaatc ggaagttgcc atgctgtatc ctgagctcta caaggatctt
     2761 ctcaagggac ggccgttgtc ctacaagaca ttcttaatat gggttttgat tagcatctat
     2821 caagggagca ccatcatgta cggggcgctg ctgctgtttg agtcggagtt cgtgcacatc
     2881 gtggccatct ccttcacctc gctgatcctc accgagctgc tcatggtggc gctgaccatc
     2941 cagacctggc actggctcat gacagtggcg gagctgctca gcctggcctg ctacatcgcc
     3001 tccctggtgt tcttacacga gttcatcgat gtgtacttca tcgccacctt gtcattcttg
     3061 tggaaagtct ccgtcatcac tctggtcagc tgcctccccc tctatgtcct caagtacctg
     3121 cgaagacggt tctctccccc cagctactca aagctcacat cataggccgt gcgttcgctg
     3181 gagggggccc tggtcttggc gcttccctga tggacagagc tcaagttcca tttatattaa
     3241 ccgccacctg tggattttgc agtaattgct aacacatgca gttttaatgg gaagtggctc
     3301 tgcgcctaaa cggagtccta acgctgcatc aacgggaggg agggtcctga aagagaccca
     3361 tctgggcctg tctgaacccc tcgttcttca tgtttaggtg aatatgaata tgttaaagct
     3421 ggtggctcag ctgggagatt tatatgggtc actgtgcgag cttccttatg acttgaattt
     3481 tgttgtcaca tgataaaagt ttctgtgtag ctgaaggttg tagaaggctt gtgtgtgtgt
     3541 gtgtgtgtgt gtgtgtgtgt gtgtgtgttt ttaaagagtc ctaatgtgta tgtactcttt
     3601 atgtctttct tgctcttaca aagaggtgtc agaaaaatag aaagctcttg gtgtcggttt
     3661 gggaggaaaa gacagtgaca tttggtaaaa agttatccac acaataatct ccattcggaa
     3721 atgctcagta tcgtctccag ccagccctgc ttatccaggt tacactggat tcctgggatc
     3781 gtaaccagta aatgagagga gagggagaga gagtgtccta agtccaatct gttatccttg
     3841 atctgattca gcatccatag tgtgtgagtt aacttcacct gccacctcgt aaaagaattt
     3901 cagaggtgtg atcccgcttt attgggacct ggtaacaatc acaaagccag tggctgtttg
     3961 agaaggacct cagacatttt cagcagagtt gttttagcag gaaacgtgcc actgaatggc
     4021 ccctaaatgt gtcgacagtg tgataagaga ctcaactaat tctttaggca acatggcaga
     4081 tgtgactcag atcctccaag accaaagcgg aaaggtcagg gggctgggac tcttctcttc
     4141 catagaagcc tgtttcctgt taggaggcat aatggaagat gaccccacaa aggcagaggc
     4201 atctttcgga acaacactgg tggcagcttt cagaacaagg aacccctggt gggaggacgc
     4261 ccaagctaca gcgttgggat ctgggatctg ttccactgcc ggcagatttc aaggggaact
     4321 tgctgaaagg cagccagtgg tgaagatttc tcccctccca ggatggacta catgccggca
     4381 tgtttcttat aaagctgtgg ctgcttgttt cagaggaagg gagtttgcag tcgcgggacg
     4441 tggtagagca aggcattctt gggttttcaa gttgcttctt gcagaagcca catatgcatg
     4501 ccataagggt taagttggtg gatctttaag agccaagtgt ggttgagatc ttggatttgc
     4561 gtttacttct tgatgaatac atatccttca aaccctctgc ctggcgctac ttctgtgtgc
     4621 ttcagagatg tacatcacag cctggtttct gatgcctact aactcctgct cttggagagc
     4681 tggagacacg aggatcagat agtcccttgc ctttggagca ctcttgataa gcttttgtat
     4741 tttgtgttgt ccttttaaaa tgttctagaa tgactttacg ttgcaggtac tggttaattg
     4801 gctgttgaca ccacatctat tttgtcttat gattctgcag ttttgcagta cttttctcta
     4861 tctgattcag ccatttctgc cagagggaaa aggtcggcag aaaagatgta ttgagtgaat
     4921 agttaaggat aggatctttg tccaaaaatt tcagaaagat tgagcaaatc tgacgtattc
     4981 attgagtgag tttctgtgtt ttcaaaggtg gaggagaaat ttgtgctgga agtttttaag
     5041 cctccgtttt cttggaaatc agtctgtaac actggcaagt cttaagatag tcccatttag
     5101 actttgcaga tgctgaacct ggctctgtaa cgctgggaag tcttaagata gtcctgttta
     5161 gactttgcaa accctgtacc tggctttgct cggagattcg ggatgctggc tcctgcaggc
     5221 agggcgtgtg ggagcctcgt cagaaagttt tagaggtttc cagcagaagc agaatgaaga
     5281 tggtctccct ggccttttcc ttaattctca attttgattg aggtgcacaa gttgactttt
     5341 aaagccaacg cttaagatac tgattgacat cttcaaggga gaatgctccc aggaggggct
     5401 gaagaagcca tagttggaag tggaaggtac tcgtcagtgt tctccacaaa cctttttact
     5461 ctgttgtctc agccgcactg gggcggaggc ggtcaagggt gagaagtacc gacactcaag
     5521 tgcaaactgc cacgtcgttg gcccatccca tcagtgggca gctggctgac gccattcact
     5581 ggacggtccc tgaacaccta ggaatgcaca caccgtgctt ctcagacact ggagacgcaa
     5641 aggcaggagg atgcagtccg gtgagaggac acgatcttta cctgcacaat cagactgtaa
     5701 gcccagcaga gaaccccagg ggcgcctggg tacttctcgg aggtcatctt agttgtggtg
     5761 gggaagacaa agaaataagc aaacaagaaa ctagagttac tatacaagaa actctcctga
     5821 gtttgtaaac cttaagcata aggattcagt tgaccttttt cttggttcat caatctggaa
     5881 agaacttaca taaagcgcca ttgacactgt cacctgggag ctccatgggc cgtaagtctt
     5941 tgacagccaa tttaatttga ggtcagaggg ccttgaggta cacagtcagc actgtttgaa
     6001 cacttttcct gaaagcaaaa ctcacagctc cctgcgccct ctgacaacac tagctatttc
     6061 tgccagagta agaacttcta ttactatttt attattgttc atatgtcttt tgatgatggt
     6121 tgtgtgacag ggggaagcag gatctatttg gtttcttccc ctccccccac cccttccttt
     6181 ttgtctctct ttttttttct ctaagaaaat caccagacta gtttttccat cttgagtaat
     6241 ttcttatgtg ggacagtttt gatcctcatt ttgaaagcat gcgtgtgcac atgtgtgttg
     6301 cctgtggtgc caggtgagac aggtggcact aactccagct gcttggaagg catcccaagg
     6361 gcgcatctta aagttggagc agacctccct tttccagccc ctggggccat tagaccacgt
     6421 gctggaacta gcattgtaaa attcccatcc cagttccact cccctgaagt gaaacccttt
     6481 tttttttgtg acagtaaatc ttaaaaatca ttgtctcttt atgaacattt cctcagtttc
     6541 ttctctgctg aaaatgtaag ccatgctact ttttaatgta ttttgaattt tgtgctcatt
     6601 ggaaattgat atgctaatgc ctcccccacc ccccgccaga cttttctttt tatactttgt
     6661 cttgttttta ctggggtagg ctgggcatgc gtgcgtgcct ttagggcagc attttaaacc
     6721 tttgccaaaa ttgcaaatgg gacatgtaca ttcttctgct ccatcctact taaacaccta
     6781 tcagctattt ttatctttaa ccttttctgt atgtttgaag tgtgtggggg gtgtgtgtgt
     6841 gtgtgaaaga gcgagagaat gatgtcatct aaagtttttt gaagaattat ttggttttca
     6901 ttgcattaaa attctatcac tcccagcttt gttttcattt aaaaaaatat acaaagagct
     6961 ttgtaaatac aacacatttt atttctcccc cttcttttaa tgtacagctt ttttgccact
     7021 tatatatact taaaatattc ccatgaatta tgtccagttc ttcttggaaa aaaatttggt
     7081 tttgaatgaa cctgcaaagc atcctgcagc gtgagcagct cctccacctg gagctccgaa
     7141 gcatcttctc aggccaaagc ggcattaccc gtgaatctgt cttctccgcc acagcatggt
     7201 ttgaggcgca gtctgttaat atagctgggc catgtcagtg actgttgtgt ttgtggggtc
     7261 aggtgggggg catggtattt gcaaaaaaaa caaattatgg ctaatttatt attttgttgc
     7321 agtggggtta actgtaaact catgtaagag tctgtgattt cctcattggt tgatctctct
     7381 ctctgtaatc ctcattgcaa attttcacca ggacagcgtt ttttgattag aggggagctc
     7441 tggcacagta tgctttaatt tagcaggaac ttccagatga tttaaattct cgatgctgtg
     7501 atgacacaca tatgatcttt cgtgtttctg agcgactcta ctttcattgt ttgccagcgt
     7561 ggctcgttgc tgttgcccaa taaagcttgt gtacgttctg ccttggggga ttattttaat
     7621 ttgtacagaa acatgaattc tggtatcaaa atgaggactt tttattataa cgctcctatt
     7681 ttttctttat ttcatggtac atgaaatgta aagaaaactc tttccagttc agaaaattat
     7741 tttgattttg gcaaaaaaaa ccccaaatca atgcatgtta tttattattt tgtactattg
     7801 tccatcccag acgtgtcaga atttcaaaag gtgatagata taaatggaaa ataagatgaa
     7861 aa
//
