LOCUS       NM_024837               5688 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ATPase phospholipid transporting 8B4 (putative)
            (ATP8B4), transcript variant 1, mRNA.
ACCESSION   NM_024837 XM_370863
VERSION     NM_024837.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5688)
  AUTHORS   Zhao,M., Xu,J., Zhong,S., Liu,Y., Xiao,H., Geng,L. and Liu,H.
  TITLE     Expression profiles and potential functions of circular RNAs in
            extracellular vesicles isolated from radioresistant glioma cells
  JOURNAL   Oncol Rep 41 (3), 1893-1900 (2019)
   PUBMED   30664179
  REMARK    GeneRIF: Study found that circATP8B4 in extracellular vesicles
            isolated from radioresistant U251 glioma cells acts as a U251
            miR766 sponge, which may be involved in glioma radioresistance.
REFERENCE   2  (bases 1 to 5688)
  AUTHORS   Lopez-Isac,E., Bossini-Castillo,L., Palma,A.B., Assassi,S.,
            Mayes,M.D., Simeon,C.P., Ortego-Centeno,N., Vicente,E., Tolosa,C.,
            Rubio-Rivas,M., Roman-Ivorra,J.A., Beretta,L., Moroncini,G.,
            Hunzelmann,N., Distler,J.H.W., Riemekasten,G., de
            Vries-Bouwstra,J., Voskuyl,A.E., Radstake,T.R.D.J., Herrick,A.,
            Denton,C.P., Fonseca,C. and Martin,J.
  TITLE     Analysis of ATP8B4 F436L Missense Variant in a Large Systemic
            Sclerosis Cohort
  JOURNAL   Arthritis Rheumatol 69 (6), 1337-1338 (2017)
   PUBMED   28141915
  REMARK    GeneRIF: Study did not find statistically significant differences
            in the frequency of the ATP8B4 rs55687265*C allele between the SSc
            patients and controls.
REFERENCE   3  (bases 1 to 5688)
  AUTHORS   Gao,L., Emond,M.J., Louie,T., Cheadle,C., Berger,A.E., Rafaels,N.,
            Vergara,C., Kim,Y., Taub,M.A., Ruczinski,I., Mathai,S.C.,
            Rich,S.S., Nickerson,D.A., Hummers,L.K., Bamshad,M.J.,
            Hassoun,P.M., Mathias,R.A. and Barnes,K.C.
  CONSRTM   National Heart, Lung, and Blood Institute GO Exome Sequencing
            Project
  TITLE     Identification of Rare Variants in ATP8B4 as a Risk Factor for
            Systemic Sclerosis by Whole-Exome Sequencing
  JOURNAL   Arthritis Rheumatol 68 (1), 191-200 (2016)
   PUBMED   26473621
  REMARK    GeneRIF: ATP8B4 gene was associated with a significant increase in
            the risk of systemic sclerosis. ATP8B4 is overexpressed in systemic
            sclerosis patients.
REFERENCE   4  (bases 1 to 5688)
  AUTHORS   Ni,I.B., Ching,N.C., Meng,C.K. and Zakaria,Z.
  TITLE     Translocation t(11;14) (q13;q32) and genomic imbalances in
            multi-ethnic multiple myeloma patients: a Malaysian study
  JOURNAL   Hematol Rep 4 (3), e19 (2012)
   PUBMED   23087808
REFERENCE   5  (bases 1 to 5688)
  AUTHORS   Bryde,S., Hennrich,H., Verhulst,P.M., Devaux,P.F., Lenoir,G. and
            Holthuis,J.C.
  TITLE     CDC50 proteins are critical components of the human class-1
            P4-ATPase transport machinery
  JOURNAL   J Biol Chem 285 (52), 40562-40572 (2010)
   PUBMED   20961850
REFERENCE   6  (bases 1 to 5688)
  AUTHORS   van der Velden,L.M., Wichers,C.G., van Breevoort,A.E.,
            Coleman,J.A., Molday,R.S., Berger,R., Klomp,L.W. and van de
            Graaf,S.F.
  TITLE     Heteromeric interactions required for abundance and subcellular
            localization of human CDC50 proteins and class 1 P4-ATPases
  JOURNAL   J Biol Chem 285 (51), 40088-40096 (2010)
   PUBMED   20947505
REFERENCE   7  (bases 1 to 5688)
  AUTHORS   Li,H., Wetten,S., Li,L., St Jean,P.L., Upmanyu,R., Surh,L.,
            Hosford,D., Barnes,M.R., Briley,J.D., Borrie,M., Coletta,N.,
            Delisle,R., Dhalla,D., Ehm,M.G., Feldman,H.H., Fornazzari,L.,
            Gauthier,S., Goodgame,N., Guzman,D., Hammond,S., Hollingworth,P.,
            Hsiung,G.Y., Johnson,J., Kelly,D.D., Keren,R., Kertesz,A.,
            King,K.S., Lovestone,S., Loy-English,I., Matthews,P.M., Owen,M.J.,
            Plumpton,M., Pryse-Phillips,W., Prinjha,R.K., Richardson,J.C.,
            Saunders,A., Slater,A.J., St George-Hyslop,P.H., Stinnett,S.W.,
            Swartz,J.E., Taylor,R.L., Wherrett,J., Williams,J., Yarnall,D.P.,
            Gibson,R.A., Irizarry,M.C., Middleton,L.T. and Roses,A.D.
  TITLE     Candidate single-nucleotide polymorphisms from a genomewide
            association study of Alzheimer disease
  JOURNAL   Arch Neurol 65 (1), 45-53 (2008)
   PUBMED   17998437
  REMARK    GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 5688)
  AUTHORS   Harris,M.J. and Arias,I.M.
  TITLE     FIC1, a P-type ATPase linked to cholestatic liver disease, has
            homologues (ATP8B2 and ATP8B3) expressed throughout the body
  JOURNAL   Biochim Biophys Acta 1633 (2), 127-131 (2003)
   PUBMED   12880872
REFERENCE   9  (bases 1 to 5688)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009753.5, BE241899.1,
            BC144297.1, BC144298.1, BC057236.1 and BX647496.1.
            
            On Aug 20, 2019 this sequence version replaced NM_024837.3.
            
            Summary: This gene encodes a member of the cation transport ATPase
            (P-type) family and type IV subfamily. The encoded protein is
            involved in phospholipid transport in the cell membrane.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.577297.1,
                                           SRR14038196.2666709.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284509.11/ ENSP00000284509.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC009753.5         26137-26147         c
            12-74               BE241899.1         2-64
            75-1506             BC144297.1         60-1491
            1507-1606           BC144298.1         1579-1678
            1607-2294           BC144297.1         1592-2279
            2295-4287           BC144298.1         2178-4170
            4288-4499           BC057236.1         1367-1578
            4500-5688           BX647496.1         1617-2805
FEATURES             Location/Qualifiers
     source          1..5688
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..5688
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /note="ATPase phospholipid transporting 8B4 (putative)"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
     exon            1..111
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            112..181
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..3732
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /EC_number="7.6.2.1"
                     /note="potential phospholipid-transporting ATPase IM;
                     P4-ATPase flippase complex alpha subunit ATP8B4; ATPase,
                     class I, type 8B, member 4"
                     /codon_start=1
                     /product="probable phospholipid-transporting ATPase IM"
                     /protein_id="NP_079113.2"
                     /db_xref="CCDS:CCDS32238.1"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
                     /translation="MFCSEKKLREVERIVKANDREYNEKFQYADNRIHTSKYNILTFL
                     PINLFEQFQRVANAYFLCLLILQLIPEISSLTWFTTIVPLVLVITMTAVKDATDDYFR
                     HKSDNQVNNRQSEVLINSKLQNEKWMNVKVGDIIKLENNQFVAADLLLLSSSEPHGLC
                     YVETAELDGETNLKVRHALSVTSELGADISRLAGFDGIVVCEVPNNKLDKFMGILSWK
                     DSKHSLNNEKIILRGCILRNTSWCFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTL
                     VLWIFGFLICLGIILAIGNSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIIL
                     NTVVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVARTTTLNEELGQIEYIFSD
                     KTGTLTQNIMTFKRCSINGRIYGEVHDDLDQKTEITQEKEPVDFSVKSQADREFQFFD
                     HHLMESIKMGDPKVHEFLRLLALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGF
                     IFKSRTPETITIEELGTLVTYQLLAFLDFNNTRKRMSVIVRNPEGQIKLYSKGADTIL
                     FEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEE
                     RDERIAGLYEEIERDLMLLGATAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAI
                     NIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQNLFGQNRNFSNGHVVCEKKQQL
                     ELDSIVEETITGDYALIINGHSLAHALESDVKNDLLELACMCKTVICCRVTPLQKAQV
                     VELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQEGLQAVLASDYSFAQFRYLQR
                     LLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVY
                     TSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFI
                     PYGAFYNVAGEDGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIA
                     IYFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFL
                     KVDLYPTLSDQIRRWQKAQKKARPPSSRRPRTRRSSSRRSGYAFAHQEGYGELITSGK
                     NMRAKNPPPTSGLEKTHYNSTSWIENLCKKTTDTVSSFSQDKTVKL"
     exon            182..240
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            241..354
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            355..453
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            454..515
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            516..588
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            589..659
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            660..742
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            743..901
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            902..990
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1187
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1396
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1440
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1606
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1795
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1911
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2076
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2188
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2294
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2442
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2626
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2850
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2934
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3180
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3319
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3450
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..5688
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4905..4910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /note="hexamer: TATAAA"
     polyA_site      4924
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
     regulatory      5664..5669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /note="hexamer: AGTAAA"
     polyA_site      5688
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /note="major polyA site"
ORIGIN      
        1 agagtagcct tgcttttctc cttggcatgg tcacggaatg gatacctgtt tgatcttcct
       61 gcactgctga gaaatcttcc ttttggggga gaggattaag tctgggttga ggtaggccac
      121 ctgttgagac ctggtgaaag atcaggtata ataatgttct gcagtgaaaa gaaattgcgt
      181 gaagtggaac ggatagtgaa agccaatgac cgtgaatata atgaaaagtt ccagtatgcg
      241 gataatcgta tccacacatc gaaatataat attctcacct tcttgccaat taatttattt
      301 gaacagttcc aaagagtggc aaatgcctat tttctttgcc ttctgatttt acagctaatt
      361 ccagaaattt cctccttgac ctggtttacc accattgtgc ctttggtcct ggtgataact
      421 atgacagctg tcaaagatgc cacagatgac tattttcgcc acaagagtga taatcaagtg
      481 aataatcggc agtctgaagt gctcatcaac agcaaactgc agaatgaaaa atggatgaat
      541 gtcaaagtgg gagacatcat taaattagaa aataaccaat ttgttgctgc tgatttactt
      601 ctcctatcaa gtagtgagcc acatggtctc tgttatgttg aaactgctga gcttgatggg
      661 gaaacgaacc taaaagtccg ccatgcacta tcagttactt cagaacttgg agcagatatc
      721 agcagacttg cagggtttga tgggattgtt gtctgtgagg tgcctaacaa caagttagat
      781 aaattcatgg gaatcctttc ttggaaagac agcaagcatt ccctcaacaa tgagaagata
      841 atcctgagag gctgcatcct gagaaatacc agctggtgtt ttggaatggt tatttttgca
      901 ggtcctgaca ctaaactaat gcagaatagt ggtaagacaa agtttaaaag gacaagcatt
      961 gatagattga tgaatactct agtactatgg atttttgggt ttctgatatg cttgggaatt
     1021 attcttgcaa taggaaattc aatctgggag agtcaaactg gggaccaatt cagaactttc
     1081 ctcttttgga atgaaggaga gaagagctct gtgttctccg gattcttaac attctggtca
     1141 tatattatta ttctcaatac agttgtaccc atttccttat atgtgagtgt ggaagtaatt
     1201 cgtctaggac acagttattt tataaactgg gaccggaaga tgtattattc tcgaaaagca
     1261 atacctgcag tggctcgaac gaccacgctc aatgaggaac tggggcagat tgagtacatt
     1321 ttctccgaca aaacgggtac cctcactcaa aacatcatga cctttaaaag atgttccatt
     1381 aatgggagaa tctatggtga agtacatgat gacctggatc agaagacaga aataactcag
     1441 gaaaaagagc ctgtggattt ctcagtcaaa tctcaagcgg atagagaatt tcagttcttt
     1501 gaccaccatc tgatggaatc cattaaaatg ggtgatccca aagttcatga attccttagg
     1561 ttacttgctc tctgccacac tgtaatgtca gaagagaata gcgcaggaga gctgatttac
     1621 caagttcagt cacctgatga aggggctcta gtgactgccg ctagaaattt tgggttcatt
     1681 tttaaatccc ggaccccaga gaccataaca atagaagaat tgggaacact agttacttat
     1741 caattacttg cctttttgga tttcaacaac accagaaaaa ggatgtctgt catagttcga
     1801 aacccagaag gacagataaa gctttattcc aaaggagcag atactattct gtttgaaaaa
     1861 cttcatcctt ccaatgaagt ccttttgtct ttgacgtcag accacctcag tgaatttgca
     1921 ggggaaggcc ttcggacctt ggccatcgca tacagagacc tggatgacaa gtactttaaa
     1981 gagtggcata agatgcttga agatgcgaat gctgccacag aagagaggga tgaacgaata
     2041 gctgggctat atgaagaaat tgaaagagat ttgatgctac taggtgccac tgctgtagaa
     2101 gataagttac aggagggtgt tattgaaaca gttacaagtt tatcactagc caatattaag
     2161 atctgggtcc taacaggaga caaacaagaa actgccatca acatcggtta tgcctgcaac
     2221 atgctgactg acgacatgaa tgatgtgttt gtgatagcag ggaataatgc tgtggaagtg
     2281 agagaagaac tcaggaaagc aaaacaaaat ttgtttggac aaaacagaaa tttttccaat
     2341 ggccatgtag tttgtgaaaa aaagcagcag ctggagttgg attctattgt agaagaaacc
     2401 ataacaggag attatgcctt aatcataaat ggccacagtt tggctcatgc cctagaaagt
     2461 gatgtcaaga atgatctcct agaacttgct tgcatgtgta agactgtaat ttgctgcagg
     2521 gtcactccac tccagaaagc ccaagtggta gagctggtga agaagtacag aaatgctgtt
     2581 actttggcca ttggtgatgg agccaatgat gtcagcatga ttaaaagtgc tcacattggt
     2641 gttggcatca gcggccagga aggattgcaa gcagtcttag ccagcgacta ttcatttgca
     2701 cagtttagat atctccaaag gcttctcctt gttcatggaa ggtggtctta tttccgaatg
     2761 tgcaaattct tatgctattt cttctataag aattttgcat ttacacttgt gcatttctgg
     2821 tttggtttct tctgtggttt ctcagcccag actgtttatg accagtggtt catcaccctt
     2881 tttaacattg tttacacatc actgcctgtt ttagccatgg ggatttttga ccaggatgtg
     2941 agtgaccaga acagcgtgga ctgtccccag ctctacaaac caggacagct gaatctgctt
     3001 tttaacaagc gtaaattttt catttgcgtg ttgcatggaa tctacacctc attagtcctt
     3061 ttcttcatcc cctatggggc cttttacaac gtggctggag aagatgggca acatattgct
     3121 gactaccagt cctttgcagt taccatggcc acatctttgg tcattgtggt cagtgtgcag
     3181 atagccttgg ataccagtta ctggactttc attaatcacg tcttcatctg ggggagcatt
     3241 gccatttatt tctccatttt atttacaatg cacagtaatg gcatctttgg catcttccca
     3301 aaccagtttc catttgttgg taatgcacga cattccctga cccagaagtg catctggctt
     3361 gtaattctct taacaacagt ggcttcagtt atgccagtgg tggcattcag atttttgaag
     3421 gtggatttat acccaaccct gagtgatcag atccgccggt ggcagaaggc tcaaaagaag
     3481 gcaaggcctc caagtagccg aaggcctcgg acccgcaggt caagctcaag aaggtctgga
     3541 tatgcttttg ctcaccaaga aggctatgga gagcttatca catctggaaa aaatatgcga
     3601 gctaaaaatc cacccccaac atcagggctg gaaaagacac attataatag cactagctgg
     3661 attgaaaatt tatgtaagaa aaccacagac accgtgagca gctttagcca ggataaaaca
     3721 gtgaaactgt gagtcaatat gaatttaaac cacgtagtta tcttttcact tcaggtggag
     3781 ctgaaattct gctggctcca gagtttgaga tttgaggcaa gaggtggggc aggcagattg
     3841 cctcacttaa cttaaatctg cggcagacaa ctgccagtgc ccatcaaaca ggagtgtgcg
     3901 ctatggaaaa ccaggccaga gggtcactgt ctggtttgtg atttggtgga caaaacactc
     3961 gctgttacaa gtacagattt tttttttttt taaatcaacc tagataccaa ttgacctgaa
     4021 ctttagaatc ttatttatgg agaaaaactt gtaaagctgc atattcactg aatggatcct
     4081 caggcggata aaagggtgca ttttaaaggt atatatccaa gctgaaaagc atgcctattg
     4141 acagataaac atgtatctgt aagatcagcc tttcccaagg tatactttta aaatttaaag
     4201 cgtgtactgt gttgctttca gactgagttg catgtcactc tttagtcttg atatctacct
     4261 gtctgttcag ccaggacaac aaatggcttc caagcctgaa gaatacaaaa gtgtgcttgt
     4321 gtttctcatt tttataccag tctagggaca aaggagactg aacatctttg cagcaggata
     4381 ggctggtaat ttgatcaaat ttattcaaaa agctctcagt ctgtgtcatg taaggacatg
     4441 cttatgaaat gtgagagagg ctcgccacta agtattctaa atacttttca atggcttttc
     4501 taacaacctc agtagtaatt tgctgagcat catccagacc attaatagaa tcagcaaagc
     4561 actggaattt cacactttaa tgataatatt ccacatagtc tatgggcaaa tattttcaac
     4621 atttccaatt tttaaagctt cagaattgaa gccaaacaaa ttaataaata attgttttaa
     4681 ttactattta aaaactcagg tttagattgt ttaaaattag ttgcttttga tactcagctg
     4741 tcatgtttat aattcaaaca tgtagtaaac atatgtaggt aaggttgttt ttttggagat
     4801 gttgcagctc aaatttcagt ccacatatga atcatcagtg tattttccat aaagtgattc
     4861 gggcatattt gtgtgaaaac ctcagttctg tcacttctta cctctataaa cttggacgat
     4921 aatgtgcctt ctctgagact cagtttcttc ctctgtaaaa tgaggacata ctacctacct
     4981 catgtggttg gttgatgatt gtctgtcaaa gcacaaactc tgaaattatt aaaaacataa
     5041 ttatttcata aacagatgag ttaagttcca gttaactcaa catcagtata acagagcaat
     5101 tggaagagaa tatgaaaaaa ctggaatcta aatagtcagt gaggaaggct ttgataaaat
     5161 gaaattgcca gaaagatata aaactggtta gggtcctaca gggaaataaa attataaccg
     5221 tggaggtaca tttctctacc agaaagcaaa aataaagcat catgtcttaa tggttttcta
     5281 caaatcaact tctaattcta cagagtcctt aatctggtcc ctattaaatt cttggtcaga
     5341 caaagttaca tttcccaaga gagtcaggtg acacttgagt gagtttgatg gataatgagc
     5401 taatgtgata tctataggtc acaatttttt aaaaccaaaa ttttcaagtc tgggataatc
     5461 tttcctaaat gggatcaaat gaaataatat gtgtaaaaga gtcaaatgca gtcctttacc
     5521 atagtaactg cctatggacg ttgtctttcc cttacatgcc tgcctacact taaccagatg
     5581 ttggttttca atgtctaatt tgtcattagt ttcaccacat ttgctcactt tttgtaacat
     5641 ttttgcaaga tttgaaaact ttcagtaaat gttttggcac tattggta
//
