LOCUS       NM_001370597            5974 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ATPase phospholipid transporting 8B2 (ATP8B2),
            transcript variant 5, mRNA.
ACCESSION   NM_001370597
VERSION     NM_001370597.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5974)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   2  (bases 1 to 5974)
  AUTHORS   Takatsu,H., Tanaka,G., Segawa,K., Suzuki,J., Nagata,S., Nakayama,K.
            and Shin,H.W.
  TITLE     Phospholipid flippase activities and substrate specificities of
            human type IV P-type ATPases localized to the plasma membrane
  JOURNAL   J Biol Chem 289 (48), 33543-33556 (2014)
   PUBMED   25315773
  REMARK    Erratum:[J Biol Chem. 2016 Oct 7;291(41):21421. doi:
            10.1074/jbc.A114.593012.. PMID: 27825076]
REFERENCE   3  (bases 1 to 5974)
  AUTHORS   Bryde,S., Hennrich,H., Verhulst,P.M., Devaux,P.F., Lenoir,G. and
            Holthuis,J.C.
  TITLE     CDC50 proteins are critical components of the human class-1
            P4-ATPase transport machinery
  JOURNAL   J Biol Chem 285 (52), 40562-40572 (2010)
   PUBMED   20961850
REFERENCE   4  (bases 1 to 5974)
  AUTHORS   van der Velden,L.M., Wichers,C.G., van Breevoort,A.E.,
            Coleman,J.A., Molday,R.S., Berger,R., Klomp,L.W. and van de
            Graaf,S.F.
  TITLE     Heteromeric interactions required for abundance and subcellular
            localization of human CDC50 proteins and class 1 P4-ATPases
  JOURNAL   J Biol Chem 285 (51), 40088-40096 (2010)
   PUBMED   20947505
REFERENCE   5  (bases 1 to 5974)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 5974)
  AUTHORS   Paulusma,C.C. and Oude Elferink,R.P.
  TITLE     The type 4 subfamily of P-type ATPases, putative aminophospholipid
            translocases with a role in human disease
  JOURNAL   Biochim Biophys Acta 1741 (1-2), 11-24 (2005)
   PUBMED   15919184
  REMARK    Review article
REFERENCE   7  (bases 1 to 5974)
  AUTHORS   Kuhlbrandt,W.
  TITLE     Biology, structure and mechanism of P-type ATPases
  JOURNAL   Nat Rev Mol Cell Biol 5 (4), 282-295 (2004)
   PUBMED   15071553
  REMARK    Review article
REFERENCE   8  (bases 1 to 5974)
  AUTHORS   Harris,M.J. and Arias,I.M.
  TITLE     FIC1, a P-type ATPase linked to cholestatic liver disease, has
            homologues (ATP8B2 and ATP8B3) expressed throughout the body
  JOURNAL   Biochim Biophys Acta 1633 (2), 127-131 (2003)
   PUBMED   12880872
REFERENCE   9  (bases 1 to 5974)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5974)
  AUTHORS   Abbott,W.M., Mellor,A., Edwards,Y. and Feizi,T.
  TITLE     Soluble bovine galactose-binding lectin. cDNA cloning reveals the
            complete amino acid sequence and an antigenic relationship with the
            major encephalitogenic domain of myelin basic protein
  JOURNAL   Biochem J 259 (1), 283-290 (1989)
   PUBMED   2470348
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162591.16.
            
            Summary: The protein encoded by this gene belongs to the family of
            P-type cation transport ATPases, and to the subfamily of
            aminophospholipid-transporting ATPases. The aminophospholipid
            translocases transport phosphatidylserine and
            phosphatidylethanolamine from one side of a bilayer to another.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.46644.1,
                                           SRR1803615.166442.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368489.6/ ENSP00000357475.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AL162591.16        198184-198361       c
            179-246             AL162591.16        195714-195781       c
            247-305             AL162591.16        193432-193490       c
            306-419             AL162591.16        192958-193071       c
            420-518             AL162591.16        192740-192838       c
            519-580             AL162591.16        192381-192442       c
            581-653             AL162591.16        192208-192280       c
            654-724             AL162591.16        191862-191932       c
            725-804             AL162591.16        191189-191268       c
            805-963             AL162591.16        189621-189779       c
            964-1052            AL162591.16        189295-189383       c
            1053-1249           AL162591.16        186342-186538       c
            1250-1458           AL162591.16        182824-183032       c
            1459-1502           AL162591.16        181363-181406       c
            1503-1668           AL162591.16        180925-181090       c
            1669-1857           AL162591.16        180585-180773       c
            1858-1973           AL162591.16        180318-180433       c
            1974-2138           AL162591.16        179829-179993       c
            2139-2250           AL162591.16        179632-179743       c
            2251-2356           AL162591.16        179386-179491       c
            2357-2501           AL162591.16        179101-179245       c
            2502-2685           AL162591.16        178732-178915       c
            2686-2909           AL162591.16        178341-178564       c
            2910-2993           AL162591.16        178003-178086       c
            2994-3239           AL162591.16        177410-177655       c
            3240-3378           AL162591.16        177128-177266       c
            3379-3509           AL162591.16        175348-175478       c
            3510-5974           AL162591.16        172582-175046       c
FEATURES             Location/Qualifiers
     source          1..5974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..5974
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /note="ATPase phospholipid transporting 8B2"
                     /db_xref="GeneID:57198"
                     /db_xref="HGNC:HGNC:13534"
                     /db_xref="MIM:605867"
     exon            1..178
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            179..246
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..3788
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /EC_number="7.6.2.1"
                     /note="isoform e is encoded by transcript variant 5;
                     phospholipid-transporting ATPase ID; probable
                     phospholipid-transporting ATPase ID; ATPase, class I, type
                     8B, member 2; P4-ATPase flippase complex alpha subunit
                     ATP8B2; 36/8-9 fusion protein with epitope for anti-lectin
                     antibody; ATPase, aminophospholipid transporter, class I,
                     type 8B, member 2"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase ID isoform e"
                     /protein_id="NP_001357526.1"
                     /db_xref="CCDS:CCDS1066.2"
                     /db_xref="GeneID:57198"
                     /db_xref="HGNC:HGNC:13534"
                     /db_xref="MIM:605867"
                     /translation="MAVCAKKRPPEEERRARANDREYNEKFQYASNCIKTSKYNILTF
                     LPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYF
                     RHKSDNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGL
                     CYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWK
                     ENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTL
                     VLWIFGFLVCMGVILAIGNAIWEHEVGMRFQVYLPWDEAVDSAFFSGFLSFWSYIIIL
                     NTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSD
                     KTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWD
                     PSLLEAVKIGDPHTHEFFRLLSLCHTVMSEEKNEGELYYKAQSPDEGALVTAARNFGF
                     VFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTIL
                     LDRLHHSTQELLNTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQDS
                     REDRLASIYEEVENNMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAV
                     NIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSS
                     KLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVV
                     ELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRL
                     LLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYT
                     SLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIP
                     YGVFADATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAV
                     YFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLR
                     LNLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKN
                     MRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADKPLKG"
     exon            247..305
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            306..419
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            420..518
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            519..580
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            581..653
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            654..724
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            725..804
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            805..963
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1052
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1249
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1458
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1502
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1668
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1857
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1973
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2138
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2250
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2356
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2501
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2685
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2909
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..2993
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3239
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3378
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3509
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..5974
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5955..5960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /note="hexamer: TATAAA"
     polyA_site      5974
                     /gene="ATP8B2"
                     /gene_synonym="ATPID"
                     /note="major polyA site"
ORIGIN      
        1 acttccgccc cgccgtggcc gaaactgaca caaagtagcg ggccgaggcc ccgggggagc
       61 ggggccgcag ctgggggggc gggagcccgt ggggagccga gccgagcgcc ccccgcccca
      121 gcccccggca tgggcagtac ggggccgccg gggcgggcgc cgagcgctga gcgctgaggg
      181 tctcccatgg gattgctggg atcttgctgg gtgagatggc agtgtgtgca aaaaagcgcc
      241 ccccagaaga agaaaggagg gcgcgggcta atgaccgaga atacaatgag aaattccagt
      301 atgcgagtaa ctgcatcaag acctccaagt acaatattct caccttcctg cctgtcaacc
      361 tctttgagca gttccaggaa gttgccaaca cttacttcct gttcctcctc attctgcagt
      421 tgatccccca gatctcttcc ctgtcctggt tcaccaccat tgtgcctttg gttcttgtcc
      481 tcaccatcac agctgttaaa gatgccactg atgactattt ccgccacaag agcgataacc
      541 aggtgaataa ccgccagtct caggtgctga tcaatggaat cctccagcag gagcagtgga
      601 tgaatgtctg tgttggtgat attatcaagc tagaaaataa ccagtttgtg gcggcggatc
      661 tcctcctcct ttccagcagt gagccccatg ggctgtgtta catagagaca gcagaacttg
      721 atggcgagac caacatgaaa gtacgtcagg cgattccagt cacctcagaa ttgggagaca
      781 tcagtaagct tgccaagttt gacggtgaag tgatctgtga acctcccaac aacaaactgg
      841 acaaattcag cggaaccctc tactggaagg aaaataagtt ccctctgagc aaccagaaca
      901 tgctgctgcg gggctgtgtg ctgcgaaaca ccgagtggtg cttcgggctg gtcatctttg
      961 caggtcccga cactaagctg atgcaaaaca gcggcagaac aaagttcaaa agaacgagta
     1021 tcgatcgcct aatgaatacc ctggtgctct ggatttttgg attcctggtt tgcatggggg
     1081 tgatcctggc cattggcaat gccatctggg agcacgaggt ggggatgcgt ttccaggtct
     1141 acctgccgtg ggatgaggca gtggacagtg ccttcttctc tggcttcctc tccttctggt
     1201 cctacatcat catcctcaac accgttgtgc ccatttcact ctatgtcagt gtggaggtca
     1261 tccgtctggg ccacagctac ttcatcaact gggataagaa gatgttctgc atgaagaagc
     1321 ggacgcctgc agaagcccgc accaccaccc taaacgagga gctgggccag gtggagtaca
     1381 tcttctccga caagacgggc accctcaccc agaacatcat ggttttcaac aagtgctcca
     1441 tcaatggcca cagctatggt gatgtgtttg acgtcctggg acacaaagct gaattgggag
     1501 agaggcctga acctgttgac ttctccttca atcctctggc tgacaagaag ttcttatttt
     1561 gggaccccag cctgctggag gctgtcaaga tcggggaccc ccacacgcat gagttcttcc
     1621 gcctcctttc cctgtgtcat actgtcatgt cagaagaaaa gaacgaagga gagctgtact
     1681 acaaagctca gtccccagat gagggggccc tggtcaccgc agccaggaac tttggttttg
     1741 ttttccgctc tcgcaccccc aaaacaatca ccgtccatga gatgggcaca gccatcacct
     1801 accagctgct ggccatcctg gacttcaaca acatccgcaa gcggatgtcg gtcatagtgc
     1861 ggaatccaga ggggaagatc cgactctact gcaaaggggc tgacactatc ctactggaca
     1921 gactgcacca ctccactcaa gagctgctca acaccaccat ggaccacctt aatgagtacg
     1981 caggggaagg gctgaggacc ctggtgctgg cctacaagga tctggatgaa gagtactacg
     2041 aggagtgggc tgagcgacgc ctccaggcca gcctggccca ggacagccgg gaggacaggc
     2101 tggctagcat ctatgaggag gttgagaaca acatgatgct gctgggtgca acggccattg
     2161 aggacaaact tcagcaaggg gttccagaga ccattgccct cctgacactg gccaacatca
     2221 agatttgggt gctaaccgga gacaagcaag agacggctgt gaacatcggc tattcctgca
     2281 agatgctgac ggatgacatg actgaggttt tcatagtcac tggccatact gtcctggagg
     2341 tgcgggagga gctcaggaaa gcccgggaga agatgatgga ctcatcccgc tccgtaggca
     2401 acggcttcac ctatcaggac aagctttctt cttccaagct aacttctgtc ctggaggccg
     2461 ttgctgggga gtacgccctg gtcataaatg gtcacagcct ggcccacgca ctggaggcag
     2521 acatggagct ggagtttctg gagacagcgt gtgcctgcaa agctgtcatc tgctgccggg
     2581 tgaccccctt gcagaaggca caggtggtag aactggtcaa gaagtacaag aaggctgtga
     2641 cgcttgccat tggagacgga gccaatgatg tcagcatgat caaaacggct cacattggtg
     2701 tggggatcag tgggcaggaa gggatccagg ctgtcttggc ctccgattac tccttctccc
     2761 agttcaagtt cctgcagcgc ctcctgctgg tgcatgggcg ctggtcctac ctgcgaatgt
     2821 gcaagtttct ttgctatttc ttctacaaaa actttgcttt caccatggtc cacttctggt
     2881 ttggcttctt ctgtggcttc tcagcccaga ccgtctatga ccagtatttc atcaccctgt
     2941 ataacatcgt gtacacctcc ctgccagtcc tggctatggg ggtctttgat caggatgtcc
     3001 ccgagcagcg gagcatggag taccctaagc tgtatgagcc gggccagctg aaccttctct
     3061 tcaacaagcg ggagttcttc atctgcatcg cccagggcat ctacacctcc gtgctcatgt
     3121 tcttcattcc ctatggggtg tttgctgatg ccacccggga tgatggcact cagctggctg
     3181 actaccagtc ctttgcagtc actgtggcca catccttggt cattgtggtt agcgtgcaga
     3241 ttgggctcga cacaggctac tggacggcca tcaaccactt cttcatctgg ggaagccttg
     3301 ctgtttactt tgccatcctc tttgccatgc acagcaatgg gctcttcgac atgtttccca
     3361 accagttccg gtttgtgggg aatgcccaga acaccttggc ccagcccacg gtgtggctga
     3421 ccattgtgct caccacagtc gtctgcatca tgcccgtggt tgccttccga ttcctcaggc
     3481 tcaacctgaa gccggatctc tccgacacgg tccgctacac acagctcgtg aggaagaagc
     3541 agaaggccca gcaccgctgc atgcggcggg ttggccgcac tggctcccgg cgctccggct
     3601 atgccttctc ccatcaggag ggcttcgggg agctcatcat gtctggcaag aacatgcggc
     3661 tgagctctct cgcgctctcc agcttcacca cccgctccag ctccagctgg attgagagcc
     3721 tgcgcaggaa gaagagtgac agtgccagta gccccagtgg cggtgccgac aagcccctca
     3781 agggctgaag gccgaggatg gatgccctgt gccagtgacc agagcaccca gggctggcca
     3841 gtcactgagg gaacagcgtc tcggaactgc tggtcctcat tccttgcttc ccgtcccccc
     3901 ggtagactct gtcctgctgg tcccaccaca catggctggg acatctgttc ccagctgtag
     3961 gcccttccac cagctgggga gctagaggga gcaggcccaa gggcagagca gaggctgagg
     4021 cacggggagc cagccccact cggggaccag aagtggaacc aaaaacaaga aaaaactgtg
     4081 agagattgtg tctgcccctg ccctgcctgg gacccacagg gagactataa tctccttatt
     4141 tttttactcc tactccccag aggggcccta gtgcctctgt tcctgaatta cataagaatg
     4201 taccatgccg ggaagccaga gacctgcagg ggcctcggcc cctcacatcg tgtatgtctc
     4261 tccttgattt gtgttgtgtc cagtttggtt ttgtcttttt ttatttggca agtggaggag
     4321 gcttttatgt gacttttatg ttgtggttgg tgtcttaact ctcctgggaa aaggaggctg
     4381 gcacacactg ggatgccgca gcctggccgg ctgtggggtg gtttgggagg atccatgtcg
     4441 gctctgcctg cagtgaccag tgctctgtgg ggcagaggag ctgaccaggg agggaggtac
     4501 ccatgagcag agggtagtgg gagagtgtaa aggagggttt ggtcctgtct gcttcctcac
     4561 cttgagagta aagtgctgcc ctctgccccc aacacacaca catatcaatt cctggattcc
     4621 ttagtcctgc tggccttggg ctggagccta ggaaagtggc ccccaaatcc ttagtgagct
     4681 aaagctgggt ctgaaatttg gtcagtgggg aggggtagtt ttcttttctt ttttcttttt
     4741 ctttttttct tttttttttt gagatggagt ctcactcttg tcacctaggc aagagtgcaa
     4801 tggcacaatc tcagctcact gcaacctcca cctcctgggt tcaagcgatt ctcctgcctc
     4861 agcctcctga gtagctggga ttacaggcac acaccaccac gcttggttaa tttttgtatt
     4921 tttagtagag atgtttcacc atgttggcca ggctagtctt gaattcctga cctcctgacc
     4981 tgcccacctc aacctcccaa agtgctgaga ttacaggcgt gagccaccac acccagctca
     5041 gggaggcgta gttttcttta attttaaatt taaacccaag tttattggca gactcccttt
     5101 tgacctccct ttgcctcccc atctggtgct ttcttgcatc tacaccccag ggccctgtgg
     5161 tggggctgca gggggaagct gtgcacctga gatgaggctg gaacgggaat tggcctctct
     5221 gctcccttct tcagtaagca aggagccccg cccctcaggc ccagcctctg gcaagaggtg
     5281 gtggaatcct tgtgccgggt agtagaggag gataagggca aaaccaggcc caggccagtg
     5341 cctggcttgg tctggatggg acactgtcag agtttggcca cagcctgtcc tttacttcat
     5401 ccacacctat gaagctattc cctaaataag gcatttccca agttagtcgc tacctaatca
     5461 gccttgagaa gaatcctttc ctcttctttg atagtgggtc gggggattct tcaggaatgg
     5521 tttggagctg ggagtgggta gggggatttt aaatgttcca tatgggagcc ccaaaggaac
     5581 tggatgggct gcagtgaggt gggggcgggt gggcagggaa tgggagaggg gaagtcttgg
     5641 cagggaaatc ccttttggcc acacagttta caaacccagt atcatgtctg tctgtgtgtc
     5701 tctcaaggtg agagtctgat ttttatacca aagaggaaat gatttttttt catattttgt
     5761 ttgtctatat tatataaata tatatataca gttatatata tatatattat tttttggttc
     5821 tctctcgttt tttagggagg gaagaaagta ccaagttgca ttgagctgta attaaggaac
     5881 attataattt atgacacatt tctatacttg caaaaattat atcattttat ggatataaga
     5941 gaaaaatgcc tttttataaa atttcaattt ctga
//
