LOCUS       NM_000053               6598 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ATPase copper transporting beta (ATP7B), transcript
            variant 1, mRNA.
ACCESSION   NM_000053
VERSION     NM_000053.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6598)
  AUTHORS   Zhang,K., Qu,C., Zhou,P., Yang,Z. and Wu,X.
  TITLE     Integrative analysis of the cuproptosis-related gene ATP7B in the
            prognosis and immune infiltration of IDH1 wild-type glioma
  JOURNAL   Gene 905, 148220 (2024)
   PUBMED   38286269
  REMARK    GeneRIF: Integrative analysis of the cuproptosis-related gene ATP7B
            in the prognosis and immune infiltration of IDH1 wild-type glioma.
REFERENCE   2  (bases 1 to 6598)
  AUTHORS   Ruturaj, Mishra,M., Saha,S., Maji,S., Rodriguez-Boulan,E.,
            Schreiner,R. and Gupta,A.
  TITLE     Regulation of the apico-basolateral trafficking polarity of the
            homologous copper-ATPases ATP7A and ATP7B
  JOURNAL   J Cell Sci 137 (5) (2024)
   PUBMED   38032054
  REMARK    GeneRIF: Regulation of the apico-basolateral trafficking polarity
            of the homologous copper-ATPases ATP7A and ATP7B.
REFERENCE   3  (bases 1 to 6598)
  AUTHORS   Tavares,L.A., Rodrigues,R.L., Santos da Costa,C., Nascimento,J.A.,
            Vargas de Carvalho,J., Nogueira de Carvalho,A., Mardones,G.A. and
            daSilva,L.L.P.
  TITLE     AP-1gamma2 is an adaptor protein 1 variant required for
            endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR)
            and ATP7B copper transporter
  JOURNAL   J Biol Chem 300 (3), 105700 (2024)
   PUBMED   38307383
  REMARK    GeneRIF: AP-1gamma2 is an adaptor protein 1 variant required for
            endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR)
            and ATP7B copper transporter.
REFERENCE   4  (bases 1 to 6598)
  AUTHORS   Gorukmez,O., Ozgur,T., Gorukmez,O. and Topak,A.
  TITLE     ATP7B Gene Variant Profile Identified by NGS in Wilson's Disease
  JOURNAL   Fetal Pediatr Pathol 42 (6), 891-900 (2023)
   PUBMED   37737146
  REMARK    GeneRIF: ATP7B Gene Variant Profile Identified by NGS in Wilson's
            Disease.
REFERENCE   5  (bases 1 to 6598)
  AUTHORS   Petrukhin,K., Lutsenko,S., Chernov,I., Ross,B.M., Kaplan,J.H. and
            Gilliam,T.C.
  TITLE     Characterization of the Wilson disease gene encoding a P-type
            copper transporting ATPase: genomic organization, alternative
            splicing, and structure/function predictions
  JOURNAL   Hum Mol Genet 3 (9), 1647-1656 (1994)
   PUBMED   7833924
REFERENCE   6  (bases 1 to 6598)
  AUTHORS   Petrukhin,K., Fischer,S.G., Pirastu,M., Tanzi,R.E., Chernov,I.,
            Devoto,M., Brzustowicz,L.M., Cayanis,E., Vitale,E., Russo,J.J. et
            al.
  TITLE     Mapping, cloning and genetic characterization of the region
            containing the Wilson disease gene
  JOURNAL   Nat Genet 5 (4), 338-343 (1993)
   PUBMED   8298640
REFERENCE   7  (bases 1 to 6598)
  AUTHORS   Bull,P.C., Thomas,G.R., Rommens,J.M., Forbes,J.R. and Cox,D.W.
  TITLE     The Wilson disease gene is a putative copper transporting P-type
            ATPase similar to the Menkes gene
  JOURNAL   Nat Genet 5 (4), 327-337 (1993)
   PUBMED   8298639
  REMARK    Erratum:[Nat Genet 1994 Feb;6(2):214]
REFERENCE   8  (bases 1 to 6598)
  AUTHORS   Yamaguchi,Y., Heiny,M.E. and Gitlin,J.D.
  TITLE     Isolation and characterization of a human liver cDNA as a candidate
            gene for Wilson disease
  JOURNAL   Biochem Biophys Res Commun 197 (1), 271-277 (1993)
   PUBMED   8250934
REFERENCE   9  (bases 1 to 6598)
  AUTHORS   Weiss,K.H. and Schilsky,M.
  TITLE     Wilson Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301685
REFERENCE   10 (bases 1 to 6598)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA125470.1, U11700.1,
            BC143976.1, AL162377.10 and BU682287.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000053.3.
            
            Summary: This gene is a member of the P-type cation transport
            ATPase family and encodes a protein with several membrane-spanning
            domains, an ATPase consensus sequence, a hinge domain, a
            phosphorylation site, and at least 2 putative copper-binding sites.
            This protein is a monomer, and functions as a copper-transporting
            ATPase which exports copper out of the cells, such as the efflux of
            hepatic copper into the bile. Alternate transcriptional splice
            variants, encoding different isoforms with distinct cellular
            localizations, have been characterized. Mutations in this gene have
            been associated with Wilson disease which is characterized by
            copper accumulation. [provided by RefSeq, Dec 2019].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U11700.1, SRR18074967.1465113.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242839.10/ ENSP00000242839.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               DA125470.1         107-596
            491-2735            U11700.1           540-2784
            2736-4581           BC143976.1         2553-4398
            4582-6365           AL162377.10        161938-163721       c
            6366-6598           BU682287.1         14-246              c
FEATURES             Location/Qualifiers
     source          1..6598
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..6598
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /note="ATPase copper transporting beta"
                     /db_xref="GeneID:540"
                     /db_xref="HGNC:HGNC:870"
                     /db_xref="MIM:606882"
     exon            1..164
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..4511
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /EC_number="7.2.2.8"
                     /note="isoform a is encoded by transcript variant 1;
                     copper-transporting ATPase 2; copper pump 2; ATPase, Cu++
                     transporting, beta polypeptide; Wilson disease-associated
                     protein; ATPase, Cu(2+)- transporting, beta polypeptide;
                     copper-transporting protein ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform a"
                     /protein_id="NP_000044.2"
                     /db_xref="CCDS:CCDS41892.1"
                     /db_xref="GeneID:540"
                     /db_xref="HGNC:HGNC:870"
                     /db_xref="MIM:606882"
                     /translation="MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGY
                     EGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKY
                     VPSVVCLQQVCHQIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSS
                     IEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLS
                     LGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIE
                     ENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGS
                     GTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISV
                     SLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTD
                     GTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIER
                     NLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNI
                     ELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEE
                     IGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSM
                     VLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIA
                     YVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSL
                     QATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESL
                     ITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQ
                     QLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAF
                     QTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTG
                     TITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETL
                     GYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSV
                     LIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAAL
                     AVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKV
                     AMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRR
                     IRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKK
                     PDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSD
                     KPSRHSAAADDDGDKWSLLLNGRDEEQYI"
     exon            165..1398
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1656
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1820
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1982
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2059
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2234
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2468
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2560
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2688
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2843
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2978
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3173
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3356
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3525
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3669
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3812
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..4016
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            4017..4134
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4237
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            4238..6598
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6571..6576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /note="hexamer: AATAAA"
     polyA_site      6598
                     /gene="ATP7B"
                     /gene_synonym="PWD; WC1; WD; WND"
                     /note="major polyA site"
ORIGIN      
        1 ctcacactct gcgcctcctc tcccgggact ttaacacccc gctctcctcc accgaccagg
       61 tgaccttttg ctctgagcca gatcagagaa gaattcggtg tccgtgcggg acgatgcctg
      121 agcaggagag acagatcaca gccagagaag gggccagtcg gaaaatctta tctaagcttt
      181 ctttgcctac ccgtgcctgg gaaccagcaa tgaagaagag ttttgctttt gacaatgttg
      241 gctatgaagg tggtctggat ggcctgggcc cttcttctca ggtggccacc agcacagtca
      301 ggatcttggg catgacttgc cagtcatgtg tgaagtccat tgaggacagg atttccaatt
      361 tgaaaggcat catcagcatg aaggtttccc tggaacaagg cagtgccact gtgaaatatg
      421 tgccatcggt tgtgtgcctg caacaggttt gccatcaaat tggggacatg ggcttcgagg
      481 ccagcattgc agaaggaaag gcagcctcct ggccctcaag gtccttgcct gcccaggagg
      541 ctgtggtcaa gctccgggtg gagggcatga cctgccagtc ctgtgtcagc tccattgaag
      601 gcaaggtccg gaaactgcaa ggagtagtga gagtcaaagt ctcactcagc aaccaagagg
      661 ccgtcatcac ttatcagcct tatctcattc agcccgaaga cctcagggac catgtaaatg
      721 acatgggatt tgaagctgcc atcaagagca aagtggctcc cttaagcctg ggaccaattg
      781 atattgagcg gttacaaagc actaacccaa agagaccttt atcttctgct aaccagaatt
      841 ttaataattc tgagaccttg gggcaccaag gaagccatgt ggtcaccctc caactgagaa
      901 tagatggaat gcattgtaag tcttgcgtct tgaatattga agaaaatatt ggccagctcc
      961 taggggttca aagtattcaa gtgtccttgg agaacaaaac tgcccaagta aagtatgacc
     1021 cttcttgtac cagcccagtg gctctgcaga gggctatcga ggcacttcca cctgggaatt
     1081 ttaaagtttc tcttcctgat ggagccgaag ggagtgggac agatcacagg tcttccagtt
     1141 ctcattcccc tggctcccca ccgagaaacc aggtccaggg cacatgcagt accactctga
     1201 ttgccattgc cggcatgacc tgtgcatcct gtgtccattc cattgaaggc atgatctccc
     1261 aactggaagg ggtgcagcaa atatcggtgt ctttggccga agggactgca acagttcttt
     1321 ataatccctc tgtaattagc ccagaagaac tcagagctgc tatagaagac atgggatttg
     1381 aggcttcagt cgtttctgaa agctgttcta ctaaccctct tggaaaccac agtgctggga
     1441 attccatggt gcaaactaca gatggtacac ctacatctgt gcaggaagtg gctccccaca
     1501 ctgggaggct ccctgcaaac catgccccgg acatcttggc aaagtcccca caatcaacca
     1561 gagcagtggc accgcagaag tgcttcttac agatcaaagg catgacctgt gcatcctgtg
     1621 tgtctaacat agaaaggaat ctgcagaaag aagctggtgt tctctccgtg ttggttgcct
     1681 tgatggcagg aaaggcagag atcaagtatg acccagaggt catccagccc ctcgagatag
     1741 ctcagttcat ccaggacctg ggttttgagg cagcagtcat ggaggactac gcaggctccg
     1801 atggcaacat tgagctgaca atcacaggga tgacctgcgc gtcctgtgtc cacaacatag
     1861 agtccaaact cacgaggaca aatggcatca cttatgcctc cgttgccctt gccaccagca
     1921 aagcccttgt taagtttgac ccggaaatta tcggtccacg ggatattatc aaaattattg
     1981 aggaaattgg ctttcatgct tccctggccc agagaaaccc caacgctcat cacttggacc
     2041 acaagatgga aataaagcag tggaagaagt ctttcctgtg cagcctggtg tttggcatcc
     2101 ctgtcatggc cttaatgatc tatatgctga tacccagcaa cgagccccac cagtccatgg
     2161 tcctggacca caacatcatt ccaggactgt ccattctaaa tctcatcttc tttatcttgt
     2221 gtacctttgt ccagctcctc ggtgggtggt acttctacgt tcaggcctac aaatctctga
     2281 gacacaggtc agccaacatg gacgtgctca tcgtcctggc cacaagcatt gcttatgttt
     2341 attctctggt catcctggtg gttgctgtgg ctgagaaggc ggagaggagc cctgtgacat
     2401 tcttcgacac gccccccatg ctctttgtgt tcattgccct gggccggtgg ctggaacact
     2461 tggcaaagag caaaacctca gaagccctgg ctaaactcat gtctctccaa gccacagaag
     2521 ccaccgttgt gacccttggt gaggacaatt taatcatcag ggaggagcaa gtccccatgg
     2581 agctggtgca gcggggcgat atcgtcaagg tggtccctgg gggaaagttt ccagtggatg
     2641 ggaaagtcct ggaaggcaat accatggctg atgagtccct catcacagga gaagccatgc
     2701 cagtcactaa gaaacccgga agcactgtaa ttgcggggtc tataaatgca catggctctg
     2761 tgctcattaa agctacccac gtgggcaatg acaccacttt ggctcagatt gtgaaactgg
     2821 tggaagaggc tcagatgtca aaggcaccca ttcagcagct ggctgaccgg tttagtggat
     2881 attttgtccc atttatcatc atcatgtcaa ctttgacgtt ggtggtatgg attgtaatcg
     2941 gttttatcga ttttggtgtt gttcagagat actttcctaa ccccaacaag cacatctccc
     3001 agacagaggt gatcatccgg tttgctttcc agacgtccat cacggtgctg tgcattgcct
     3061 gcccctgctc cctggggctg gccacgccca cggctgtcat ggtgggcacc ggggtggccg
     3121 cgcagaacgg catcctcatc aagggaggca agcccctgga gatggcgcac aagataaaga
     3181 ctgtgatgtt tgacaagact ggcaccatta cccatggcgt ccccagggtc atgcgggtgc
     3241 tcctgctggg ggatgtggcc acactgcccc tcaggaaggt tctggctgtg gtggggactg
     3301 cggaggccag cagtgaacac cccttgggcg tggcagtcac caaatactgt aaagaggaac
     3361 ttggaacaga gaccttggga tactgcacgg acttccaggc agtgccaggc tgtggaattg
     3421 ggtgcaaagt cagcaacgtg gaaggcatcc tggcccacag tgagcgccct ttgagtgcac
     3481 cggccagtca cctgaatgag gctggcagcc ttcccgcaga aaaagatgca gtcccccaga
     3541 ccttctctgt gctgattgga aaccgtgagt ggctgaggcg caacggttta accatttcta
     3601 gcgatgtcag tgacgctatg acagaccacg agatgaaagg acagacagcc atcctggtgg
     3661 ctattgacgg tgtgctctgt gggatgatcg caatcgcaga cgctgtcaag caggaggctg
     3721 ccctggctgt gcacacgctg cagagcatgg gtgtggacgt ggttctgatc acgggggaca
     3781 accggaagac agccagagct attgccaccc aggttggcat caacaaagtc tttgcagagg
     3841 tgctgccttc gcacaaggtg gccaaggtcc aggagctcca gaataaaggg aagaaagtcg
     3901 ccatggtggg ggatggggtc aatgactccc cggccttggc ccaggcagac atgggtgtgg
     3961 ccattggcac cggcacggat gtggccatcg aggcagccga cgtcgtcctt atcagaaatg
     4021 atttgctgga tgtggtggct agcattcacc tttccaagag gactgtccga aggatacgca
     4081 tcaacctggt cctggcactg atttataacc tggttgggat acccattgca gcaggtgtct
     4141 tcatgcccat cggcattgtg ctgcagccct ggatgggctc agcggccatg gcagcctcct
     4201 ctgtgtctgt ggtgctctca tccctgcagc tcaagtgcta taagaagcct gacctggaga
     4261 ggtatgaggc acaggcgcat ggccacatga agcccctgac ggcatcccag gtcagtgtgc
     4321 acataggcat ggatgacagg tggcgggact cccccagggc cacaccatgg gaccaggtca
     4381 gctatgtcag ccaggtgtcg ctgtcctccc tgacgtccga caagccatct cggcacagcg
     4441 ctgcagcaga cgatgatggg gacaagtggt ctctgctcct gaatggcagg gatgaggagc
     4501 agtacatctg atgacttcag gcaggcgggc cggggcaggg acttgcctcc actcaccaca
     4561 agctgagcag gacagccagc agcaggatgg gctgagctag cctccagctt tggggacttc
     4621 cgctccctgg atatgtccag tcatcctgcc ctgcagcacg cggccttgtc tgggtgcagc
     4681 tgggcttggc ctggagagga cggccctgcc tgcctcttgg cctcacggga ccgtcagcat
     4741 gggctttgtc ttggactcta gtccttggct ggactgtaga aggtgagagg cgagtcaccc
     4801 tcctcacaga cctctgcttg gagtatttag gatgactgct gtgaaatgga gaacagtttc
     4861 atcaggacca aaaaacctca ctgggccttt ccagagaact gcagacctca ctgtcagggt
     4921 ctttctgatg acgcctgtct gtgtgcatca tgtttctgag accacagttt acctcaggtg
     4981 tgcctgttgc tttcttcctg catagtctgt tcctttcttc gtacatagtc tgttcctttt
     5041 ctctcctgtg tgcttgtcag tggggacccc tcgcaaccct gcctgtcacc tgggagggtg
     5101 ggaccaatgt ccttgtggtc tttgctgctg ctctcaggcg cttctccaat gctctggagt
     5161 gtgcatttca gcttgaacct gcttcctggc tcacacatcc ccagccaggg agcttgccac
     5221 actcttcttc aagttgagga gagttctttt ttgcttaaag cccccttctc catggagtgt
     5281 tggcttctca atagagtgtt gttgctgacc agctggagtg agggcctcag agcctgacct
     5341 gagagtccgt actcggcttc ctgtggggtg taggttctcg cgattcagga cgtccttcca
     5401 tatccctgcc cagcctgtgg tgcttgaaac gtttgcccca tgggaaacgt atgtgtgcag
     5461 gagcctccct gcacggccca aggggcttcg ttttcagtct tctgactgtc acctcgtggg
     5521 gttcagtaga gaattcatgt gactagcgcc tggccttgtg tggcttggag gaaatggtac
     5581 tgcccaaata ggaggaaaac acagcctccc tgagcctgca ttctgcacgc tgcccagggg
     5641 cttcagaaaa ggagtggcca cagcaccccg aagggagcat ctgtttacct ggcagtggct
     5701 ctcagagcag cagaacgggt tcagttttag actctgaagt tggttgtgat tgacagaacc
     5761 ctttgggagc aaactagtag agttggatta aattctgggt gaaacccttt tctcccacac
     5821 aaaatagttt tagtgatttt tttcattgtc cattacttgc caggggcagt tttagcagca
     5881 cttttgatag attacgtcta atcctcccaa ccaaccagca gggtagctat tactgtccac
     5941 attttacagg caaggaaaca ggctccaaga ggctgaggac tttgcccagg atgacatagc
     6001 caatggacaa gcagtgtctg tcagctgtga aggcttcact cttattgtcc ttctaccttg
     6061 aatagaagtt ttcctgataa gaataaacga ggaaaaggtc cttgcctcct ggaagaacaa
     6121 atctaccagg tgatctattc attgtttcaa ctcagaatgc acttgattca ggaggtcatc
     6181 tgaccttcac cttggatggt tagtttcact ttttacatat agtttttgca gggttttatt
     6241 ttataaaatc caagcgcgct gttgattgtg ttttccttgt tttcagcccc cccactccag
     6301 cccgcagcac atttccgctg tccgtcagta attgtgtcct ctctttatgc ttgcttgggg
     6361 aatgttgttt tctgactagg ctgatcatta tctaaagaat ctaattctgt tgatttttaa
     6421 aacttttagg accataaacg ttgtgttcat atatggacat ggaaatattt atataatttt
     6481 atagaaaata accttttaga tggtcaaagt gtaaggagtt tttttgtcag ataatcattt
     6541 ctacttcaaa aacatttcat gcaatattag aataaagttc ctgtcattcc tctaaaaa
//
