LOCUS       NM_004888               1563 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ATPase H+ transporting V1 subunit G1 (ATP6V1G1), mRNA.
ACCESSION   NM_004888
VERSION     NM_004888.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1563)
  AUTHORS   Li,Y., Wang,Y., Kou,L., Yin,S., Chi,X., Sun,Y., Wu,J., Jin,Z.,
            Zhou,Q., Zou,W., Wang,T. and Xia,Y.
  TITLE     Plasma exosomes impair microglial degradation of alpha-synuclein
            through V-ATPase subunit V1G1
  JOURNAL   CNS Neurosci Ther 30 (5), e14738 (2024)
   PUBMED   38702933
  REMARK    GeneRIF: Plasma exosomes impair microglial degradation of
            alpha-synuclein through V-ATPase subunit V1G1.
REFERENCE   2  (bases 1 to 1563)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1563)
  AUTHORS   De Luca,M., Romano,R. and Bucci,C.
  TITLE     Role of the V1G1 subunit of V-ATPase in breast cancer cell
            migration
  JOURNAL   Sci Rep 11 (1), 4615 (2021)
   PUBMED   33633298
  REMARK    GeneRIF: Role of the V1G1 subunit of V-ATPase in breast cancer cell
            migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1563)
  AUTHORS   Wang,L., Wu,D., Robinson,C.V., Wu,H. and Fu,T.M.
  TITLE     Structures of a Complete Human V-ATPase Reveal Mechanisms of Its
            Assembly
  JOURNAL   Mol Cell 80 (3), 501-511 (2020)
   PUBMED   33065002
REFERENCE   5  (bases 1 to 1563)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1563)
  AUTHORS   Forgac,M.
  TITLE     Structure and properties of the vacuolar (H+)-ATPases
  JOURNAL   J Biol Chem 274 (19), 12951-12954 (1999)
   PUBMED   10224039
  REMARK    Review article
REFERENCE   7  (bases 1 to 1563)
  AUTHORS   Nelson,N. and Harvey,W.R.
  TITLE     Vacuolar and plasma membrane proton-adenosinetriphosphatases
  JOURNAL   Physiol Rev 79 (2), 361-385 (1999)
   PUBMED   10221984
  REMARK    Review article
REFERENCE   8  (bases 1 to 1563)
  AUTHORS   Finbow,M.E. and Harrison,M.A.
  TITLE     The vacuolar H+-ATPase: a universal proton pump of eukaryotes
  JOURNAL   Biochem J 324 (Pt 3) (Pt 3), 697-712 (1997)
   PUBMED   9210392
  REMARK    Review article
REFERENCE   9  (bases 1 to 1563)
  AUTHORS   Stevens,T.H. and Forgac,M.
  TITLE     Structure, function and regulation of the vacuolar (H+)-ATPase
  JOURNAL   Annu Rev Cell Dev Biol 13, 779-808 (1997)
   PUBMED   9442887
  REMARK    Review article
REFERENCE   10 (bases 1 to 1563)
  AUTHORS   Dautry-Varsat,A.
  TITLE     Receptor-mediated endocytosis: the intracellular journey of
            transferrin and its receptor
  JOURNAL   Biochimie 68 (3), 375-381 (1986)
   PUBMED   2874839
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF692207.1, BC008452.1,
            AL160275.14 and AI092246.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004888.3.
            
            Summary: This gene encodes a component of vacuolar ATPase
            (V-ATPase), a multisubunit enzyme that mediates acidification of
            eukaryotic intracellular organelles. V-ATPase dependent organelle
            acidification is necessary for such intracellular processes as
            protein sorting, zymogen activation, receptor-mediated endocytosis,
            and synaptic vesicle proton gradient generation. V-ATPase is
            composed of a cytosolic V1 domain and a transmembrane V0 domain.
            The V1 domain consists of three A, three B, and two G subunits, as
            well as a C, D, E, F, and H subunit. The V1 domain contains the ATP
            catalytic site. The protein encoded by this gene is one of three V1
            domain G subunit proteins. Pseudogenes of this gene have been
            characterized. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.67861.1,
                                           SRR3476690.91132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374050.4/ ENSP00000363162.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BF692207.1         57-75
            20-1057             BC008452.1         1-1038
            1058-1521           AL160275.14        72690-73153
            1522-1556           AI092246.1         1-35                c
            1557-1563           AL160275.14        73189-73195
FEATURES             Location/Qualifiers
     source          1..1563
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1563
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /note="ATPase H+ transporting V1 subunit G1"
                     /db_xref="GeneID:9550"
                     /db_xref="HGNC:HGNC:864"
                     /db_xref="MIM:607296"
     exon            1..152
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..427
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal (vacuolar proton
                     pump), member J; vacuolar H(+)-ATPase subunit G 1;
                     V-ATPase 13 kDa subunit 1; vacuolar ATP synthase subunit
                     M16; V-ATPase subunit G 1; vacuolar proton pump subunit G
                     1; vacuolar proton pump subunit M16; ATPase, H+
                     transporting, lysosomal 13kDa, V1 subunit G1"
                     /codon_start=1
                     /product="V-type proton ATPase subunit G 1"
                     /protein_id="NP_004879.1"
                     /db_xref="CCDS:CCDS6807.1"
                     /db_xref="GeneID:9550"
                     /db_xref="HGNC:HGNC:864"
                     /db_xref="MIM:607296"
                     /translation="MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEI
                     EQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAF
                     VCDIRPEIHENYRING"
     exon            153..253
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /inference="alignment:Splign:2.1.0"
     exon            254..1563
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /note="hexamer: AGTAAA"
     polyA_site      1057
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /note="major polyA site"
     polyA_site      1234
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
     regulatory      1259..1264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /note="hexamer: AACAAA"
     polyA_site      1282
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
     regulatory      1527..1532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
                     /note="hexamer: AATACA"
     polyA_site      1563
                     /gene="ATP6V1G1"
                     /gene_synonym="ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10"
ORIGIN      
        1 gtgtcagctg acccaagggg ccttcgaggt gccttaggcc gcttgccttg ctctcagaat
       61 cgctgccgcc atggctagtc agtctcaggg gattcagcag ctgctgcagg ccgagaagcg
      121 ggcagccgag aaggtgtccg aggcccgcaa aagaaagaac cggaggctga agcaggccaa
      181 agaagaagct caggctgaaa ttgaacagta ccgcctgcag agggagaaag aattcaaggc
      241 caaggaagct gcggcattgg gatcccgtgg cagttgcagc actgaagtgg agaaggagac
      301 ccaggagaag atgaccatcc tccagacata cttccggcag aacagggatg aagtcttgga
      361 caacctcttg gcttttgtct gtgacattcg gccagaaatc catgaaaact accgcataaa
      421 tggatagaag agagaagcac ctgtgctgtg gagtggcatt ttagatgccc tcacgaatat
      481 gaagcttagc acagctctag ttacattctt atgatatggc attaaattat ttccatatat
      541 tatataatag gtccttccac tttttggaga gtagcaaatc tagctttttt gtacagactt
      601 agaaattatc taaagatttc atctttttac ctcatatttc ttaggaattt aatggttata
      661 tgttgtcttt ttttcctatg tcttttggct caagcaacat gtatatcagt gttgactttt
      721 tctttcttag atctagttta aaaaaaaaaa aaaccacata acaattcttt gaagaaagga
      781 agggattaaa taattttttt ccctaacact ttcttgaagg tcaggggctt tatctatgaa
      841 aaagtagtaa atagttcttt gtaacctgtg tgaagcagca gccagcctta aagtagtcca
      901 ttcttgctaa tggttagaac agtgaatact agtggaattg tttgggctgc ttttagtttc
      961 tcttaatcaa aattactaga tgatagaatt caagaacttg ttacatgtat tacttggtgt
     1021 atcgataatc atttaaaagt aaagactctg tcatgcattt ttccccattc tttttttttt
     1081 ccctgtctcc gtgacaacca gtggttcttc atttttgatc atgcgaaatg cattttgacc
     1141 cagatggtct gcagaacttc acttaggaca ttagcacaca aatagcacac atatcacata
     1201 cccatttata tacataatta gaaaatgttc ctgatacatg tgtcatgtga tttcttccaa
     1261 caaatgtttt ggaaaacagc aagcaactag tctgtaggtt gtcttttctc tagagatcct
     1321 tgtcctggga cagcctgggg caagttatta agcatatttc cttcctggtg ggctagatga
     1381 tgtgcattat acctgtagta ccttcatact agcccttaca agttaaatgt cctgtggcca
     1441 tcttagccga aagtctttgg ttgcaaaatc ttataggtaa aaacagttga aagaacatta
     1501 tgggatttcc ttgcttgttc tgatacaata caactagatg accttaaaaa ccctcatatt
     1561 taa
//
