LOCUS       NM_015994               1599 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ATPase H+ transporting V1 subunit D (ATP6V1D), mRNA.
ACCESSION   NM_015994
VERSION     NM_015994.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Wang,L., Wu,D., Robinson,C.V., Wu,H. and Fu,T.M.
  TITLE     Structures of a Complete Human V-ATPase Reveal Mechanisms of Its
            Assembly
  JOURNAL   Mol Cell 80 (3), 501-511 (2020)
   PUBMED   33065002
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Vasanthakumar,T. and Rubinstein,J.L.
  TITLE     Structure and Roles of V-type ATPases
  JOURNAL   Trends Biochem Sci 45 (4), 295-307 (2020)
   PUBMED   32001091
  REMARK    Review article
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Forgac,M.
  TITLE     Structure and properties of the vacuolar (H+)-ATPases
  JOURNAL   J Biol Chem 274 (19), 12951-12954 (1999)
   PUBMED   10224039
  REMARK    Review article
REFERENCE   7  (bases 1 to 1599)
  AUTHORS   Nelson,N. and Harvey,W.R.
  TITLE     Vacuolar and plasma membrane proton-adenosinetriphosphatases
  JOURNAL   Physiol Rev 79 (2), 361-385 (1999)
   PUBMED   10221984
  REMARK    Review article
REFERENCE   8  (bases 1 to 1599)
  AUTHORS   Finbow,M.E. and Harrison,M.A.
  TITLE     The vacuolar H+-ATPase: a universal proton pump of eukaryotes
  JOURNAL   Biochem J 324 (Pt 3) (Pt 3), 697-712 (1997)
   PUBMED   9210392
  REMARK    Review article
REFERENCE   9  (bases 1 to 1599)
  AUTHORS   Stevens,T.H. and Forgac,M.
  TITLE     Structure, function and regulation of the vacuolar (H+)-ATPase
  JOURNAL   Annu Rev Cell Dev Biol 13, 779-808 (1997)
   PUBMED   9442887
  REMARK    Review article
REFERENCE   10 (bases 1 to 1599)
  AUTHORS   Dautry-Varsat,A.
  TITLE     Receptor-mediated endocytosis: the intracellular journey of
            transferrin and its receptor
  JOURNAL   Biochimie 68 (3), 375-381 (1986)
   PUBMED   2874839
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB039102.1, BC001411.2,
            AL139785.5 and BU726615.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015994.3.
            
            Summary: This gene encodes a component of vacuolar ATPase
            (V-ATPase), a multisubunit enzyme that mediates acidification of
            eukaryotic intracellular organelles. V-ATPase dependent organelle
            acidification is necessary for such intracellular processes as
            protein sorting, zymogen activation, receptor-mediated endocytosis,
            and synaptic vesicle proton gradient generation. V-ATPase is
            composed of a cytosolic V1 domain and a transmembrane V0 domain.
            The V1 domain consists of three A and three B subunits, two G
            subunits plus the C, D, E, F, and H subunits. The V1 domain
            contains the ATP catalytic site. The V0 domain consists of five
            different subunits: a, c, c', c', and d. Additional isoforms of
            many of the V1 and V0 subunit proteins are encoded by multiple
            genes or alternatively spliced transcript variants. This gene
            encodes the V1 domain D subunit protein. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315784.1, AF145316.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216442.12/ ENSP00000216442.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DB039102.1         200-221
            23-900              BC001411.2         1-878
            901-1598            AL139785.5         26499-27196         c
            1599-1599           BU726615.1         26-26               c
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..1599
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /note="ATPase H+ transporting V1 subunit D"
                     /db_xref="GeneID:51382"
                     /db_xref="HGNC:HGNC:13527"
                     /db_xref="MIM:609398"
     exon            1..147
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     exon            148..265
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     exon            266..345
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     exon            346..413
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     exon            414..458
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     exon            459..562
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     exon            563..629
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     exon            630..708
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1599
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1380..1385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /note="hexamer: AGTAAA"
     polyA_site      1400
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /note="major polyA site"
     regulatory      1577..1582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /note="hexamer: AATAAA"
     polyA_site      1599
                     /gene="ATP6V1D"
                     /gene_synonym="ATP6M; VATD; VMA8"
                     /note="major polyA site"
ORIGIN      
        1 acaaccagct gactcccgta gaggaagaca ctgtggaggc cagttctgga gctattgcag
       61 cctcggttgc ccggccgggg acccgagccg aaaagttatc gtcagaatgt cgggcaaaga
      121 ccgaattgaa atctttccct cgcgaatggc acagaccatc atgaaggctc gtttaaaggg
      181 agcacagaca ggtcgaaacc tcctgaagaa aaaatctgat gccttaactc ttcgatttcg
      241 acagatccta aagaagataa tagagactaa aatgttgatg ggcgaagtga tgagagaagc
      301 tgccttttca ctagctgaag ccaagttcac agcaggtgac ttcagcacta cagttatcca
      361 aaatgtcaat aaagcgcaag tgaagattcg agcgaagaaa gataatgtag caggtgttac
      421 tttgccagta tttgaacatt accatgaagg aactgacagt tatgaactga ctggtttagc
      481 cagaggtggg gaacagttgg ctaaattaaa gaggaattat gccaaagcag tggaactact
      541 ggtggaacta gcttctctgc agacttcttt tgttactttg gatgaagcta ttaagataac
      601 caacaggcgt gtaaatgcca ttgaacatgt catcattccc cggattgaac gtactcttgc
      661 ttatatcatc acagagctgg atgagagaga gcgagaagag ttctataggt taaagaaaat
      721 acaagagaag aaaaagattc taaaggaaaa atctgagaag gacttggagc aaaggagagc
      781 agctggagag gtgttggagc ctgctaatct tctggctgaa gagaaggacg aggatcttct
      841 atttgaataa tctttcctgt tctggttctt tgagaaaccc taacactggc ttcattttaa
      901 ttcacagtgt gtaggtttga tttgtgtggc tatttatttt ttggcctaag aatttcactg
      961 gttgtaaaat ttacctagat gtctatttat gggattactt ttgcagaatc ataatttagc
     1021 aaccatttat catggatgaa agagatctgt aaaacctgcc caggaactta cagaatttac
     1081 tttgcagaag cgttatcata ctccatttac atctgtgtta cacgtgatct gcttaccaag
     1141 catattagga aatacctctt aggaagcatt agcggtctca ggccaattac tgtggagcag
     1201 ctttcattcc tacccacttg caaaccttgg cgctgttgtc tgagattgct gcagccattc
     1261 ttgttaccat ggtacttctc aaactttgtg aaaacctgca cttttccttg catgacaggt
     1321 tcctgtcttg tctgtcatgg gagccattct gccaatttaa atgcgactgt ggtataaaca
     1381 gtaaaatgat ttaaaagtaa gtcattccgt ttttattaat ttactgttaa gtcatgttct
     1441 catgctcaga tcagtagtgt cagccagagc tttctctgca gacatgtagg aagtgggtag
     1501 ctatttttcc cactccatgt attagagttt tacaaaaagg cttacttttg agacaactgt
     1561 tgcattttgg ggtactaata aatgattgcc gatgagtta
//
