LOCUS       NM_001695               5635 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ATPase H+ transporting V1 subunit C1 (ATP6V1C1), mRNA.
ACCESSION   NM_001695
VERSION     NM_001695.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5635)
  AUTHORS   Yao,X., Chen,H., Xu,B., Lu,J., Gu,J., Chen,F., Ju,M. and Sun,X.
  TITLE     The ATPase subunit of ATP6V1C1 inhibits autophagy and enhances
            radiotherapy resistance in esophageal squamous cell carcinoma
  JOURNAL   Gene 768, 145261 (2021)
   PUBMED   33183740
  REMARK    GeneRIF: The ATPase subunit of ATP6V1C1 inhibits autophagy and
            enhances radiotherapy resistance in esophageal squamous cell
            carcinoma.
REFERENCE   2  (bases 1 to 5635)
  AUTHORS   Couto-Vieira,J., Nicolau-Neto,P., Costa,E.P., Figueira,F.F.,
            Simao,T.A., Okorokova-Facanha,A.L., Ribeiro Pinto,L.F. and
            Facanha,A.R.
  TITLE     Multi-cancer V-ATPase molecular signatures: A distinctive balance
            of subunit C isoforms in esophageal carcinoma
  JOURNAL   EBioMedicine 51, 102581 (2020)
   PUBMED   31901859
  REMARK    GeneRIF: Multi-cancer V-ATPase molecular signatures: A distinctive
            balance of subunit C isoforms in esophageal carcinoma.
REFERENCE   3  (bases 1 to 5635)
  AUTHORS   Jing,F., Geng,Y., Xu,X.Y., Xu,H.Y., Shi,J.S. and Xu,Z.H.
  TITLE     MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the
            Regression of Hepatic Fibrosis through Regulation of ATPase H
            Transporting V1 Subunit C1
  JOURNAL   Int J Mol Sci 20 (4), 796 (2019)
   PUBMED   30781750
  REMARK    GeneRIF: MIR29a plays an important role during the
            trans-differentiation of Activated hepatic stellate cells in the
            resolution of liver fibrosis, in part, through regulation of
            ATP6V1C1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5635)
  AUTHORS   McConnell,M., Feng,S., Chen,W., Zhu,G., Shen,D., Ponnazhagan,S.,
            Deng,L. and Li,Y.P.
  TITLE     Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer
            growth by activating the mTORC1 pathway and bone metastasis by
            increasing V-ATPase activity
  JOURNAL   Oncotarget 8 (29), 47675-47690 (2017)
   PUBMED   28504970
  REMARK    GeneRIF: knockdown of C1 reduces breast cancer growth, metastasis,
            and osteolytic lesion formation.
REFERENCE   5  (bases 1 to 5635)
  AUTHORS   Perez-Sayans,M., Suarez-Penaranda,J.M., Aguirre-Urizar,J.M.,
            Rodriguez-Tojo,M.J., Barros-Angueira,F., Gallas-Torreira,M. and
            Garcia-Garcia,A.
  TITLE     The use of tissue microarrays for semiquantitative evaluation of
            ATPaseC1 expression is ineffective
  JOURNAL   Biotech Histochem 90 (6), 439-444 (2015)
   PUBMED   25901422
  REMARK    GeneRIF: We assessed ATPaseC1 expression in a sample of oral
            squamous cell carcinoma using tissue microarrays to analyze the
            relation between ATPaseC1 expression and clinical,
            histopathological and prognostic parameters.
REFERENCE   6  (bases 1 to 5635)
  AUTHORS   Finbow,M.E. and Harrison,M.A.
  TITLE     The vacuolar H+-ATPase: a universal proton pump of eukaryotes
  JOURNAL   Biochem J 324 (Pt 3) (Pt 3), 697-712 (1997)
   PUBMED   9210392
  REMARK    Review article
REFERENCE   7  (bases 1 to 5635)
  AUTHORS   Stevens,T.H. and Forgac,M.
  TITLE     Structure, function and regulation of the vacuolar (H+)-ATPase
  JOURNAL   Annu Rev Cell Dev Biol 13, 779-808 (1997)
   PUBMED   9442887
  REMARK    Review article
REFERENCE   8  (bases 1 to 5635)
  AUTHORS   van Hille,B., Vanek,M., Richener,H., Green,J.R. and Bilbe,G.
  TITLE     Cloning and tissue distribution of subunits C, D, and E of the
            human vacuolar H(+)-ATPase
  JOURNAL   Biochem Biophys Res Commun 197 (1), 15-21 (1993)
   PUBMED   8250920
REFERENCE   9  (bases 1 to 5635)
  AUTHORS   Nelson,H., Mandiyan,S., Noumi,T., Moriyama,Y., Miedel,M.C. and
            Nelson,N.
  TITLE     Molecular cloning of cDNA encoding the C subunit of H(+)-ATPase
            from bovine chromaffin granules
  JOURNAL   J Biol Chem 265 (33), 20390-20393 (1990)
   PUBMED   2147024
REFERENCE   10 (bases 1 to 5635)
  AUTHORS   Dautry-Varsat,A.
  TITLE     Receptor-mediated endocytosis: the intracellular journey of
            transferrin and its receptor
  JOURNAL   Biochimie 68 (3), 375-381 (1986)
   PUBMED   2874839
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003550.2 and X69151.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001695.4.
            
            Summary: This gene encodes a component of vacuolar ATPase
            (V-ATPase), a multisubunit enzyme that mediates acidification of
            intracellular compartments of eukaryotic cells. V-ATPase dependent
            acidification is necessary for such intracellular processes as
            protein sorting, zymogen activation, receptor-mediated endocytosis,
            and synaptic vesicle proton gradient generation. V-ATPase is
            composed of a cytosolic V1 domain and a transmembrane V0 domain.
            The V1 domain consists of three A and three B subunits, two G
            subunits plus the C, D, E, F, and H subunits. The V1 domain
            contains the ATP catalytic site. The V0 domain consists of five
            different subunits: a, c, c', c'', and d. Additional isoforms of
            many of the V1 and V0 subunit proteins are encoded by multiple
            genes or alternatively spliced transcript variants. This gene is
            one of two genes that encode the V1 domain C subunit proteins and
            is found ubiquitously. This C subunit is analogous but not
            homologous to gamma subunit of F-ATPases. Previously, this gene was
            designated ATP6D. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.70718.1,
                                           SRR1803612.140832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518738.2/ ENSP00000430282.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AP003550.2         14577-14592
            17-1440             X69151.1           1-1424
            1441-5635           AP003550.2         62351-66545
FEATURES             Location/Qualifiers
     source          1..5635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..5635
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /note="ATPase H+ transporting V1 subunit C1"
                     /db_xref="GeneID:528"
                     /db_xref="HGNC:HGNC:856"
                     /db_xref="MIM:603097"
     exon            1..143
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            144..314
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1331
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /EC_number="7.1.2.2"
                     /note="subunit C of vacuolar proton-ATPase V1 domain;
                     vacuolar proton-ATPase, subunit C, VI domain; ATPase, H+
                     transporting, lysosomal 42kDa, V1 subunit C1;
                     H+-transporting ATPase chain C, vacuolar; vacuolar proton
                     pump C subunit; vacuolar ATP synthase subunit C; V-ATPase
                     C subunit; H(+)-transporting two-sector ATPase, subunit C;
                     vacuolar proton pump, 42-kD subunit; H+ -ATPase C subunit;
                     V-ATPase subunit C 1; vacuolar proton pump subunit C 1;
                     testicular tissue protein Li 223"
                     /codon_start=1
                     /product="V-type proton ATPase subunit C 1"
                     /protein_id="NP_001686.1"
                     /db_xref="CCDS:CCDS6296.1"
                     /db_xref="GeneID:528"
                     /db_xref="HGNC:HGNC:856"
                     /db_xref="MIM:603097"
                     /translation="MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLK
                     VGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYI
                     TRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGS
                     LLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSE
                     DQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNRLSTDKKKQF
                     GPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTLKKLREV
                     LHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK"
     exon            315..382
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            383..468
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            469..563
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            564..655
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            656..754
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            755..823
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            824..916
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1010
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1108
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1235
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..5635
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1844..1849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /note="major polyA site"
     regulatory      5054..5059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /note="hexamer: AATAAA"
     polyA_site      5074
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
     regulatory      5615..5620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /note="hexamer: AATAAA"
     polyA_site      5635
                     /gene="ATP6V1C1"
                     /gene_synonym="ATP6C; ATP6D; VATC; Vma5"
                     /note="major polyA site"
ORIGIN      
        1 gttctgtgtt cgcttgggta gaggaagccg tgaggccgga gcttaggtcg ggaagggatg
       61 gatcgctgag ccgatagcgt ccgctaggct gtctgcctcg gtacctgtta ctgctgctac
      121 ttcctcgttt gacaccttcc tggaatctct cttgattttt gaggaaatac ctagtaacaa
      181 acatgactga gttctggctt atatctgctc ctggggagaa aacctgtcag caaacatggg
      241 agaaattgca tgcggcaact tcaaagaaca ataatcttgc tgtcacttcc aagttcaata
      301 ttcctgactt aaaggttggc acgttggatg tcttggttgg cttgtcagat gaactggcta
      361 aactggatgc atttgtagaa ggagtggtta agaaagtagc tcaatacatg gctgatgtat
      421 tggaagatag caaagacaaa gttcaagaga atctgttggc taatggagtg gacttggtta
      481 cttatataac aaggttccag tgggacatgg ccaaatatcc aatcaagcag tccctgaaaa
      541 atatttctga aataattgcc aagggagtaa ctcagattga taatgacctg aaatctcgag
      601 catctgcata caataacctg aaaggaaatc ttcagaattt ggaacgaaag aatgcaggaa
      661 gtttgctaac tagaagtcta gcagaaattg tgaagaagga tgactttgtt cttgattcag
      721 agtatctcgt cacattactg gtagtagttc ccaagttaaa ccacaacgac tggattaagc
      781 agtatgaaac actagccgaa atggtagttc caaggtctag caatgttctt tcagaggacc
      841 aagacagtta cctgtgtaat gtcaccttgt ttaggaaggc agttgatgac ttcagacaca
      901 aagccagaga aaacaaattc attgttcgtg acttccagta taatgaagag gagatgaaag
      961 cagataaaga agaaatgaac aggctttcta ctgataagaa aaaacaattt ggaccacttg
     1021 tacggtggct gaaagtgaat tttagtgaag catttattgc atggattcac gtgaaagcat
     1081 tacgggtttt cgttgagtct gttttaaggt atggcttgcc agtgaacttc caagcaatgc
     1141 tacttcagcc caataagaaa actttgaaga aactgagaga agtattacat gaattgtata
     1201 aacatctaga cagcagtgca gcagctatta ttgatgctcc tatggatatt ccaggtttaa
     1261 acctgagtca acaagaatac tacccctatg tgtactacaa gattgattgc aacttgctgg
     1321 aattcaagtg aaaatgggct cctcccccga caatcctgtc cttgtgtttg tgtgtgctaa
     1381 cagaaataag ttgcagtatg gtcgtacttt taactctagt atcctttgct tgcttcttac
     1441 gccctttcct aggtgaattc tcccacagtg gtctgtatct caacattttc tttttaaagg
     1501 aaaaaatata tatatatagt ttctttttat tgatcaggtc tgtaaatgtg tactaaaaaa
     1561 atcagagttt atttataaac aaaatagttt atttaaagag aaggtctctt ccttattgat
     1621 atcatggtat gcattaattc catttgttac tattgtgcac aaaagccctg ttcacagggg
     1681 aatggtgtaa acatttatac tgttttgttc actgtattta gtagacataa ctgttgaata
     1741 gttactgaat catgatgtaa agaatatgtg accatcttca ggtatgggat ttctgaacgt
     1801 ttcaaatttc aatcaatgag cactgtcaac acccacagga gagaataaaa ttacctgtgc
     1861 aaaggtgtat tgtggtgtgt gtaacttaag attacagttc tgtttgagag ttaaatgatg
     1921 tcatagctca cttgctatgc tgcttccagg attttgttat atgctgaggt gtaaccattt
     1981 gtgttgtctg actttcgtat gatttaattg agccaaattt gggtcagaac acaaatttga
     2041 agatgacttt tcagtatatg atgggtattt acatttgaac actagaattt taggtctctc
     2101 aaataattaa gaatagagcc agttttgaat aaagtctagc agaactatgc agctttagtc
     2161 atttgttttg tctaagtctg tattttatgt gttgtcttct taagatctat aattttggca
     2221 tttatgtcat ttgtgacata gtctgaaaat agagacattg ttggccttta aaatctcaga
     2281 aatgaatgac ttaatttagt gtcctgaaag agcttttaaa agaggatttt gtggcaatgt
     2341 ttctcttact acgtactcac aggtttgcaa atgggaaaaa agtttacatt tcagtttagg
     2401 ggcatatcta agctatgcta ttccctttag aaaattagcc tccaaaatct tttgtttcaa
     2461 aatattatat tatttcataa ataatttcaa gcaaatacag acatccacaa tgtagaacat
     2521 gagagacccc ctccctcaat ttccacctcc caagggaagt ttatgtattt ttctaggccc
     2581 ttttctatgt ctttacatct ctgtctcaca cacacacacg tatacacaca cacagtttat
     2641 ttttaataaa ataggattat accacacaca tcctgtcact tgcttttttg cttaagagta
     2701 tatctaagag aatcctttgt gtcagtgaag ctggagctac ctcattcttt taactggctg
     2761 cgtggcgttc cattgagtgt ctgtcatcat gtgtttagcc gagtggatgg atagtctgct
     2821 tgtttttagt ttttgctctt aacaaacact gctgcagtca gcatccttgc acagatttct
     2881 ttgtatactt gtattagtat ttctgtaaga tctgagaagt ggaatttgta gggtcatagg
     2941 ttatgtacac ttaagttttt gacactcact gccaagtcat ctgtcagaat tctaaactaa
     3001 agacatgttt ggagtgtgga tttatcttca gtttttcttt ggacaagagg aagctgtgaa
     3061 agattttgct atcagaaaat tttggttctt tgtcttttgc acatgttctt tgagtcttag
     3121 tatctgtaac gtggcgctac tctctctatc atgggggggc atgttttgac attaaattga
     3181 cttttaagaa aaacatgtca ctaacctgaa gctcagccac acagtgactt ttaaggtttt
     3241 atttagactt tactgttgtt ctcatgagag taggtacaga ctgcataagg tttagaatcc
     3301 cagcatatgt ctgaaacgac gggactttca ctgtgatttc caccagagaa attatagcag
     3361 agtggctgag catgtgctct gaggccaggc cccagctctg ctgctgacga gctgtgtggt
     3421 cctgggcaga gtggtctccg agttccagtc cctcctctgt aaaatgggca tgattagagt
     3481 gcccaccgca ttagggatgt tggggtgagt cagtgtgacc ccacgtgcac agaaagtgct
     3541 gcgagtggtg catggtgaga ggttgatgca ggtacttagc ccttggggaa cacaggtagt
     3601 tccttttcac tgtgtttaat ttgggaaaat ccagatccac atcattgtag agtctgaggg
     3661 ttagaaggaa gtcattgtgt ctaacataac aacagagcag tttgtgtcac tgagctccag
     3721 tctgtgctgg attattgata ttgttggtgg cggtcaccat tcctggaaag ggactgtccc
     3781 aagccactta ccttcccgag gagtctgctg gttctccttg aggatagtgc ttagataaca
     3841 gactcattaa acatttactg agtgtctgtc agggatcatt cacatccaca tcatcctccc
     3901 ggcccctccc cgtgttgttc atggagggag tactggcggt ccccattttc atgtatggag
     3961 acttcaggtg aaagaagtta agtgaattct ttgttgagtc acaaatcttg agccagtcag
     4021 aatttgaacc taagattttt gactgctggt tgtcacactt cccgccccac actcaactgt
     4081 tgtgtgaatg agccagacac attgcttaac ctgagtccga gatggacaat ggtataggaa
     4141 agatattcgg tatggagaat cagatgttaa cttgtgttgc tatttttgtt ttgttttgtt
     4201 ttgttttgtt tttgagacaa ggtcttgctc tgtcacccag gctagagtgc agtggcatga
     4261 tcagggctta ctgcagcctc accctcgatt tcctgggctc aagcaatcct cccacctcag
     4321 cccccaagta gctgggccta caggtgcgtg ctaccacgcc tggccaattt tttaaatttt
     4381 agcacagatg aggtctcact atgttgcccg ggctggtctc gaactcctga gctcaaggga
     4441 tcctcccgcc tcagcctccc aaagtgctgg tgttacaggc ataagccacc acgcctggcc
     4501 tgtgttgcta ttatatttgg caggaaccca gagtccagaa catttcatct atgatgggtt
     4561 agataatgtg tctagttgtt tgcatgccaa tttcagtagc ctcagttatt caacctagga
     4621 gatttttcta cctctttact accctgctga agttgctctt cagcagaaaa tctttgtgga
     4681 acacattcca cactttgaaa tcttcgtgga acaaaagata tttgtggaac caatctttgt
     4741 ggaacatatt ccagcttttt gaatgagtgc atatccagta gtacctttaa agtaacactt
     4801 tgtacataac aaatactcag caaatgtgaa actttatttg ctcttacttc aaaattagtc
     4861 caaaatgttg gaaataaaat ataagacatt gatctagata tgaggttttt ctccttcatt
     4921 ctcagctgtc gaagaaatca aagtagcata tgcacaaggt taaaaaccac atatacaaat
     4981 actatagaac agcttataat gaaaaccttg cctgccttta taaaaaatgt gattatcttc
     5041 ttctgttaat gtcaataaaa gatggtttgt cctagaaggt ctataaatgg tattatgttc
     5101 tggaggaaac ctagcaaaaa ctttgctagt ttagtacttg tctctaaatt gatgttcacc
     5161 catttcaata ttgcacttat taatggtctt tatttttcta gcatagataa caattgattc
     5221 tttagattca tatatggagg taattcttgc tttctaaaga aaggaatatg gcacattgga
     5281 accattttat tcaccagtgg atttaccctt agagtatttt tagatctgag ctgatgactt
     5341 gtgagagaaa aagggaacag agtaaagcca tggaagccat gaacagtaag agactgccgc
     5401 ctggcatggt ttcttcttct gcagaagatg aaactgagga gaaacaagac aacatccttc
     5461 ataccaggaa tggtcaagat aatgcaagaa gaaaaaagct ttcaaacaaa tcagaaggca
     5521 gtcaacaaac agaaaggggg acattccttc cctggcagtt actcaaaact gaaattgctt
     5581 attgtgtaca ccggggcttg tacttgggga atttaataaa aatgctcatt accaa
//
