LOCUS       NM_001690               4575 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ATPase H+ transporting V1 subunit A (ATP6V1A), mRNA.
ACCESSION   NM_001690
VERSION     NM_001690.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4575)
  AUTHORS   Sirchia,F., Taietti,I., Donesana,M., Bassanese,F., Clemente,A.M.,
            Barbato,E., Orsini,A., Ferretti,A., Marseglia,G.L., Savasta,S. and
            Foiadelli,T.
  TITLE     Expanding the Spectrum of Autosomal Dominant ATP6V1A-Related
            Disease: Case Report and Literature Review
  JOURNAL   Genes (Basel) 15 (9), 1219 (2024)
   PUBMED   39336810
  REMARK    GeneRIF: Expanding the Spectrum of Autosomal Dominant
            ATP6V1A-Related Disease: Case Report and Literature Review.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4575)
  AUTHORS   Li,B., Lan,S., Liu,X.R., Ji,J.J., He,Y.Y., Zhang,D.M., Xu,J.,
            Sun,H., Shi,Z., Wang,J. and Tian,Y.
  CONSRTM   China Epilepsy Gene 1.0 Project
  TITLE     ATP6V1A variants are associated with childhood epilepsy with
            favorable outcome
  JOURNAL   Seizure 116, 81-86 (2024)
   PUBMED   37574426
  REMARK    GeneRIF: ATP6V1A variants are associated with childhood epilepsy
            with favorable outcome.
REFERENCE   3  (bases 1 to 4575)
  AUTHORS   Wang,X., Wu,R., Zhai,P., Liu,Z., Xia,R., Zhang,Z., Qin,X., Li,C.,
            Chen,W., Li,J. and Zhang,J.
  TITLE     Hypoxia promotes EV secretion by impairing lysosomal homeostasis in
            HNSCC through negative regulation of ATP6V1A by HIF-1alpha
  JOURNAL   J Extracell Vesicles 12 (2), e12310 (2023)
   PUBMED   36748335
  REMARK    GeneRIF: Hypoxia promotes EV secretion by impairing lysosomal
            homeostasis in HNSCC through negative regulation of ATP6V1A by
            HIF-1alpha.
            Erratum:[J Extracell Vesicles. 2023 Jun;12(6):e12330. doi:
            10.1002/jev2.12330.. PMID: 37243398]
REFERENCE   4  (bases 1 to 4575)
  AUTHORS   Guerrini,R., Mei,D., Kerti-Szigeti,K., Pepe,S., Koenig,M.K., Von
            Allmen,G., Cho,M.T., McDonald,K., Baker,J., Bhambhani,V., Powis,Z.,
            Rodan,L., Nabbout,R., Barcia,G., Rosenfeld,J.A., Bacino,C.A.,
            Mignot,C., Power,L.H., Harris,C.J., Marjanovic,D., Moller,R.S.,
            Hammer,T.B., Keski Filppula,R., Vieira,P., Hildebrandt,C.,
            Sacharow,S., Maragliano,L., Benfenati,F., Lachlan,K., Benneche,A.,
            Petit,F., de Sainte Agathe,J.M., Hallinan,B., Si,Y.,
            Wentzensen,I.M., Zou,F., Narayanan,V., Matsumoto,N.,
            Boncristiano,A., la Marca,G., Kato,M., Anderson,K., Barba,C.,
            Sturiale,L., Garozzo,D., Bei,R., Masuelli,L., Conti,V., Novarino,G.
            and Fassio,A.
  CONSRTM   DDD Study; Undiagnosed Diseases Network; ATP6V1A collaborators
  TITLE     Phenotypic and genetic spectrum of ATP6V1A encephalopathy: a
            disorder of lysosomal homeostasis
  JOURNAL   Brain 145 (8), 2687-2703 (2022)
   PUBMED   35675510
  REMARK    GeneRIF: Phenotypic and genetic spectrum of ATP6V1A encephalopathy:
            a disorder of lysosomal homeostasis.
REFERENCE   5  (bases 1 to 4575)
  AUTHORS   Vogt,G., El Choubassi,N., Herczegfalvi,A., Kolbel,H., Lekaj,A.,
            Schara,U., Holtgrewe,M., Krause,S., Horvath,R., Schuelke,M.,
            Hubner,C., Mundlos,S., Roos,A., Lochmuller,H., Karcagi,V.,
            Kornak,U. and Fischer-Zirnsak,B.
  TITLE     Expanding the clinical and molecular spectrum of ATP6V1A related
            metabolic cutis laxa
  JOURNAL   J Inherit Metab Dis 44 (4), 972-986 (2021)
   PUBMED   33320377
  REMARK    GeneRIF: Expanding the clinical and molecular spectrum of ATP6V1A
            related metabolic cutis laxa.
REFERENCE   6  (bases 1 to 4575)
  AUTHORS   Finbow,M.E. and Harrison,M.A.
  TITLE     The vacuolar H+-ATPase: a universal proton pump of eukaryotes
  JOURNAL   Biochem J 324 (Pt 3) (Pt 3), 697-712 (1997)
   PUBMED   9210392
  REMARK    Review article
REFERENCE   7  (bases 1 to 4575)
  AUTHORS   Stevens,T.H. and Forgac,M.
  TITLE     Structure, function and regulation of the vacuolar (H+)-ATPase
  JOURNAL   Annu Rev Cell Dev Biol 13, 779-808 (1997)
   PUBMED   9442887
  REMARK    Review article
REFERENCE   8  (bases 1 to 4575)
  AUTHORS   van Hille,B., Richener,H., Green,J.R. and Bilbe,G.
  TITLE     The ubiquitous VA68 isoform of subunit A of the vacuolar
            H(+)-ATPase is highly expressed in human osteoclasts
  JOURNAL   Biochem Biophys Res Commun 214 (3), 1108-1113 (1995)
   PUBMED   7575517
REFERENCE   9  (bases 1 to 4575)
  AUTHORS   van Hille,B., Richener,H., Evans,D.B., Green,J.R. and Bilbe,G.
  TITLE     Identification of two subunit A isoforms of the vacuolar
            H(+)-ATPase in human osteoclastoma
  JOURNAL   J Biol Chem 268 (10), 7075-7080 (1993)
   PUBMED   8463241
REFERENCE   10 (bases 1 to 4575)
  AUTHORS   Dautry-Varsat,A.
  TITLE     Receptor-mediated endocytosis: the intracellular journey of
            transferrin and its receptor
  JOURNAL   Biochimie 68 (3), 375-381 (1986)
   PUBMED   2874839
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC350361.1, AK314779.1,
            AF339827.1 and BC012169.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001690.3.
            
            Summary: This gene encodes a component of vacuolar ATPase
            (V-ATPase), a multisubunit enzyme that mediates acidification of
            eukaryotic intracellular organelles. V-ATPase dependent organelle
            acidification is necessary for such intracellular processes as
            protein sorting, zymogen activation, receptor-mediated endocytosis,
            and synaptic vesicle proton gradient generation. V-ATPase is
            composed of a cytosolic V1 domain and a transmembrane V0 domain.
            The V1 domain consists of three A and three B subunits, two G
            subunits plus the C, D, E, F, and H subunits. The V1 domain
            contains the ATP catalytic site. The V0 domain consists of five
            different subunits: a, c, c', c', and d. Additional isoforms of
            many of the V1 and V0 subunit proteins are encoded by multiple
            genes or alternatively spliced transcript variants. This encoded
            protein is one of two V1 domain A subunit isoforms and is found in
            all tissues. Transcript variants derived from alternative
            polyadenylation exist. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.257939.1,
                                           SRR1660809.46685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273398.8/ ENSP00000273398.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DC350361.1         17-37
            22-1946             AK314779.1         1-1925
            1947-2932           AF339827.1         325-1310
            2933-4575           BC012169.1         858-2500
FEATURES             Location/Qualifiers
     source          1..4575
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..4575
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /note="ATPase H+ transporting V1 subunit A"
                     /db_xref="GeneID:523"
                     /db_xref="HGNC:HGNC:851"
                     /db_xref="MIM:607027"
     exon            1..79
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..174
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1946
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal, subunit A1;
                     H+-transporting ATPase chain A, vacuolar (VA68 type);
                     V-ATPase A subunit 1; vacuolar proton pump alpha subunit
                     1; vacuolar-type H(+)-ATPase; V-ATPase 69 kDa subunit 1;
                     V-type proton ATPase (V-ATPase) catalytic subunit A;
                     H(+)-transporting two-sector ATPase, subunit A; ATPase, H+
                     transporting, lysosomal 70kDa, V1 subunit A; V-ATPase
                     subunit A; vacuolar proton pump subunit alpha"
                     /codon_start=1
                     /product="V-type proton ATPase catalytic subunit A"
                     /protein_id="NP_001681.2"
                     /db_xref="CCDS:CCDS2976.1"
                     /db_xref="GeneID:523"
                     /db_xref="HGNC:HGNC:851"
                     /db_xref="MIM:607027"
                     /translation="MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVR
                     VGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGI
                     QRPLSDISSQTQSIYIPRGVNVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENS
                     LIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVT
                     EKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVG
                     CGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLS
                     EYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRV
                     KCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNW
                     LISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKIT
                     LEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKIT
                     WSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSDYAQLLEDMQNAFRSLED"
     exon            175..303
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..518
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..656
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..808
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..971
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1080
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1203
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1318
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1382
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1586
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1681
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1853
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..4575
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4553..4558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /note="hexamer: AATAAA"
     polyA_site      4575
                     /gene="ATP6V1A"
                     /gene_synonym="ARCL2D; ATP6A1; ATP6V1A1; DEE93; HO68;
                     IECEE3; VA68; Vma1; VPP2"
                     /note="major polyA site"
ORIGIN      
        1 gcagctgagg acttcccctc cgtggtgaca gcctctgggt cctcggtcgg tacagtctct
       61 gcacctcgcg ccccagcagg taaactaaca ttatggattt ttccaagcta cccaaaatac
      121 tcgatgaaga taaagaaagc acatttggtt atgtgcatgg ggtctcagga cctgtggtta
      181 cagcctgtga catggcgggt gcagccatgt atgagctggt gagagtgggc cacagcgaat
      241 tggttggaga gattattcga ttggagggtg acatggctac tattcaggtg tatgaagaaa
      301 cttctggtgt gtctgttgga gatcctgtac ttcgcactgg taaacccctc tctgtagagc
      361 ttggtcctgg cattatggga gccatttttg atggtattca aagacctttg tcggatatca
      421 gcagtcagac ccaaagcatc tacatcccca gaggagtaaa cgtgtctgct cttagcagag
      481 atatcaaatg ggactttaca ccttgcaaaa acctacgggt tggtagtcat atcactggcg
      541 gagacattta tggaattgtc agtgagaact cgcttatcaa acacaaaatc atgttacccc
      601 cacgaaacag aggaactgta acttacattg ctccacctgg gaattatgat acctctgatg
      661 ttgtcttgga gcttgaattt gaaggtgtaa aggagaagtt caccatggtg caagtatggc
      721 ctgtacgtca agttcgacct gtcactgaga agctgccagc caatcatcct ctgttgactg
      781 gccagagagt ccttgatgcc ctttttccgt gtgtccaggg aggaactact gctatccctg
      841 gagcctttgg ctgtggaaag acagtgatat cacagtctct atccaagtat tctaacagtg
      901 atgtaatcat ctatgtagga tgtggtgaaa gaggaaatga gatgtctgaa gtcctccggg
      961 acttcccaga gctcacaatg gaggttgatg gtaaggtaga gtcaattatg aagaggacag
     1021 ctttggtagc caatacctcc aatatgcctg ttgctgctag agaagcctct atttatactg
     1081 gaatcacact gtcagagtac ttccgtgaca tgggctatca tgtcagtatg atggctgact
     1141 ctacctctag atgggctgag gcccttagag aaatctctgg tcgtttagct gaaatgcctg
     1201 cagatagtgg atatccagcc tatcttggtg cccgtctggc ctcgttttat gaacgagcag
     1261 gcagggtgaa atgtcttgga aatcctgaaa gagaagggag tgtcagcatt gtaggagcag
     1321 tttctccacc tggtggtgat ttttctgatc cagttacatc tgccactctt ggtatcgttc
     1381 aggtgttctg gggcttagat aagaaactag ctcaacgtaa gcatttcccc tctgtcaatt
     1441 ggctcatcag ctacagcaag tatatgcgtg ccttggatga atactatgac aaacacttca
     1501 cagagttcgt tcctctgagg acgaaagcta aggaaattct gcaggaagaa gaagacctgg
     1561 cagaaattgt acagcttgtg ggaaaggctt ctttggcaga aacagataaa atcactctgg
     1621 aggtagcaaa acttatcaaa gatgatttcc tacaacaaaa tggatatact ccttatgaca
     1681 ggttctgccc attctacaag acagtaggga tgctgtccaa catgattgca ttttatgata
     1741 tggctcgtag agctgttgaa accactgccc agagtgacaa taaaatcaca tggtccatta
     1801 ttcgtgagca catgggagac atcctctata aactttcctc catgaaattc aaggatccac
     1861 tgaaagatgg tgaggcaaag atcaaaagcg actatgcaca acttcttgaa gacatgcaga
     1921 atgcattccg tagccttgaa gattagaagc cttgaagatt acaactgtga tttccttttc
     1981 ctcagcaagc tcctatgtgt atattttcct gaatttctca tctcaaaccc tttgcttctt
     2041 tattgtgcag ctttgagact agtgcctatg tgtgttattt gtttccctgt ttttttggta
     2101 ggtcttatat aaaacaaaca ttcctttgtt ctagtgttgt gaagggcctc cctcttcctt
     2161 tatctgaagt ggtgaatata gtaaatatac attctggtta cactactgta aacttgtatg
     2221 tagggtgatg accctctttg tcctaggtgt accctttcct catctctatt aaattgtaaa
     2281 caggactact gcatgtactc tctttgcagt gaatttggaa tggaaggcca ggtttctata
     2341 acttttgaac aggtactttg tgaaatgact caatttctat tgtggtaagc tcattggcag
     2401 cttagcattt tgcaaaggaa ttgctttgca ggaaatattt aattttcaaa aacataatga
     2461 ttaatgttcc aattatgcat cacttccccc agtataaatc aggaatgttt gtgagaaacc
     2521 attgggaact atactctttt tatttttatt ttttattttt tttattattt tttttttggg
     2581 gacggagtgt ccctcttgtt gcccaggctg gagtgcaatg gcgtgatctt ggctcactgc
     2641 agccttcgcc tcccgggttc aagtgattct cctgcctcag cctcccgagt agctgggatt
     2701 acaggcatgc tccaccatgc ccagctaatt ttgtattttt agtagaaacg gggtttcacc
     2761 atattggtca ggctggtctc gaactccaga cctcaggtga tccgcccacc tcggcctccc
     2821 aaactgctgg gattacaggc gtgagccacc gcgcctggcc agggactata ctctttttaa
     2881 aatagacatt tgtggggctc acacaatata tgaaatagta ccctctaaaa aagagaaaaa
     2941 aaaaatcagg cggtcaaact tagagcaaca ttgtcttatt aaagcatagt ttatttcact
     3001 agaaaaaatt taatatcaag gactattaca tacttcatta ctaggaagtt ctttttaaaa
     3061 tgacacttaa aacaatcact gaaaacttga tccacatcac accctgttta ttttccttaa
     3121 acatcttgga agcctaagct tctgagaatc atgtggcaag tgtgatgggc agtaaaatac
     3181 cagagaagat gtttagtagc aattaaaggc tgtttgcacc tttaaggacc agctgggctg
     3241 tagtgattcc tggggccaga gtggcattat gtttttacaa aataatgaca tatgtcacat
     3301 gtttgcatgt ttgtttgctt gttgaatttt tgaacagcca gttgaccaat catagaaagt
     3361 attactttct ttcatatggt ttttggttca ctggcttaag aggtttctca gaatatctat
     3421 ggccacagca gcataccagt ttccatccta ataggaatga aattaatttt gtatctactg
     3481 ataacagaat ctgggtcaca tgaaaaaaaa tcattttatc cgtcttttaa gtatatgttt
     3541 aaaataataa tttatgtgtc tgcatattgc agaacagctc tgagagcaac agtttcccat
     3601 taactctttc tgaccaatag tgctggcacc gttgcttcct ctttgggaag aggaaagggt
     3661 gtgtgaacat ggctaacaat cttcaaatac ccaaattgtg atagcataaa taaagtattt
     3721 attttatgcc tcagtatatt attatttaat tttttaggta atgcctatct cttggtctat
     3781 taaggaaaga agcaatcagt agagaattca ggatagtttt gtttaaattc ttgcagatta
     3841 catgttttta cagtggcctg ctattgagga aaggtattct tctatacaac ttgttttaac
     3901 ctttgagaac attgacagaa attatgcaat ggtttgttga gatacggact tgatggtgct
     3961 gtttaatcag tttgcttcca aagtggccta ctcaagaggc cctaagactg gtagaaatta
     4021 aaaggatttc aaaaactttc tattcctttc ttaaacctac cagcaaacta ggattgtgat
     4081 agcaatgaat ggtatgatga agaaagtttg accaaatttg tttttttgtt gttgttgttg
     4141 ttttgaattt gaaatcattc ttattccctt taagaatgtt tatgtatgag tgtgaagatg
     4201 ctagcgaacc tatgctcaga tattcatcgt aagtctccct tcacctgtta cagagtttca
     4261 gatcggtcac tgatagtatg tatttcttta gtaagaatgt gttaaaatta caatgatctt
     4321 ttaaaaagat gatgcagttc tgtatttatt gtgctgtgtc tggtcctaag tggagccaat
     4381 taaacaagtt tcatatgtat ttttccagtg ttgaatctca cacactgtac tttgaaaatt
     4441 tccttccatc ctgaataacg aatagaagag gccatatata ttgcctcctt atccttgaga
     4501 tttcactacc tttatgttaa aagttgtgta taattgttaa aatctgtgaa agaataaaaa
     4561 gtggatttaa attaa
//
