LOCUS       NM_152565               2370 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ATPase H+ transporting V0 subunit d2 (ATP6V0D2), mRNA.
ACCESSION   NM_152565
VERSION     NM_152565.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Sun,Y. and Wang,X.
  TITLE     Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis
  JOURNAL   Autophagy 20 (6), 1457-1458 (2024)
   PUBMED   38348842
  REMARK    GeneRIF: Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis.
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Qi,M., Liu,D.M., Ji,W. and Wang,H.L.
  TITLE     ATP6V0D2, a subunit associated with proton transport, serves an
            oncogenic role in esophagus cancer and is correlated with
            epithelial-mesenchymal transition
  JOURNAL   Esophagus 17 (4), 456-467 (2020)
   PUBMED   32240421
  REMARK    GeneRIF: ATP6V0D2, a subunit associated with proton transport,
            serves an oncogenic role in esophagus cancer and is correlated with
            epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 2370)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2370)
  AUTHORS   Liu,N., Luo,J., Kuang,D., Xu,S., Duan,Y., Xia,Y., Wei,Z., Xie,X.,
            Yin,B., Chen,F., Luo,S., Liu,H., Wang,J., Jiang,K., Gong,F.,
            Tang,Z.H., Cheng,X., Li,H., Li,Z., Laurence,A., Wang,G. and
            Yang,X.P.
  TITLE     Lactate inhibits ATP6V0d2 expression in tumor-associated
            macrophages to promote HIF-2alpha-mediated tumor progression
  JOURNAL   J Clin Invest 129 (2), 631-646 (2019)
   PUBMED   30431439
  REMARK    GeneRIF: Lactate inhibits ATP6V0d2 expression in tumor-associated
            macrophages to promote HIF-2alpha-mediated tumor progression.
REFERENCE   5  (bases 1 to 2370)
  AUTHORS   Zhu,X., Zeng,Z., Qiu,D. and Chen,J.
  TITLE     Vgamma9Vdelta2 T cells inhibit immature dendritic cell
            transdifferentiation into osteoclasts through downregulation of
            RANK, c-Fos and ATP6V0D2
  JOURNAL   Int J Mol Med 42 (4), 2071-2079 (2018)
   PUBMED   30066839
  REMARK    GeneRIF: gammadelta T cells suppressed iDCs osteoclastogenesis by
            downregulation of the RANK/cFos/ATP6V0D2 signaling pathway.
REFERENCE   6  (bases 1 to 2370)
  AUTHORS   Smith,A.N., Lovering,R.C., Futai,M., Takeda,J., Brown,D. and
            Karet,F.E.
  TITLE     Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit
            genes
  JOURNAL   Mol Cell 12 (4), 801-803 (2003)
   PUBMED   14580332
REFERENCE   7  (bases 1 to 2370)
  AUTHORS   Kawasaki-Nishi,S., Nishi,T. and Forgac,M.
  TITLE     Proton translocation driven by ATP hydrolysis in V-ATPases
  JOURNAL   FEBS Lett 545 (1), 76-85 (2003)
   PUBMED   12788495
  REMARK    Review article
REFERENCE   8  (bases 1 to 2370)
  AUTHORS   Smith,A.N., Borthwick,K.J. and Karet,F.E.
  TITLE     Molecular cloning and characterization of novel tissue-specific
            isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and
            their evaluation in autosomal recessive distal renal tubular
            acidosis
  JOURNAL   Gene 297 (1-2), 169-177 (2002)
   PUBMED   12384298
REFERENCE   9  (bases 1 to 2370)
  AUTHORS   Nishi,T. and Forgac,M.
  TITLE     The vacuolar (H+)-ATPases--nature's most versatile proton pumps
  JOURNAL   Nat Rev Mol Cell Biol 3 (2), 94-103 (2002)
   PUBMED   11836511
  REMARK    Review article
REFERENCE   10 (bases 1 to 2370)
  AUTHORS   Dautry-Varsat,A.
  TITLE     Receptor-mediated endocytosis: the intracellular journey of
            transferrin and its receptor
  JOURNAL   Biochimie 68 (3), 375-381 (1986)
   PUBMED   2874839
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096027.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096027.1, BC065207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285393.4/ ENSP00000285393.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2370              AK096027.1         1-2370
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..2370
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /note="ATPase H+ transporting V0 subunit d2"
                     /db_xref="GeneID:245972"
                     /db_xref="HGNC:HGNC:18266"
                     /db_xref="MIM:618072"
     exon            1..199
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1122
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal 38kDa, V0
                     subunit d2; V-ATPase subunit d 2; vacuolar proton pump
                     subunit d 2"
                     /codon_start=1
                     /product="V-type proton ATPase subunit d 2"
                     /protein_id="NP_689778.1"
                     /db_xref="CCDS:CCDS6241.1"
                     /db_xref="GeneID:245972"
                     /db_xref="HGNC:HGNC:18266"
                     /db_xref="MIM:618072"
                     /translation="MLEGAELYFNVDHGYLEGLVRGCKASLLTQQDYINLVQCETLED
                     LKIHLQTTDYGNFLANHTNPLTVSKIDTEMRKRLCGEFEYFRNHSLEPLSTFLTYMTC
                     SYMIDNVILLMNGALQKKSVKEILGKCHPLGRFTEMEAVNIAETPSDLFNAILIETPL
                     APFFQDCMSENALDELNIELLRNKLYKSYLEAFYKFCKNHGDVTAEVMCPILEFEADR
                     RAFIITLNSFGTELSKEDRETLYPTFGKLYPEGLRLLAQAEDFDQMKNVADHYGVYKP
                     LFEAVGGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYVKLKEQEIRNIVWIAEC
                     ISQRHRTKINSYIPIL"
     exon            200..371
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /inference="alignment:Splign:2.1.0"
     exon            372..550
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /inference="alignment:Splign:2.1.0"
     exon            551..630
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /inference="alignment:Splign:2.1.0"
     exon            631..708
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /inference="alignment:Splign:2.1.0"
     exon            709..885
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /inference="alignment:Splign:2.1.0"
     exon            886..960
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /inference="alignment:Splign:2.1.0"
     exon            961..2370
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /note="hexamer: AATAAA"
     polyA_site      2370
                     /gene="ATP6V0D2"
                     /gene_synonym="ATP6D2; VMA6"
                     /note="major polyA site"
ORIGIN      
        1 gcaaatcttc aggggccgtc caggactaca gagctgtttc accctacctt ggcttcaatc
       61 tcttccccca tgctcgaagg tgcggagctg tacttcaacg tggaccatgg ctacctggag
      121 ggcctggttc gaggatgcaa ggccagcctc ctgacccagc aagactatat caacctggtc
      181 cagtgtgaga ccctagaaga cctgaaaatt catctccaga ctactgatta tggtaacttt
      241 ttggctaatc acacaaatcc tcttactgtt tccaaaattg acactgagat gaggaaaaga
      301 ctatgtggag aatttgagta tttccggaat cattccctgg agcccctcag cacatttctc
      361 acctatatga cgtgcagtta tatgatagac aatgtgattc tgctgatgaa tggtgcattg
      421 cagaaaaaat ctgtgaaaga aattctgggg aagtgccacc ccttgggccg tttcacagaa
      481 atggaagctg tcaacattgc agagacacct tcagatctct ttaatgccat tctgatcgaa
      541 acgccattag ctccattctt ccaagactgc atgtctgaaa atgctctaga tgaactgaat
      601 attgaattgc tacgcaataa actatacaag tcttaccttg aggcattcta taaattctgt
      661 aagaatcatg gtgatgtcac agcagaagtt atgtgtccca ttcttgagtt tgaggccgac
      721 agacgtgctt ttatcatcac tcttaactcc tttggcactg aattgagcaa agaagaccga
      781 gagaccctct atccaacctt cggcaaactc tatcctgagg ggttgcggct gttggctcaa
      841 gcagaagact ttgaccagat gaagaacgta gcggatcatt acggagtata caaaccttta
      901 tttgaagctg taggtggcag tgggggaaag acattggagg acgtgtttta cgagcgtgag
      961 gtacaaatga atgtgctggc attcaacaga cagttccact acggtgtgtt ttatgcatat
     1021 gtaaagctga aggaacagga aattagaaat attgtgtgga tagcagaatg tatttcacag
     1081 aggcatcgaa ctaaaatcaa cagttacatt ccaattttat aacccaagta aggttctcaa
     1141 atgtagaaaa ttataaatgt taaaaggaag ttattgaaga aaataaaaga aattatgtta
     1201 tattatctag actacacaaa agtaagccac actatatctt catgagttgc aaatccatgg
     1261 aaacacagta aaccagccct gaaacaaagc atttccttgt tttcagtggt attagatctt
     1321 gtttccacat gtctgtctca ttcttcactg ggccttacag gttagtttta attaactcta
     1381 tggtattttt cttattcttg tttgatcatg ttaaaaattg gacctaataa aagtatttta
     1441 ttcttgcttt tccatgcttc tctacaggtc caaatactga atgtctcctt tactttttct
     1501 cttttaaatt tttttctaga cagggtctca ctctgtcacc taggctacag tgcagtggtg
     1561 tgatcacagc tcactgcagc ctcgacttcc caggctcaag tgatcctccc agctctcagc
     1621 ctccaaagta gctggcacta caagtgtaca cccccacaca aggctaagtt ttgtattttt
     1681 tgtagagaca gggtttcaac atattatcca ggctggtgtc gaattcctgg gctccaggga
     1741 tccacagtcc cccttggcct cccaaagtgt tgggattaca tgcatgagcc actgtgctgg
     1801 gcttcattta cattttaact gtctgttcct tgcctagatt cacagaaatc caaagctgta
     1861 tgtagtcaac atggttcaca agtgttggaa aatgtgtttt ttgttttgtt ttgttttgtt
     1921 tcgttttgtt ttgagacaga gtttccctct gtcgcccagg ctagagtgca atggcgtgat
     1981 ctcggctcac tgcaacctcc acctcccaga ttcaagcaac tctctgcctc agcctcccga
     2041 gtagctggga ttacaagcac ccaccactac actcagctaa ttttttgtat ttttagtaga
     2101 gccggggttt caccatcttg gccaggctga tcttgaactc ctgagctcat gatccacccg
     2161 cctcagcctc ccaaagtgct gggattacag gccccttgtt cagccactgc acctggcccc
     2221 ttattttgtt tttgttttct aatatacttt gatgtaatca gcttgagaaa gcaacacaat
     2281 ttcaaatcct atcttctaga tgcaagcagt gttaaatttg ttaataaatt tgcttttcac
     2341 acctttcttt aaataaaagg tatatctctc
//
