LOCUS       NM_004691               1636 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ATPase H+ transporting V0 subunit d1 (ATP6V0D1), mRNA.
ACCESSION   NM_004691
VERSION     NM_004691.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1636)
  AUTHORS   Chen,F., Zhu,S., Kang,R., Tang,D. and Liu,J.
  TITLE     ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal
            pH homeostasis
  JOURNAL   Cell Rep 42 (1), 111911 (2023)
   PUBMED   36640329
  REMARK    GeneRIF: ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated
            lysosomal pH homeostasis.
REFERENCE   2  (bases 1 to 1636)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1636)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1636)
  AUTHORS   Jung,Y.S., Jun,S., Kim,M.J., Lee,S.H., Suh,H.N., Lien,E.M.,
            Jung,H.Y., Lee,S., Zhang,J., Yang,J.I., Ji,H., Wu,J.Y., Wang,W.,
            Miller,R.K., Chen,J., McCrea,P.D., Kopetz,S. and Park,J.I.
  TITLE     TMEM9 promotes intestinal tumorigenesis through
            vacuolar-ATPase-activated Wnt/beta-catenin signalling
  JOURNAL   Nat Cell Biol 20 (12), 1421-1433 (2018)
   PUBMED   30374053
REFERENCE   5  (bases 1 to 1636)
  AUTHORS   Hashimoto,Y., Shirane,M. and Nakayama,K.I.
  TITLE     TMEM55B contributes to lysosomal homeostasis and amino acid-induced
            mTORC1 activation
  JOURNAL   Genes Cells 23 (6), 418-434 (2018)
   PUBMED   29644770
REFERENCE   6  (bases 1 to 1636)
  AUTHORS   Finbow,M.E. and Harrison,M.A.
  TITLE     The vacuolar H+-ATPase: a universal proton pump of eukaryotes
  JOURNAL   Biochem J 324 (Pt 3) (Pt 3), 697-712 (1997)
   PUBMED   9210392
  REMARK    Review article
REFERENCE   7  (bases 1 to 1636)
  AUTHORS   Stevens,T.H. and Forgac,M.
  TITLE     Structure, function and regulation of the vacuolar (H+)-ATPase
  JOURNAL   Annu Rev Cell Dev Biol 13, 779-808 (1997)
   PUBMED   9442887
  REMARK    Review article
REFERENCE   8  (bases 1 to 1636)
  AUTHORS   van Hille,B., Vanek,M., Richener,H., Green,J.R. and Bilbe,G.
  TITLE     Cloning and tissue distribution of subunits C, D, and E of the
            human vacuolar H(+)-ATPase
  JOURNAL   Biochem Biophys Res Commun 197 (1), 15-21 (1993)
   PUBMED   8250920
REFERENCE   9  (bases 1 to 1636)
  AUTHORS   Wang,S.Y., Moriyama,Y., Mandel,M., Hulmes,J.D., Pan,Y.C., Danho,W.,
            Nelson,H. and Nelson,N.
  TITLE     Cloning of cDNA encoding a 32-kDa protein. An accessory polypeptide
            of the H+-ATPase from chromaffin granules
  JOURNAL   J Biol Chem 263 (33), 17638-17642 (1988)
   PUBMED   2903164
REFERENCE   10 (bases 1 to 1636)
  AUTHORS   Dautry-Varsat,A.
  TITLE     Receptor-mediated endocytosis: the intracellular journey of
            transferrin and its receptor
  JOURNAL   Biochimie 68 (3), 375-381 (1986)
   PUBMED   2874839
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008861.2 and BM677562.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004691.4.
            
            Summary: This gene encodes a component of vacuolar ATPase
            (V-ATPase), a multisubunit enzyme that mediates acidification of
            eukaryotic intracellular organelles. V-ATPase dependent organelle
            acidification is necessary for such intracellular processes as
            protein sorting, zymogen activation, receptor-mediated endocytosis,
            and synaptic vesicle proton gradient generation. V-ATPase is
            composed of a cytosolic V1 domain and a transmembrane V0 domain.
            The V1 domain consists of three A and three B subunits, two G
            subunits plus the C, D, E, F, and H subunits. The V1 domain
            contains the ATP catalytic site. The V0 domain consists of five
            different subunits: a, c, c', c'', and d. Additional isoforms of
            many of the V1 and V0 subunit proteins are encoded by multiple
            genes or alternatively spliced transcript variants. This encoded
            protein is known as the D subunit and is found ubiquitously.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.175846.1,
                                           SRR3476690.332825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290949.8/ ENSP00000290949.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1633              BC008861.2         8-1640
            1634-1636           BM677562.1         24-26               c
FEATURES             Location/Qualifiers
     source          1..1636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1636
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /note="ATPase H+ transporting V0 subunit d1"
                     /db_xref="GeneID:9114"
                     /db_xref="HGNC:HGNC:13724"
                     /db_xref="MIM:607028"
     exon            1..201
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1127
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal (vacuolar proton
                     pump), member D; V-ATPase AC39 subunit; H(+)-transporting
                     two-sector ATPase, subunit D; V-ATPase, subunit D;
                     V-ATPase 40 KDa accessory protein; ATPase, H+
                     transporting, lysosomal 38kDa, V0 subunit d1; V-ATPase
                     subunit d 1; 32 kDa accessory protein; vacuolar proton
                     pump subunit d 1"
                     /codon_start=1
                     /product="V-type proton ATPase subunit d 1"
                     /protein_id="NP_004682.2"
                     /db_xref="CCDS:CCDS10838.1"
                     /db_xref="GeneID:9114"
                     /db_xref="HGNC:HGNC:13724"
                     /db_xref="MIM:607028"
                     /translation="MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLED
                     LKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITY
                     SYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPL
                     AAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADR
                     RAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKL
                     LFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAE
                     CIAQRHRAKIDNYIPIF"
     exon            202..373
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /inference="alignment:Splign:2.1.0"
     exon            374..552
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /inference="alignment:Splign:2.1.0"
     exon            553..632
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /inference="alignment:Splign:2.1.0"
     exon            633..710
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /inference="alignment:Splign:2.1.0"
     exon            711..887
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /inference="alignment:Splign:2.1.0"
     exon            888..965
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1636
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /note="hexamer: AATAAA"
     polyA_site      1636
                     /gene="ATP6V0D1"
                     /gene_synonym="ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD"
                     /note="major polyA site"
ORIGIN      
        1 agctgacctg gggagtcgcg attcgtgccg gccggtcctg gttctccggt cccgccgctc
       61 ccgcagcagc catgtcgttc ttcccggagc tttactttaa cgtggacaat ggctacttgg
      121 agggactggt gcgcggcctg aaggccgggg tgctcagcca ggccgactac ctcaacctgg
      181 tgcagtgcga gacgctagag gacttgaaac tgcatctgca gagcactgat tatggtaact
      241 tcctggccaa cgaggcatca cctctgacgg tgtcagtcat cgatgaccgg ctcaaggaga
      301 agatggtggt ggagttccgc cacatgagga accatgccta tgagccactc gccagcttcc
      361 tagacttcat tacttacagt tacatgatcg acaacgtgat cctgctcatc acaggcacgc
      421 tgcaccagcg ctccatcgct gagctcgtgc ccaagtgcca cccactaggc agcttcgagc
      481 agatggaggc cgtgaacatt gctcagacac ctgctgagct ctacaatgcc attctggtgg
      541 acacgcctct tgcggctttt ttccaggact gcatttcaga gcaggacctt gacgagatga
      601 acatcgagat catccgcaac accctctaca aggcctacct ggagtccttc tacaagttct
      661 gcaccctact gggcgggact acggctgatg ccatgtgccc catcctggag tttgaagcag
      721 accgccgcgc cttcatcatc accatcaatt ctttcggcac agagctgtcc aaagaggacc
      781 gtgccaagct ctttccacac tgtgggcggc tctaccctga gggcctggcg cagctggctc
      841 gggctgacga ctatgaacag gtcaagaacg tggccgatta ctacccggag tacaagctgc
      901 tcttcgaggg tgcaggtagc aaccctggag acaagacgct ggaggaccga ttctttgagc
      961 acgaggtaaa gctgaacaag ttggccttcc tgaaccagtt ccactttggt gtcttctatg
     1021 ccttcgtgaa gctcaaggag caggagtgtc gcaacatcgt gtggatcgct gaatgtatcg
     1081 cccagcgcca ccgcgccaaa atcgacaact acatccctat cttctagcgt cctggcccaa
     1141 ggctctcaat tgcactcttt gtgtgtgtgt gtgtgtgtgt gcgcgtgtgt gtgcgtgtgt
     1201 gtgtatgtgg tctgtgacaa gcctgtggct cacctgcctg tccggggtgt agtacgctgt
     1261 cctagcggct gcccagttct cctgaccctc ttagagactg ttcttaggcc tgaaaagggg
     1321 ctgggcaccc ccccccacca aggatggacg aagaccccct ccagagcaag gaggccccct
     1381 cagccctgtg gttacagccg ctgatgtatc taagaagcat gtcactttca tgttcctccc
     1441 taactccctg acctgagaac cctggggcct gggggcagtt tgagcctcct ctcccttctg
     1501 tgggtcgctc ccagagccat ggcccatggg aaggacagag tgtgtgtgtc cttggggcct
     1561 ggggggatgt tgctcctcag ctccctccct cagccctgcc cctctgagac aataaaactg
     1621 ccctctctaa ggccaa
//
