LOCUS       NM_001688               2628 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ATP synthase peripheral stalk-membrane subunit b
            (ATP5PB), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001688
VERSION     NM_001688.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2628)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2628)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2628)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2628)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 2628)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2628)
  AUTHORS   Elston,T., Wang,H. and Oster,G.
  TITLE     Energy transduction in ATP synthase
  JOURNAL   Nature 391 (6666), 510-513 (1998)
   PUBMED   9461222
REFERENCE   7  (bases 1 to 2628)
  AUTHORS   Houstek,J., Andersson,U., Tvrdik,P., Nedergaard,J. and Cannon,B.
  TITLE     The expression of subunit c correlates with and thus may limit the
            biosynthesis of the mitochondrial F0F1-ATPase in brown adipose
            tissue
  JOURNAL   J Biol Chem 270 (13), 7689-7694 (1995)
   PUBMED   7706317
REFERENCE   8  (bases 1 to 2628)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   9  (bases 1 to 2628)
  AUTHORS   Higuti,T., Tsurumi,C., Osaka,F., Kawamura,Y., Tsujita,H.,
            Yoshihara,Y., Tani,I., Tanaka,K. and Ichihara,A.
  TITLE     Molecular cloning of cDNA for the import precursor of human subunit
            B of H(+)-ATP synthase in mitochondria
  JOURNAL   Biochem Biophys Res Commun 178 (3), 1014-1020 (1991)
   PUBMED   1831354
REFERENCE   10 (bases 1 to 2628)
  AUTHORS   Boyer,P.D., Cross,R.L. and Momsen,W.
  TITLE     A new concept for energy coupling in oxidative phosphorylation
            based on a molecular explanation of the oxygen exchange reactions
  JOURNAL   Proc Natl Acad Sci U S A 70 (10), 2837-2839 (1973)
   PUBMED   4517936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF237506.1, AL390195.10,
            AW778751.1 and AI754631.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001688.4.
            
            Summary: This gene encodes a subunit of mitochondrial ATP synthase.
            Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an
            electrochemical gradient of protons across the inner membrane
            during oxidative phosphorylation. ATP synthase is composed of two
            linked multi-subunit complexes: the soluble catalytic core, F1, and
            the membrane-spanning component, Fo, comprising the proton channel.
            The catalytic portion of mitochondrial ATP synthase consists of 5
            different subunits (alpha, beta, gamma, delta, and epsilon)
            assembled with a stoichiometry of 3 alpha, 3 beta, and a single
            representative of the other 3. The proton channel seems to have
            nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes
            the b subunit of the proton channel. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291077.1, SRR14038191.3597740.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000369722.8/
                                                  ENSP00000358737.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BF237506.1         460-489
            31-118              AL390195.10        48536-48623
            119-155             AL390195.10        48879-48915
            156-301             AL390195.10        53253-53398
            302-465             AL390195.10        55128-55291
            466-591             AL390195.10        55672-55797
            592-771             AL390195.10        58499-58678
            772-1250            AL390195.10        59959-60437
            1251-1758           AW778751.1         1-508               c
            1759-1773           AI754631.1         2-16                c
            1774-2628           AL390195.10        60961-61815
FEATURES             Location/Qualifiers
     source          1..2628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..2628
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /note="ATP synthase peripheral stalk-membrane subunit b"
                     /db_xref="GeneID:515"
                     /db_xref="HGNC:HGNC:840"
                     /db_xref="MIM:603270"
     exon            1..118
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..849
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /note="ATP synthase, H+ transporting, mitochondrial F0
                     complex, subunit B1; ATP synthase, H+ transporting,
                     mitochondrial F0 complex, subunit b; ATP synthase B chain,
                     mitochondrial; H+-ATP synthase subunit b; ATP synthase
                     F(0) complex subunit B1, mitochondrial; ATP synthase
                     subunit b, mitochondrial; cell proliferation-inducing
                     protein 47; ATP synthase, H+ transporting, mitochondrial
                     Fo complex subunit B1; ATPase subunit b; ATP synthase
                     proton-transporting mitochondrial F(0) complex subunit B1"
                     /codon_start=1
                     /product="ATP synthase F(0) complex subunit B1,
                     mitochondrial precursor"
                     /protein_id="NP_001679.2"
                     /db_xref="CCDS:CCDS836.1"
                     /db_xref="GeneID:515"
                     /db_xref="HGNC:HGNC:840"
                     /db_xref="MIM:603270"
                     /translation="MLSRVVLSAAATAAPSLKNAAFLGPGVLQATRTFHTGQPHLVPV
                     PPLPEYGGKVRYGLIPEEFFQFLYPKTGVTGPYVLGTGLILYALSKEIYVISAETFTA
                     LSVLGVMVYGIKKYGPFVADFADKLNEQKLAQLEEAKQASIQHIQNAIDTEKSQQALV
                     QKRHYLFDVQRNNIAMALEVTYRERLYRVYKEVKNRLDYHISVQNMMRRKEQEHMINW
                     VEKHVVQSISTQQEKETIAKCIADLKLLAKKAQAQPVM"
     exon            119..155
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /inference="alignment:Splign:2.1.0"
     exon            156..301
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /inference="alignment:Splign:2.1.0"
     exon            302..465
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /inference="alignment:Splign:2.1.0"
     exon            466..591
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /inference="alignment:Splign:2.1.0"
     exon            592..771
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /inference="alignment:Splign:2.1.0"
     exon            772..2628
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1163..1168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /note="hexamer: AATAAA"
     polyA_site      1185
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /note="major polyA site"
     regulatory      1245..1250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /note="hexamer: ATTAAA"
     polyA_site      1266
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /note="hexamer: ACTAAA"
     polyA_site      1377
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
     polyA_site      2444
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
     regulatory      2610..2615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
                     /note="hexamer: AACAAA"
     polyA_site      2628
                     /gene="ATP5PB"
                     /gene_synonym="ATP5F1; PIG47"
ORIGIN      
        1 catcttggtc ctgccctgac agattctcct atcggggtca cagggacgct aagattgcta
       61 cctggacttt cgttgaccat gctgtcccgg gtggtacttt ccgccgccgc cacagcggcc
      121 ccctctctga agaatgcagc cttcctaggt ccaggggtat tgcaggcaac aaggaccttt
      181 catacagggc agccacacct tgtccctgta ccacctcttc ctgaatacgg aggaaaagtt
      241 cgttatggac tgatccctga ggaattcttc cagtttcttt atcctaaaac tggtgtaaca
      301 ggaccctatg tactcggaac tgggcttatc ttgtacgctt tatccaaaga aatatatgtg
      361 attagcgcag agaccttcac tgccctatca gtactaggtg taatggtcta tggaattaaa
      421 aaatatggtc cctttgttgc agactttgct gataaactca atgagcaaaa acttgcccaa
      481 ctagaagagg cgaagcaggc ttccatccaa cacatccaga atgcaattga tacggagaag
      541 tcacaacagg cactggttca gaagcgccat tacctttttg atgtgcaaag gaataacatt
      601 gctatggctt tggaagttac ttaccgggaa cgactgtata gagtatataa ggaagtaaag
      661 aatcgcctgg actatcatat atctgtgcag aacatgatgc gtcgaaagga acaagaacac
      721 atgataaatt gggtggagaa gcacgtggtg caaagcatct ccacacagca ggaaaaggag
      781 acaattgcca agtgcattgc ggacctaaag ctgctggcaa agaaggctca agcacagcca
      841 gttatgtaaa tgtatctatc ccaattgaga cagctagaaa cagttgactg actaaatgga
      901 aactagtcta tttgacaaag tctttctgtg ttggtgtcta ctgaagttat agtttaccct
      961 tcctaaaaat gaaaagtttg tttcatatag tgagagaacg aaatctctat cggccagtca
     1021 gatgtttctc atccttcttg ctctgccttt gagttgttcc gtgatcactt ctgaataagc
     1081 agtttgcctt tataaaaact tgctgcctga ctaaagatta acaggttata gtttaaattt
     1141 gtaattaatt ctaccatctt gcaataaagt gacaattgaa tgaaacaggg tttttcaagt
     1201 tgtataattc tctgaaatac tcagcttttg tcatatgggt aaaaattaaa gatgtcattg
     1261 aactactgtc ttgtttatga gaccattcag tggtgaactg tttctggctg ataggttatg
     1321 agatatgtaa agctttctag tactcttaaa ataactaaat ggagtattat atatcaattc
     1381 atatcattga ctttattatt ttagtagtat gcctatagaa aatattatgg actcagagtg
     1441 tcataaaatc actcttaaga atccatgcag caggccaggc acagtggctc acacctgtaa
     1501 tgcctgcact ttggaaggcc gagacaggcg gatcacttga ggtcaggagt ttgaaaccag
     1561 ccaggccaac acagtgaaac cctgtctcta ctaaaaatac aaaaggttag ccgggcatgg
     1621 tggcaggcgc ctgtaatccc agctactcag gaggctgagg caggagaatt gcttgaacgc
     1681 aggaggcaaa ggttgcagtg agctgagatc acgccactgc actccagcct gggcaacaga
     1741 cctcgactcc atctagaaaa aaaaaaaaaa aaatccagca gacacctatc aggaacatag
     1801 aaaataacaa gtgttggcaa ggaagtggag aagttggaac acttgtgcac tgttcgtaga
     1861 aatatgaaat ggtacagcca ttatggaaaa gtgtggtgat tcctcataaa attaaaatgg
     1921 aaataccatg atccagcaat cccagtcgac atatatactc aaaaaaatta aaagcagggt
     1981 cttgaagaga tacttgtgtt ccatggtgat agcagccatt gttcacaata gctaaaacat
     2041 agaagcagcc caatcggcca tcagtagatg aatggataag caaaatgtag tatatccatg
     2101 caatggaata ttattccact tcaaggaaga aaattctgac actggctaca gcatgaatga
     2161 accttgagga cgttatgcag ttttacagga tgagttatgg agctggatag tggtgatggt
     2221 ggcacattaa ggatgtattt aatactgttc ttaaatggta cacttaaaaa tggtaaattt
     2281 tatgtgtatt ttacaatctt tttttaaatt gaagaaaaat cctgtagata aattagaaaa
     2341 ttcttccctt cataggttta tctgcatttg attctcccat acttgtacaa ggatttattt
     2401 gtattcaaat ggacaaatta cgcaatagga aatatttgaa aatatttatc atgggtaatt
     2461 gctattttca ttgacttcct aagattttat gtaataatca tttgagtcaa tattggtagc
     2521 taatgtacta atctaatatt gaaatcagat tgatatcttt gttacttaaa gataatttga
     2581 ttggatcagc agttatttca aattgattaa acaaaaaatt ataaaaca
//
