LOCUS       NM_006476               1121 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ATP synthase membrane subunit g (ATP5MG), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_006476
VERSION     NM_006476.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1121)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1121)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1121)
  AUTHORS   Zhdanov,A.V., Andreev,D.E., Baranov,P.V. and Papkovsky,D.B.
  TITLE     Low energy costs of F1Fo ATP synthase reversal in colon carcinoma
            cells deficient in mitochondrial complex IV
  JOURNAL   Free Radic Biol Med 106, 184-195 (2017)
   PUBMED   28189850
  REMARK    GeneRIF: this study demonstrates that F1Fo ATP synthase can support
            general mitochondrial and cellular functions, working in extremely
            efficient 'energy saving' reverse mode and flexibly recruiting free
            radical detoxication and ATP producing / transporting pathways.
REFERENCE   4  (bases 1 to 1121)
  AUTHORS   Dahiya,N., Sarachana,T., Kulkarni,S., Wood,W.H. III, Zhang,Y.,
            Becker,K.G., Wang,B.D. and Atreya,C.D.
  TITLE     miR-570 interacts with mitochondrial ATPase subunit g (ATP5L)
            encoding mRNA in stored platelets
  JOURNAL   Platelets 28 (1), 74-81 (2017)
   PUBMED   27561077
  REMARK    GeneRIF: Overexpression of miR-570-3p in platelets resulted in
            reduced levels of ATP5L mRNA and concomitant ATP loss.
REFERENCE   5  (bases 1 to 1121)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   6  (bases 1 to 1121)
  AUTHORS   Aggeler,R., Coons,J., Taylor,S.W., Ghosh,S.S., Garcia,J.J.,
            Capaldi,R.A. and Marusich,M.F.
  TITLE     A functionally active human F1F0 ATPase can be purified by
            immunocapture from heart tissue and fibroblast cell lines. Subunit
            structure and activity studies
  JOURNAL   J Biol Chem 277 (37), 33906-33912 (2002)
   PUBMED   12110673
REFERENCE   7  (bases 1 to 1121)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   8  (bases 1 to 1121)
  AUTHORS   Wang,H. and Oster,G.
  TITLE     Energy transduction in the F1 motor of ATP synthase
  JOURNAL   Nature 396 (6708), 279-282 (1998)
   PUBMED   9834036
REFERENCE   9  (bases 1 to 1121)
  AUTHORS   Elston,T., Wang,H. and Oster,G.
  TITLE     Energy transduction in ATP synthase
  JOURNAL   Nature 391 (6666), 510-513 (1998)
   PUBMED   9461222
REFERENCE   10 (bases 1 to 1121)
  AUTHORS   Boyer,P.D., Cross,R.L. and Momsen,W.
  TITLE     A new concept for energy coupling in oxidative phosphorylation
            based on a molecular explanation of the oxygen exchange reactions
  JOURNAL   Proc Natl Acad Sci U S A 70 (10), 2837-2839 (1973)
   PUBMED   4517936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA258888.1, BC070165.1 and
            AI337729.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006476.4.
            
            Summary: Mitochondrial ATP synthase catalyzes ATP synthesis,
            utilizing an electrochemical gradient of protons across the inner
            membrane during oxidative phosphorylation. It is composed of two
            linked multi-subunit complexes: the soluble catalytic core, F1, and
            the membrane-spanning component, Fo, which comprises the proton
            channel. The F1 complex consists of 5 different subunits (alpha,
            beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3
            beta, and a single representative of the other 3. The Fo seems to
            have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene
            encodes the g subunit of the Fo complex. Alternative splicing
            results in multiple transcript variants.[provided by RefSeq, Jun
            2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and is protein coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.136332.1,
                                           SRR5189655.120912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000300688.8/
                                                  ENSP00000300688.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AA258888.1         218-243
            27-1119             BC070165.1         1-1093
            1120-1121           AI337729.1         6-7                 c
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..1121
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
                     /note="ATP synthase membrane subunit g"
                     /db_xref="GeneID:10632"
                     /db_xref="HGNC:HGNC:14247"
                     /db_xref="MIM:617473"
     exon            1..112
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..372
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
                     /EC_number="3.6.1.14"
                     /note="ATP synthase, H+ transporting, mitochondrial F0
                     complex, subunit G; ATP synthase, H+ transporting,
                     mitochondrial F1F0, subunit g; ATP synthase g chain,
                     mitochondrial; ATPase subunit G; F1F0-type ATP synthase
                     subunit g; F1Fo-ATP synthase complex Fo membrane domain g
                     subunit; ATP synthase, H+ transporting, mitochondrial Fo
                     complex subunit G"
                     /codon_start=1
                     /product="ATP synthase subunit g, mitochondrial"
                     /protein_id="NP_006467.4"
                     /db_xref="CCDS:CCDS8397.1"
                     /db_xref="GeneID:10632"
                     /db_xref="HGNC:HGNC:14247"
                     /db_xref="MIM:617473"
                     /translation="MAQFVRNLVEKTPALVNAAVTYSKPRLATFWYYAKVELVPPTPA
                     EIPRAIQSLKKIVNSAQTGSFKQLTVKEAVLNGLVATEVLMWFYVGEIIGKRGIIGYD
                     V"
     exon            113..273
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
                     /inference="alignment:Splign:2.1.0"
     exon            274..1121
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      457..462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
                     /note="hexamer: AATAAG"
     polyA_site      473
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
                     /note="major polyA site"
     regulatory      1100..1105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="ATP5MG"
                     /gene_synonym="ATP5JG; ATP5L"
ORIGIN      
        1 ccttccggcg ggtgacattc agccggcggt tcggggcgac ggactctcca ttccagaacc
       61 atggcccaat ttgtccgtaa ccttgtggag aagaccccgg cgctggtgaa cgctgctgtg
      121 acttactcga agcctcgatt ggccacattt tggtactacg ccaaggttga gctggttcct
      181 cccacccctg ctgagatccc tagagctatt cagagcctga aaaaaatagt caatagtgct
      241 cagactggta gcttcaaaca gctcacagtt aaggaagctg tgctgaatgg tttggtggcc
      301 actgaggtgt tgatgtggtt ttatgtcgga gagattatag gcaagcgggg catcattggc
      361 tatgatgttt gaagaccaat ctttaacatc tgattatatt tgatttatta tttgagtgtt
      421 gttggaccat gtgtgatcag actgctatct gaataaaata agatttgtca aaactcagtg
      481 ttttctccat cagatactcc atgaaaggtc acaatttctc ttgatattaa gctgggttgt
      541 ctttaaacaa ccctaaatac acgtctgttt agcccgcaat tggaaaggat atatgtggca
      601 atattaacct ggtacatgaa tatatgggga taacatttta atttgaaggt ttggaatata
      661 tatatttaag ctttatttcc agaacagtga gggttaggtc ttgggaaaac tataacttgc
      721 caaagtagaa gaaatagtag taccatatgc caaagtgata gagatgaatc atgtcagtag
      781 ttagaataac atttcaactg ttttctttgc taaaatcaca gaaagaccct attgacaaca
      841 tctatgtctg taaaaatgtt agagtacttg tcatcttgaa tatagcctcc ccaagagaga
      901 acagggtggt attctaagta tgtttctttg taacatcttt agcagtagga cagagccata
      961 catgtgaaat ctgattttta tgtgtgttat tcgtttgtct ggttttacta cctttgcaaa
     1021 aacaaaatac cccaaagata tttaaacaag gttataattt agcatcttcc ctggatctaa
     1081 atagtatatt atatcctgaa ataaatgaaa tgattgctat a
//
