LOCUS       NM_007100                303 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ATP synthase membrane subunit e (ATP5ME), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_007100 XM_943307
VERSION     NM_007100.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 303)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 303)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 303)
  AUTHORS   Fujikawa,M., Sugawara,K., Tanabe,T. and Yoshida,M.
  TITLE     Assembly of human mitochondrial ATP synthase through two separate
            intermediates, F1-c-ring and b-e-g complex
  JOURNAL   FEBS Lett 589 (19 Pt B), 2707-2712 (2015)
   PUBMED   26297831
REFERENCE   4  (bases 1 to 303)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 303)
  AUTHORS   Hase,Y., Tatsuno,M., Nishi,T., Kataoka,K., Kabe,Y., Yamaguchi,Y.,
            Ozawa,N., Natori,M., Handa,H. and Watanabe,H.
  TITLE     Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial
            function in sperm
  JOURNAL   Biochem Biophys Res Commun 366 (1), 66-72 (2008)
   PUBMED   18060860
  REMARK    GeneRIF: The inhibitory activity against mitochondria and
            F(1)F(0)-ATP synthase is not limited to atrazine but is likely to
            be applicable to other triazine-based compounds.
REFERENCE   6  (bases 1 to 303)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Bouffard,G.G. and Miller,J.L.
  TITLE     Gene expression in proliferating human erythroid cells
  JOURNAL   Genomics 59 (2), 168-177 (1999)
   PUBMED   10409428
REFERENCE   7  (bases 1 to 303)
  AUTHORS   Wang,H. and Oster,G.
  TITLE     Energy transduction in the F1 motor of ATP synthase
  JOURNAL   Nature 396 (6708), 279-282 (1998)
   PUBMED   9834036
REFERENCE   8  (bases 1 to 303)
  AUTHORS   Elston,T., Wang,H. and Oster,G.
  TITLE     Energy transduction in ATP synthase
  JOURNAL   Nature 391 (6666), 510-513 (1998)
   PUBMED   9461222
REFERENCE   9  (bases 1 to 303)
  AUTHORS   Swartz,D.A., Park,E.I., Visek,W.J. and Kaput,J.
  TITLE     The e subunit gene of murine F1F0-ATP synthase. Genomic sequence,
            chromosomal mapping, and diet regulation
  JOURNAL   J Biol Chem 271 (34), 20942-20948 (1996)
   PUBMED   8702853
REFERENCE   10 (bases 1 to 303)
  AUTHORS   Boyer,P.D., Cross,R.L. and Momsen,W.
  TITLE     A new concept for energy coupling in oxidative phosphorylation
            based on a molecular explanation of the oxygen exchange reactions
  JOURNAL   Proc Natl Acad Sci U S A 70 (10), 2837-2839 (1973)
   PUBMED   4517936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF215596.1, BC003679.1 and
            BG940181.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007100.3.
            
            Summary: Mitochondrial ATP synthase catalyzes ATP synthesis,
            utilizing an electrochemical gradient of protons across the inner
            membrane during oxidative phosphorylation. It is composed of two
            linked multi-subunit complexes: the soluble catalytic core, F1, and
            the membrane-spanning component, Fo, which comprises the proton
            channel. The F1 complex consists of 5 different subunits (alpha,
            beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3
            beta, and a single representative of the other 3. The Fo seems to
            have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene
            encodes the e subunit of the Fo complex. Alternative splicing
            results in multiple transcript variants.[provided by RefSeq, Jun
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM770207.1, BP377717.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000304312.5/
                                                  ENSP00000306003.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BF215596.1         64-65
            3-301               BC003679.1         1-299
            302-303             BG940181.1         292-293
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..303
                     /gene="ATP5ME"
                     /gene_synonym="ATP5I; ATP5K"
                     /note="ATP synthase membrane subunit e"
                     /db_xref="GeneID:521"
                     /db_xref="HGNC:HGNC:846"
                     /db_xref="MIM:601519"
     exon            1..65
                     /gene="ATP5ME"
                     /gene_synonym="ATP5I; ATP5K"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..239
                     /gene="ATP5ME"
                     /gene_synonym="ATP5I; ATP5K"
                     /EC_number="3.6.1.14"
                     /note="ATP synthase, H+ transporting, mitochondrial F0
                     complex, subunit E; ATP synthase e chain, mitochondrial;
                     F1F0-ATP synthase, murine e subunit; ATPase subunit e; ATP
                     synthase, H+ transporting, mitochondrial Fo complex
                     subunit E"
                     /codon_start=1
                     /product="ATP synthase subunit e, mitochondrial"
                     /protein_id="NP_009031.1"
                     /db_xref="CCDS:CCDS3337.1"
                     /db_xref="GeneID:521"
                     /db_xref="HGNC:HGNC:846"
                     /db_xref="MIM:601519"
                     /translation="MVPPVQVSPLIKLGRYSALFLGVAYGATRYNYLKPRAEEERRIA
                     AEEKKKQDELKRIARELAEDDSILK"
     exon            66..120
                     /gene="ATP5ME"
                     /gene_synonym="ATP5I; ATP5K"
                     /inference="alignment:Splign:2.1.0"
     exon            121..219
                     /gene="ATP5ME"
                     /gene_synonym="ATP5I; ATP5K"
                     /inference="alignment:Splign:2.1.0"
     exon            220..303
                     /gene="ATP5ME"
                     /gene_synonym="ATP5I; ATP5K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      278..283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5ME"
                     /gene_synonym="ATP5I; ATP5K"
                     /note="hexamer: AATAAA"
     polyA_site      303
                     /gene="ATP5ME"
                     /gene_synonym="ATP5I; ATP5K"
                     /note="major polyA site"
ORIGIN      
        1 gtgcttccgg tgcggaggtc agggacaaga tggtgccacc ggtgcaggtc tctccgctca
       61 tcaagctcgg ccgctactcc gccctgttcc tcggtgtggc ctacggagcc acgcgctaca
      121 attacctaaa acctcgggca gaagaggaga ggaggatagc agcagaagag aagaagaagc
      181 aggatgaact gaaacggatt gccagagaat tggcagaaga tgacagcata ttaaagtgag
      241 tgaccctgcg acccactctt tggaccagca gcggatgaat aaagcttcct gtgttgtgtg
      301 ata
//
