LOCUS       NM_016311                503 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ATP synthase inhibitory factor subunit 1 (ATP5IF1),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_016311
VERSION     NM_016311.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Carroll,J., Watt,I.N., Wright,C.J., Ding,S., Fearnley,I.M. and
            Walker,J.E.
  TITLE     The inhibitor protein IF1 from mammalian mitochondria inhibits ATP
            hydrolysis but not ATP synthesis by the ATP synthase complex
  JOURNAL   J Biol Chem 300 (3), 105690 (2024)
   PUBMED   38280428
  REMARK    GeneRIF: The inhibitor protein IF1 from mammalian mitochondria
            inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase
            complex.
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Lengele,L., Rolland,Y., Martinez,L.O., Guyonnet,S., Parini,A.,
            Lucas,A., Vellas,B. and Barreto,P.S.
  CONSRTM   MAPT/DSA Group
  TITLE     Longitudinal Associations Between ATPase Inhibitory Factor 1,
            Growth Differentiation Factor-15, and Nutritional Status in Older
            Adults From the MAPT Study
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (1) (2024)
   PUBMED   37804244
  REMARK    GeneRIF: Longitudinal Associations Between ATPase Inhibitory Factor
            1, Growth Differentiation Factor-15, and Nutritional Status in
            Older Adults From the MAPT Study.
REFERENCE   3  (bases 1 to 503)
  AUTHORS   Sgarbi,G., Righetti,R., Del Dotto,V., Grillini,S., Giorgio,V.,
            Baracca,A. and Solaini,G.
  TITLE     The pro-oncogenic protein IF1 does not contribute to the Warburg
            effect and is not regulated by PKA in cancer cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166879 (2024)
   PUBMED   37689158
  REMARK    GeneRIF: The pro-oncogenic protein IF1 does not contribute to the
            Warburg effect and is not regulated by PKA in cancer cells.
REFERENCE   4  (bases 1 to 503)
  AUTHORS   Dominguez-Zorita,S., Romero-Carraminana,I., Santacatterina,F.,
            Esparza-Molto,P.B., Simo,C., Del-Arco,A., Nunez de Arenas,C.,
            Saiz,J., Barbas,C. and Cuezva,J.M.
  TITLE     IF1 ablation prevents ATP synthase oligomerization, enhances
            mitochondrial ATP turnover and promotes an adenosine-mediated
            pro-inflammatory phenotype
  JOURNAL   Cell Death Dis 14 (7), 413 (2023)
   PUBMED   37433784
  REMARK    GeneRIF: IF1 ablation prevents ATP synthase oligomerization,
            enhances mitochondrial ATP turnover and promotes an
            adenosine-mediated pro-inflammatory phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 503)
  AUTHORS   Domin,R., Pytka,M., Nizinski,J., Zolynski,M., Zybek-Kocik,A.,
            Wrotkowska,E., Zielinski,J., Guzik,P. and Ruchala,M.
  TITLE     ATPase Inhibitory Factor 1-A Novel Marker of Cellular Fitness and
            Exercise Capacity?
  JOURNAL   Int J Mol Sci 23 (23), 15303 (2022)
   PUBMED   36499630
  REMARK    GeneRIF: ATPase Inhibitory Factor 1-A Novel Marker of Cellular
            Fitness and Exercise Capacity?
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 503)
  AUTHORS   Burwick,N.R., Wahl,M.L., Fang,J., Zhong,Z., Moser,T.L., Li,B.,
            Capaldi,R.A., Kenan,D.J. and Pizzo,S.V.
  TITLE     An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the
            activity of angiostatin on the endothelial cell surface
  JOURNAL   J Biol Chem 280 (3), 1740-1745 (2005)
   PUBMED   15528193
REFERENCE   7  (bases 1 to 503)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 503)
  AUTHORS   Aggeler,R., Coons,J., Taylor,S.W., Ghosh,S.S., Garcia,J.J.,
            Capaldi,R.A. and Marusich,M.F.
  TITLE     A functionally active human F1F0 ATPase can be purified by
            immunocapture from heart tissue and fibroblast cell lines. Subunit
            structure and activity studies
  JOURNAL   J Biol Chem 277 (37), 33906-33912 (2002)
   PUBMED   12110673
REFERENCE   9  (bases 1 to 503)
  AUTHORS   Cabezon,E., Runswick,M.J., Leslie,A.G. and Walker,J.E.
  TITLE     The structure of bovine IF(1), the regulatory subunit of
            mitochondrial F-ATPase
  JOURNAL   EMBO J 20 (24), 6990-6996 (2001)
   PUBMED   11742976
REFERENCE   10 (bases 1 to 503)
  AUTHORS   Ichikawa,N., Ushida,S., Kawabata,M. and Masazumi,Y.
  TITLE     Nucleotide sequence of cDNA coding the mitochondrial precursor
            protein of the ATPase inhibitor from humans
  JOURNAL   Biosci Biotechnol Biochem 63 (12), 2225-2227 (1999)
   PUBMED   10664857
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP271519.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016311.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI458221.1, BP271519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000335514.10/
                                                  ENSP00000335203.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               BP271519.1         30-532
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..503
                     /gene="ATP5IF1"
                     /gene_synonym="ATPI; ATPIF1; ATPIP; IP"
                     /note="ATP synthase inhibitory factor subunit 1"
                     /db_xref="GeneID:93974"
                     /db_xref="HGNC:HGNC:871"
                     /db_xref="MIM:614981"
     exon            1..147
                     /gene="ATP5IF1"
                     /gene_synonym="ATPI; ATPIF1; ATPIP; IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..381
                     /gene="ATP5IF1"
                     /gene_synonym="ATPI; ATPIF1; ATPIP; IP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ATPase inhibitor protein; ATPase inhibitor,
                     mitochondrial; ATP synthase inhibitor protein; IF1; IF(1);
                     inhibitor of F(1)F(o)-ATPase; ATPase inhibitory factor 1;
                     ATP synthase F1 subunit epsilon"
                     /codon_start=1
                     /product="ATPase inhibitor, mitochondrial isoform 1
                     precursor"
                     /protein_id="NP_057395.1"
                     /db_xref="CCDS:CCDS319.1"
                     /db_xref="GeneID:93974"
                     /db_xref="HGNC:HGNC:871"
                     /db_xref="MIM:614981"
                     /translation="MAVTALAARTWLGVWGVRTMQARGFGSDQSENVDRGAGSIREAG
                     GAFGKREQAEEERYFRAQSREQLAALKKHHEEEIVHHKKEIERLQKEIERHKQKIKML
                     KHDD"
     exon            148..239
                     /gene="ATP5IF1"
                     /gene_synonym="ATPI; ATPIF1; ATPIP; IP"
                     /inference="alignment:Splign:2.1.0"
     exon            240..503
                     /gene="ATP5IF1"
                     /gene_synonym="ATPI; ATPIF1; ATPIP; IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      484..489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5IF1"
                     /gene_synonym="ATPI; ATPIF1; ATPIP; IP"
                     /note="hexamer: AATAAA"
     polyA_site      503
                     /gene="ATP5IF1"
                     /gene_synonym="ATPI; ATPIF1; ATPIP; IP"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgtaac gagagactgc ttgctgcggc agagacgcca gaggtgcagc tccagcagca
       61 atggcagtga cggcgttggc ggcgcggacg tggcttggcg tgtggggcgt gaggaccatg
      121 caagcccgag gcttcggctc ggatcagtcc gagaatgtcg accggggcgc gggctccatc
      181 cgggaagccg gtggggcctt cggaaagaga gagcaggctg aagaggaacg atatttccga
      241 gcacagagta gagaacaact ggcagctttg aaaaaacacc atgaagaaga aatcgttcat
      301 cataagaagg agattgagcg tctgcagaaa gaaattgagc gccataagca gaagatcaaa
      361 atgctaaaac atgatgatta agtgcacacc gtgtgccata gaatggcaca tgtcattgcc
      421 cacttctgtg tagacatggt tctggtttaa ctaatatttg tctgtgtgct actaacagat
      481 tataataaat tgtcatcagt gaa
//
