LOCUS       NM_006886               3610 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ATP synthase F1 subunit epsilon (ATP5F1E), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_006886 NM_001001977
VERSION     NM_006886.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3610)
  AUTHORS   Lin,R.Y. and Huang,Z.M.
  TITLE     Hsa_circ_0079480 enhances cell proliferation, migration, and
            invasion in colorectal cancer through miR-498/ATP5E axis
  JOURNAL   Kaohsiung J Med Sci 39 (3), 209-220 (2023)
   PUBMED   36625260
  REMARK    GeneRIF: Hsa_circ_0079480 enhances cell proliferation, migration,
            and invasion in colorectal cancer through miR-498/ATP5E axis.
REFERENCE   2  (bases 1 to 3610)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3610)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3610)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3610)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3610)
  AUTHORS   Tu,Q., Yu,L., Zhang,P., Zhang,M., Zhang,H., Jiang,J., Chen,C. and
            Zhao,S.
  TITLE     Cloning, characterization and mapping of the human ATP5E gene,
            identification of pseudogene ATP5EP1, and definition of the ATP5E
            motif
  JOURNAL   Biochem J 347 Pt 1 (Pt 1), 17-21 (2000)
   PUBMED   10727396
REFERENCE   7  (bases 1 to 3610)
  AUTHORS   Wang,H. and Oster,G.
  TITLE     Energy transduction in the F1 motor of ATP synthase
  JOURNAL   Nature 396 (6708), 279-282 (1998)
   PUBMED   9834036
REFERENCE   8  (bases 1 to 3610)
  AUTHORS   Elston,T., Wang,H. and Oster,G.
  TITLE     Energy transduction in ATP synthase
  JOURNAL   Nature 391 (6666), 510-513 (1998)
   PUBMED   9461222
REFERENCE   9  (bases 1 to 3610)
  AUTHORS   Vinas,O., Powell,S.J., Runswick,M.J., Iacobazzi,V. and Walker,J.E.
  TITLE     The epsilon-subunit of ATP synthase from bovine heart mitochondria.
            Complementary DNA sequence, expression in bovine tissues and
            evidence of homologous sequences in man and rat
  JOURNAL   Biochem J 265 (2), 321-326 (1990)
   PUBMED   2137333
REFERENCE   10 (bases 1 to 3610)
  AUTHORS   Boyer,P.D., Cross,R.L. and Momsen,W.
  TITLE     A new concept for energy coupling in oxidative phosphorylation
            based on a molecular explanation of the oxygen exchange reactions
  JOURNAL   Proc Natl Acad Sci U S A 70 (10), 2837-2839 (1973)
   PUBMED   4517936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB106920.1, DA202623.1,
            AL109840.24 and KF495837.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006886.3.
            
            Summary: This gene encodes a subunit of mitochondrial ATP synthase.
            Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an
            electrochemical gradient of protons across the inner membrane
            during oxidative phosphorylation. ATP synthase is composed of two
            linked multi-subunit complexes: the soluble catalytic core, F1, and
            the membrane-spanning component, Fo, comprising the proton channel.
            The catalytic portion of mitochondrial ATP synthase consists of 5
            different subunits (alpha, beta, gamma, delta, and epsilon)
            assembled with a stoichiometry of 3 alpha, 3 beta, and a single
            representative of the other 3. The proton channel consists of three
            main subunits (a, b, c). This gene encodes the epsilon subunit of
            the catalytic core. Two pseudogenes of this gene are located on
            chromosomes 4 and 13. Read-through transcripts that include exons
            from this gene are expressed from the upstream gene SLMO2.[provided
            by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.195812.1,
                                           SRR1803612.248998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000243997.8/
                                                  ENSP00000243997.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               CB106920.1         48-447
            401-407             DA202623.1         413-419
            408-982             AL109840.24        125530-126104       c
            983-1546            KF495837.1         1-564               c
            1547-3610           AL109840.24        122902-124965       c
FEATURES             Location/Qualifiers
     source          1..3610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..3610
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
                     /note="ATP synthase F1 subunit epsilon"
                     /db_xref="GeneID:514"
                     /db_xref="HGNC:HGNC:838"
                     /db_xref="MIM:606153"
     exon            1..116
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..240
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
                     /EC_number="7.1.2.2"
                     /note="H(+)-transporting two-sector ATPase;
                     F(0)F(1)-ATPase; mitochondrial ATPase; mitochondrial ATP
                     synthase epsilon chain; ATP synthase, H+ transporting,
                     mitochondrial F1 complex, epsilon subunit"
                     /codon_start=1
                     /product="ATP synthase subunit epsilon, mitochondrial"
                     /protein_id="NP_008817.1"
                     /db_xref="CCDS:CCDS13476.1"
                     /db_xref="GeneID:514"
                     /db_xref="HGNC:HGNC:838"
                     /db_xref="MIM:606153"
                     /translation="MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAEKTSGSNVK
                     IVKVKKE"
     exon            117..243
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
                     /inference="alignment:Splign:2.1.0"
     exon            244..3610
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      374..379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
                     /note="hexamer: AATAAA"
     polyA_site      407
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
                     /note="major polyA site"
     regulatory      3590..3595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="ATP5F1E"
                     /gene_synonym="ATP5E; ATPE; MC5DN3"
ORIGIN      
        1 cttcctgcgg ctgaaccgcc cggctgagcc gacattgccg gcgtcttggc gattcggccc
       61 gacgagctcc gctttcgcta cagcatggtg gcctactgga gacaggctgg actcagctac
      121 atccgatact cccagatctg tgcaaaagca gtgagagatg cactgaagac agaattcaaa
      181 gcaaatgctg agaagacttc tggcagcaac gtaaaaattg tgaaagtaaa gaaggaataa
      241 tctaccctga ctaaagcttg aaatgctaca tttccaaggt gaagatgtgt gggcacatgt
      301 tatggcagat tgaaaaggat ctcattccat gggaaaaaaa aaaatcctgt cttgttcata
      361 aattgacaat gtcaataaat tgaaatatgg ttcactgtta ctcttgattt tagtttgtga
      421 gactttttca ttttctttaa aggaactgtc tgcacagctg catgattatg gccatgtgaa
      481 ccagggtttc ttaaaagcag gggaagccag atttaatatt tagtgaccaa agggatacag
      541 aaagcatttt gaaaatgtct caaaatagtt gtttcatgac attaattggt gatcaaaatt
      601 atctgctgtc attgaggctt cgtagtccct tatttttgaa ttgttgtcat gtcagaataa
      661 tgacatggtt atcagtaaca aatggaaata attattaaat actaaaagtg tagattagaa
      721 gaagaaatac taaattgtac ttgttttgta ttgtgcactt aaagcctata gataagaacg
      781 gttacagaat ttaagcacaa agtgtttttc acattgtttt gtaaatgaat ctttatactc
      841 tggtagcatt tctcatagga aatgaggcaa agctattgaa taacttgctc attgagttga
      901 tggccaaact gaaattaaaa cctaggagtt ttgactgcaa gtctgggaca cggtgaccac
      961 aacagcagtt tcgtggtatt tccatagtga ttcattcatt cattatttag ggatgaaaaa
     1021 ttgttgcaag ttatgttttt atctttcttt gaaacttgaa agggcttggg caagtaaaac
     1081 accattgcaa agttaactgc ctgattttaa ctgtttttgg agactggaga aataaatttg
     1141 aactggaaat tttgaaacac cattctagga tcagttctca catggtactt aagctcacaa
     1201 tgatttatca gggccactgt cagcaatgcc gaggataagc cgaaaagaac atctttgttc
     1261 tcggcttctg ggaatgactt attgtcccga cacttgacct gtaggtttta ctgaattctc
     1321 agcacagagc gagcagggag gcagagccaa ttgagtggaa gagggtgcct ctggaaaaca
     1381 gcaggttagg agcccttgga gtcctccgcc tcggagctgt catcctgctg ttggcaagtt
     1441 agggcacctc agttcagtgc tgtggccccc aagattaagg tactaggaag tatcctccat
     1501 tacagggaac aggaataaat gaatcaaaaa gctatcgggc ctttttgaca tgggacgaat
     1561 aaagtaacta ataggcaaag gggctaaatg atttccagtc aagtaattag agataagtca
     1621 tttattaagg aggcagatgg ggtattattg gtatatagat ggcatagtag attgctagta
     1681 tattggtaga ttattggtat atagatggta tgttaaggag gcagatgggg tattactggt
     1741 atatagatgg tatggtagat tggtagtata ttggcagatt attggtatat ggtatgttga
     1801 ggcagatggg gtattactgg tatatagatg gcatagtaga ttggtagtat attggtagat
     1861 tattggtata gagatggtat attattaagg aggcagatgg ggtaattaga ggtgagactt
     1921 agggacaggg cttgtgatat ggaaaggagt gaagtcactg agtaaaagac aagtttactg
     1981 tcagcagaga ttcttagagg ctcttttctc cgtgattaaa aaaaaatcct aaaccagtag
     2041 tataataaac ttcctgcctc cagcagtgct gggtagctgg caggatgact gtgcccagtg
     2101 atgaggtgac cccagtcaga ccaacttaat gagtatccca ctaattagtt ggatgatgtt
     2161 tgaagctgtc agttaatctc ttagttcaca tcgttcttgt gagcaaagtg aaggaatcgg
     2221 ataagctcta aatttcggtg atgctgctgc tctgagagac caaggtcgct ggagcaaccg
     2281 tactgctaaa ggataagctc ttcaaaatca aaagggacag atttcttaag tttctagttt
     2341 gttttgtgtt tttacatcta tttctaccat acgaaagagt aggatggtga gatgcatttc
     2401 taaatatttt taactactca gtctggatgg ttaggcttca agaaaaggaa tttatttagt
     2461 ctgaaataaa gcaattttgc catttaaaat tgaattactt tgtagtttaa tgattactat
     2521 tgagcaaaca aatctttaca gtaatataag tcagcaaaag ttttttaaaa ggtttaaatc
     2581 cctccttcct tacatctatt tcattgcttt tttaggtttg ggaagtaaag caccagagga
     2641 agcatgtgta aatccttgta taatcgcagg ctgtaagtct ttagcatctc aggaagttac
     2701 taacttcaaa ctaagtatat aggtagagtt tcttactaaa tctagtgctt cttgaaccac
     2761 aagtagaaag catttaaaac atgaatgttg ttttgtgttt tttgaagttt gtaaatagaa
     2821 gacttgttga tgatccgatg gcaaggtatt tttctcttgg tatgtatttt agttatttcc
     2881 tcgtgatgca taagtgaaaa gagtgaagtt tctcagaatg agcaactgtc atccatctac
     2941 ctgctatttt attattgctg attacaaaag caaatcaaga gatgagaacc cagttgcctg
     3001 caagtaaata tttactgcat tgagggtcgg agcattttcc cattaccggt tatccatgga
     3061 tcaaatagtg tatctcagtg gtaattctag agggccatta aaaccctgat ggtgctggaa
     3121 gagatggcag tgctgcatgt cagaaatagg taaactgtaa ttaagaagtt acagatgatt
     3181 tgattacgct cttgtgtatt tggtcctgtt ataatgtgag cagattaaaa tcatgtagtg
     3241 cttaaagcta tgtcattatg caaacattta tggcaacttc tgcaaattaa tttgaactgt
     3301 aaaagttccc taatgagacg atgtcctcca taactgagaa ggacactgca gccattgctg
     3361 cttaattcct gcatttgaat ggttgccgag cgcatggtgt gccctttctc aaagagcaga
     3421 gaggctgcag agcattttgg ggggtgatga ctgaatgaaa gtgaaaagac catttcaaaa
     3481 tagcctttaa aaggaaagcc aaggatgatt attaatgaat tcctgggatc taacagtagt
     3541 aagaaattta aactatataa acatatatgt taaaggctag ctcttcagaa ataaagatca
     3601 gaagactgca
//
