LOCUS       NM_001687                995 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ATP synthase F1 subunit delta (ATP5F1D), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001687
VERSION     NM_001687.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 995)
  AUTHORS   Lai,Y., Zhang,Y., Zhou,S., Xu,J., Du,Z., Feng,Z., Yu,L., Zhao,Z.,
            Wang,W., Tang,Y., Yang,X., Guddat,L.W., Liu,F., Gao,Y., Rao,Z. and
            Gong,H.
  TITLE     Structure of the human ATP synthase
  JOURNAL   Mol Cell 83 (12), 2137-2147 (2023)
   PUBMED   37244256
REFERENCE   2  (bases 1 to 995)
  AUTHORS   Wang,Y.B., Zhai,C.Y., Yao,G.P., Chen,T.B., Xue,L.L., Zhou,L.,
            Xiong,L.L. and Wang,T.H.
  TITLE     ATP5D Is a Potential Biomarker for Male Fertility
  JOURNAL   Oxid Med Cell Longev 2023, 4923614 (2023)
   PUBMED   36686378
  REMARK    GeneRIF: ATP5D Is a Potential Biomarker for Male Fertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 995)
  AUTHORS   Wu,Y., Chen,Z., Xie,G., Zhang,H., Wang,Z., Zhou,J., Chen,F., Li,J.,
            Chen,L., Niu,H. and Wang,H.
  TITLE     RNA m1A methylation regulates glycolysis of cancer cells through
            modulating ATP5D
  JOURNAL   Proc Natl Acad Sci U S A 119 (28), e2119038119 (2022)
   PUBMED   35867754
  REMARK    GeneRIF: RNA m(1)A methylation regulates glycolysis of cancer cells
            through modulating ATP5D.
REFERENCE   4  (bases 1 to 995)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 995)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 995)
  AUTHORS   Wang,H. and Oster,G.
  TITLE     Energy transduction in the F1 motor of ATP synthase
  JOURNAL   Nature 396 (6708), 279-282 (1998)
   PUBMED   9834036
REFERENCE   7  (bases 1 to 995)
  AUTHORS   Yasuda,R., Noji,H., Kinosita,K. Jr. and Yoshida,M.
  TITLE     F1-ATPase is a highly efficient molecular motor that rotates with
            discrete 120 degree steps
  JOURNAL   Cell 93 (7), 1117-1124 (1998)
   PUBMED   9657145
REFERENCE   8  (bases 1 to 995)
  AUTHORS   Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
            al.
  TITLE     Human liver protein map: a reference database established by
            microsequencing and gel comparison
  JOURNAL   Electrophoresis 13 (12), 992-1001 (1992)
   PUBMED   1286669
REFERENCE   9  (bases 1 to 995)
  AUTHORS   Jordan,E.M. and Breen,G.A.
  TITLE     Molecular cloning of an import precursor of the delta-subunit of
            the human mitochondrial ATP synthase complex
  JOURNAL   Biochim Biophys Acta 1130 (1), 123-126 (1992)
   PUBMED   1531933
REFERENCE   10 (bases 1 to 995)
  AUTHORS   Boyer,P.D., Cross,R.L. and Momsen,W.
  TITLE     A new concept for energy coupling in oxidative phosphorylation
            based on a molecular explanation of the oxygen exchange reactions
  JOURNAL   Proc Natl Acad Sci U S A 70 (10), 2837-2839 (1973)
   PUBMED   4517936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC018817.2 and X63422.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001687.4.
            
            Summary: This gene encodes a subunit of mitochondrial ATP synthase.
            Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an
            electrochemical gradient of protons across the inner membrane
            during oxidative phosphorylation. ATP synthase is composed of two
            linked multi-subunit complexes: the soluble catalytic core, F1, and
            the membrane-spanning component, Fo, comprising the proton channel.
            The catalytic portion of mitochondrial ATP synthase consists of 5
            different subunits (alpha, beta, gamma, delta, and epsilon)
            assembled with a stoichiometry of 3 alpha, 3 beta, and a single
            representative of the other 3. The proton channel consists of three
            main subunits (a, b, c). This gene encodes the delta subunit of the
            catalytic core. Alternatively spliced transcript variants encoding
            the same isoform have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002389.2, S87916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000215375.7/
                                                  ENSP00000215375.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BC018817.2         2-18
            18-995              X63422.1           1-978
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..995
                     /gene="ATP5F1D"
                     /gene_synonym="ATP5D; MC5DN5"
                     /note="ATP synthase F1 subunit delta"
                     /db_xref="GeneID:513"
                     /db_xref="HGNC:HGNC:837"
                     /db_xref="MIM:603150"
     exon            1..241
                     /gene="ATP5F1D"
                     /gene_synonym="ATP5D; MC5DN5"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..607
                     /gene="ATP5F1D"
                     /gene_synonym="ATP5D; MC5DN5"
                     /EC_number="3.6.1.14"
                     /note="mitochondrial ATP synthase, delta subunit; ATP
                     synthase, H+ transporting, mitochondrial F1 complex, delta
                     subunit; ATP synthase subunit delta, mitochondrial;
                     mitochondrial ATP synthase complex delta-subunit precusor;
                     F-ATPase delta subunit"
                     /codon_start=1
                     /product="ATP synthase subunit delta, mitochondrial
                     precursor"
                     /protein_id="NP_001678.1"
                     /db_xref="CCDS:CCDS12058.1"
                     /db_xref="GeneID:513"
                     /db_xref="HGNC:HGNC:837"
                     /db_xref="MIM:603150"
                     /translation="MLPAALLRRPGLGRLVRHARAYAEAAAAPAAASGPNQMSFTFAS
                     PTQVFFNGANVRQVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSG
                     SIAVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQAELVGTADEATRAEIQIRIEAN
                     EALVKALE"
     exon            242..395
                     /gene="ATP5F1D"
                     /gene_synonym="ATP5D; MC5DN5"
                     /inference="alignment:Splign:2.1.0"
     exon            396..484
                     /gene="ATP5F1D"
                     /gene_synonym="ATP5D; MC5DN5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..995
                     /gene="ATP5F1D"
                     /gene_synonym="ATP5D; MC5DN5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      975..980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5F1D"
                     /gene_synonym="ATP5D; MC5DN5"
                     /note="hexamer: ATTAAA"
     polyA_site      995
                     /gene="ATP5F1D"
                     /gene_synonym="ATP5D; MC5DN5"
                     /note="major polyA site"
ORIGIN      
        1 agacgtccct gcgcgtcgtc ctcctcgccc tccaggccgc ccgcgccgcg ccggagtccg
       61 ctgtccgcca gctacccgct tcctgccgcc cgccgctgcc atgctgcccg ccgcgctgct
      121 ccgccgcccg ggacttggcc gcctcgtccg ccacgcccgt gcctatgccg aggccgccgc
      181 cgccccggct gccgcctctg gccccaacca gatgtccttc accttcgcct ctcccacgca
      241 ggtgttcttc aacggtgcca acgtccggca ggtggacgtg cccacgctga ccggagcctt
      301 cggcatcctg gcggcccacg tgcccacgct gcaggtcctg cggccggggc tggtcgtggt
      361 gcatgcagag gacggcacca cctccaaata ctttgtgagc agcggttcca tcgcagtgaa
      421 cgccgactct tcggtgcagt tgttggccga agaggccgtg acgctggaca tgttggacct
      481 gggggcagcc aaggcaaact tggagaaggc ccaggcggag ctggtgggga cagctgacga
      541 ggccacgcgg gcagagatcc agatccgaat cgaggccaac gaggccctgg tgaaggccct
      601 ggagtaggcg gtgcgtaccc ggtgtcccga ggcccggcca ggggctgggc agggatgcca
      661 ggtgggccca gccagctcct ggggtcccgg ccacctgggg aagccgcgcc tgccaaggag
      721 gccaccagag ggcagtgcag gcttctgcct gggccccagg ccctgcctgt gttgaaagct
      781 ctggggactg ggccagggaa gctcctcctc agctttgagc tgtggctgcc acccatgggg
      841 ctctccttcc gcctctcaag atccccccag cctgacgggc cgcttaccat cccctctgcc
      901 ctgcagagcc agccgccaag gttgacctca gcttcggagc cacctctgga tgaactgccc
      961 ccagcccccg ccccattaaa gacccggaag cctga
//
