LOCUS       NM_004046               5761 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ATP synthase F1 subunit alpha (ATP5F1A), transcript
            variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_004046
VERSION     NM_004046.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5761)
  AUTHORS   Hui,Y., Leng,J., Jin,D., Wang,G., Liu,K., Bu,Y. and Wang,Q.
  TITLE     BRG1 promotes liver cancer cell proliferation and metastasis by
            enhancing mitochondrial function and ATP5A1 synthesis through
            TOMM40
  JOURNAL   Cancer Biol Ther 25 (1), 2375440 (2024)
   PUBMED   38978225
  REMARK    GeneRIF: BRG1 promotes liver cancer cell proliferation and
            metastasis by enhancing mitochondrial function and ATP5A1 synthesis
            through TOMM40.
REFERENCE   2  (bases 1 to 5761)
  AUTHORS   Xu,M., Zhang,H., Chang,Y., Hua,X., Chen,X., Sheng,Y., Shan,D.,
            Bao,M., Hu,S. and Song,J.
  TITLE     Overexpression of ATP5F1A in Cardiomyocytes Promotes Cardiac
            Reverse Remodeling
  JOURNAL   Circ Heart Fail 17 (7), e011504 (2024)
   PUBMED   38910562
  REMARK    GeneRIF: Overexpression of ATP5F1A in Cardiomyocytes Promotes
            Cardiac Reverse Remodeling.
REFERENCE   3  (bases 1 to 5761)
  AUTHORS   Pasternack,H., Polzer,M., Gemoll,T., Kumpers,C., Sauer,T.,
            Lazar-Karsten,P., Hinrichs,S., Bohnet,S., Perner,S., Dressler,F.F.
            and Kirfel,J.
  TITLE     Proteomic analyses identify HK1 and ATP5A to be overexpressed in
            distant metastases of lung adenocarcinomas compared to matched
            primary tumors
  JOURNAL   Sci Rep 13 (1), 20948 (2023)
   PUBMED   38016997
  REMARK    GeneRIF: Proteomic analyses identify HK1 and ATP5A to be
            overexpressed in distant metastases of lung adenocarcinomas
            compared to matched primary tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5761)
  AUTHORS   Lai,Y., Zhang,Y., Zhou,S., Xu,J., Du,Z., Feng,Z., Yu,L., Zhao,Z.,
            Wang,W., Tang,Y., Yang,X., Guddat,L.W., Liu,F., Gao,Y., Rao,Z. and
            Gong,H.
  TITLE     Structure of the human ATP synthase
  JOURNAL   Mol Cell 83 (12), 2137-2147 (2023)
   PUBMED   37244256
REFERENCE   5  (bases 1 to 5761)
  AUTHORS   Katz Shroitman,N., Yitzhaky,A., Ben Shachar,D., Gurwitz,D. and
            Hertzberg,L.
  TITLE     Meta-analysis of brain samples of individuals with schizophrenia
            detects down-regulation of multiple ATP synthase encoding genes in
            both females and males
  JOURNAL   J Psychiatr Res 158, 350-359 (2023)
   PUBMED   36640659
  REMARK    GeneRIF: Meta-analysis of brain samples of individuals with
            schizophrenia detects down-regulation of multiple ATP synthase
            encoding genes in both females and males.
REFERENCE   6  (bases 1 to 5761)
  AUTHORS   Kovalyov,L.I., Shishkin,S.S., Efimochkin,A.S., Kovalyova,M.A.,
            Ershova,E.S., Egorov,T.A. and Musalyamov,A.K.
  TITLE     The major protein expression profile and two-dimensional protein
            database of human heart
  JOURNAL   Electrophoresis 16 (7), 1160-1169 (1995)
   PUBMED   7498159
REFERENCE   7  (bases 1 to 5761)
  AUTHORS   Abrahams,J.P., Leslie,A.G., Lutter,R. and Walker,J.E.
  TITLE     Structure at 2.8 A resolution of F1-ATPase from bovine heart
            mitochondria
  JOURNAL   Nature 370 (6491), 621-628 (1994)
   PUBMED   8065448
REFERENCE   8  (bases 1 to 5761)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   9  (bases 1 to 5761)
  AUTHORS   Kataoka,H. and Biswas,C.
  TITLE     Nucleotide sequence of a cDNA for the alpha subunit of human
            mitochondrial ATP synthase
  JOURNAL   Biochim Biophys Acta 1089 (3), 393-395 (1991)
   PUBMED   1830491
REFERENCE   10 (bases 1 to 5761)
  AUTHORS   Boyer,P.D., Cross,R.L. and Momsen,W.
  TITLE     A new concept for energy coupling in oxidative phosphorylation
            based on a molecular explanation of the oxygen exchange reactions
  JOURNAL   Proc Natl Acad Sci U S A 70 (10), 2837-2839 (1973)
   PUBMED   4517936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CK002707.1, D14710.1,
            AW207528.1 and AC012569.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004046.5.
            
            Summary: This gene encodes a subunit of mitochondrial ATP synthase.
            Mitochondrial ATP synthase catalyzes ATP synthesis, using an
            electrochemical gradient of protons across the inner membrane
            during oxidative phosphorylation. ATP synthase is composed of two
            linked multi-subunit complexes: the soluble catalytic core, F1, and
            the membrane-spanning component, Fo, comprising the proton channel.
            The catalytic portion of mitochondrial ATP synthase consists of 5
            different subunits (alpha, beta, gamma, delta, and epsilon)
            assembled with a stoichiometry of 3 alpha, 3 beta, and a single
            representative of the other 3. The proton channel consists of three
            main subunits (a, b, c). This gene encodes the alpha subunit of the
            catalytic core. Alternatively spliced transcript variants encoding
            the different isoforms have been identified. Pseudogenes of this
            gene are located on chromosomes 9, 2, and 16. [provided by RefSeq,
            Mar 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 both encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129739.1, SRR1803613.105761.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000398752.11/
                                                  ENSP00000381736.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CK002707.1         58-59
            3-1859              D14710.1           1-1857
            1860-1865           AW207528.1         18-23               c
            1866-5761           AC012569.18        66840-70735
FEATURES             Location/Qualifiers
     source          1..5761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..5761
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /note="ATP synthase F1 subunit alpha"
                     /db_xref="GeneID:498"
                     /db_xref="HGNC:HGNC:823"
                     /db_xref="MIM:164360"
     exon            1..125
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1727
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; mitochondrial ATP synthetase,
                     oligomycin-resistant; ATP synthase alpha chain,
                     mitochondrial; ATP sythase (F1-ATPase) alpha subunit;
                     epididymis secretory sperm binding protein Li 123m; ATP
                     synthase, H+ transporting, mitochondrial F1 complex, alpha
                     subunit 1, cardiac muscle"
                     /codon_start=1
                     /product="ATP synthase subunit alpha, mitochondrial
                     isoform a precursor"
                     /protein_id="NP_004037.1"
                     /db_xref="CCDS:CCDS11927.1"
                     /db_xref="GeneID:498"
                     /db_xref="HGNC:HGNC:823"
                     /db_xref="MIM:164360"
                     /translation="MLSVRVAAAVVRALPRRAGLVSRNALGSSFIAARNFHASNTHLQ
                     KTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGL
                     KGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDG
                     KGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGK
                     TSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVS
                     ATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGR
                     EAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQ
                     IFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFG
                     SDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFE
                     NAFLSHVVSQHQALLGTIRADGKISEQSDAKLKEIVTNFLAGFEA"
     exon            126..204
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            205..374
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            375..548
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            549..715
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            716..864
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1016
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1241
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1349
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1494
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1645
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..5761
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /note="hexamer: AATAAA"
     polyA_site      1862
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /note="major polyA site"
     regulatory      4772..4777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
                     /note="hexamer: AATAAA"
     polyA_site      4790
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
     polyA_site      5761
                     /gene="ATP5F1A"
                     /gene_synonym="ATP5A; ATP5A1; ATP5AL2; ATPM; COXPD22;
                     hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR;
                     ORM"
ORIGIN      
        1 cattttgtcc cagtcagtcc ggaggctgcg gctgcagaag taccgcctgc ggagtaactg
       61 caaagatgct gtccgtgcgc gttgctgcgg ccgtggtccg cgcccttcct cggcgggccg
      121 gactggtctc cagaaatgct ttgggttcat ctttcattgc tgcaaggaac ttccatgcct
      181 ctaacactca tcttcaaaag actgggactg ctgagatgtc ctctattctt gaagagcgta
      241 ttcttggagc tgatacctct gttgatcttg aagaaactgg gcgtgtctta agtattggtg
      301 atggtattgc ccgcgtacat gggctgagga atgttcaagc agaagaaatg gtagagtttt
      361 cttcaggctt aaagggtatg tccttgaact tggaacctga caatgttggt gttgtcgtgt
      421 ttggaaatga taaactaatt aaggaaggag atatagtgaa gaggacagga gccattgtgg
      481 acgttccagt tggtgaggag ctgttgggtc gtgtagttga tgcccttggt aatgctattg
      541 atggaaaggg tccaattggt tccaagacgc gtaggcgagt tggtctgaaa gcccccggta
      601 tcattcctcg aatttcagtg cgggaaccaa tgcagactgg cattaaggct gtggatagct
      661 tggtgccaat tggtcgtggt cagcgtgaac tgattattgg tgaccgacag actgggaaaa
      721 cctcaattgc tattgacaca atcattaacc agaaacgttt caatgatgga tctgatgaaa
      781 agaagaagct gtactgtatt tatgttgcta ttggtcaaaa gagatccact gttgcccagt
      841 tggtgaagag acttacagat gcagatgcca tgaagtacac cattgtggtg tcggctacgg
      901 cctcggatgc tgccccactt cagtacctgg ctccttactc tggctgttcc atgggagagt
      961 attttagaga caatggcaaa catgctttga tcatctatga cgacttatcc aaacaggctg
     1021 ttgcttaccg tcagatgtct ctgttgctcc gccgaccccc tggtcgtgag gcctatcctg
     1081 gtgatgtgtt ctacctacac tcccggttgc tggagagagc agccaaaatg aacgatgctt
     1141 ttggtggtgg ctccttgact gctttgccag tcatagaaac acaggctggt gatgtgtctg
     1201 cttacattcc aacaaatgtc atttccatca ctgacggaca gatcttcttg gaaacagaat
     1261 tgttctacaa aggtatccgc cctgcaatta acgttggtct gtctgtatct cgtgtcggat
     1321 ccgctgccca aaccagggct atgaagcagg tagcaggtac catgaagctg gaattggctc
     1381 agtatcgtga ggttgctgct tttgcccagt tcggttctga cctcgatgct gccactcaac
     1441 aacttttgag tcgtggcgtg cgtctaactg agttgctgaa gcaaggacag tattctccca
     1501 tggctattga agaacaagtg gctgttatct atgcgggtgt aaggggatat cttgataaac
     1561 tggagcccag caagattaca aagtttgaga atgctttctt gtctcatgtc gtcagccagc
     1621 accaagcctt gttgggcact atcagggctg atggaaagat ctcagaacaa tcagatgcaa
     1681 agctgaaaga gattgtaaca aatttcttgg ctggatttga agcttaaact cctgtggatt
     1741 cacatcaaat accagttcag ttttgtcatt gttctagtaa attagttcca tttgtaaaag
     1801 ggttactctc atactcctta tgtacagaaa tcacatgaaa aataaaggtt ccataatgca
     1861 tagttgtttt ctgtcatttg tgttattctt taaaaccaag atcaaattga gaaattggta
     1921 agcaaatgct tcttgatcta ttttacttga atattggtac agtcaactgg gctagataat
     1981 tcaaggctga gctctttgta agtttttttt ttgttttttt ttttgagact gattctcact
     2041 ctgtcactga ggctggagtg cagtggcacc ctgtcggccc actgcaacct ccgtctccgg
     2101 gttcaagcaa ttctcttgcc tcagcctccc acgtagctgg gattacaggt gcccaccacc
     2161 acgcctggct agttttttag tatttttagt agagacgggg tttcaccatg ttggccaggc
     2221 cggtcacgaa ctcctgacct caggtgatcc acctgccttg gcctacctac cacagtgctg
     2281 ggattacagg tgtgagccac cgcacccggc tgctctttgt aagtttctag agtactttgt
     2341 gtttaagaga aattcctaaa ctggatatat gtggcaggct gacaatactg aagagcatag
     2401 ctggcttctc tgcccagagg atgtacctgc ataaagaggt actgtaggca ggaaaataat
     2461 aggacagtta aaattctcag ggaaatgaaa aaattgctgg aacaaaagct gagaagatag
     2521 aatgcatagg attatgaaaa cttgtcaata tctcttttgt ttgttttgtg acagggtctc
     2581 catctctctc acccaggctg gagtacagtg gtgtgatctc agctcactgc agcttctgcc
     2641 acctgggttc aattgattct tccacctcag cctcctgagt agctggggtt acaggcacat
     2701 accaccacgc ccagccaatt tttctacttt ttgtagaggg agggtcttgc catgttgtcc
     2761 aggctgatga tgaactcctt ggctcaagtg atcctcctgc cttggtctcc caaagtgctg
     2821 ggattacagg tgtgaactac catgcccggc catcttttaa tattttcaca gctactttat
     2881 ttcctctgtt actagctttt catagccttt gctcattctt actgcattaa atttttttta
     2941 ctgatttatt tatttttttg agacagagtc ttgctctgtc acctaggctg gagagcagtg
     3001 gcgtaatctc agctcactgc acctttcacc tcctgggttc aagcgattct cctgccttag
     3061 cctcccaatt agctgggacc acaggcccat gccaccacac ccggctaaca ttttgtattt
     3121 ttagtagaga caaggtttca ccatgttggc catgctgctc ttgagctcct gacctcgtgg
     3181 tctgcccgcc tcagcttccc aaagtgctgg gattacaggt gtgagccacc acgcccagcc
     3241 tactgattta tttatttact tttaattttt catagccttt gctcattctt aatgtgttac
     3301 cttttttttt acttagttat ttatttattt gagatggagt ctccgtcgtc caggctggag
     3361 tgcagtgacc tgatcttggc tcactgcaac ctctgcctcc aggttcaagc aattctcctg
     3421 cctcagcctc ccgagaagct ggaactacag gcacccacca ccatgccctg ctaatttttg
     3481 tatttttagt agaggcgggg tttcaccata ttggccaggc tggtctcgaa ctcctgacct
     3541 tgtgatctgc ctgccttggc ctcccacagt gctgggatta caggtgtgag ccaccacacc
     3601 tggccttttt tttttttttt tgagacggag tctcactgtc tcccaggctg gagtgcagtg
     3661 gtgcgatgtc ggctcactgc aagctctgcc ccctgggttt gcgccgttct cctgcctcag
     3721 cctcccgatt agctggtact acaggcgcct gccatcacgc ccagctaatt tttttttttt
     3781 tgtattttta gtagagacgg ggtttcacca tgttcgccag gatggtctcg atctcctgac
     3841 ctcatgatcc acttacctcg gcctcccaaa gtgctgggat tacaggcttg agccaccgcg
     3901 cccggcctct tttttttttt ttttttttta ctgatatata aaggcttttg tctgtaaggg
     3961 tcatacatgg tcatgttcta aaatattttt cctagggttc ccccttcctt gccattttat
     4021 tttgttgatg gggatttgct gtaccgaaac ttcattctta tccatctctc tgtctccagt
     4081 aagtcaaaat atatttacat atgtgggctc caatatcttt ggtaggaaaa ggagagttct
     4141 taaagtactc ataagtcctt ttcagtactt agaggaacac taaacttgat agcagttggt
     4201 catttctgat caactcttgc tttctagcta cttgagaaat aacttctaga tctgattttc
     4261 cttttctgaa ataaggaagt tacttttagt tagaaggttc tgcacatttc gttttttttt
     4321 tttttttttt tttttgtttt ttttttttga gagttttgct cttgttgccc aggctggagt
     4381 gcaatggcac gatctcggct caccacaacc accgcctcct ggggtcaagc aattctcctg
     4441 cctcaggctc ctgagtagct gggattacag gcatgcacca ccacgcctgg ctaattttgt
     4501 atttttagta gagatggggt ttctccatgt tggtcaggct ggtctcaaac tcctgacctt
     4561 aggtggtcca ccggcctccc aaagtactgg gattacaggg gtgagccact gcgcccggct
     4621 tgttggagca ttttatacct agtgtcagtg gtgattacta ctttggagaa aaatactttg
     4681 gctaatggat tggaattaat ttattactgg gagtatgtat tgtttgtttg ttgactggat
     4741 ctcgtagccc actcctggca cgtaaatgct caataaactt ctcaaatgaa gacaaccatg
     4801 tttgtccatt ataaatcaaa ttccaaatgt taactactgg tctggtctga tgagattttt
     4861 tttttttttt ttttttttga gacggagttt tgtttttgtt gcccaggctg gagtgcaatg
     4921 gcgcgatctc ggctcactgc aacctccacc tcctgggttc aagtgattct cctacctcag
     4981 cctcctgagt agctgtgatt ataggtgtgc accaccatgc ctggctaatt tttgtatttt
     5041 tagtagagac ggggtttcac catgttggcc aggctggttt cgaactcctg accttagatg
     5101 atccacgtgc ctcgacctcc taaagtgctg ggattacagg cgtgagccac tgtgcctggc
     5161 ccacgccagg cacagtgata tttaaaaatg tgatttttaa atatcacatt taaaaatatg
     5221 tgatattttt aaagaatatg atagcccagg cgcagtggct tacgcctgta atctcagcac
     5281 tttgggacga tcacttgagc ccaggagttt gaaacaggct gcagtcagct atgatcacgc
     5341 cactgcactc cagcctaggt gacagagacc ctgactctta aaaaaagttg tgctagaaga
     5401 cttcaagatc tcccctaaaa ctgtatagtc ctttccctgg tgtttttgct gagctataga
     5461 gtccagccct ttctgttaca gcaatgaacc atgagattca aatactgctt tttactaagt
     5521 acttacagac taatgacata ggagacctca taggcacctg gctgttttta accaggcagg
     5581 cctaaataca ctgcccaagt ggcccttctg tgtggcaaca aaatggctgt cataaaattg
     5641 tgtctgtgtg catttatctt atcactgggg gtggtgaaca tttgagaagg cacttgacct
     5701 ttgaaatgtg aagttttatg gatttcagac ttgtatttta aaaactattt gttaactgta
     5761 a
//
