LOCUS       NM_000705               1500 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ATPase H+/K+ transporting subunit beta (ATP4B), mRNA.
ACCESSION   NM_000705 XM_939372
VERSION     NM_000705.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1500)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1500)
  AUTHORS   Yang,T., Li,M.H., Liu,J., Huang,N., Li,N., Liu,S.N., Liu,Y.,
            Zhang,T., Zou,Q. and Li,H.
  TITLE     Benzimidazole derivative, BMT-1, induces apoptosis in multiple
            myeloma cells via a mitochondrial-mediated pathway involving
            H+/K+-ATPase inhibition
  JOURNAL   Oncol Rep 31 (6), 2743-2750 (2014)
   PUBMED   24700195
  REMARK    GeneRIF: these findings demonstrated that a decrease in pHi, caused
            by H+/K+-ATPase inhibition induced by BMT-1, triggered the
            dysfunction of the mitochondria resulting in the apoptosis of MM
            cells
REFERENCE   3  (bases 1 to 1500)
  AUTHORS   Raja,U.M., Gopal,G. and Rajkumar,T.
  TITLE     Intragenic DNA methylation concomitant with repression of ATP4B and
            ATP4A gene expression in gastric cancer is a potential serum
            biomarker
  JOURNAL   Asian Pac J Cancer Prev 13 (11), 5563-5568 (2012)
   PUBMED   23317218
  REMARK    GeneRIF: Downregulation of ATP4B gene is associated with gastric
            cancer.
REFERENCE   4  (bases 1 to 1500)
  AUTHORS   Bab-Dinitz,E., Albeck,S., Peleg,Y., Brumfeld,V., Gottschalk,K.E.
            and Karlish,S.J.
  TITLE     A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase
            resembles cell adhesion molecules
  JOURNAL   Biochemistry 48 (36), 8684-8691 (2009)
   PUBMED   19694409
  REMARK    GeneRIF: Use of fold recognition methods enables the prediction
            that a C-terminal domain of the beta subunits of Na,K-ATPase and
            H,K-ATPase has an immunoglobulin-like fold, which resembles cell
            adhesion molecules.
REFERENCE   5  (bases 1 to 1500)
  AUTHORS   Knouff,C.W., Lim,N., Song,K., Yuan,X., Walker,M.C., Townsend,R.,
            Waeber,G., Matthews,P.M., Vollenweider,P., Waterworth,D.M. and
            Mooser,V.
  TITLE     Pharmacological effects of lipid-lowering drugs recapitulate with a
            larger amplitude the phenotypic effects of common variants within
            their target genes
  JOURNAL   Pharmacogenet Genomics 18 (12), 1051-1057 (2008)
   PUBMED   18787507
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1500)
  AUTHORS   Sachs,G.
  TITLE     Proton pump inhibitors and acid-related diseases
  JOURNAL   Pharmacotherapy 17 (1), 22-37 (1997)
   PUBMED   9017763
  REMARK    Review article
REFERENCE   7  (bases 1 to 1500)
  AUTHORS   Callaghan,J.M., Tan,S.S., Khan,M.A., Curran,K.A., Campbell,W.G.,
            Smolka,A.J., Toh,B.H., Gleeson,P.A., Wingo,C.S., Cain,B.D. et al.
  TITLE     Renal expression of the gene encoding the gastric H(+)-K(+)-ATPase
            beta-subunit
  JOURNAL   Am J Physiol 268 (3 Pt 2), F363-F374 (1995)
   PUBMED   7900835
REFERENCE   8  (bases 1 to 1500)
  AUTHORS   Song,I., Brown,D.R., Yamada,T. and Trent,J.M.
  TITLE     Mapping of the gene encoding the beta-subunit of H+,K(+)-ATPase to
            human chromosome 13q34 by fluorescence in situ hybridization
  JOURNAL   Genomics 14 (4), 1114-1115 (1992)
   PUBMED   1335958
REFERENCE   9  (bases 1 to 1500)
  AUTHORS   Ma,J.Y., Song,Y.H., Sjostrand,S.E., Rask,L. and Mardh,S.
  TITLE     cDNA cloning of the beta-subunit of the human gastric H,K-ATPase
  JOURNAL   Biochem Biophys Res Commun 180 (1), 39-45 (1991)
   PUBMED   1656976
REFERENCE   10 (bases 1 to 1500)
  AUTHORS   Maeda,M., Oshiman,K., Tamura,S. and Futai,M.
  TITLE     Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ +
            K+)-ATPase genes in exon/intron organization but difference in
            control region
  JOURNAL   J Biol Chem 265 (16), 9027-9032 (1990)
   PUBMED   2160952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA964061.1, BC029059.1,
            BI764514.1 and BX100065.1.
            
            On May 17, 2019 this sequence version replaced NM_000705.3.
            
            Summary: The protein encoded by this gene belongs to a family of
            P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a
            heterodimer consisting of a high molecular weight catalytic alpha
            subunit and a smaller but heavily glycosylated beta subunit. This
            enzyme is a proton pump that catalyzes the hydrolysis of ATP
            coupled with the exchange of H(+) and K(+) ions across the plasma
            membrane. It is also responsible for gastric acid secretion. This
            gene encodes the beta subunit of the gastric H+, K+-ATPase.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029059.1, M75110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157511 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335288.5/ ENSP00000334216.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA964061.1         1-12
            13-854              BC029059.1         1-842
            855-1034            BI764514.1         16-195
            1035-1500           BX100065.1         10-475              c
FEATURES             Location/Qualifiers
     source          1..1500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..1500
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /note="ATPase H+/K+ transporting subunit beta"
                     /db_xref="GeneID:496"
                     /db_xref="HGNC:HGNC:820"
                     /db_xref="MIM:137217"
     exon            1..166
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..930
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /note="gastric hydrogen-potassium ATPase, beta; proton
                     pump beta chain; gastric H+/K+ ATPase beta subunit;
                     potassium-transporting ATPase beta chain; ATPase, H+/K+
                     transporting, beta polypeptide; gastric H(+)/K(+) ATPase
                     subunit beta; ATPase, H+/K+ exchanging, beta polypeptide;
                     ATPase H+/K+ transporting beta subunit"
                     /codon_start=1
                     /product="potassium-transporting ATPase subunit beta"
                     /protein_id="NP_000696.1"
                     /db_xref="CCDS:CCDS9539.1"
                     /db_xref="GeneID:496"
                     /db_xref="HGNC:HGNC:820"
                     /db_xref="MIM:137217"
                     /translation="MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYY
                     VAFYVVMTGLFALCLYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSD
                     NRTWADLTQTLHAFLAGYSPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQ
                     NCSGLADPNFGFEEGKPCFIIKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKY
                     YPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPH
                     DPYEGKVEFKLKIEK"
     exon            167..295
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /inference="alignment:Splign:2.1.0"
     exon            296..409
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /inference="alignment:Splign:2.1.0"
     exon            410..609
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /inference="alignment:Splign:2.1.0"
     exon            610..666
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /inference="alignment:Splign:2.1.0"
     exon            667..768
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1500
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1412..1417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /note="hexamer: ATTAAA"
     polyA_site      1442
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /note="major polyA site"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /note="hexamer: AATAAA"
     polyA_site      1500
                     /gene="ATP4B"
                     /gene_synonym="ATP6B"
                     /note="major polyA site"
ORIGIN      
        1 agtctgggcg tagagggtgc agggagcaga cgggaggatc tcaggccagg gacgatggcg
       61 gctctgcagg agaagaagac gtgtggccag cgcatggagg agttccagcg ttactgctgg
      121 aacccggaca cggggcagat gctgggccgc accctgtccc ggtgggtgtg gatcagcctg
      181 tactacgtgg ccttctacgt ggtgatgact gggctcttcg ccctgtgcct ctatgtgctg
      241 atgcagacag tggacccgta cacaccggac taccaagacc agctacggtc accaggggta
      301 accttaaggc cggatgttta cggggagaaa ggcctggaaa ttgtctacaa cgtctctgat
      361 aacagaacct gggcagacct cacacagact ctccacgcct tcctagcagg ctactctcca
      421 gcagcccagg aggacagcat caactgcacc tccgagcagt acttcttcca ggagagtttc
      481 cgcgctccca accacaccaa gttctcctgc aagttcacgg cagatatgct gcagaactgc
      541 tcaggcctgg cggatcccaa cttcggcttt gaagaaggaa agccatgttt tattattaaa
      601 atgaacagga tcgtcaagtt cctccccagc aacggctcgg cccccagagt ggactgcgcc
      661 ttcctggacc agccccgcga gctcggccag ccgctgcagg tcaagtacta ccctcccaac
      721 ggcaccttca gtctgcacta cttcccttat tacgggaaga aagcccagcc ccactacagc
      781 aaccccctgg tggcagcgaa gctcctcaac atccccagga acgctgaggt cgccatcgtg
      841 tgcaaggtca tggcggagca cgtgaccttc aacaatcccc acgacccgta tgaagggaaa
      901 gtggagttca aactcaagat tgagaagtga aacggtttgc gcaggggtcc tgggcacgcc
      961 tgcggggtcg ctcaaggaca ccctcctggt tgggcttacc ttgcccgtca gttccctgcc
     1021 aaatcatccc caaagtggtt tggagcaacg gtgttgtcag tgtgcgaact ccagagaagc
     1081 gcccacatct gaaggacctg ctcgcgagta tcagttcttc cttgttgaat tcttacagtt
     1141 tttagatgga atttgctgct ataagaatgt ccagctacca tgggaacgca aggcagcaac
     1201 tctctaatta accaggtcat aaaaacgatt cgtcttctat gtagacatca ctttcttact
     1261 ataatttatt tttctacact tcaatatgaa ctgccccccc cacattaata taaaaactac
     1321 taatgcactg atatgaaaca cggcttacac taatgacatt ctgaattctt gcttttaaaa
     1381 ttgcaattcc taagttgtaa acataaaata tattaaagtt actcttattg tatgtaaaaa
     1441 aagaaatcgt gtttcctgat atgggagaaa ttaaataaaa accaaacgct tccttaaaaa
//
