LOCUS       NM_001378687            4994 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens ATPase secretory pathway Ca2+ transporting 1 (ATP2C1),
            transcript variant 16, mRNA.
ACCESSION   NM_001378687
VERSION     NM_001378687.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4994)
  AUTHORS   Omi,M., Takeichi,T., Ito,Y., Yoshikawa,T., Mizutani,Y., Nagai,M.,
            Seishima,M., Ogi,T., Muro,Y. and Akiyama,M.
  TITLE     Two patients with Hailey-Hailey disease with novel pathogenic
            ATP2C1 variants suggesting possible genotype/phenotype correlations
  JOURNAL   J Dermatol 51 (6), e185-e187 (2024)
   PUBMED   38111361
  REMARK    GeneRIF: Two patients with Hailey-Hailey disease with novel
            pathogenic ATP2C1 variants suggesting possible genotype/phenotype
            correlations.
REFERENCE   2  (bases 1 to 4994)
  AUTHORS   Zonfrilli,A., Truglio,F., Simeone,A., Pelullo,M., De Turris,V.,
            Benelli,D., Checquolo,S., Bellavia,D., Palermo,R., Uccelletti,D.,
            Screpanti,I., Cialfi,S. and Talora,C.
  TITLE     Loss of ATP2C1 function promotes trafficking and degradation of
            NOTCH1: Implications for Hailey-Hailey disease
  JOURNAL   Exp Dermatol 32 (6), 787-798 (2023)
   PUBMED   36789506
  REMARK    GeneRIF: Loss of ATP2C1 function promotes trafficking and
            degradation of NOTCH1: Implications for Hailey-Hailey disease.
REFERENCE   3  (bases 1 to 4994)
  AUTHORS   Steimle,B.L., Bailey,D.K., Smith,F.M., Rosenblum,S.L. and
            Kosman,D.J.
  TITLE     Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance
            of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular
            endothelial cells
  JOURNAL   J Biol Chem 298 (8), 102211 (2022)
   PUBMED   35787370
  REMARK    GeneRIF: Calcium and the Ca-ATPase SPCA1 modulate plasma membrane
            abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain
            microvascular endothelial cells.
REFERENCE   4  (bases 1 to 4994)
  AUTHORS   Miyazaki,S., Nakano,H., Mizuno,M., Ozaki,S., Hoashi,T., Kanda,N.
            and Saeki,H.
  TITLE     Two novel mutations in the ATP2C1 gene found in Japanese patients
            with Hailey-Hailey disease
  JOURNAL   J Dermatol 49 (6), 656-660 (2022)
   PUBMED   35274376
  REMARK    GeneRIF: Two novel mutations in the ATP2C1 gene found in Japanese
            patients with Hailey-Hailey disease.
REFERENCE   5  (bases 1 to 4994)
  AUTHORS   Rahman,M.S., Winsvold,B.S., Chavez Chavez,S.O., Borte,S.,
            Tsepilov,Y.A., Sharapov,S.Z., Aulchenko,Y.S., Hagen,K., Fors,E.A.,
            Hveem,K., Zwart,J.A., van Meurs,J.B., Freidin,M.B. and
            Williams,F.M.
  CONSRTM   HUNT All-In Pain
  TITLE     Genome-wide association study identifies RNF123 locus as associated
            with chronic widespread musculoskeletal pain
  JOURNAL   Ann Rheum Dis 80 (9), 1227-1235 (2021)
   PUBMED   33926923
  REMARK    GeneRIF: Genome-wide association study identifies RNF123 locus as
            associated with chronic widespread musculoskeletal pain.
REFERENCE   6  (bases 1 to 4994)
  AUTHORS   Ton,V.K., Mandal,D., Vahadji,C. and Rao,R.
  TITLE     Functional expression in yeast of the human secretory pathway
            Ca(2+), Mn(2+)-ATPase defective in Hailey-Hailey disease
  JOURNAL   J Biol Chem 277 (8), 6422-6427 (2002)
   PUBMED   11741891
REFERENCE   7  (bases 1 to 4994)
  AUTHORS   Dobson-Stone,C., Fairclough,R., Dunne,E., Brown,J., Dissanayake,M.,
            Munro,C.S., Strachan,T., Burge,S., Sudbrak,R., Monaco,A.P. and
            Hovnanian,A.
  TITLE     Hailey-Hailey disease: molecular and clinical characterization of
            novel mutations in the ATP2C1 gene
  JOURNAL   J Invest Dermatol 118 (2), 338-343 (2002)
   PUBMED   11841554
  REMARK    GeneRIF: failed to yield any clear correlation between the nature
            of the mutation and clinical features of Hailey-Hailey disease.
REFERENCE   8  (bases 1 to 4994)
  AUTHORS   Sudbrak,R., Brown,J., Dobson-Stone,C., Carter,S., Ramser,J.,
            White,J., Healy,E., Dissanayake,M., Larregue,M., Perrussel,M.,
            Lehrach,H., Munro,C.S., Strachan,T., Burge,S., Hovnanian,A. and
            Monaco,A.P.
  TITLE     Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a
            novel Ca(2+) pump
  JOURNAL   Hum Mol Genet 9 (7), 1131-1140 (2000)
   PUBMED   10767338
REFERENCE   9  (bases 1 to 4994)
  AUTHORS   Hu,Z., Bonifas,J.M., Beech,J., Bench,G., Shigihara,T., Ogawa,H.,
            Ikeda,S., Mauro,T. and Epstein,E.H. Jr.
  TITLE     Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey
            disease
  JOURNAL   Nat Genet 24 (1), 61-65 (2000)
   PUBMED   10615129
REFERENCE   10 (bases 1 to 4994)
  AUTHORS   Ikeda,S., Welsh,E.A., Peluso,A.M., Leyden,W., Duvic,M.,
            Woodley,D.T. and Epstein,E.H. Jr.
  TITLE     Localization of the gene whose mutations underlie Hailey-Hailey
            disease to chromosome 3q
  JOURNAL   Hum Mol Genet 3 (7), 1147-1150 (1994)
   PUBMED   7981684
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055733.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene belongs to the family of
            P-type cation transport ATPases. This magnesium-dependent enzyme
            catalyzes the hydrolysis of ATP coupled with the transport of
            calcium ions. Defects in this gene cause Hailey-Hailey disease, an
            autosomal dominant disorder. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2403804.1,
                                           SRR11853559.23656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000510168.6/ ENSP00000427461.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AC055733.16        149661-149914       c
            255-440             AC055733.16        149223-149408       c
            441-551             AC055733.16        113472-113582       c
            552-668             AC055733.16        111860-111976       c
            669-758             AC055733.16        109287-109376       c
            759-794             AC055733.16        106535-106570       c
            795-856             AC055733.16        103307-103368       c
            857-965             AC055733.16        102299-102407       c
            966-1121            AC055733.16        90022-90177         c
            1122-1190           AC055733.16        88918-88986         c
            1191-1266           AC055733.16        87819-87894         c
            1267-1333           AC055733.16        84657-84723         c
            1334-1458           AC055733.16        79903-80027         c
            1459-1556           AC055733.16        78953-79050         c
            1557-1652           AC055733.16        76758-76853         c
            1653-1742           AC055733.16        76579-76668         c
            1743-1847           AC055733.16        74602-74706         c
            1848-2004           AC055733.16        68510-68666         c
            2005-2175           AC055733.16        64579-64749         c
            2176-2273           AC055733.16        63319-63416         c
            2274-2324           AC055733.16        50997-51047         c
            2325-2491           AC055733.16        49900-50066         c
            2492-2560           AC055733.16        47887-47955         c
            2561-2677           AC055733.16        47202-47318         c
            2678-2825           AC055733.16        46245-46392         c
            2826-2921           AC055733.16        45609-45704         c
            2922-3063           AC055733.16        44339-44480         c
            3064-4994           AC055733.16        40848-42778         c
FEATURES             Location/Qualifiers
     source          1..4994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..4994
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /note="ATPase secretory pathway Ca2+ transporting 1"
                     /db_xref="GeneID:27032"
                     /db_xref="HGNC:HGNC:13211"
                     /db_xref="MIM:604384"
     exon            1..254
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..440
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..3194
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /EC_number="7.2.2.10"
                     /note="isoform 1a is encoded by transcript variant 16;
                     secretory pathway Ca2+/Mn2+ ATPase 1; ATPase,
                     Ca(2+)-sequestering; ATPase 2C1; HUSSY-28;
                     calcium-transporting ATPase type 2C member 1;
                     ATP-dependent Ca(2+) pump PMR1; ATPase, Ca++ transporting,
                     type 2C, member 1; Ca(2+)/Mn(2+)-ATPase 2C1; secretory
                     pathway Ca(2+)-transporting ATPase type 1"
                     /codon_start=1
                     /product="calcium-transporting ATPase type 2C member 1
                     isoform 1a"
                     /protein_id="NP_001365616.1"
                     /db_xref="CCDS:CCDS46914.1"
                     /db_xref="GeneID:27032"
                     /db_xref="HGNC:HGNC:13211"
                     /db_xref="MIM:604384"
                     /translation="MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQN
                     GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDD
                     AVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDT
                     VCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAF
                     MGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGI
                     IGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKK
                     LPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDV
                     VHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKA
                     EYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRD
                     VYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSI
                     KMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRH
                     KMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDF
                     QTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINII
                     MDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWREL
                     RDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQL
                     LVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVSSTSS
                     SFLEV"
     exon            441..551
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..668
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..758
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..794
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..856
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..965
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1121
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1190
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1266
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1333
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1458
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1556
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1652
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1742
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1847
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2004
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2175
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2273
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2324
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2491
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2560
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2677
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2825
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2921
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3063
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..4994
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3597..3602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /note="hexamer: AATAAA"
     polyA_site      3621
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /note="major polyA site"
     regulatory      3817..3822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /note="hexamer: AGTAAA"
     polyA_site      3837
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /note="major polyA site"
     regulatory      4931..4936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /note="hexamer: AATAAA"
     polyA_site      4952
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
     regulatory      4971..4976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
                     /note="hexamer: AATAAA"
     polyA_site      4994
                     /gene="ATP2C1"
                     /gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
ORIGIN      
        1 agaccagcac ggcctcgcgg agccggcccg gcggaccgtg acgggtcccc tcacctcctc
       61 ttctctcccc tccccgcccg ccctctctcc ctcccttcct ccctcccgct cgcttcttct
      121 cacgccggga gcaggctccc gcctcgcacc gctgccccgc gagcagctcc tcttctcccg
      181 aggcgcgcgg ggcgcccccg cgagccccgc ggctgagacc ccgcagcctg gaggagggct
      241 gtccggggct ttggatgctg ctgctagggg tggtgggagc agccgtggga cgcgtggccg
      301 ggagcggggg tgacagcctg ggattccggg ggcttctctt ccttgtcctc ctcctctcct
      361 ctctattccc agtgtggccg tggctgacac taaagacttt gtagccatca acccgagtgc
      421 agtttcgatg gaaaatgaag gttgcacgtt ttcaaaaaat acctaatggt gaaaatgaga
      481 caatgattcc tgtattgaca tcaaaaaaag caagtgaatt accagtcagt gaagttgcaa
      541 gcattctcca agctgatctt cagaatggtc taaacaaatg tgaagttagt cataggcgag
      601 cctttcatgg ctggaatgag tttgatatta gtgaagatga gccactgtgg aagaagtata
      661 tttctcagtt taaaaatccc cttattatgc tgcttctggc ttctgcagtc atcagtgttt
      721 taatgcatca gtttgatgat gccgtcagta tcactgtggc aatacttatc gttgttacag
      781 ttgcctttgt tcaggaatat cgttcagaaa aatctcttga agaattgagt aaacttgtgc
      841 caccagaatg ccattgtgtg cgtgaaggaa aattggagca tacacttgcc cgagacttgg
      901 ttccaggtga tacagtttgc ctttctgttg gggatagagt tcctgctgac ttacgcttgt
      961 ttgaggctgt ggatctttcc attgatgagt ccagcttgac aggtgagaca acgccttgtt
     1021 ctaaggtgac agctcctcag ccagctgcaa ctaatggaga tcttgcatcg agaagtaaca
     1081 ttgcctttat gggaacactg gtcagatgtg gcaaagcaaa gggtgttgtc attggaacag
     1141 gagaaaattc tgaatttggg gaggttttta aaatgatgca agcagaagag gcaccaaaaa
     1201 cccctctgca gaagagcatg gacctcttag gaaaacaact ttccttttac tcctttggta
     1261 taataggaat catcatgttg gttggctggt tactgggaaa agatatcctg gaaatgttta
     1321 ctattagtgt aagtttggct gtagcagcaa ttcctgaagg tctccccatt gtggtcacag
     1381 tgacgctagc tcttggtgtt atgagaatgg tgaagaaaag ggccattgtg aaaaagctgc
     1441 ctattgttga aactctgggc tgctgtaatg tgatttgttc agataaaact ggaacactga
     1501 cgaagaatga aatgactgtt actcacatat ttacttcaga tggtctgcat gctgaggtta
     1561 ctggagttgg ctataatcaa tttggggaag tgattgttga tggtgatgtt gttcatggat
     1621 tctataaccc agctgttagc agaattgttg aggcgggctg tgtgtgcaat gatgctgtaa
     1681 ttagaaacaa tactctaatg gggaagccaa cagaaggggc cttaattgct cttgcaatga
     1741 agatgggtct tgatggactt caacaagact acatcagaaa agctgaatac ccttttagct
     1801 ctgagcaaaa gtggatggct gttaagtgtg tacaccgaac acagcaggac agaccagaga
     1861 tttgttttat gaaaggtgct tacgaacaag taattaagta ctgtactaca taccagagca
     1921 aagggcagac cttgacactt actcagcagc agagagatgt gtaccaacaa gagaaggcac
     1981 gcatgggctc agcgggactc agagttcttg ctttggcttc tggtcctgaa ctgggacagc
     2041 tgacatttct tggcttggtg ggaatcattg atccacctag aactggtgtg aaagaagctg
     2101 ttacaacact cattgcctca ggagtatcaa taaaaatgat tactggagat tcacaggaga
     2161 ctgcagttgc aatcgccagt cgtctgggat tgtattccaa aacttcccag tcagtctcag
     2221 gagaagaaat agatgcaatg gatgttcagc agctttcaca aatagtacca aaggttgcag
     2281 tattttacag agctagccca aggcacaaga tgaaaattat taagtcgcta cagaagaacg
     2341 gttcagttgt agccatgaca ggagatggag taaatgatgc agttgctctg aaggctgcag
     2401 acattggagt tgcgatgggc cagactggta cagatgtttg caaagaggca gcagacatga
     2461 tcctagtgga tgatgatttt caaaccataa tgtctgcaat cgaagagggt aaagggattt
     2521 ataataacat taaaaatttc gttagattcc agctgagcac gagtatagca gcattaactt
     2581 taatctcatt ggctacatta atgaactttc ctaatcctct caatgccatg cagattttgt
     2641 ggatcaatat tattatggat ggacccccag ctcagagcct tggagtagaa ccagtggata
     2701 aagatgtcat tcgtaaacct cctcgcaact ggaaagacag cattttgact aaaaacttga
     2761 tacttaaaat acttgtttca tcaataatca ttgtttgtgg gactttgttt gtcttctggc
     2821 gtgagctacg agacaatgtg attacacctc gagacacaac aatgaccttc acatgctttg
     2881 tgttttttga catgttcaat gcactaagtt ccagatccca gaccaagtct gtgtttgaga
     2941 ttggactctg cagtaataga atgttttgct atgcagttct tggatccatc atgggacaat
     3001 tactagttat ttactttcct ccgcttcaga aggtttttca gactgagagc ctaagcatac
     3061 tggatctgtt gtttcttttg ggtctcacct catcagtgtg catagtggca gaaattataa
     3121 agaaggttga aaggagcagg gaaaagatcc agaagcatgt tagttcgaca tcatcatctt
     3181 ttcttgaagt atgatgcata ttgcattatt ttatttgcaa actaggaatt gcagtctgag
     3241 gatcatttag aagggcaagt tcaagaggat atgaagattt gagaactttt taactattca
     3301 ttgactaaaa atgaacatta atgttaaaga cttaagactt taacctgctg gcagtcccaa
     3361 atgaaattat gcaactttga tatcatattc cttgatttaa attggctttt gtgattgagt
     3421 gaaactttat aaagcatatg gtcagttatt taattaaaaa ggcaaaacct gaaccacctt
     3481 ctgcacttaa agaagtctaa cagtacaaat acactatcta tcttagatag atatattttt
     3541 ttttattttt aaatattgta ctatttatgg tggtggggct ttcttactaa tacacaaata
     3601 aatttaatca tttcaaaggc attctatttg gtttagaagt tgattcccag gagtgccata
     3661 tttcagctac tgtatttcct ttttcttgta atgtaagcag ctcagatacc atgtgctatc
     3721 atttttgtat caagtttttt gcacaggatg tgaccactgt cagatcactg ttcttttctt
     3781 tctttttgtg attgaaaagc ctatactaca atttgaagta aatttttgtt tttcttagta
     3841 agtgtaaatg gttgctttat ttttatttta aaaaggtatg tctttggttt ggcagaattc
     3901 atgcagggct atcaagtggt gttctagggt aacagtgtcc ataattaacg cttagtcata
     3961 gagtcaaaaa catttaagac tgattgggtt gaagtttata ataaattata ttaacatgtc
     4021 ttcctttttg aggtaaagat atatactttg tcaaatatca ttttgtcatc ctctaaatat
     4081 aaatccaaat acctcagcta agtaattcta ttttattatt tttactgtta tgtatgtttt
     4141 taatcatatt tcttaggaag tataggctac tggacttaga ataaaaagtc cccaaaccca
     4201 aacaaatggt ttatgaacca gagtatatgt ggaagattct ttgctggtct tgctctgtgt
     4261 gcatctgaag cttctttggc ctagatttta gcacaaacct gagtatatct cttctacttt
     4321 catcatgtgt tctgtacctt ctttttgttt cattgggcat gctagggaaa taggtggatt
     4381 ttgtgtgtaa tgccatcagt ttttatgaaa gcttgatgag gtataggtca tttgttttga
     4441 gtatgtgggc cagaaattta aaattagaaa tttgtttttc tgttgagtat ataaacaaaa
     4501 attggtccca attctaacag gtttaatcct tcttgaagcc aataagtttt atcttttata
     4561 atctgtcagg atgaaccact ccttagcttt tatccaatat taaactgcaa gtgttagcac
     4621 tgaaatattg tcattgatag ggaaaatatc tattctttga gtcattgtta ctgaggcagt
     4681 tgagtgtaag gagctggctg cagtttattc tacttaaccc tttaaggctg aattgtcaaa
     4741 tgtacattgt tccatgtcgt tagatggaac atggaagcca ttgtctaatc aactctatca
     4801 ttagtgactt gatgtctcat accttaattt tgtaatgatt tttattctct gttacaaaga
     4861 cttgaaatac gtattaaatg cacgttaatg ttttgctttg cattttaggt tcagattatg
     4921 acttgattga aataaatgtg cctatacatt catttgcttt gtactataaa aataaaaatg
     4981 atttcttaag ttaa
//
