LOCUS       XM_011533752            8963 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ATPase plasma membrane Ca2+ transporting 2
            (ATP2B2), transcript variant X6, mRNA.
ACCESSION   XM_011533752
VERSION     XM_011533752.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011533752.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..8963
                     /gene="ATP2B2"
                     /gene_synonym="DFNA82; PMCA2; PMCA2a; PMCA2i"
                     /note="ATPase plasma membrane Ca2+ transporting 2; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 5 mRNAs, 24 ESTs, 1332 long SRA reads, 11 Proteins,
                     and 99% coverage of the annotated genomic feature by
                     RNAseq alignments, including 3 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:491"
                     /db_xref="HGNC:HGNC:815"
                     /db_xref="MIM:108733"
     CDS             441..4172
                     /gene="ATP2B2"
                     /gene_synonym="DFNA82; PMCA2; PMCA2a; PMCA2i"
                     /codon_start=1
                     /product="plasma membrane calcium-transporting ATPase 2
                     isoform X1"
                     /protein_id="XP_011532054.1"
                     /db_xref="GeneID:491"
                     /db_xref="HGNC:HGNC:815"
                     /db_xref="MIM:108733"
                     /translation="MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVV
                     KIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEA
                     LQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLS
                     VICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY
                     GDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAV
                     GVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNG
                     KMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTK
                     LAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTV
                     LVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNR
                     MTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVG
                     NKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYS
                     KGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSS
                     PEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARA
                     IAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHT
                     LVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDD
                     NFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVN
                     LIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFV
                     GEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNP
                     IFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSR
                     LKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKA
                     FRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPS
                     SLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL"
ORIGIN      
        1 atacgctgca gacttctgca gtgactgtag gtgctggagc cgagcagtca gagagggtac
       61 ttgtgtccgt ggcctgaaac ccagcgggga caccgggtga ttcaccgcca tctctggcca
      121 ggagccacca cccctgacca tgtagatgcc agttccaggg agcagcatgg gccccactga
      181 atggagactc ctgggtctac agccctgagc ccctccggcc cctggacctc gtcccacacc
      241 ggaggacacc tcttggagct caccaccact gtcaccagcc cgcctcggcc acccccaccc
      301 cccgggaccc ggagtcggcc gcctggtgcc acagctgacc agtgagggtg tgctgaggac
      361 agccacaagc agccatcacc cggcagcctc ttgtccagcg ctgacccttg ggcccagccc
      421 gagcaaggac cgcagcaaac atgggtgaca tgaccaacag cgacttttac tccaaaaacc
      481 aaagaaatga gtcgagccat gggggcgagt tcgggtgcac aatggaggag ctccgctccc
      541 tcatggagct gcggggcact gaggctgtgg tcaagatcaa ggagacttat ggggacaccg
      601 aagccatctg ccggcgcctc aaaacctcac ctgttgaagg tttgccgggc accgctccag
      661 acctggaaaa gagaaagcaa atttttgggc aaaactttat acctccaaag aagccaaaaa
      721 ccttcctgca gctcgtgtgg gaggcgctgc aggacgtgac gctcatcatc ctggagattg
      781 ccgccatcat ctccctgggg ctgtccttct accacccgcc cggcgagggc aacgaaggat
      841 gtgcgacggc ccagggtggg gcagaggatg aaggagaggc agaggcaggt tggatcgagg
      901 gggccgccat tctcctctca gttatctgtg tggtcctggt cacggccttc aatgactgga
      961 gcaaagagaa acagttccgg ggcctgcaga gccgcatcga gcaggaacag aaatttaccg
     1021 tggtccgggc tggccaggtg gtccagatcc ctgtggctga gatcgtggtt ggggacatag
     1081 cccaggtcaa atatggtgac ctcctccctg ccgacggcct cttcatccag ggcaatgacc
     1141 tcaagattga tgaaagctcc ctaactggag agtctgacca ggtgcgcaag tccgtggaca
     1201 aggaccccat gctgctgtca ggaacccacg tgatggaggg ctcaggacgg atgttggtga
     1261 ctgctgtggg tgtgaactct cagactggca tcatctttac cctcctgggg gctggtggtg
     1321 aagaggaaga gaagaaagac aaaaaaggtg tgaagaaggg ggatggcctt cagctaccag
     1381 cagcagacgg tgcggcagct tcaaatgctg cagatagtgc gaatgccagc ctagtcaatg
     1441 gtaaaatgca ggatggcaat gtggacgcca gccagagcaa agccaaacaa caggacgggg
     1501 cagccgccat ggagatgcag cccctcaaga gtgccgaggg cggcgacgct gacgacagga
     1561 agaaggccag catgcacaag aaggagaagt ccgtgctgca gggcaagctc accaagctgg
     1621 ctgtgcagat cgggaaggcg ggcttggtga tgtcagccat cacggtgatc atcctggtgc
     1681 tctacttcac tgtggacacc ttcgtggtca acaagaagcc gtggctgcct gagtgcacgc
     1741 ccgtctacgt gcagtacttt gtcaagttct tcatcattgg cgtgacggtg ctggtggtcg
     1801 ccgtgcccga ggggctccct ctggccgtca ccatctcgtt ggcctattcg gtgaagaaaa
     1861 tgatgaagga caacaacctg gtacgccacc tggatgcctg tgagaccatg ggcaatgcca
     1921 cagccatctg ctcagacaag acaggcacgc tgaccaccaa tcgcatgaca gtggtacagg
     1981 cctatgtcgg cgacgtccac tataaagaga tccccgaccc cagctccatc aacaccaaga
     2041 ccatggagct gctgatcaat gccatcgcca tcaacagcgc ctacaccacc aagattctgc
     2101 ccccagagaa ggagggcgcc ctgcctcggc aggtgggcaa caagacggag tgcggcctgc
     2161 tgggcttcgt gctggacctg aagcaggact acgagcccgt gcgcagccag atgccagagg
     2221 agaagttgta caaagtgtac accttcaact ccgtgcgcaa gtccatgagc actgtcatca
     2281 agctgcccga cgagagcttc cgcatgtaca gcaagggggc ttctgagatc gtgctcaaga
     2341 agtgctgcaa aatcctcaat ggggcgggag agcctcgtgt cttccggccc cgcgaccggg
     2401 acgagatggt aaagaaggtg attgagccca tggcttgcga tgggctccgc actatctgcg
     2461 tggcctaccg cgacttcccc agcagcccgg agccggactg ggacaatgag aatgacatcc
     2521 tcaacgaact cacctgcatc tgcgtggtgg gcatcgagga cccggtgcgg ccagaggtcc
     2581 cagaagccat ccgcaagtgc cagcgggcag gcatcacggt ccgcatggtc actggcgaca
     2641 atatcaacac ggctcgggcc atcgccatca agtgtggcat catccatcct ggggaggact
     2701 ttctgtgcct cgagggcaag gagttcaaca ggaggatccg caacgagaag ggggagattg
     2761 agcaggagcg aattgacaag atctggccaa agctgcgggt gctggctcgc tcctccccaa
     2821 cggacaagca taccctggtt aaaggcatca tcgacagcac acacactgag cagcggcagg
     2881 tggtggccgt gacgggggac gggaccaacg acgggcctgc actcaagaag gccgacgtgg
     2941 gcttcgccat gggcatcgca ggcactgacg tggccaagga ggcctcagac atcatcctga
     3001 cagacgacaa tttcagcagc atcgtcaagg cagtgatgtg gggccgcaac gtctatgaca
     3061 gcatctccaa attcttgcag ttccagctca ccgtcaacgt ggtggccgtg attgtggcct
     3121 tcacaggcgc ctgcatcacg caggactccc ctctgaaggc cgtgcagatg ctctgggtga
     3181 acctcatcat ggacacgttt gcctcgctgg cactggccac tgagccgccc acggagaccc
     3241 tgctgctgag gaagccgtac ggccgcaaca agccgctcat ctccaggacc atgatgaaga
     3301 acatcctggg ccatgctgtc taccagcttg ccctcatctt caccctgctc tttgttggcg
     3361 agaagatgtt ccagatcgac agcgggagga acgcgcccct gcattcgcca ccctcagaac
     3421 attacaccat catcttcaac accttcgtca tgatgcagct cttcaacgag atcaacgccc
     3481 gcaagatcca cggcgagcgc aatgtctttg acggcatctt ccggaacccc atcttctgca
     3541 ccatcgtgct gggcaccttt gccatccaga tagtgatcgt gcagtttgga gggaagccat
     3601 tcagctgctc tccactgcag ctggaccagt ggatgtggtg catattcatt gggttaggag
     3661 agctcgtttg gggccaggtc atcgccacca tcccgaccag cagactcaag ttcctcaagg
     3721 aggcaggcag gctcacacag aaggaggaga tcccggagga ggagctcaac gaggacgtgg
     3781 aggagatcga ccacgcggag cgggagctgc ggcggggcca gatcctgtgg ttccgaggcc
     3841 tgaatcggat ccagacacag atccgcgtcg tgaaggcgtt ccgtagctct ctctatgaag
     3901 gtttagaaaa gcctgaatct cgaacctcca tccataactt catggctcat cctgaattcc
     3961 ggatcgaaga ttcccagccc cacatccccc tcattgatga caccgacctg gaagaagatg
     4021 ccgcgctcaa gcagaactcg agcccgccgt catccctcaa caagaacaac agcgccatcg
     4081 acagtgggat caacctgacg accgacacaa gcaaatcagc tacctcttca agtccaggga
     4141 gccccatcca cagcctggag acgtcgcttt agctgaggac cctctcgcct gcccgcccgc
     4201 cctcatggac cccgctgcca cccgctttcc gggcacccat ccatccaggc acccaactca
     4261 cccaagcagc aacgagcaac aatcggaaac caaatactgg agagaaaacc aacgtttcca
     4321 cccacagacc ctttctctgg ctgcgatgct gtttgaactc tttttcactt caaggcaagg
     4381 ggcgggatct ccactggggg cttacgggag tgagcggttt tcccaaaaca agcccttcct
     4441 ggctcccacc cagacatgga ccagccatgc acccgcccag ccaccacgtc ccccgcatga
     4501 atgtactgta cactttcaat cctccccttg tttggttttt gggggttggg gaggggtttt
     4561 tgtttgtttg tttgttttct taggcgggaa ctgcaaacag actcttttct gagactattt
     4621 atccaatcca ctggtctgtg agtttttgaa atgcttgcac agcatggtct cagttgtata
     4681 gattaattta ataacttttt gaaattgcag agcttaactc gcctagtaga tttgcaccaa
     4741 tggaaccgaa gaacttcata gacactcaca aggttatatc catttctttg tatctatatc
     4801 aacgtatact tttccgagac tgtatacgtc catatagata ggtagatata tatatatata
     4861 tataaatata tatacatgga tatataaagt ttctttgccg gcatgttgcc ttgtttccgc
     4921 ttaaattgct ctattttaac ttatttatgt cctaaaagaa gaatgtaatt tgtttacaaa
     4981 cctgtagata acgtctttgg ctatttgtat ggtttaagaa cactggtggc tgagatgcta
     5041 taaaaacagc tcggcccaac agacacttcc cctgggttgc atcctggatg ttttatgata
     5101 gccatgctct gatttttgcc tgctatttcc gttcaataat gtcactaccg tgagaggctc
     5161 aggcagaagc caaatgctac cgagttgcca tcctgagggg tttaacaaca tgctccgtag
     5221 acgaagggag aggaggagag aaggcttcct gggtttgcaa cactaacggc catccggccc
     5281 aaggatgcca ggatctgcaa agcactgctc gaagactttt ctctcaatga aactcgcttg
     5341 agtttactaa gagcatttca aaaataggtt ctctttggca ctgtctgtac agagattgag
     5401 gtagtgttga aatattataa atggtattgt gttgattttt ttttttattt agtaacttac
     5461 aggtttgttt ccttattaat ggcagcatct gagctgttgg catattggat gaggatcagt
     5521 atggcttgct gcttttattt ttatttttga agaagaatag cctttttctc tgcactattt
     5581 agatccgaat gaaccttatg atgtgtatat tgagatgtac tcagtgtgat tttaaaccaa
     5641 attgtcttcc tgtagtcaca atatatactg tagcctttta acagcaagtc ttgctttccc
     5701 aaacagaaag ccattctgaa accctacagt atcacaggtg agaaaaggtg gttatttttt
     5761 ccccaagaca acagcactag taatcccact taataagagc ttatttaatt ggatgtcagc
     5821 ctcttaactg ctaagcactt tgtgggtctc agcgtttttc ataaaagaac ttttgtattt
     5881 aatacaaagt ttgctttgag acttttcagc atatgatctt ttttccataa acttgtacag
     5941 tgcaaaagac attttgaata ccatgatcga tgatgtccca tgcttcgagg aaaaccaaac
     6001 actttccgcc tctcttgcaa aatccattcc tcatgctgac cctcctcacg atggctgtgt
     6061 cagcccagcc ccttcccttc tccaggccca gagaactctt ccacaaacaa gatgagagcc
     6121 actcgggaaa agagccatag tcaactggga gggcctacat ctggatggcg gtggaaaaac
     6181 ttgagggttt ggggttcaaa gtcagcccat cccacctggc aaaatcctcc tggaaggagg
     6241 accttcaaga gcgcatcacc tgaatgtcgt gaagaagtat ctctgaatgt atccaggaga
     6301 ggaactgcat aaccaaaggg gtgaccagcc ctcagatgtg cttattggat tccagtacaa
     6361 acgccaccaa agccagccca ctgctctcct acaaggaagg aaagatctgc acgtgtaaaa
     6421 catggggcag ccttggaaca tggtgttttt tggagtttcc tttctcacag ttttccatct
     6481 ccccacttct ttgatcagtc atgtgtccgt gacctcgttc catgacatca ggatagctgt
     6541 gtttgcacac catgctccat gttcattcgg agccaggagg ggttctcagt ggagcctggc
     6601 ttagggaaca gggagcgatg gaagaatgcc aacattagcg ttggtcttct cttgtcagga
     6661 atgaaggatg cttgcacaca tgcaccccct cactctcaca cttgcacaca tacacacaca
     6721 cacacacgaa atggttggtt tgtcaaaact cactgtagta cataaagctt gcactctgcg
     6781 tcctatatct agcagcatgg ggtacgtttg gcagttcact ccattagggg gtaaataatt
     6841 tatgaccatt catctgtttt tatgaatttt tttatctaga caataatgta aataaagaac
     6901 tcaccatctc tgttcattta atactatgca atggttatgc tttcaatcgc tggctcttct
     6961 gactcgtgca gtgtggttct gaaatgtttg tggtttaaaa aaaaaagcaa aaaacaacat
     7021 caaacagaac atagtaaata tatctgtaat gtatactttt ttctactttg ggactgcatc
     7081 atccacatag cttcttttct gtcctctaga caagggctcc aggagtaagt ggcagatttg
     7141 gttctgagag ctaagctcac caacttgtct ccccctcaac agatgaggga agggcaggga
     7201 gcccgttcag tgactcctgg cgctgcagaa tcactcatct ttggaggtga gcagagagag
     7261 ctctgaggag tttccttctt gcaactcagg cggagctttc tttaactcag gagcagcctc
     7321 cattgctccc gccaacccct caccatggcc ccttgtcccc ttgtcccaac catagcatag
     7381 agatgacaag agagaggcag tcctatttct gagactggac caattaaaat gactgcactg
     7441 gctcaaagga ctctgaacct gtcttgtcct gggtcctcca gttgttggaa gccactcttt
     7501 tccccaacca tgctgaaatg ccacctttac cacacactga tgtcttacat agacttagat
     7561 ctatttctgg aacttctctt ctcttcgctt acttgggtgt ctcatctggc accagccata
     7621 caattttaac tattgtcaat ttctaatgtc ttattatgtg gtgggatgag tcccttcact
     7681 cttcttttac aaaatttcct agttattctc tcacatctat tcttccacat aaactttaaa
     7741 ttgtgcccag tcctccaccc cctgtcccat tcccaccccc aaattctggg ctctgtcatt
     7801 ccctgtgcca tcatcttccc cccattgtaa ttactgtcca ctcagggctg tgaaatagac
     7861 tatgttctgt aaagagggac aaaaagggca tcctgatctt gagagaagcc tgctgttcct
     7921 cccatcattt cacctgcccc ctaagcccag gagttgtcat gagaggtcac caggccccca
     7981 ctcaatctca gcttgggaac caaagtcacc caccttggtt gtgttggggt ggacccgcca
     8041 tctgtccctg gtccagacga gaaagaggag tctctcctag gcctggagct gggaaagaat
     8101 gtgtggccca gttgtctgca cttctaattc tcatcatgga gaaaccttta ttcctatctc
     8161 cctttcctga actggttttt tgttgttttt gtttcatttt gttttggggg gatagtttct
     8221 tgctctttaa tttggagtct ccagtacctt tgggatgcag gcagttcttg cctgggcctt
     8281 ctcggaaccc tcactcccct agcccactct tgcgctacct gcaggaggct gccaacctgg
     8341 tgcattctga caagcctccc acccaaatct ctctcctgcc attgtgtcca aaatcccacc
     8401 attagaggct cttgtaggga agagcgtttc ttgaaggctt ttaggccttc cagagccagg
     8461 agggaagtca gacaatagca ggaagtcccc aggccttttc aaagttccaa accaagctct
     8521 cctgatttta atgtagagat cataccaacc caggtggggg aggagggtcc ccagccccag
     8581 gcagcagcca tcaccccctc cactgaaaac aatattggag gctgctttgg gactgccctt
     8641 ctcagccccc taagtctgtt ttgtaatgcc tgtggtgctc tccctcctgg acctttcctc
     8701 tcgggggtca ccacactttg ctaactcttg tgtgcacata ttttataata gagtagcgag
     8761 ggaatggtgc cgcctccagc ttccgtaagc tgcccgggct ctggggggct ctgggacaat
     8821 cggggctggg aagtgactgt gctcttattg tacactcttt atttctctgt atctttggct
     8881 tgtgctcttt gtaattaatg ggatttgtct gccttttcaa cactatactg agcaataaca
     8941 ataaatgcac acgtggaaat gca
//
