LOCUS       NM_001413052            6921 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens ATPase plasma membrane Ca2+ transporting 1 (ATP2B1),
            transcript variant 22, mRNA.
ACCESSION   NM_001413052
VERSION     NM_001413052.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6921)
  AUTHORS   Kobayashi,Y., Yatsu,K., Haruna,A., Kawano,R., Ozawa,M., Haze,T.,
            Komiya,S., Suzuki,S., Ohki,Y., Fujiwara,A., Saka,S., Hirawa,N.,
            Toya,Y. and Tamura,K.
  TITLE     ATP2B1 gene polymorphisms associated with resistant hypertension in
            the Japanese population
  JOURNAL   J Clin Hypertens (Greenwich) 26 (4), 355-362 (2024)
   PUBMED   38430457
  REMARK    GeneRIF: ATP2B1 gene polymorphisms associated with resistant
            hypertension in the Japanese population.
REFERENCE   2  (bases 1 to 6921)
  AUTHORS   Gao,Y., Liu,Y., Jiang,Y., Qin,M., Guan,Z., Gao,Y. and Yang,Y.
  TITLE     Association between polymorphism and haplotype of ATP2B1 gene and
            skeletal fluorosis in Han population
  JOURNAL   Int J Environ Health Res 34 (3), 1410-1420 (2024)
   PUBMED   37211801
  REMARK    GeneRIF: Association between polymorphism and haplotype of ATP2B1
            gene and skeletal fluorosis in Han population.
REFERENCE   3  (bases 1 to 6921)
  AUTHORS   Berrocal,M. and Mata,A.M.
  TITLE     The Plasma Membrane Ca2+-ATPase, a Molecular Target for Tau-induced
            Cytosolic Calcium Dysregulation
  JOURNAL   Neuroscience 518, 112-118 (2023)
   PUBMED   35469971
  REMARK    GeneRIF: The Plasma Membrane Ca[2+]-ATPase, a Molecular Target for
            Tau-induced Cytosolic Calcium Dysregulation.
            Review article
REFERENCE   4  (bases 1 to 6921)
  AUTHORS   Yang,X., Lu,L., Wu,C. and Zhang,F.
  TITLE     ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and
            inflammation by regulating miR-23a-3p/TLR4 axis
  JOURNAL   Allergol Immunopathol (Madr) 51 (2), 17-26 (2023)
   PUBMED   36916084
  REMARK    GeneRIF: ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and
            inflammation by regulating miR-23a-3p/TLR4 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6921)
  AUTHORS   Rahimi,M.J., Urban,N., Wegler,M., Sticht,H., Schaefer,M., Popp,B.,
            Gaunitz,F., Morleo,M., Nigro,V., Maitz,S., Mancini,G.M.S.,
            Ruivenkamp,C., Suk,E.K., Bartolomaeus,T., Merkenschlager,A.,
            Koboldt,D., Bartholomew,D., Stegmann,A.P.A., Sinnema,M.,
            Duynisveld,I., Salvarinova,R., Race,S., de Vries,B.B.A.,
            Trimouille,A., Naudion,S., Marom,D., Hamiel,U., Henig,N.,
            Demurger,F., Rahner,N., Bartels,E., Hamm,J.A., Putnam,A.M.,
            Person,R., Abou Jamra,R. and Oppermann,H.
  TITLE     De novo variants in ATP2B1 lead to neurodevelopmental delay
  JOURNAL   Am J Hum Genet 109 (5), 944-952 (2022)
   PUBMED   35358416
  REMARK    GeneRIF: De novo variants in ATP2B1 lead to neurodevelopmental
            delay.
REFERENCE   6  (bases 1 to 6921)
  AUTHORS   Kessler,F., Falchetto,R., Heim,R., Meili,R., Vorherr,T.,
            Strehler,E.E. and Carafoli,E.
  TITLE     Study of calmodulin binding to the alternatively spliced C-terminal
            domain of the plasma membrane Ca2+ pump
  JOURNAL   Biochemistry 31 (47), 11785-11792 (1992)
   PUBMED   1332771
REFERENCE   7  (bases 1 to 6921)
  AUTHORS   Wang,K.K., Wright,L.C., Machan,C.L., Allen,B.G., Conigrave,A.D. and
            Roufogalis,B.D.
  TITLE     Protein kinase C phosphorylates the carboxyl terminus of the plasma
            membrane Ca(2+)-ATPase from human erythrocytes
  JOURNAL   J Biol Chem 266 (14), 9078-9085 (1991)
   PUBMED   1827443
REFERENCE   8  (bases 1 to 6921)
  AUTHORS   Olson,S., Wang,M.G., Carafoli,E., Strehler,E.E. and McBride,O.W.
  TITLE     Localization of two genes encoding plasma membrane
            Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and
            12q21-23
  JOURNAL   Genomics 9 (4), 629-641 (1991)
   PUBMED   1674727
REFERENCE   9  (bases 1 to 6921)
  AUTHORS   Strehler,E.E., Strehler-Page,M.A., Vogel,G. and Carafoli,E.
  TITLE     mRNAs for plasma membrane calcium pump isoforms differing in their
            regulatory domain are generated by alternative splicing that
            involves two internal donor sites in a single exon
  JOURNAL   Proc Natl Acad Sci U S A 86 (18), 6908-6912 (1989)
   PUBMED   2528729
REFERENCE   10 (bases 1 to 6921)
  AUTHORS   James,P.H., Pruschy,M., Vorherr,T.E., Penniston,J.T. and
            Carafoli,E.
  TITLE     Primary structure of the cAMP-dependent phosphorylation site of the
            plasma membrane calcium pump
  JOURNAL   Biochemistry 28 (10), 4253-4258 (1989)
   PUBMED   2548572
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009522.11, AC068641.18 and
            AC025034.22.
            
            Summary: The protein encoded by this gene belongs to the family of
            P-type primary ion transport ATPases characterized by the formation
            of an aspartyl phosphate intermediate during the reaction cycle.
            These enzymes remove bivalent calcium ions from eukaryotic cells
            against very large concentration gradients and play a critical role
            in intracellular calcium homeostasis. The mammalian plasma membrane
            calcium ATPase isoforms are encoded by at least four separate genes
            and the diversity of these enzymes is further increased by
            alternative splicing of transcripts. The expression of different
            isoforms and splice variants is regulated in a developmental,
            tissue- and cell type-specific manner, suggesting that these pumps
            are functionally adapted to the physiological needs of particular
            cells and tissues. This gene encodes the plasma membrane calcium
            ATPase isoform 1. Alternatively spliced transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.3529318.1,
                                           SRR14038194.1166715.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AC009522.11        113414-113656
            244-672             AC068641.18        39483-39911
            673-870             AC068641.18        53235-53432
            871-1125            AC068641.18        60339-60593
            1126-1251           AC068641.18        60687-60812
            1252-1290           AC068641.18        67874-67912
            1291-1452           AC068641.18        68975-69136
            1453-1667           AC068641.18        71193-71407
            1668-1910           AC068641.18        73799-74041
            1911-2152           AC068641.18        75350-75591
            2153-2390           AC068641.18        78551-78788
            2391-2570           AC068641.18        84218-84397
            2571-2658           AC068641.18        85082-85169
            2659-2765           AC068641.18        85547-85653
            2766-2957           AC068641.18        91244-91435
            2958-3171           AC068641.18        91665-91878
            3172-3383           AC068641.18        92336-92547
            3384-3491           AC068641.18        94157-94264
            3492-3674           AC068641.18        96291-96473
            3675-3901           AC068641.18        104295-104521
            3902-6921           AC025034.22        1-3020
FEATURES             Location/Qualifiers
     source          1..6921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.33"
     gene            1..6921
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="ATPase plasma membrane Ca2+ transporting 1"
                     /db_xref="GeneID:490"
                     /db_xref="HGNC:HGNC:814"
                     /db_xref="MIM:108731"
     exon            1..243
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            244..672
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..3986
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /EC_number="7.2.2.10"
                     /note="isoform 10 is encoded by transcript variant 22;
                     plasma membrane calcium pump; ATPase, Ca++ transporting,
                     plasma membrane 1; plasma membrane calcium-transporting
                     ATPase 1"
                     /codon_start=1
                     /product="plasma membrane calcium-transporting ATPase 1
                     isoform 10"
                     /protein_id="NP_001399981.1"
                     /db_xref="GeneID:490"
                     /db_xref="HGNC:HGNC:814"
                     /db_xref="MIM:108731"
                     /translation="MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTD
                     ALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLV
                     WEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAIL
                     LSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQV
                     KYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSDKKQDGAIENRNKA
                     KAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMS
                     AITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAV
                     TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHY
                     KKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGLLLD
                     LKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFK
                     ILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIV
                     TGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGE
                     DFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSD
                     QRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWG
                     RNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALA
                     TEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRN
                     APLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVV
                     QIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQ
                     KEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKP
                     ESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSG
                     IHLTIEMNKSATSSSPGSPLHSLETSL"
     exon            673..870
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1125
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1251
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1290
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1452
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1667
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1910
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2152
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2390
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2570
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2658
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2765
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2957
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3171
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3383
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3491
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3674
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..6921
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5140..5145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="hexamer: AATAAA"
     polyA_site      5166
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="major polyA site"
     regulatory      6893..6898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="hexamer: AATAAA"
     regulatory      6897..6902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="hexamer: AATATA"
     polyA_site      6915
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
     polyA_site      6921
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcagc gtgagtaggg agccccggct ggtggacgcc gagcctctcg gctccttggc
       61 cgccccatcc ccgaggtgca gctgcacctc cgcgtggcgc cccgagccct gcgagccggc
      121 tgcggacgcg ctgaggacgg agcccccatc ctctgcgttt cccgctgccc cttaacgccc
      181 cgcgaccctc ccgcagcctg cctttccttc cccctcggaa aatggttccc actgccgggc
      241 gagatgtgta tatctcatga ttgatatgga gaaactagtc atgggccaaa ggtcaagata
      301 cttctctggg aaatgttgct gctgatgctg ctttacaaag tcatacaatg agtgtttggt
      361 ttaagaaaga ttttcatact taaaagattt tcatcttgga aatacatcaa gtgaaaatta
      421 aattcttttg ggaaacattt tccttctgat atattatact tgtaatgggc gacatggcaa
      481 acaactcagt tgcttacagt ggtgtgaaaa actctttgaa ggaagctaat catgatggag
      541 actttggaat tacgctcgca gagctgcggg ctctcatgga gctcaggtcc acagatgcat
      601 tacgaaaaat acaggaaagc tatggagatg tctatggaat ttgcaccaaa ttgaaaacat
      661 ctcccaatga aggtttaagt ggaaaccctg cagatttaga aagaagagaa gcagtgtttg
      721 gaaagaattt tatacctcct aaaaagccaa aaacctttct tcaattagta tgggaagcat
      781 tacaagatgt cactttaatt atattagaaa ttgcagccat agtatcattg ggcctttctt
      841 tttatcagcc tccagaaggg gataatgcac tttgtggaga agtttctgtt ggggaggaag
      901 aaggtgaagg tgaaactggt tggattgaag gagctgcaat cctcttgtct gtagtgtgtg
      961 tggtgttagt aacagctttc aatgactgga gtaaggaaaa acagtttaga ggtttgcaga
     1021 gccgaattga acaagaacag aagttcactg tcatcagggg tggtcaggtc attcagatac
     1081 ctgtagctga cattactgtt ggagatattg ctcaagtgaa atatggtgat cttcttccag
     1141 ctgacggcat acttattcaa ggcaacgatc ttaaaattga tgaaagctca ttgactggtg
     1201 aatcagatca tgttaaaaag tctttagata aggatccctt acttctatca gataagaaac
     1261 aagatggagc tattgagaat cgcaacaaag caaaagccca ggatggtgca gccatggaaa
     1321 tgcagccatt gaagagtgaa gaaggtggag atggtgatga aaaagataaa aagaaagcaa
     1381 atttgccaaa aaaggaaaaa tctgttttac aagggaaact tacaaaactg gctgttcaga
     1441 ttggcaaagc aggtctgttg atgtctgcca tcacagttat cattctagta ttatattttg
     1501 tcattgacac cttctgggtt cagaaaagac catggcttgc tgagtgcaca ccaatttata
     1561 tacaatactt tgtgaagttc ttcattattg gagttacagt tttagtggtc gcagtgccag
     1621 aaggtcttcc acttgcagtc acgatctcac tggcttattc agtcaaaaaa atgatgaaag
     1681 ataataactt agtaaggcat ctggatgctt gtgaaaccat gggaaatgct acagctattt
     1741 gttcagataa aacaggaact ttgacaatga acagaatgac agtcgttcaa gcttacataa
     1801 atgaaaaaca ttataaaaag gttcctgaac cagaagctat tccaccaaat attttgtcct
     1861 atcttgtaac aggaatttct gtgaattgtg cttatacatc aaaaatattg ccaccagaga
     1921 aagagggtgg attacctcgt cacgttggta ataaaactga atgtgccttg ttgggacttc
     1981 ttttggattt aaaacgggat tatcaggatg ttagaaatga aataccagaa gaagcactgt
     2041 acaaagtcta caccttcaat tctgttagga agtccatgag tactgtcctg aaaaattcag
     2101 atggaagtta tcgaatattc agcaagggtg catctgagat aattctgaaa aagtgtttca
     2161 aaatcttgag tgctaatggt gaggcaaaag tattcagacc aagggaccgt gatgatattg
     2221 taaaaactgt gattgaaccg atggcatcag aaggcttgag aaccatatgt cttgcattca
     2281 gagattttcc agcaggagaa ccagaaccag agtgggataa tgaaaatgat attgtcaccg
     2341 gccttacatg cattgctgtt gtggggattg aagatcctgt gagacctgag gtgccagatg
     2401 caattaaaaa gtgtcagagg gctggaatta ctgtgcggat ggtcactggt gataatatta
     2461 atactgctcg ggccattgct accaaatgtg gtattttaca tcctggggaa gattttctgt
     2521 gcctagaagg taaagatttt aacagaagaa tacgaaatga aaaaggagag attgagcaag
     2581 agaggataga caagatttgg ccaaaacttc gagtacttgc aagatcatct cctactgata
     2641 agcatacact ggttaaaggt ataattgaca gcactgtctc agaccaacgc caggttgtag
     2701 ctgtaactgg tgatggtaca aatgatggcc cagcactaaa gaaagcagat gttggatttg
     2761 caatgggtat tgctggaact gatgtagcta aagaagcatc cgatattatt ctcacagatg
     2821 acaactttac aagcattgtt aaagcagtta tgtggggacg aaatgtctat gacagcatct
     2881 caaaattcct tcagttccaa cttactgtta atgtagtagc agtgattgtt gcttttacgg
     2941 gcgcctgcat tactcaagac tcaccgctta aggctgtgca gatgctgtgg gtaaacctca
     3001 taatggatac actcgcttcc ctggctctgg caacggaacc acccactgag tctctcttgc
     3061 ttcggaaacc ttatggtaga aataagcctc tcatctcacg tacaatgatg aagaatattt
     3121 tgggtcatgc attctatcaa cttgtagtag tctttacact cttatttgct ggagaaaagt
     3181 tttttgacat tgatagtgga agaaatgctc ctttgcatgc tcctccttca gaacattata
     3241 ctattgtttt taataccttt gtgctgatgc aacttttcaa cgaaataaat gcccggaaaa
     3301 ttcatggtga aagaaatgta ttcgaaggaa tctttaacaa tgccatcttc tgcacaattg
     3361 ttttaggcac ttttgtggta cagataataa ttgtgcagtt tggtggaaaa cctttcagtt
     3421 gttcagaact ttcaatagaa cagtggctat ggtcaatatt cctaggaatg ggaacattac
     3481 tctggggcca gcttatttca acaattccaa ctagccgttt aaaattcctc aaagaagctg
     3541 gtcatggaac acaaaaggaa gaaatacctg aggaggaatt agcagaggat gttgaagaga
     3601 ttgatcacgc tgaaagggag ttgcggcgtg gccaaatctt gtggtttaga ggtctgaaca
     3661 gaatccaaac acagattcga gtggtgaatg catttcgtag ttctttatat gaagggttag
     3721 aaaaaccgga atcaagaagt tcgattcaca actttatgac acatcctgag tttaggatag
     3781 aagattcaga gcctcatatc ccccttattg atgacactga tgccgaagat gatgctccta
     3841 caaaacgtaa ctccagtcct ccaccctctc ccaacaaaaa taacaatgct gttgacagtg
     3901 gaattcacct tacaatagaa atgaacaagt ctgctacctc ttcatcccca ggaagcccac
     3961 tacatagttt ggaaacatca ctctgattgt aagctgaatg ttaacacact agctgcattg
     4021 taaagaaaca aattgaaact gggtcttttc acatattgtg atggacaagc tagtattctt
     4081 gtctttggac ttcaacagaa gacacacttg tacgaatgta gatttatttt tttaaaaaaa
     4141 aaaaagcaaa gctttctgcc agactgaggg tgctttttgg ggggtgggag aaatgaactg
     4201 acagataaac agtaactcag cgtaagtgac ctgtggatca tcagtagtac ccaagcatgg
     4261 tcctgaacag tgtattagca gagctttagt ttatctcagt cctggatggg agagagaggg
     4321 aggagtaaaa ctgggcaaga caaagagccc tggatcgttg aattgatagt ttaatttctg
     4381 ctgttggctg ttaataattt ggattattta tgtttataaa tgatacagat ctgtttacaa
     4441 ggtttgtaga tacttttttt gttcctgttc atagatggga agcttcctta taactgatgc
     4501 agagaaaaat tagtccttca aatactgctg tattttcagg aaaaaaaaaa aaaggggtgt
     4561 ttctattgaa actgtactaa atttttgcct acaatttacc ttgttaaata ttgtagataa
     4621 attgctaata ctaatagcca aatagataac actaatgctt tgtttaaaaa aacgaaaaaa
     4681 acaaaacaaa acaaaaaaac atgagcagtg gtgttctaat gaagttatga catctgtcct
     4741 aattagtttc ttaaatacat ttactactta atggttttga agcaactgtt taatttttaa
     4801 aatttttgaa aacttgctaa taaccttttg ttcagaattt agtagattgt ttaatgcagg
     4861 acatcaacta cataatgaaa gatgcttgaa atgcttttgt tatttcaggc aaatcaaatt
     4921 aaatcagact atcaaactac aagagaacct tagtcttttt tgtttttgtc taaacatgtt
     4981 agtttagtga tgtcttggtg aactgtgagt gaactgtatt gatttttcta atctttagag
     5041 accttcacac agcatgaggg ctgttggcat tttgaaaaag gttaataagt agaagcatac
     5101 atgttttcct tttgtttttg aaacttgttt gtaaacataa ataaatatgc ccttttatta
     5161 aataaattca tggcaatgtt tttttaaaag acatttcagc ttctttactc agttctgcat
     5221 atacagtgca tcagtctgtt ctctttgacc acaattggaa tacatttcaa gatggtaaca
     5281 gccccatgaa gtaccgcttt aattccttgc tggtaatcta atagaatcag attaagaaaa
     5341 ttaacacaat tttaccattt gacatactct tcattgaatt tagtttgtct aaaatagtct
     5401 cacaggtaaa aaacataaca acaatgacca ccattgtctt tgatacattt attttaattc
     5461 ttaagtggcc aaataacaga ttaggtaaaa tgagattaca tgaaaaggtt ctaaaatgat
     5521 atatttagat gcaataatta accatatgct agaatgccca cctctaagcc aattggattc
     5581 tttagctctc tttttctttc cttcatctac cttcttctct tttttgcctc tgtctttacc
     5641 ctttagaaac tggcatgtgt tagggcccag atttcaccag atacacaatc ctcaggctga
     5701 cataaagttt acgaggactg ctactataac tgagagtgct gaccaagcaa agaaacattt
     5761 agttgatggt gcttgatatt tttggtgggt gggggaaatc tttttctcac catcaaatct
     5821 ttgcagtaat cctctgcagg tcttagaaac acattggctc tgtcagcatt tgtaattgta
     5881 catttattca tcaggtattt atagtgaatc atactgtaaa aaagaggtag catgatatgc
     5941 tggaaagcat attagactag gagtcaagac ctggtttcta gtcttggttt tgccattaat
     6001 gtgctgcatg atcttgggaa aatcatttac cctaaataag ggtggtggac tatcttgaag
     6061 aaccctttca actctaaaaa ttgaccctat caactggaga gcccacaagg catagggaat
     6121 agagaaaagg gaaatgtttt cagttttctt ttttattttg gttatgctta aatatgaatg
     6181 taattaccaa aagatttaga agtgcatgtg ctttggagga tttgtattga gcttttacag
     6241 tattcatttt tcaactcaag gcaatggctt tctacaccaa ctctaatcca taaacgggtc
     6301 ttatgacatc tatgaagtag tagcaagaca tgcttagtgt gtatttctct ctttgagaca
     6361 ctgtaatttc taccagaaat ttccagagca ttatgtaggt agaaaaaaat gcaagcaagc
     6421 tgttaaagat cttggatccc attatatagt atgtatagct gaaatctgta attcaatcac
     6481 tttttctctt ttatcctcta accaaaaaat tgtttaattt tgcatcccaa atgtttttaa
     6541 tctttgtata ttttttaaaa atccttttct cctcatcatt gccttttttg tggttgtaaa
     6601 tagacttact tgcactttga agatgagtta ctccttgtca tcttacaaat atgtgatatg
     6661 gtaattttca taacagatgt cagttttgaa ccaagaattg gtgatttgtt tataagaaaa
     6721 aaactggctt catttctgtg aaattgctct ttgaaaattt ctttttacac gtgtaagcca
     6781 actgagatac cgtgatggtg ttgatttctt tcaatgatgc ttaccatcta ttttagccac
     6841 tgagcctttt attatttgtc tatttgtaaa gtttatttgt cttaactcat ttaataaata
     6901 tactgtttat ctgtttctga a
//
