LOCUS       NM_001366521            7062 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens ATPase plasma membrane Ca2+ transporting 1 (ATP2B1),
            transcript variant 4, mRNA.
ACCESSION   NM_001366521 XM_024448990
VERSION     NM_001366521.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7062)
  AUTHORS   Kobayashi,Y., Yatsu,K., Haruna,A., Kawano,R., Ozawa,M., Haze,T.,
            Komiya,S., Suzuki,S., Ohki,Y., Fujiwara,A., Saka,S., Hirawa,N.,
            Toya,Y. and Tamura,K.
  TITLE     ATP2B1 gene polymorphisms associated with resistant hypertension in
            the Japanese population
  JOURNAL   J Clin Hypertens (Greenwich) 26 (4), 355-362 (2024)
   PUBMED   38430457
  REMARK    GeneRIF: ATP2B1 gene polymorphisms associated with resistant
            hypertension in the Japanese population.
REFERENCE   2  (bases 1 to 7062)
  AUTHORS   Gao,Y., Liu,Y., Jiang,Y., Qin,M., Guan,Z., Gao,Y. and Yang,Y.
  TITLE     Association between polymorphism and haplotype of ATP2B1 gene and
            skeletal fluorosis in Han population
  JOURNAL   Int J Environ Health Res 34 (3), 1410-1420 (2024)
   PUBMED   37211801
  REMARK    GeneRIF: Association between polymorphism and haplotype of ATP2B1
            gene and skeletal fluorosis in Han population.
REFERENCE   3  (bases 1 to 7062)
  AUTHORS   Berrocal,M. and Mata,A.M.
  TITLE     The Plasma Membrane Ca2+-ATPase, a Molecular Target for Tau-induced
            Cytosolic Calcium Dysregulation
  JOURNAL   Neuroscience 518, 112-118 (2023)
   PUBMED   35469971
  REMARK    GeneRIF: The Plasma Membrane Ca[2+]-ATPase, a Molecular Target for
            Tau-induced Cytosolic Calcium Dysregulation.
            Review article
REFERENCE   4  (bases 1 to 7062)
  AUTHORS   Yang,X., Lu,L., Wu,C. and Zhang,F.
  TITLE     ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and
            inflammation by regulating miR-23a-3p/TLR4 axis
  JOURNAL   Allergol Immunopathol (Madr) 51 (2), 17-26 (2023)
   PUBMED   36916084
  REMARK    GeneRIF: ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and
            inflammation by regulating miR-23a-3p/TLR4 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7062)
  AUTHORS   Rahimi,M.J., Urban,N., Wegler,M., Sticht,H., Schaefer,M., Popp,B.,
            Gaunitz,F., Morleo,M., Nigro,V., Maitz,S., Mancini,G.M.S.,
            Ruivenkamp,C., Suk,E.K., Bartolomaeus,T., Merkenschlager,A.,
            Koboldt,D., Bartholomew,D., Stegmann,A.P.A., Sinnema,M.,
            Duynisveld,I., Salvarinova,R., Race,S., de Vries,B.B.A.,
            Trimouille,A., Naudion,S., Marom,D., Hamiel,U., Henig,N.,
            Demurger,F., Rahner,N., Bartels,E., Hamm,J.A., Putnam,A.M.,
            Person,R., Abou Jamra,R. and Oppermann,H.
  TITLE     De novo variants in ATP2B1 lead to neurodevelopmental delay
  JOURNAL   Am J Hum Genet 109 (5), 944-952 (2022)
   PUBMED   35358416
  REMARK    GeneRIF: De novo variants in ATP2B1 lead to neurodevelopmental
            delay.
REFERENCE   6  (bases 1 to 7062)
  AUTHORS   Kessler,F., Falchetto,R., Heim,R., Meili,R., Vorherr,T.,
            Strehler,E.E. and Carafoli,E.
  TITLE     Study of calmodulin binding to the alternatively spliced C-terminal
            domain of the plasma membrane Ca2+ pump
  JOURNAL   Biochemistry 31 (47), 11785-11792 (1992)
   PUBMED   1332771
REFERENCE   7  (bases 1 to 7062)
  AUTHORS   Wang,K.K., Wright,L.C., Machan,C.L., Allen,B.G., Conigrave,A.D. and
            Roufogalis,B.D.
  TITLE     Protein kinase C phosphorylates the carboxyl terminus of the plasma
            membrane Ca(2+)-ATPase from human erythrocytes
  JOURNAL   J Biol Chem 266 (14), 9078-9085 (1991)
   PUBMED   1827443
REFERENCE   8  (bases 1 to 7062)
  AUTHORS   Olson,S., Wang,M.G., Carafoli,E., Strehler,E.E. and McBride,O.W.
  TITLE     Localization of two genes encoding plasma membrane
            Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and
            12q21-23
  JOURNAL   Genomics 9 (4), 629-641 (1991)
   PUBMED   1674727
REFERENCE   9  (bases 1 to 7062)
  AUTHORS   Strehler,E.E., Strehler-Page,M.A., Vogel,G. and Carafoli,E.
  TITLE     mRNAs for plasma membrane calcium pump isoforms differing in their
            regulatory domain are generated by alternative splicing that
            involves two internal donor sites in a single exon
  JOURNAL   Proc Natl Acad Sci U S A 86 (18), 6908-6912 (1989)
   PUBMED   2528729
REFERENCE   10 (bases 1 to 7062)
  AUTHORS   James,P.H., Pruschy,M., Vorherr,T.E., Penniston,J.T. and
            Carafoli,E.
  TITLE     Primary structure of the cAMP-dependent phosphorylation site of the
            plasma membrane calcium pump
  JOURNAL   Biochemistry 28 (10), 4253-4258 (1989)
   PUBMED   2548572
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009522.11, AC068641.18 and
            AC025034.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 10, 2018 this sequence version replaced XM_024448990.1.
            
            Summary: The protein encoded by this gene belongs to the family of
            P-type primary ion transport ATPases characterized by the formation
            of an aspartyl phosphate intermediate during the reaction cycle.
            These enzymes remove bivalent calcium ions from eukaryotic cells
            against very large concentration gradients and play a critical role
            in intracellular calcium homeostasis. The mammalian plasma membrane
            calcium ATPase isoforms are encoded by at least four separate genes
            and the diversity of these enzymes is further increased by
            alternative splicing of transcripts. The expression of different
            isoforms and splice variants is regulated in a developmental,
            tissue- and cell type-specific manner, suggesting that these pumps
            are functionally adapted to the physiological needs of particular
            cells and tissues. This gene encodes the plasma membrane calcium
            ATPase isoform 1. Alternatively spliced transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4), as well as variants 2, 3, 5,
            16, and 17, encodes isoform 1b.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.7604.1,
                                           SRR14038195.1384828.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428670.8/ ENSP00000392043.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AC009522.11        113414-113656
            244-672             AC068641.18        39483-39911
            673-870             AC068641.18        53235-53432
            871-1125            AC068641.18        60339-60593
            1126-1251           AC068641.18        60687-60812
            1252-1392           AC068641.18        64945-65085
            1393-1431           AC068641.18        67874-67912
            1432-1593           AC068641.18        68975-69136
            1594-1808           AC068641.18        71193-71407
            1809-2051           AC068641.18        73799-74041
            2052-2293           AC068641.18        75350-75591
            2294-2531           AC068641.18        78551-78788
            2532-2711           AC068641.18        84218-84397
            2712-2799           AC068641.18        85082-85169
            2800-2906           AC068641.18        85547-85653
            2907-3098           AC068641.18        91244-91435
            3099-3312           AC068641.18        91665-91878
            3313-3524           AC068641.18        92336-92547
            3525-3632           AC068641.18        94157-94264
            3633-3815           AC068641.18        96291-96473
            3816-4042           AC068641.18        104295-104521
            4043-7062           AC025034.22        1-3020
FEATURES             Location/Qualifiers
     source          1..7062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.33"
     gene            1..7062
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="ATPase plasma membrane Ca2+ transporting 1"
                     /db_xref="GeneID:490"
                     /db_xref="HGNC:HGNC:814"
                     /db_xref="MIM:108731"
     exon            1..243
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            244..672
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            673..870
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1125
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1251
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1392
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1431
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1593
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1808
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..2051
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2293
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2531
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2711
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2799
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2906
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3098
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3312
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3524
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3632
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3815
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..7062
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5281..5286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="hexamer: AATAAA"
     polyA_site      5307
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="major polyA site"
     regulatory      7034..7039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="hexamer: AATAAA"
     regulatory      7038..7043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="hexamer: AATATA"
     polyA_site      7056
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
     polyA_site      7062
                     /gene="ATP2B1"
                     /gene_synonym="MRD66; PMCA1; PMCA1kb"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcagc gtgagtaggg agccccggct ggtggacgcc gagcctctcg gctccttggc
       61 cgccccatcc ccgaggtgca gctgcacctc cgcgtggcgc cccgagccct gcgagccggc
      121 tgcggacgcg ctgaggacgg agcccccatc ctctgcgttt cccgctgccc cttaacgccc
      181 cgcgaccctc ccgcagcctg cctttccttc cccctcggaa aatggttccc actgccgggc
      241 gagatgtgta tatctcatga ttgatatgga gaaactagtc atgggccaaa ggtcaagata
      301 cttctctggg aaatgttgct gctgatgctg ctttacaaag tcatacaatg agtgtttggt
      361 ttaagaaaga ttttcatact taaaagattt tcatcttgga aatacatcaa gtgaaaatta
      421 aattcttttg ggaaacattt tccttctgat atattatact tgtaatgggc gacatggcaa
      481 acaactcagt tgcttacagt ggtgtgaaaa actctttgaa ggaagctaat catgatggag
      541 actttggaat tacgctcgca gagctgcggg ctctcatgga gctcaggtcc acagatgcat
      601 tacgaaaaat acaggaaagc tatggagatg tctatggaat ttgcaccaaa ttgaaaacat
      661 ctcccaatga aggtttaagt ggaaaccctg cagatttaga aagaagagaa gcagtgtttg
      721 gaaagaattt tatacctcct aaaaagccaa aaacctttct tcaattagta tgggaagcat
      781 tacaagatgt cactttaatt atattagaaa ttgcagccat agtatcattg ggcctttctt
      841 tttatcagcc tccagaaggg gataatgcac tttgtggaga agtttctgtt ggggaggaag
      901 aaggtgaagg tgaaactggt tggattgaag gagctgcaat cctcttgtct gtagtgtgtg
      961 tggtgttagt aacagctttc aatgactgga gtaaggaaaa acagtttaga ggtttgcaga
     1021 gccgaattga acaagaacag aagttcactg tcatcagggg tggtcaggtc attcagatac
     1081 ctgtagctga cattactgtt ggagatattg ctcaagtgaa atatggtgat cttcttccag
     1141 ctgacggcat acttattcaa ggcaacgatc ttaaaattga tgaaagctca ttgactggtg
     1201 aatcagatca tgttaaaaag tctttagata aggatccctt acttctatca ggtactcatg
     1261 taatggaagg ctctggaaga atggtagtta cagctgtagg tgtaaattct caaactggaa
     1321 ttatctttac cttacttgga gctggaggtg aagaggaaga gaagaaagat gagaagaaaa
     1381 aggaaaagaa aaataagaaa caagatggag ctattgagaa tcgcaacaaa gcaaaagccc
     1441 aggatggtgc agccatggaa atgcagccat tgaagagtga agaaggtgga gatggtgatg
     1501 aaaaagataa aaagaaagca aatttgccaa aaaaggaaaa atctgtttta caagggaaac
     1561 ttacaaaact ggctgttcag attggcaaag caggtctgtt gatgtctgcc atcacagtta
     1621 tcattctagt attatatttt gtcattgaca ccttctgggt tcagaaaaga ccatggcttg
     1681 ctgagtgcac accaatttat atacaatact ttgtgaagtt cttcattatt ggagttacag
     1741 ttttagtggt cgcagtgcca gaaggtcttc cacttgcagt cacgatctca ctggcttatt
     1801 cagtcaaaaa aatgatgaaa gataataact tagtaaggca tctggatgct tgtgaaacca
     1861 tgggaaatgc tacagctatt tgttcagata aaacaggaac tttgacaatg aacagaatga
     1921 cagtcgttca agcttacata aatgaaaaac attataaaaa ggttcctgaa ccagaagcta
     1981 ttccaccaaa tattttgtcc tatcttgtaa caggaatttc tgtgaattgt gcttatacat
     2041 caaaaatatt gccaccagag aaagagggtg gattacctcg tcacgttggt aataaaactg
     2101 aatgtgcctt gttgggactt cttttggatt taaaacggga ttatcaggat gttagaaatg
     2161 aaataccaga agaagcactg tacaaagtct acaccttcaa ttctgttagg aagtccatga
     2221 gtactgtcct gaaaaattca gatggaagtt atcgaatatt cagcaagggt gcatctgaga
     2281 taattctgaa aaagtgtttc aaaatcttga gtgctaatgg tgaggcaaaa gtattcagac
     2341 caagggaccg tgatgatatt gtaaaaactg tgattgaacc gatggcatca gaaggcttga
     2401 gaaccatatg tcttgcattc agagattttc cagcaggaga accagaacca gagtgggata
     2461 atgaaaatga tattgtcacc ggccttacat gcattgctgt tgtggggatt gaagatcctg
     2521 tgagacctga ggtgccagat gcaattaaaa agtgtcagag ggctggaatt actgtgcgga
     2581 tggtcactgg tgataatatt aatactgctc gggccattgc taccaaatgt ggtattttac
     2641 atcctgggga agattttctg tgcctagaag gtaaagattt taacagaaga atacgaaatg
     2701 aaaaaggaga gattgagcaa gagaggatag acaagatttg gccaaaactt cgagtacttg
     2761 caagatcatc tcctactgat aagcatacac tggttaaagg tataattgac agcactgtct
     2821 cagaccaacg ccaggttgta gctgtaactg gtgatggtac aaatgatggc ccagcactaa
     2881 agaaagcaga tgttggattt gcaatgggta ttgctggaac tgatgtagct aaagaagcat
     2941 ccgatattat tctcacagat gacaacttta caagcattgt taaagcagtt atgtggggac
     3001 gaaatgtcta tgacagcatc tcaaaattcc ttcagttcca acttactgtt aatgtagtag
     3061 cagtgattgt tgcttttacg ggcgcctgca ttactcaaga ctcaccgctt aaggctgtgc
     3121 agatgctgtg ggtaaacctc ataatggata cactcgcttc cctggctctg gcaacggaac
     3181 cacccactga gtctctcttg cttcggaaac cttatggtag aaataagcct ctcatctcac
     3241 gtacaatgat gaagaatatt ttgggtcatg cattctatca acttgtagta gtctttacac
     3301 tcttatttgc tggagaaaag ttttttgaca ttgatagtgg aagaaatgct cctttgcatg
     3361 ctcctccttc agaacattat actattgttt ttaatacctt tgtgctgatg caacttttca
     3421 acgaaataaa tgcccggaaa attcatggtg aaagaaatgt attcgaagga atctttaaca
     3481 atgccatctt ctgcacaatt gttttaggca cttttgtggt acagataata attgtgcagt
     3541 ttggtggaaa acctttcagt tgttcagaac tttcaataga acagtggcta tggtcaatat
     3601 tcctaggaat gggaacatta ctctggggcc agcttatttc aacaattcca actagccgtt
     3661 taaaattcct caaagaagct ggtcatggaa cacaaaagga agaaatacct gaggaggaat
     3721 tagcagagga tgttgaagag attgatcacg ctgaaaggga gttgcggcgt ggccaaatct
     3781 tgtggtttag aggtctgaac agaatccaaa cacagattcg agtggtgaat gcatttcgta
     3841 gttctttata tgaagggtta gaaaaaccgg aatcaagaag ttcgattcac aactttatga
     3901 cacatcctga gtttaggata gaagattcag agcctcatat cccccttatt gatgacactg
     3961 atgccgaaga tgatgctcct acaaaacgta actccagtcc tccaccctct cccaacaaaa
     4021 ataacaatgc tgttgacagt ggaattcacc ttacaataga aatgaacaag tctgctacct
     4081 cttcatcccc aggaagccca ctacatagtt tggaaacatc actctgattg taagctgaat
     4141 gttaacacac tagctgcatt gtaaagaaac aaattgaaac tgggtctttt cacatattgt
     4201 gatggacaag ctagtattct tgtctttgga cttcaacaga agacacactt gtacgaatgt
     4261 agatttattt ttttaaaaaa aaaaaagcaa agctttctgc cagactgagg gtgctttttg
     4321 gggggtggga gaaatgaact gacagataaa cagtaactca gcgtaagtga cctgtggatc
     4381 atcagtagta cccaagcatg gtcctgaaca gtgtattagc agagctttag tttatctcag
     4441 tcctggatgg gagagagagg gaggagtaaa actgggcaag acaaagagcc ctggatcgtt
     4501 gaattgatag tttaatttct gctgttggct gttaataatt tggattattt atgtttataa
     4561 atgatacaga tctgtttaca aggtttgtag atactttttt tgttcctgtt catagatggg
     4621 aagcttcctt ataactgatg cagagaaaaa ttagtccttc aaatactgct gtattttcag
     4681 gaaaaaaaaa aaaaggggtg tttctattga aactgtacta aatttttgcc tacaatttac
     4741 cttgttaaat attgtagata aattgctaat actaatagcc aaatagataa cactaatgct
     4801 ttgtttaaaa aaacgaaaaa aacaaaacaa aacaaaaaaa catgagcagt ggtgttctaa
     4861 tgaagttatg acatctgtcc taattagttt cttaaataca tttactactt aatggttttg
     4921 aagcaactgt ttaattttta aaatttttga aaacttgcta ataacctttt gttcagaatt
     4981 tagtagattg tttaatgcag gacatcaact acataatgaa agatgcttga aatgcttttg
     5041 ttatttcagg caaatcaaat taaatcagac tatcaaacta caagagaacc ttagtctttt
     5101 ttgtttttgt ctaaacatgt tagtttagtg atgtcttggt gaactgtgag tgaactgtat
     5161 tgatttttct aatctttaga gaccttcaca cagcatgagg gctgttggca ttttgaaaaa
     5221 ggttaataag tagaagcata catgttttcc ttttgttttt gaaacttgtt tgtaaacata
     5281 aataaatatg cccttttatt aaataaattc atggcaatgt ttttttaaaa gacatttcag
     5341 cttctttact cagttctgca tatacagtgc atcagtctgt tctctttgac cacaattgga
     5401 atacatttca agatggtaac agccccatga agtaccgctt taattccttg ctggtaatct
     5461 aatagaatca gattaagaaa attaacacaa ttttaccatt tgacatactc ttcattgaat
     5521 ttagtttgtc taaaatagtc tcacaggtaa aaaacataac aacaatgacc accattgtct
     5581 ttgatacatt tattttaatt cttaagtggc caaataacag attaggtaaa atgagattac
     5641 atgaaaaggt tctaaaatga tatatttaga tgcaataatt aaccatatgc tagaatgccc
     5701 acctctaagc caattggatt ctttagctct ctttttcttt ccttcatcta ccttcttctc
     5761 ttttttgcct ctgtctttac cctttagaaa ctggcatgtg ttagggccca gatttcacca
     5821 gatacacaat cctcaggctg acataaagtt tacgaggact gctactataa ctgagagtgc
     5881 tgaccaagca aagaaacatt tagttgatgg tgcttgatat ttttggtggg tgggggaaat
     5941 ctttttctca ccatcaaatc tttgcagtaa tcctctgcag gtcttagaaa cacattggct
     6001 ctgtcagcat ttgtaattgt acatttattc atcaggtatt tatagtgaat catactgtaa
     6061 aaaagaggta gcatgatatg ctggaaagca tattagacta ggagtcaaga cctggtttct
     6121 agtcttggtt ttgccattaa tgtgctgcat gatcttggga aaatcattta ccctaaataa
     6181 gggtggtgga ctatcttgaa gaaccctttc aactctaaaa attgacccta tcaactggag
     6241 agcccacaag gcatagggaa tagagaaaag ggaaatgttt tcagttttct tttttatttt
     6301 ggttatgctt aaatatgaat gtaattacca aaagatttag aagtgcatgt gctttggagg
     6361 atttgtattg agcttttaca gtattcattt ttcaactcaa ggcaatggct ttctacacca
     6421 actctaatcc ataaacgggt cttatgacat ctatgaagta gtagcaagac atgcttagtg
     6481 tgtatttctc tctttgagac actgtaattt ctaccagaaa tttccagagc attatgtagg
     6541 tagaaaaaaa tgcaagcaag ctgttaaaga tcttggatcc cattatatag tatgtatagc
     6601 tgaaatctgt aattcaatca ctttttctct tttatcctct aaccaaaaaa ttgtttaatt
     6661 ttgcatccca aatgttttta atctttgtat attttttaaa aatccttttc tcctcatcat
     6721 tgcctttttt gtggttgtaa atagacttac ttgcactttg aagatgagtt actccttgtc
     6781 atcttacaaa tatgtgatat ggtaattttc ataacagatg tcagttttga accaagaatt
     6841 ggtgatttgt ttataagaaa aaaactggct tcatttctgt gaaattgctc tttgaaaatt
     6901 tctttttaca cgtgtaagcc aactgagata ccgtgatggt gttgatttct ttcaatgatg
     6961 cttaccatct attttagcca ctgagccttt tattatttgt ctatttgtaa agtttatttg
     7021 tcttaactca tttaataaat atactgttta tctgtttctg aa
//
