LOCUS       NM_005173               4695 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ATPase sarcoplasmic/endoplasmic reticulum Ca2+
            transporting 3 (ATP2A3), transcript variant 1, mRNA.
ACCESSION   NM_005173
VERSION     NM_005173.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4695)
  AUTHORS   Adle-Biassette,H., Ricci,R., Martin,A., Martini,M., Ravegnini,G.,
            Kaci,R., Gelebart,P., Poirot,B., Sandor,Z., Lehman-Che,J., Toth,E.
            and Papp,B.
  TITLE     Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in
            gastrointestinal stromal tumours
  JOURNAL   Pathology 56 (3), 343-356 (2024)
   PUBMED   38184384
  REMARK    GeneRIF: Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3)
            expression in gastrointestinal stromal tumours.
REFERENCE   2  (bases 1 to 4695)
  AUTHORS   Li,M., Shao,F., Qian,Q., Yu,W., Zhang,Z., Chen,B., Su,D., Guo,Y.,
            Phan,A.V., Song,L.S., Stephens,S.B., Sebag,J., Imai,Y., Yang,L. and
            Cao,H.
  TITLE     A putative long noncoding RNA-encoded micropeptide maintains
            cellular homeostasis in pancreatic beta cells
  JOURNAL   Mol Ther Nucleic Acids 26, 307-320 (2021)
   PUBMED   34513312
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4695)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4695)
  AUTHORS   Meneses-Morales,I., Izquierdo-Torres,E., Flores-Peredo,L.,
            Rodriguez,G., Hernandez-Oliveras,A. and Zarain-Herzberg,A.
  TITLE     Epigenetic regulation of the human ATP2A3 gene promoter in gastric
            and colon cancer cell lines
  JOURNAL   Mol Carcinog 58 (6), 887-897 (2019)
   PUBMED   30657210
  REMARK    GeneRIF: Data show that the nucleotide sequence from -280 to -135
            position is an ATP2A3 epigenetic regulatory CpG region. SERCA3 mRNA
            expression is decreased during gastric and colorectal carcinoma
            development and tumors with high SERCA3 expression are associated
            with increased overall survival. These results suggest an essential
            role for SERCA3 in the regulation of cellular identity and growth,
            through cellular Ca2+ management.
REFERENCE   5  (bases 1 to 4695)
  AUTHORS   Zhang,Y., Li,F., Liu,L., Jiang,H., Hu,H., Du,X., Ge,X., Cao,J. and
            Wang,Y.
  TITLE     Salinomycin triggers endoplasmic reticulum stress through ATP2A3
            upregulation in PC-3 cells
  JOURNAL   BMC Cancer 19 (1), 381 (2019)
   PUBMED   31023247
  REMARK    GeneRIF: This study demonstrates that ATP2A3 might be one of the
            potential targets for salinomycin, which can inhibit Ca(2+) release
            and trigger ER stress to exert anti-cancer effects.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4695)
  AUTHORS   Martin,V., Bredoux,R., Corvazier,E., Van Gorp,R., Kovacs,T.,
            Gelebart,P. and Enouf,J.
  TITLE     Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3
            isoforms. Expression, regulation, and function of the membranes of
            the SERCA3 family
  JOURNAL   J Biol Chem 277 (27), 24442-24452 (2002)
   PUBMED   11956212
  REMARK    GeneRIF: novel sarco/endoplasmic isoforms; data suggest that the
            SERCA3 gene products have a more widespread role in cellular Ca2+
            signaling than previously appreciated
REFERENCE   7  (bases 1 to 4695)
  AUTHORS   Poch,E., Leach,S., Snape,S., Cacic,T., MacLennan,D.H. and Lytton,J.
  TITLE     Functional characterization of alternatively spliced human SERCA3
            transcripts
  JOURNAL   Am J Physiol 275 (6), C1449-C1458 (1998)
   PUBMED   9843705
REFERENCE   8  (bases 1 to 4695)
  AUTHORS   Dode,L., De Greef,C., Mountian,I., Attard,M., Town,M.M.,
            Casteels,R. and Wuytack,F.
  TITLE     Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3
            gene. Promoter analysis and alternative splicing of the SERCA3
            pre-mRNA
  JOURNAL   J Biol Chem 273 (22), 13982-13994 (1998)
   PUBMED   9593748
REFERENCE   9  (bases 1 to 4695)
  AUTHORS   Dode,L., Wuytack,F., Kools,P.F., Baba-Aissa,F., Raeymaekers,L.,
            Brike,F., van de Ven,W.J. and Casteels,R.
  TITLE     cDNA cloning, expression and chromosomal localization of the human
            sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene
  JOURNAL   Biochem J 318 (Pt 2) (Pt 2), 689-699 (1996)
   PUBMED   8809064
  REMARK    Erratum:[Biochem J 1996 Nov 1;319(Pt 3):1008. Brik F [corrected to
            Brike F]]
REFERENCE   10 (bases 1 to 4695)
  AUTHORS   Wuytack,F., Papp,B., Verboomen,H., Raeymaekers,L., Dode,L.,
            Bobe,R., Enouf,J., Bokkala,S., Authi,K.S. and Casteels,R.
  TITLE     A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is
            expressed in platelets, in lymphoid cells, and in mast cells
  JOURNAL   J Biol Chem 269 (2), 1410-1416 (1994)
   PUBMED   8288608
  REMARK    Erratum:[J Biol Chem 1994 Apr 29;269(17):13056]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292716.1, BC035729.1,
            AC005940.3, Z69881.1 and AA643105.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005173.3.
            
            Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which
            are intracellular pumps located in the sarcoplasmic or endoplasmic
            reticula of muscle cells. This enzyme catalyzes the hydrolysis of
            ATP coupled with the translocation of calcium from the cytosol to
            the sarcoplasmic reticulum lumen, and is involved in calcium
            sequestration associated with muscular excitation and contraction.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z69881.1, BC035729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397041.8/ ENSP00000380234.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AK292716.1         28-188
            162-3159            BC035729.1         144-3141
            3160-3160           AC005940.3         54839-54839
            3161-4054           BC035729.1         3143-4036
            4055-4359           Z69881.1           3915-4219
            4360-4360           AC005940.3         56039-56039
            4361-4693           Z69881.1           4221-4553
            4694-4695           AA643105.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..4695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..4695
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /note="ATPase sarcoplasmic/endoplasmic reticulum Ca2+
                     transporting 3"
                     /db_xref="GeneID:489"
                     /db_xref="HGNC:HGNC:813"
                     /db_xref="MIM:601929"
     exon            1..264
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..3146
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /EC_number="7.2.2.10"
                     /note="isoform a is encoded by transcript variant 1;
                     ATPase, Ca(2+)-transporting, ubiquitous;
                     sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SR
                     Ca(2+)-ATPase 3; calcium pump 3; adenosine triphosphatase,
                     calcium; ATPase, Ca++ transporting, ubiquitous;
                     sarco/endoplasmic reticulum Ca2+ -ATPase;
                     calcium-translocating P-type ATPase"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 3 isoform a"
                     /protein_id="NP_005164.2"
                     /db_xref="CCDS:CCDS45579.1"
                     /db_xref="GeneID:489"
                     /db_xref="HGNC:HGNC:813"
                     /db_xref="MIM:601929"
                     /translation="MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSE
                     EGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANA
                     IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVP
                     ADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGK
                     AVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINI
                     GHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPE
                     GEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
                     KMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPTGQ
                     GSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALAT
                     RDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMI
                     TGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPA
                     HKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNF
                     ASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLV
                     TDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWF
                     VYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALN
                     SVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQ
                     ISLPVILLDEALKYLSRNHMHEEMSQK"
     exon            265..282
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            283..365
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            366..470
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            471..609
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            610..690
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..776
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1241
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1330
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1433
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1565
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1691
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1910
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2246
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2467
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2670
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2756
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2890
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3008
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3126
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..4695
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4671..4676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /note="hexamer: AATAAA"
     polyA_site      4695
                     /gene="ATP2A3"
                     /gene_synonym="SERCA3"
                     /note="major polyA site"
ORIGIN      
        1 gccactgccg tcgggtaagg tcccagcacg gacatggcct cgcgcggcgc ccgcccgggc
       61 ccgagtcccc cgcgccccgc tttgtagccc cccggcggag aggcggcctc gacggtgcgg
      121 acggcgcaga cggccgggcg ggcggcatgg aggcggcgca tctgctcccg gccgccgacg
      181 tgctgcgcca cttctcggtg acagccgagg gcggcctgag cccggcgcag gtgaccggcg
      241 cgcgggagcg ctacggcccc aacgagctcc cgagtgagga agggaagtcc ctgtgggagc
      301 tggtgctgga acagtttgag gacctcctgg tgcgcatcct gctgctggct gcccttgtct
      361 cctttgtcct ggcctggttc gaggagggcg aggagaccac gaccgccttc gtggagcccc
      421 tggtcatcat gctgatcctc gtggccaacg ccattgtggg cgtgtggcag gaacgcaacg
      481 ccgagagtgc catcgaggcc ctgaaggagt atgagcctga gatgggcaag gtgatccgct
      541 cggaccgcaa gggcgtgcag aggatccgtg cccgggacat cgtcccaggg gacattgtag
      601 aagtggcagt gggggacaaa gtgcctgctg acctccgcct catcgagatc aagtccacca
      661 cgctgcgagt ggaccagtcc atcctgacgg gtgaatctgt gtccgtgacc aagcacacag
      721 aggccatccc agaccccaga gctgtgaacc aggacaagaa gaacatgctg ttttctggca
      781 ccaatatcac atcgggcaaa gcggtgggtg tggccgtggc caccggcctg cacacggagc
      841 tgggcaagat ccggagccag atggcggcag tcgagcccga gcggacgccg ctgcagcgca
      901 agctggacga gtttggacgg cagctgtccc acgccatctc tgtgatctgc gtggccgtgt
      961 gggtcatcaa catcggccac ttcgccgacc cggcccacgg tggctcctgg ctgcgtggcg
     1021 ctgtctacta cttcaagatc gccgtggccc tggcggtggc ggccatcccc gagggcctcc
     1081 cggctgtcat cactacatgc ctggcactgg gcacgcggcg catggcacgc aagaacgcca
     1141 tcgtgcgaag cctgccgtcc gtggagaccc tgggctgcac ctcagtcatc tgctccgaca
     1201 agacgggcac gctcaccacc aatcagatgt ctgtctgccg gatgttcgtg gtagccgagg
     1261 ccgatgcggg ctcctgcctt ttgcacgagt tcaccatctc gggtaccacg tatacccccg
     1321 agggcgaagt gcggcagggg gatcagcctg tgcgctgcgg ccagttcgac gggctggtgg
     1381 agctggcgac catctgcgcc ctgtgcaacg actcggctct ggactacaac gaggccaagg
     1441 gtgtgtatga gaaggtggga gaggccacgg agacagctct gacttgcctg gtggagaaga
     1501 tgaacgtgtt cgacaccgac ctgcaggctc tgtcccgggt ggagcgagct ggcgcctgta
     1561 acacggtcat caagcagctg atgcggaagg agttcaccct ggagttctcc cgagaccgga
     1621 aatccatgtc cgtgtactgc acgcccaccc gccctcaccc tactggccag ggcagcaaga
     1681 tgtttgtgaa gggggctcct gagagtgtga tcgagcgctg tagctcagtc cgcgtgggga
     1741 gccgcacagc acccctgacc cccacctcca gggagcagat cctggcaaag atccgggatt
     1801 ggggctcagg ctcagacacg ctgcgctgcc tggcactggc cacccgggac gcgcccccaa
     1861 ggaaggagga catggagctg gacgactgca gcaagtttgt gcagtacgag acggacctga
     1921 ccttcgtggg ctgcgtaggc atgctggacc cgccgcgacc tgaggtggct gcctgcatca
     1981 cacgctgcta ccaggcgggc atccgcgtgg tcatgatcac gggggataac aaaggcactg
     2041 ccgtggccat ctgccgcagg cttggcatct ttggggacac ggaagacgtg gcgggcaagg
     2101 cctacacggg ccgcgagttt gatgacctca gccccgagca gcagcgccag gcctgccgca
     2161 ccgcccgctg cttcgcccgc gtggagcccg cacacaagtc ccgcatcgtg gagaacctgc
     2221 agtcctttaa cgagatcact gctatgactg gcgatggagt gaacgacgca ccagccctga
     2281 agaaagcaga gatcggcatc gccatgggct caggcacggc cgtggccaag tcggcggcag
     2341 agatggtgct gtcagatgac aactttgcct ccatcgtggc tgcggtggag gagggccggg
     2401 ccatctacag caacatgaag caattcatcc gctacctcat ctcctccaat gttggcgagg
     2461 tcgtctgcat cttcctcacg gcaattctgg gcctgcccga agccctgatc cctgtgcagc
     2521 tgctctgggt gaacctggtg acagacggcc tacctgccac ggctctgggc ttcaacccgc
     2581 cagacctgga catcatggag aagctgcccc ggagcccccg agaagccctc atcagtggct
     2641 ggctcttctt ccgatacctg gctatcggag tgtacgtagg cctggccaca gtggctgccg
     2701 ccacctggtg gtttgtgtat gacgccgagg gacctcacat caacttctac cagctgagga
     2761 acttcctgaa gtgctccgaa gacaacccgc tctttgccgg catcgactgt gaggtgttcg
     2821 agtcacgctt ccccaccacc atggccttgt ccgtgctcgt gaccattgaa atgtgcaatg
     2881 ccctcaacag cgtctcggag aaccagtcgc tgctgcggat gccgccctgg atgaacccct
     2941 ggctgctggt ggctgtggcc atgtccatgg ccctgcactt cctcatcctg ctcgtgccgc
     3001 ccctgcctct cattttccag gtgaccccac tgagcgggcg ccagtgggtg gtggtgctcc
     3061 agatatctct gcctgtcatc ctgctggatg aggccctcaa gtacctgtcc cggaaccaca
     3121 tgcacgaaga aatgagccag aagtgagcgc tgggaacaga gtggagtctc cggtgtgtac
     3181 ctcagactga tggtgcccat gtgttcgcct ccgcccccca cccttgccac cacactcgcc
     3241 cacttgccca ccgggtcccg ccggataaat gacaggcccg aggtcagaat ggccatcccc
     3301 gggccccgtc ctggggtctc tgtccccact tccttctggc ctgggaggtc tgtaattcct
     3361 gtctcctgga ctctcctggg aagttccctg ctctgcagct ctggcccagg agctgcaggc
     3421 tgggaggggg cagccaagaa gccggagctg gcagcatacc cagagatccg gggccccccc
     3481 acccccaaat cacgagtgca gctggagctt gctccccctt gttcggaagc tggacgttca
     3541 cttggtgact ggtgcctctg cactgacgga ggactctggg ggtccttctt accggctctg
     3601 acctctctct tcgtgcctgg tctgggactg ggtcagccct gggggatcag aaggggccat
     3661 ctgggcccag ctgtgtacag cgagggtggg cagccccctc cactccactc tgcttccaca
     3721 aagtcggctc ccgagagctc gaggctgctt ctgtttatat gtgcagggcc cgggcgggtg
     3781 aagggtcaga gagacggaca caaggagccg gcaggagggc ggagcgagga tgtcctttcc
     3841 cgggagacaa gtcgggaaag cctggctgga ctgcctcagc cccgcgcgcc tcctggactc
     3901 agggttcccc gtcctgagct cgggagatgt tcagagtcac actgccgccc ggtctgccac
     3961 gcagaggtcc aacttgccac ccgcgtccct ggtacctgag accaccgaca tcctcaggtt
     4021 cctgaccgtg gcgcccttct acccagccca gtgtgcggcc gccgcgctgt ctgcacagct
     4081 gggggcctct gagcctggtg ggcttcctgg actcttggcc tcactccttg ccccctcccc
     4141 acgacaccca tgagccgaaa ggatgtcact aaggatggct gattccccaa gggcacccgc
     4201 tctccctccc tccctgctgg aggaacacgt catatcagat gagaggaaga tggcctctga
     4261 tggacagaat ttttctctta actcagcttt tgctactttg gcaaaaacta gcgaggggta
     4321 gcagaaacct gcaccaagga ttgtccctat gtcttggcca ctcctagagc gtgtgcagac
     4381 tgatgatttt atatgtaaat caagactcac atccctttcc tagtccccca catccaaagc
     4441 ccctcagcct gccttgcaga ccaatgggct ccatgttctg tagccccctc ccctacgcct
     4501 cacccctcct ccctctcaca ggttctgggc ggccagtgag agaaacgcag tgggggaggc
     4561 agggagtctg gtgcctgcag agattctctg cttctttcct ggggggaggt ggggaggtct
     4621 tagcaggagc gggccctgta cccacctgct gacctgctgt ttggtagaga aataaaggtt
     4681 gtgtgactgg gggaa
//
