LOCUS       NM_170665               8295 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens ATPase sarcoplasmic/endoplasmic reticulum Ca2+
            transporting 2 (ATP2A2), transcript variant b, mRNA.
ACCESSION   NM_170665
VERSION     NM_170665.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8295)
  AUTHORS   Atzmony,L., Zagairy,F., Mawassi,B., Shehade,M., Tatour,Y.,
            Danial-Farran,N., Khayat,M., Warrour,N., Dodiuk-Gad,R. and
            Cohen-Barak,E.
  TITLE     Persistent Cutaneous Lesions of Darier Disease and Second-Hit
            Somatic Variants in ATP2A2 Gene
  JOURNAL   JAMA Dermatol 160 (5), 518-524 (2024)
   PUBMED   38536168
  REMARK    GeneRIF: Persistent Cutaneous Lesions of Darier Disease and
            Second-Hit Somatic Variants in ATP2A2 Gene.
REFERENCE   2  (bases 1 to 8295)
  AUTHORS   Yin,D., Liu,Y., Xue,B., Ding,R., Wang,G., Xia,S. and Zhang,D.
  TITLE     IL-37 Modulates Myocardial Calcium Handling via the p-STAT3/SERCA2a
            Axis in HF-Related Engineered Human Heart Tissue
  JOURNAL   Adv Healthc Mater 13 (13), e2303957 (2024)
   PUBMED   38339835
  REMARK    GeneRIF: IL-37 Modulates Myocardial Calcium Handling via the
            p-STAT3/SERCA2a Axis in HF-Related Engineered Human Heart Tissue.
REFERENCE   3  (bases 1 to 8295)
  AUTHORS   Yang,J.F., Xing,X., Luo,L., Zhou,X.W., Feng,J.X., Huang,K.B.,
            Liu,H., Jin,S., Liu,Y.N., Zhang,S.H., Pan,Y.H., Yu,B., Yang,J.Y.,
            Cao,Y.L., Cao,Y., Yang,C.Y., Wang,Y., Zhang,Y., Li,J., Xia,X.,
            Kang,T., Xu,R.H., Lan,P., Luo,J.H., Han,H., Bai,F. and Gao,S.
  TITLE     Mitochondria-ER contact mediated by MFN2-SERCA2 interaction
            supports CD8+ T cell metabolic fitness and function in tumors
  JOURNAL   Sci Immunol 8 (87), eabq2424 (2023)
   PUBMED   37738362
  REMARK    GeneRIF: Mitochondria-ER contact mediated by MFN2-SERCA2
            interaction supports CD8[+] T cell metabolic fitness and function
            in tumors.
REFERENCE   4  (bases 1 to 8295)
  AUTHORS   Dode,L., Andersen,J.P., Leslie,N., Dhitavat,J., Vilsen,B. and
            Hovnanian,A.
  TITLE     Dissection of the functional differences between sarco(endo)plasmic
            reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization
            of Darier disease (SERCA2) mutants by steady-state and transient
            kinetic analyses
  JOURNAL   J Biol Chem 278 (48), 47877-47889 (2003)
   PUBMED   12975374
  REMARK    GeneRIF: kinetic analysis of SERCA1 and SERCA2 isoforms and the
            effects of mutation
REFERENCE   5  (bases 1 to 8295)
  AUTHORS   Gelebart,P., Martin,V., Enouf,J. and Papp,B.
  TITLE     Identification of a new SERCA2 splice variant regulated during
            monocytic differentiation
  JOURNAL   Biochem Biophys Res Commun 303 (2), 676-684 (2003)
   PUBMED   12659872
  REMARK    GeneRIF: A new splice variant is identified that is regulated
            during monocytic differentiation.
REFERENCE   6  (bases 1 to 8295)
  AUTHORS   Zarain-Herzberg,A. and Alvarez-Fernandez,G.
  TITLE     Sarco(endo)plasmic reticulum Ca2+-ATPase-2 gene: structure and
            transcriptional regulation of the human gene
  JOURNAL   ScientificWorldJournal 2, 1469-1483 (2002)
   PUBMED   12805933
  REMARK    GeneRIF: Structure and transcriptional regulation of the SERCA2
            gene.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8295)
  AUTHORS   Sakuntabhai,A., Burge,S., Monk,S. and Hovnanian,A.
  TITLE     Spectrum of novel ATP2A2 mutations in patients with Darier's
            disease
  JOURNAL   Hum Mol Genet 8 (9), 1611-1619 (1999)
   PUBMED   10441323
REFERENCE   8  (bases 1 to 8295)
  AUTHORS   Toyofuku,T., Curotto Kurzydlowski,K., Narayanan,N. and
            MacLennan,D.H.
  TITLE     Identification of Ser38 as the site in cardiac sarcoplasmic
            reticulum Ca(2+)-ATPase that is phosphorylated by
            Ca2+/calmodulin-dependent protein kinase
  JOURNAL   J Biol Chem 269 (42), 26492-26496 (1994)
   PUBMED   7929371
REFERENCE   9  (bases 1 to 8295)
  AUTHORS   Otsu,K., Fujii,J., Periasamy,M., Difilippantonio,M., Uppender,M.,
            Ward,D.C. and MacLennan,D.H.
  TITLE     Chromosome mapping of five human cardiac and skeletal muscle
            sarcoplasmic reticulum protein genes
  JOURNAL   Genomics 17 (2), 507-509 (1993)
   PUBMED   8406504
REFERENCE   10 (bases 1 to 8295)
  AUTHORS   Lytton,J. and MacLennan,D.H.
  TITLE     Molecular cloning of cDNAs from human kidney coding for two
            alternatively spliced products of the cardiac Ca2+-ATPase gene
  JOURNAL   J Biol Chem 263 (29), 15024-15031 (1988)
   PUBMED   2844796
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG773489.1, BI553880.1,
            BC035588.1, BX648282.1 and AK000300.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_170665.3.
            
            Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which
            are intracellular pumps located in the sarcoplasmic or endoplasmic
            reticula of the skeletal muscle. This enzyme catalyzes the
            hydrolysis of ATP coupled with the translocation of calcium from
            the cytosol into the sarcoplasmic reticulum lumen, and is involved
            in regulation of the contraction/relaxation cycle. Mutations in
            this gene cause Darier-White disease, also known as keratosis
            follicularis, an autosomal dominant skin disorder characterized by
            loss of adhesion between epidermal cells and abnormal
            keratinization. Other types of mutations in this gene have been
            associated with various forms of muscular dystrophies. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Dec 2019].
            
            Transcript Variant: This variant (b) represents the longest
            transcript and encodes the longest isoform (b, also known as
            SERCA2b, S2b or HK1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M23114.1, BC035588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539276.7/ ENSP00000440045.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BG773489.1         134-218
            86-442              BI553880.1         6-362
            443-4525            BC035588.1         10-4092
            4526-8290           BX648282.1         1806-5570
            8291-8295           AK000300.1         2049-2053
FEATURES             Location/Qualifiers
     source          1..8295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..8295
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /note="ATPase sarcoplasmic/endoplasmic reticulum Ca2+
                     transporting 2"
                     /db_xref="GeneID:488"
                     /db_xref="HGNC:HGNC:812"
                     /db_xref="MIM:108740"
     exon            1..661
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             544..3672
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /note="isoform b is encoded by transcript variant b;
                     ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2;
                     sarcoplasmic/endoplasmic reticulum calcium ATPase 2;
                     calcium pump 2; SR Ca(2+)-ATPase 2; endoplasmic reticulum
                     class 1/2 Ca(2+) ATPase; cardiac Ca2+ ATPase; ATPase Ca++
                     transporting cardiac muscle slow twitch 2"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 2 isoform b"
                     /protein_id="NP_733765.1"
                     /db_xref="CCDS:CCDS9144.1"
                     /db_xref="GeneID:488"
                     /db_xref="HGNC:HGNC:812"
                     /db_xref="MIM:108740"
                     /translation="MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAE
                     EGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANA
                     IVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVP
                     ADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGK
                     AMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINI
                     GHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPI
                     GEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
                     KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSM
                     SKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATH
                     DNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMIT
                     GDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSH
                     KSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFS
                     TIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVT
                     DGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFI
                     AADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNS
                     LSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKI
                     SLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVY
                     STDTNFSDMFWS"
     exon            662..679
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..762
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..867
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1006
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1087
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1173
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1638
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1727
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1830
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1962
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2085
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2304
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2640
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2861
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3064
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3150
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3284
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3402
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..8295
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4496..4501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /note="hexamer: AATAAA"
     polyA_site      4525
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /note="major polyA site"
     regulatory      8274..8279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /note="hexamer: AATAAA"
     polyA_site      8295
                     /gene="ATP2A2"
                     /gene_synonym="ATP2B; DAR; DD; SERCA2"
                     /note="major polyA site"
ORIGIN      
        1 attagagcag ccgccgcgga gccgtccccg acgccacctc cttttccttc gccgcagttt
       61 cctccgccgc tgtcgggcgt gcggcgctga gggacccggg cgagcgcgcc gcgcaccgcc
      121 ccgccggctc gcctccctcg ccgcgttccg ccctcagtgg tctgccgggc gccccctcct
      181 ccggcccggg cggggcctct gatcgcctca agagagcggg gagggggctc gggggccgcg
      241 gcctgccctc ccggcgggcg gctgagggcg agggaggccc tcccttctgg cgaggggagg
      301 gagggtgggt caggagcccc caacccgccc tgcggagctc ggggccgcgc gaggggcggt
      361 tgtctggggg agggggcgcg gggtgattca gcgcccggcg aggcggaagc ggccgcaaga
      421 ggaggagggg agagcccgtc cgcgcctggg ctcccggggt ggcacgagcc cgcggccgga
      481 gtgcgaggcg gaggcgagga ggccgcgggg acgggaggcg aggccggccg ggcccccgaa
      541 gccatggaga acgcgcacac caagacggtg gaggaggtgc tgggccactt cggcgtcaac
      601 gagagtacgg ggctgagcct ggaacaggtc aagaagctta aggagagatg gggctccaac
      661 gagttaccgg ctgaagaagg aaaaaccttg ctggaacttg tgattgagca gtttgaagac
      721 ttgctagtta ggattttatt actggcagca tgtatatctt ttgttttggc ttggtttgaa
      781 gaaggtgaag aaacaattac agcctttgta gaaccttttg taattttact catattagta
      841 gccaatgcaa ttgtgggtgt atggcaggaa agaaatgctg aaaatgccat cgaagccctt
      901 aaggaatatg agcctgaaat gggcaaagtg tatcgacagg acagaaagag tgtgcagcgg
      961 attaaagcta aagacatagt tcctggtgat attgtagaaa ttgctgttgg tgacaaagtt
     1021 cctgctgata taaggttaac ttccatcaaa tctaccacac taagagttga ccagtcaatt
     1081 ctcacaggtg aatctgtctc tgtcatcaag cacactgatc ccgtccctga cccacgagct
     1141 gtcaaccaag ataaaaagaa catgctgttt tctggtacaa acattgctgc tgggaaagct
     1201 atgggagtgg tggtagcaac tggagttaac accgaaattg gcaagatccg ggatgaaatg
     1261 gtggcaacag aacaggagag aacacccctt cagcaaaaac tagatgaatt tggggaacag
     1321 ctttccaaag tcatctccct tatttgcatt gcagtctgga tcataaatat tgggcacttc
     1381 aatgacccgg ttcatggagg gtcctggatc agaggtgcta tttactactt taaaattgca
     1441 gtggccctgg ctgtagcagc cattcctgaa ggtctgcctg cagtcatcac cacctgcctg
     1501 gctcttggaa ctcgcagaat ggcaaagaaa aatgccattg ttcgaagcct cccgtctgtg
     1561 gaaacccttg gttgtacttc tgttatctgc tcagacaaga ctggtacact tacaacaaac
     1621 cagatgtcag tctgcaggat gttcattctg gacagagtgg aaggtgatac ttgttccctt
     1681 aatgagttta ccataactgg atcaacttat gcacctattg gagaagtgca taaagatgat
     1741 aaaccagtga attgtcacca gtatgatggt ctggtagaat tagcaacaat ttgtgctctt
     1801 tgtaatgact ctgctttgga ttacaatgag gcaaagggtg tgtatgaaaa agttggagaa
     1861 gctacagaga ctgctctcac ttgcctagta gagaagatga atgtatttga taccgaattg
     1921 aagggtcttt ctaaaataga acgtgcaaat gcctgcaact cagtcattaa acagctgatg
     1981 aaaaaggaat tcactctaga gttttcacgt gacagaaagt caatgtcggt ttactgtaca
     2041 ccaaataaac caagcaggac atcaatgagc aagatgtttg tgaagggtgc tcctgaaggt
     2101 gtcattgaca ggtgcaccca cattcgagtt ggaagtacta aggttcctat gacctctgga
     2161 gtcaaacaga agatcatgtc tgtcattcga gagtggggta gtggcagcga cacactgcga
     2221 tgcctggccc tggccactca tgacaaccca ctgagaagag aagaaatgca ccttgaggac
     2281 tctgccaact ttattaaata tgagaccaat ctgaccttcg ttggctgcgt gggcatgctg
     2341 gatcctccga gaatcgaggt ggcctcctcc gtgaagctgt gccggcaagc aggcatccgg
     2401 gtcatcatga tcactgggga caacaagggc actgctgtgg ccatctgtcg ccgcatcggc
     2461 atcttcgggc aggatgagga cgtgacgtca aaagctttca caggccggga gtttgatgaa
     2521 ctcaacccct ccgcccagcg agacgcctgc ctgaacgccc gctgttttgc tcgagttgaa
     2581 ccctcccaca agtctaaaat cgtagaattt cttcagtctt ttgatgagat tacagctatg
     2641 actggcgatg gcgtgaacga tgctcctgct ctgaagaaag ccgagattgg cattgctatg
     2701 ggctctggca ctgcggtggc taaaaccgcc tctgagatgg tcctggcgga tgacaacttc
     2761 tccaccattg tggctgccgt tgaggagggg cgggcaatct acaacaacat gaaacagttc
     2821 atccgctacc tcatctcgtc caacgtcggg gaagttgtct gtattttcct gacagcagcc
     2881 cttggatttc ccgaggcttt gattcctgtt cagctgctct gggtcaatct ggtgacagat
     2941 ggcctgcctg ccactgcact ggggttcaac cctcctgatc tggacatcat gaataaacct
     3001 ccccggaacc caaaggaacc attgatcagc gggtggctct ttttccgtta cttggctatt
     3061 ggctgttacg tcggcgctgc taccgtgggt gctgctgcat ggtggttcat tgctgctgac
     3121 ggtggtccaa gagtgtcctt ctaccagctg agtcatttcc tacagtgtaa agaggacaac
     3181 ccggactttg aaggcgtgga ttgtgcaatc tttgaatccc catacccgat gacaatggcg
     3241 ctctctgttc tagtaactat agaaatgtgt aacgccctca acagcttgtc cgaaaaccag
     3301 tccttgctga ggatgccccc ctgggagaac atctggctcg tgggctccat ctgcctgtcc
     3361 atgtcactcc acttcctgat cctctatgtc gaacccttgc cactcatctt ccagatcaca
     3421 ccgctgaacg tgacccagtg gctgatggtg ctgaaaatct ccttgcccgt gattctcatg
     3481 gatgagacgc tcaagtttgt ggcccgcaac tacctggaac ctggtaaaga gtgtgtgcag
     3541 cctgccacca aatcctgctc gttctcggca tgcaccgatg ggatttcctg gccgtttgtg
     3601 ctgctcataa tgcccctggt gatctgggtc tatagcacag acactaactt tagcgatatg
     3661 ttctggtctt gactgacagt tttccataaa gaagatgttt aacttaatca attaattttt
     3721 ttattgttta aagcaactgt ctatttctgc tgaattttca catgaacata ctggctggtg
     3781 atggaggttt catactctag attttgtttt gctttttctg actccagtgg ggcaagattt
     3841 tcctttttta tacacataat taaagtgtcc attgacatgt acagagaact aacactattt
     3901 tatgcaaata tttttttgta gatgaaaaag catgtacagt gttctgttta atactcatcc
     3961 ttgtataaaa aaaatagttg agccagcaga cattgtcagc aaattaattg gcagcagatt
     4021 ttaggaaatg aatgtgtgtg gttttttttc taaaactaaa tagcatgtat tgtgtctttt
     4081 gcatgatgat ccggatttaa tttgatatca cagtctaatt tttattcata agccaatttt
     4141 tctgcactga gcagagtctt gctacctcag tcagtattgt tttggtttgc tacttccctc
     4201 acccactttg gcctccgttc accccacccc accccacctc tccccacctt acccccgccc
     4261 cgcttggctt cttctttagg attgtgatgg ttcgttctgt ttacatcagt tttaacgaga
     4321 ggtatgcctg tactcgcttg tgcagaaaac attgttccag attcaatcga ctgggtttat
     4381 gtcccttcac atagttttta aggttattta tttaaatgtc taatgtattt tattgtaaca
     4441 gacattgttt tgccaacatt gcctatttca gtggcacgtc atctagtttt aaaaaaataa
     4501 aacattttaa atggacagag aaaaataact gtcttgtctt taactcgtaa gtggcttacc
     4561 tgggactaac agacatgtcc aactttctct ccagttctta gctcagaact ttagttgtac
     4621 tctgcttgag gggaagaagg ctcctgctct gctgtgtagg tagtcatagg aattgtattc
     4681 ttaatgtaca ggcactaatt gtcatctgtg atgtacattt tatgcaagtt tctgctggcc
     4741 tggtatagag aacataaggg caagtgtgta tgtgtgtgta tgtgtgtgtt ttgtaaaatc
     4801 tgtaaatagc acatgaccaa atgaacatat tgtatagaac tatttttatt tgaatgtggc
     4861 actaaccacc accaccgtta ctacgatcaa tgtttgcgca tgttcgagat gagtctcacc
     4921 aacagtgtgt aagtcattaa cagtcctaac tgtggtgttt tcctccaatg ccttccaaca
     4981 tccatcaact aacgtgagta ttttcttcct gggatttgga tgctttagcc taaaggtgac
     5041 tgccaccaag tgagataact gtatgtcact aacttataag ccgcctccat ggcagatgct
     5101 gctgtgctcc ctgatgccct gtgagcaccg gggttgcctg tggcgcctgc catgtgactc
     5161 gggcgcagca tcagctggct ggaggtgtgg ctttcataga cctccacagg ctgcctagga
     5221 caagatgacc aggagggccc aagccagaca aaagccggag tggggagaga ggcatttcag
     5281 ccagaccaac aggctgaagg agctgtgcag actattgcta aaatgagggt tcgcagctgc
     5341 caggagtcat cccagaacat tgctacttat ttattaaaaa gctaaaaact agtgaaagca
     5401 agtaactgaa ccagtgaact ctgggtatcg ataggttcgt cttaaatagg ccacttcccc
     5461 actcccccac ccccccttgc ttggtcttgt ccttggtggc taagacttag ctctgcaggg
     5521 gatgttaaag cacagttagt aggacgtggc tctgcacagc ccaaaaacca gcttactcct
     5581 tagccagggt gtgaggcctc gactatattc ttcaaaatgt acttaggctc tggttactgg
     5641 gatggccagt agatgtaatg cagatggttg gagtttgggg agggttagga ggcatcaagc
     5701 aggacaaggt gctgctgagt tcagagggcc cacgttcaag ggatggaggt ggaacctgga
     5761 gaccgactct taaaagcaca gtccgtggtt gggtgtggtg gctcatgcct gtaagtaagt
     5821 ctcagccctt tggaggccac agcagaagga ttgcttgagc ccaggtactc aaaccagcct
     5881 gggcaacaga gtgaggccct gtcaaaaaaa aatcagcctt actgtgaagc ctccaaggct
     5941 gctcgcaggc agctgtggct ctcgggaagg gaggctgctt tgcccagcag ggaacatttg
     6001 gggcaggggg taaattttgc cagtttgagc atcatgaggt gtaacaagaa atgggttgaa
     6061 tgggccaaat gcaaggagtg catctctggg ctgcaaactg acttgagtgc tgcactattg
     6121 ctattccgtg caaacaaaac tcagcttttc ctgactcagt tccttgactt agtggccttt
     6181 acaaaaaaag ttgagtagtg tgtggcctgc tgtcgcacag cccctagtta gcttcatggt
     6241 ttctcagctt cagacccctc cagcccacag aggagcccat ggagggaccc acttcccttg
     6301 gtccagacag ctgggagtgg gttaggccca ctgctgtttt gagcagggcc acttgctcca
     6361 tttcactgaa ggctttgctg ggtgaaaaca cttcagcatc tcctcctcag gtcaacccat
     6421 aaagaccagg tccagcaccg tggtcttggc acatccctgg cctcaggccc tcacctaaca
     6481 gtgaggcagc agctgcccag ccccgcaatg tgcctgctgt caggcagctc ttgcctgaaa
     6541 cttacttcca cattctttcc tgatgggcag gtggctgaag gcccagccat cagtgtcgct
     6601 tgttgccacc ccgtgcctcc cttggcctct ctgagctttg cccagaagac caacaatcat
     6661 acatacccta actgggacac cactctgcag aatgcagatg atccattctg gaggaagctg
     6721 tcccttgagc tcagtgagct cccaggcaag cagggcatct ggccgacttc cctcacaaca
     6781 gctgctccca catcccctcg gactggagct tcagccctga ctgaggtggg cagacctaag
     6841 acctgagacc acaagattag ctcagtgtct accaagcatc tagccactgt ccagggccag
     6901 agcataccac gtctgcagtg cctgtgagca gagccagcag ttgccctgtg actgtaacca
     6961 ccaaattgtc caaacacccg ctgcagttag caagaagggt aggcttcacc ctcctttact
     7021 gaggagaatg atgcggagga gtttcctctc cagggctagg caaggcaggc gagcagccag
     7081 aagccgggtg cccacagggc agggacagga aggctgtgct gctactggct gctcacttct
     7141 ccatcaacct caccctctgc accactaacc aagaccttgt cctcttgcct gtctcgctgc
     7201 tttcacagct gcaacgattg tgtctgcctc atggggtttt cctccagagc ctttattctg
     7261 tagccagacg acacgaggag tctgtgtcac tgagccagtg cttctagatg ctaccctgtg
     7321 tgggcggcac ctcagggaca gtaaatcaga aatgctggtc ttgaaacctt gaaaagatca
     7381 agctgaatgt tccttttcat ctgtcgctgt tgatcttcat ctatttaaat aggtattcta
     7441 acgtttcctc tctgtatttc atgaagctga tttcctctct ctttcctttt cagcaatact
     7501 ggagtaaccg cttcctaaac cattttgcag aaatgtaagg gtgttcggtt gcgtgcatgt
     7561 gcgtttttag caacacatct accaaccctg tgcatgactg atgttgggga aaaagaaaag
     7621 taaaaaactt cccaactcac tttgtgttat gtggaggaaa tgtgtattac caatggggtt
     7681 gttagctttt aaatcaaaat actgattaca gatgtacaat ttagcttaat cagaaagcct
     7741 ctccagagaa gtttggtttc tttgctgcaa gaggaatgag gctctgtaac cttatctaag
     7801 aacttggaag ccgtcagcca agtcgccaca tttctctgca aaatgtcata gcttatataa
     7861 atgtacagta ttcaattgta atgcatgcct tcggttgtaa gtagccagat ccctctccag
     7921 tgacattgga acatgctact ttttaattgg ccctgtacag tttgcttatt tataaattca
     7981 ttaaaaacac tacaggtgtt gaatggttaa aatgtaggcc tccagttcat tttcagttat
     8041 tttctgagtg tgcagacagc tatttcgcac tgtattaaat gtaacttatt taatgaaatc
     8101 agaagcagta gacagatgtt ggtgcaatac aaatattgtg atgcatttat cttaataaaa
     8161 tgctaaatgt caatttatca ctgcgcatgt ttgactttag actgtaaata gagatcagtt
     8221 tgtttctttc tgtgctggta acaatgagcg tcgcacagac atggtttcag gtaaataaat
     8281 ctattctatg ataaa
//
