LOCUS       NM_001679               1847 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ATPase Na+/K+ transporting subunit beta 3 (ATP1B3),
            mRNA.
ACCESSION   NM_001679 XM_941886 XM_945505 XM_945509 XM_945511 XM_945514
            XM_945518
VERSION     NM_001679.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1847)
  AUTHORS   Yang,X., Li,Y., Wu,D., Ma,Y. and Zhou,S.
  TITLE     [Screening and identification of key genes ATP1B3 and ENAH in the
            progression of hepatocellular carcinoma: based on data mining and
            clinical validation]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (6), 815-823 (2022)
   PUBMED   35790431
  REMARK    GeneRIF: [Screening and identification of key genes ATP1B3 and ENAH
            in the progression of hepatocellular carcinoma: based on data
            mining and clinical validation].
REFERENCE   2  (bases 1 to 1847)
  AUTHORS   Zhang,J., Zheng,T., Zhou,X., Wang,H., Li,Z., Huan,C., Zheng,B. and
            Zhang,W.
  TITLE     ATP1B3 Restricts Hepatitis B Virus Replication Via Reducing the
            Expression of the Envelope Proteins
  JOURNAL   Virol Sin 36 (4), 678-691 (2021)
   PUBMED   33534085
  REMARK    GeneRIF: ATP1B3 Restricts Hepatitis B Virus Replication Via
            Reducing the Expression of the Envelope Proteins.
REFERENCE   3  (bases 1 to 1847)
  AUTHORS   Lu,S., Cai,S., Peng,X., Cheng,R. and Zhang,Y.
  TITLE     Integrative Transcriptomic, Proteomic and Functional Analysis
            Reveals ATP1B3 as a Diagnostic and Potential Therapeutic Target in
            Hepatocellular Carcinoma
  JOURNAL   Front Immunol 12, 636614 (2021)
   PUBMED   33868261
  REMARK    GeneRIF: Integrative Transcriptomic, Proteomic and Functional
            Analysis Reveals ATP1B3 as a Diagnostic and Potential Therapeutic
            Target in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1847)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1847)
  AUTHORS   Zhang,S.H., Liu,D.X., Wang,L., Li,Y.H., Wang,Y.H., Zhang,H.,
            Su,Z.K., Fang,W.G., Qin,X.X., Shang,D.S., Li,B., Han,X.N.,
            Zhao,W.D. and Chen,Y.H.
  TITLE     A CASPR1-ATP1B3 protein interaction modulates plasma membrane
            localization of Na+/K+-ATPase in brain microvascular endothelial
            cells
  JOURNAL   J Biol Chem 294 (16), 6375-6386 (2019)
   PUBMED   30792309
  REMARK    GeneRIF: These results demonstrate that CASPR1 binds with ATP1B3
            and thereby contributes to the regulation of Na(+)/K(+)-ATPase
            maturation and trafficking to the plasma membrane in brain
            microvascular endothelial cells.
REFERENCE   6  (bases 1 to 1847)
  AUTHORS   Crambert,G., Hasler,U., Beggah,A.T., Yu,C., Modyanov,N.N.,
            Horisberger,J.D., Lelievre,L. and Geering,K.
  TITLE     Transport and pharmacological properties of nine different human
            Na, K-ATPase isozymes
  JOURNAL   J Biol Chem 275 (3), 1976-1986 (2000)
   PUBMED   10636900
REFERENCE   7  (bases 1 to 1847)
  AUTHORS   Malik,N., Canfield,V., Sanchez-Watts,G., Watts,A.G., Scherer,S.,
            Beatty,B.G., Gros,P. and Levenson,R.
  TITLE     Structural organization and chromosomal localization of the human
            Na,K-ATPase beta 3 subunit gene and pseudogene
  JOURNAL   Mamm Genome 9 (2), 136-143 (1998)
   PUBMED   9457675
REFERENCE   8  (bases 1 to 1847)
  AUTHORS   Malik,N., Canfield,V.A., Beckers,M.C., Gros,P. and Levenson,R.
  TITLE     Identification of the mammalian Na,K-ATPase 3 subunit
  JOURNAL   J Biol Chem 271 (37), 22754-22758 (1996)
   PUBMED   8798450
REFERENCE   9  (bases 1 to 1847)
  AUTHORS   Lingrel,J.B., Orlowski,J., Shull,M.M. and Price,E.M.
  TITLE     Molecular genetics of Na,K-ATPase
  JOURNAL   Prog Nucleic Acid Res Mol Biol 38, 37-89 (1990)
   PUBMED   2158121
  REMARK    Review article
REFERENCE   10 (bases 1 to 1847)
  AUTHORS   Jorgensen,P.L.
  TITLE     Mechanism of the Na+, K+ pump. Protein structure and conformations
            of the pure (Na+ +K+)-ATPase
  JOURNAL   Biochim Biophys Acta 694 (1), 27-68 (1982)
   PUBMED   6289898
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK131061.1, AC112504.6,
            DB307448.1 and CN295803.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001679.3.
            
            Summary: The protein encoded by this gene belongs to the family of
            Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily
            of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein
            responsible for establishing and maintaining the electrochemical
            gradients of Na and K ions across the plasma membrane. These
            gradients are essential for osmoregulation, for sodium-coupled
            transport of a variety of organic and inorganic molecules, and for
            electrical excitability of nerve and muscle. This enzyme is
            composed of two subunits, a large catalytic subunit (alpha) and a
            smaller glycoprotein subunit (beta). The beta subunit regulates,
            through assembly of alpha/beta heterodimers, the number of sodium
            pumps transported to the plasma membrane. The glycoprotein subunit
            of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a
            beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene
            exists for this gene, and it is located on chromosome 2. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.77974.1,
                                           SRR1660807.202974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286371.8/ ENSP00000286371.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               AK131061.1         1-363
            364-364             AC112504.6         57834-57834         c
            365-1263            AK131061.1         365-1263
            1264-1264           AC112504.6         35583-35583         c
            1265-1497           AK131061.1         1265-1497
            1498-1602           DB307448.1         237-341             c
            1603-1603           AC112504.6         35244-35244         c
            1604-1839           DB307448.1         1-236               c
            1840-1846           CN295803.1         13-19               c
            1847-1847           AC112504.6         35000-35000         c
FEATURES             Location/Qualifiers
     source          1..1847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..1847
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /note="ATPase Na+/K+ transporting subunit beta 3"
                     /db_xref="GeneID:483"
                     /db_xref="HGNC:HGNC:806"
                     /db_xref="MIM:601867"
     exon            1..268
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..999
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /EC_number="7.2.2.13"
                     /note="Na, K-ATPase beta-3 polypeptide;
                     sodium/potassium-transporting ATPase beta-3 chain; sodium
                     pump subunit beta-3; sodium-potassium ATPase subunit beta
                     3 (non-catalytic); sodium/potassium-dependent ATPase
                     subunit beta-3; ATPase, Na+/K+ transporting, beta 3
                     polypeptide"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-3"
                     /protein_id="NP_001670.1"
                     /db_xref="CCDS:CCDS3121.1"
                     /db_xref="GeneID:483"
                     /db_xref="HGNC:HGNC:806"
                     /db_xref="MIM:601867"
                     /translation="MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYL
                     VFYGFLAALFSFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTS
                     YAGYIEDLKKFLKPYTLEEQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDP
                     DFGYSQGNPCILVKMNRIIGLKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYY
                     GKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKIT
                     ARA"
     exon            269..397
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /inference="alignment:Splign:2.1.0"
     exon            398..505
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /inference="alignment:Splign:2.1.0"
     exon            506..690
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /inference="alignment:Splign:2.1.0"
     exon            691..741
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /inference="alignment:Splign:2.1.0"
     exon            742..828
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1847
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /note="hexamer: AAGAAA"
     polyA_site      1463
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /note="hexamer: AATAAA"
     polyA_site      1498
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /note="major polyA site"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /note="hexamer: AATAAA"
     regulatory      1796..1801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /note="hexamer: TATAAA"
     polyA_site      1809
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
     regulatory      1810..1815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
                     /note="hexamer: TATAAA"
     polyA_site      1817
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
     polyA_site      1847
                     /gene="ATP1B3"
                     /gene_synonym="ATPB-3; CD298"
ORIGIN      
        1 agtcggctcg agtactcccc gtaacgagga ggtgttctcg gccgtcccac ccttcactgc
       61 cgtctccggg ctgcgccgcc ggagccggga cgcgcctccg cagccctcgc cgcctccatc
      121 cccgcggccg cagctcctct cgccgtccgc gcgcacacca tgacgaagaa cgagaagaag
      181 tccctcaacc agagcctggc cgagtggaag ctcttcatct acaacccgac caccggagaa
      241 ttcctggggc gcaccgccaa gagctggggt ttgatcttgc tcttctacct agttttttat
      301 gggttcctgg ctgcactctt ctcattcacg atgtgggtta tgcttcagac tctcaacgat
      361 gaggttccaa aataccgtga ccagattcct agcccaggac tcatggtttt tccaaaacca
      421 gtgaccgcat tggaatatac attcagtagg tctgatccaa cttcgtatgc agggtacatt
      481 gaagacctta agaagtttct aaaaccatat actttagaag aacagaagaa cctcacagtc
      541 tgtcctgatg gagcactttt tgaacagaag ggtccagttt atgttgcatg tcagtttcct
      601 atttcattac ttcaagcatg cagtggtatg aatgatcctg attttggcta ttctcaagga
      661 aacccttgta ttcttgtgaa aatgaacaga ataattggat taaagcctga aggagtgcca
      721 aggatagatt gtgtttcaaa gaatgaagat ataccaaatg tagcagttta tcctcataat
      781 ggaatgatag acttaaaata tttcccatat tatgggaaaa aactgcatgt tgggtatcta
      841 cagccattgg ttgctgttca ggtcagcttt gctcctaaca acactgggaa agaagtaaca
      901 gttgagtgca agattgatgg atcagccaac ctaaaaagtc aggatgatcg tgacaagttt
      961 ttgggacgag ttatgttcaa aatcacagca cgtgcatagt atgagtagga tatctccaca
     1021 gagtaaatgt tgtgttgtct gtcttcattt tgtaacagct ggaccttcca ttctagaatt
     1081 atgagaccac cttggagaaa ggtgtgtggt acatgacatt gggttacatc ataacgtgct
     1141 tccagatcat agtgttcagt gtcctctgaa gtaactgcct gttgcctctg ctgccctttg
     1201 aaccagtgta cagtcgccag atagggaccg gtgaacacct gattccaaac atgtaggatg
     1261 ggggtcttgt cctcttttta tgtggtttaa ttgccaagtg tctaaagctt aatatgccgt
     1321 gctatgtaaa tattttatgg atataacaac tgtcatattt tgatgtcaac agagttttag
     1381 ggataaaatg gtacccggcc aacatcaagt gactttatag ctgcaagaaa tgtggtatgt
     1441 ggagaagttc tgtatgtgag gaaggaaaaa aagaaaataa aagtgtgttt gaaaaatatt
     1501 atcttgggtt ctttgtaaaa tttatttttt acatgctgaa ttagcctcga tctttttgat
     1561 taagagcaca aacttttttt tgtaaaacat gtaaaaaaaa aaactgggat taatttttag
     1621 tgttggaact gcctcttatt ttaggctgta gataaaatag catttttagg ttagccagtg
     1681 tgactatgca cctaattttt tatgagatta aattcataag acttaatttg tacaatagtt
     1741 tgtgaaatat cttgttactg cttttattta gcagactgtg gactgtaata aagtatataa
     1801 attgtgaaat ataaaaactt ggaacttatt caaagcttca aagcaaa
//
