LOCUS       NM_001678               3341 bp    mRNA    linear   PRI 20-MAR-2024
DEFINITION  Homo sapiens ATPase Na+/K+ transporting subunit beta 2 (ATP1B2),
            transcript variant 1, mRNA.
ACCESSION   NM_001678
VERSION     NM_001678.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3341)
  AUTHORS   Roldan,M.L., Ramirez-Salinas,G.L., Martinez-Archundia,M.,
            Cuellar-Perez,F., Vilchis-Nestor,C.A., Cancino-Diaz,J.C. and
            Shoshani,L.
  TITLE     The beta2-Subunit (AMOG) of Human Na+, K+-ATPase Is a Homophilic
            Adhesion Molecule
  JOURNAL   Int J Mol Sci 23 (14), 7753 (2022)
   PUBMED   35887102
  REMARK    GeneRIF: The beta2-Subunit (AMOG) of Human Na(+), K(+)-ATPase Is a
            Homophilic Adhesion Molecule.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3341)
  AUTHORS   Jiang,Q., Xie,Q., Hu,C., Yang,Z., Huang,P., Shen,H., Schachner,M.
            and Zhao,W.
  TITLE     Glioma malignancy is linked to interdependent and inverse AMOG and
            L1 adhesion molecule expression
  JOURNAL   BMC Cancer 19 (1), 911 (2019)
   PUBMED   31510944
  REMARK    GeneRIF: AMOG and L1 interdependently regulate their expression
            levels not only in U-87 MG cells but also in U251 and SHG44 human
            glioma cell lines. The capacity of AMOG to reduce L1 expression
            suggests that methods for increasing AMOG expression may provide a
            therapeutic choice for the management of glial tumors with high
            expression of L1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3341)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   4  (bases 1 to 3341)
  AUTHORS   Wu,C., Wang,Z., Song,X., Feng,X.S., Abnet,C.C., He,J., Hu,N.,
            Zuo,X.B., Tan,W., Zhan,Q., Hu,Z., He,Z., Jia,W., Zhou,Y., Yu,K.,
            Shu,X.O., Yuan,J.M., Zheng,W., Zhao,X.K., Gao,S.G., Yuan,Z.Q.,
            Zhou,F.Y., Fan,Z.M., Cui,J.L., Lin,H.L., Han,X.N., Li,B., Chen,X.,
            Dawsey,S.M., Liao,L., Lee,M.P., Ding,T., Qiao,Y.L., Liu,Z., Liu,Y.,
            Yu,D., Chang,J., Wei,L., Gao,Y.T., Koh,W.P., Xiang,Y.B., Tang,Z.Z.,
            Fan,J.H., Han,J.J., Zhou,S.L., Zhang,P., Zhang,D.Y., Yuan,Y.,
            Huang,Y., Liu,C., Zhai,K., Qiao,Y., Jin,G., Guo,C., Fu,J., Miao,X.,
            Lu,C., Yang,H., Wang,C., Wheeler,W.A., Gail,M., Yeager,M.,
            Yuenger,J., Guo,E.T., Li,A.L., Zhang,W., Li,X.M., Sun,L.D.,
            Ma,B.G., Li,Y., Tang,S., Peng,X.Q., Liu,J., Hutchinson,A.,
            Jacobs,K., Giffen,C., Burdette,L., Fraumeni,J.F. Jr., Shen,H.,
            Ke,Y., Zeng,Y., Wu,T., Kraft,P., Chung,C.C., Tucker,M.A., Hou,Z.C.,
            Liu,Y.L., Hu,Y.L., Liu,Y., Wang,L., Yuan,G., Chen,L.S., Liu,X.,
            Ma,T., Meng,H., Sun,L., Li,X.M., Li,X.M., Ku,J.W., Zhou,Y.F.,
            Yang,L.Q., Wang,Z., Li,Y., Qige,Q., Yang,W.J., Lei,G.Y., Chen,L.Q.,
            Li,E.M., Yuan,L., Yue,W.B., Wang,R., Wang,L.W., Fan,X.P., Zhu,F.H.,
            Zhao,W.X., Mao,Y.M., Zhang,M., Xing,G.L., Li,J.L., Han,M.,
            Ren,J.L., Liu,B., Ren,S.W., Kong,Q.P., Li,F., Sheyhidin,I., Wei,W.,
            Zhang,Y.R., Feng,C.W., Wang,J., Yang,Y.H., Hao,H.Z., Bao,Q.D.,
            Liu,B.C., Wu,A.Q., Xie,D., Yang,W.C., Wang,L., Zhao,X.H.,
            Chen,S.Q., Hong,J.Y., Zhang,X.J., Freedman,N.D., Goldstein,A.M.,
            Lin,D., Taylor,P.R., Wang,L.D. and Chanock,S.J.
  TITLE     Joint analysis of three genome-wide association studies of
            esophageal squamous cell carcinoma in Chinese populations
  JOURNAL   Nat Genet 46 (9), 1001-1006 (2014)
   PUBMED   25129146
REFERENCE   5  (bases 1 to 3341)
  AUTHORS   Suguro,M., Yoshida,N., Umino,A., Kato,H., Tagawa,H., Nakagawa,M.,
            Fukuhara,N., Karnan,S., Takeuchi,I., Hocking,T.D., Arita,K.,
            Karube,K., Tsuzuki,S., Nakamura,S., Kinoshita,T. and Seto,M.
  TITLE     Clonal heterogeneity of lymphoid malignancies correlates with poor
            prognosis
  JOURNAL   Cancer Sci 105 (7), 897-904 (2014)
   PUBMED   24815991
REFERENCE   6  (bases 1 to 3341)
  AUTHORS   Hundal,H.S., Maxwell,D.L., Ahmed,A., Darakhshan,F., Mitsumoto,Y.
            and Klip,A.
  TITLE     Subcellular distribution and immunocytochemical localization of
            Na,K-ATPase subunit isoforms in human skeletal muscle
  JOURNAL   Mol Membr Biol 11 (4), 255-262 (1994)
   PUBMED   7711835
REFERENCE   7  (bases 1 to 3341)
  AUTHORS   Hsieh,C.L., Cheng-Deutsch,A., Gloor,S., Schachner,M. and Francke,U.
  TITLE     Assignment of Amog (adhesion molecule on glia) gene to mouse
            chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17
  JOURNAL   Somat Cell Mol Genet 16 (4), 401-405 (1990)
   PUBMED   1699290
REFERENCE   8  (bases 1 to 3341)
  AUTHORS   Gloor,S., Antonicek,H., Sweadner,K.J., Pagliusi,S., Frank,R.,
            Moos,M. and Schachner,M.
  TITLE     The adhesion molecule on glia (AMOG) is a homologue of the beta
            subunit of the Na,K-ATPase
  JOURNAL   J Cell Biol 110 (1), 165-174 (1990)
   PUBMED   1688561
REFERENCE   9  (bases 1 to 3341)
  AUTHORS   Lingrel,J.B., Orlowski,J., Shull,M.M. and Price,E.M.
  TITLE     Molecular genetics of Na,K-ATPase
  JOURNAL   Prog Nucleic Acid Res Mol Biol 38, 37-89 (1990)
   PUBMED   2158121
  REMARK    Review article
REFERENCE   10 (bases 1 to 3341)
  AUTHORS   Martin-Vasallo,P., Dackowski,W., Emanuel,J.R. and Levenson,R.
  TITLE     Identification of a putative isoform of the Na,K-ATPase beta
            subunit. Primary structure and tissue-specific expression
  JOURNAL   J Biol Chem 264 (8), 4613-4618 (1989)
   PUBMED   2538450
  REMARK    GeneRIF: different members of the Na,K-ATPase beta subunit family
            may have specialized functions.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA122526.1, AK290143.1,
            AC007421.13 and AL120033.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001678.4.
            
            Summary: The protein encoded by this gene belongs to the family of
            Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily
            of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein
            responsible for establishing and maintaining the electrochemical
            gradients of Na and K ions across the plasma membrane. These
            gradients are essential for osmoregulation, for sodium-coupled
            transport of a variety of organic and inorganic molecules, and for
            electrical excitability of nerve and muscle. This enzyme is
            composed of two subunits, a large catalytic subunit (alpha) and a
            smaller glycoprotein subunit (beta). The beta subunit regulates,
            through assembly of alpha/beta heterodimers, the number of sodium
            pumps transported to the plasma membrane. The glycoprotein subunit
            of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a
            beta 2 subunit. Two transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.934702.1,
                                           SRR3476690.267881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250111.9/ ENSP00000250111.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               DA122526.1         37-258
            223-292             AK290143.1         1-70
            293-293             AC007421.13        20954-20954         c
            294-528             AK290143.1         72-306
            529-529             AC007421.13        20718-20718         c
            530-988             AK290143.1         308-766
            989-989             AC007421.13        18071-18071         c
            990-1714            AK290143.1         768-1492
            1715-3003           AC007421.13        14740-16028         c
            3004-3341           AL120033.1         1-338
FEATURES             Location/Qualifiers
     source          1..3341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3341
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /note="ATPase Na+/K+ transporting subunit beta 2"
                     /db_xref="GeneID:482"
                     /db_xref="HGNC:HGNC:805"
                     /db_xref="MIM:182331"
     exon            1..705
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..1466
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /EC_number="7.2.2.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adhesion molecule on glia; sodium/potassium-transporting
                     ATPase beta-2 chain; sodium/potassium-dependent ATPase
                     beta-2 subunit; Na, K-ATPase beta-2 polypeptide;
                     sodium/potassium-transporting ATPase subunit beta-2;
                     sodium/potassium-dependent ATPase subunit beta-2; sodium
                     pump subunit beta-2; sodium-potassium ATPase subunit beta
                     2 (non-catalytic); adhesion molecule in glia; ATPase,
                     Na+/K+ transporting, beta 2 polypeptide"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-2 isoform 1"
                     /protein_id="NP_001669.3"
                     /db_xref="CCDS:CCDS32550.1"
                     /db_xref="GeneID:482"
                     /db_xref="HGNC:HGNC:805"
                     /db_xref="MIM:182331"
                     /translation="MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFY
                     LVFYGFLTAMFTLTMWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTES
                     WDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNC
                     SGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFP
                     ANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDK
                     FAGRVAFKLRINKT"
     exon            706..834
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /inference="alignment:Splign:2.1.0"
     exon            835..939
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1145
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1202
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1301
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..3341
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3296..3301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /note="hexamer: AATAAA"
     polyA_site      3341
                     /gene="ATP1B2"
                     /gene_synonym="AMOG"
                     /note="major polyA site"
ORIGIN      
        1 gcactgctga ggagcggagc ctccgcctgg ggggcccccc atccctggct gtcccccagc
       61 tgcgcgtccc cgccccaccc ccgcggctga gccaccaccg gtgcagtggt ctccgcttgg
      121 cggagcgagc cttgagcttc gttccacagc ttctttgcat cttggatttc ggggcggccc
      181 cctcccccac ctctctctgc ctttttgtac cccgcttttt ttctgcgttc tgctcggttt
      241 ttgtagccgt ctgtttttgc accccatttc gttttgtttc tagacggttt ggtggggggt
      301 gaagctgcat tcatacccct tcctcttgtt attctcccct gctctgacag cacccctttt
      361 catcgcagtt ggggggccta ggatcggtgc atcttccgcc gcgctgccag caccccgcag
      421 cgcgtggtcg tgcaccccgg aatctgcagc agctgcatat ctgagggggg tctcctttgc
      481 ccgcgccgcc ttcgctcccc gtgcttttgg gtgtgtggag ggcttcagcg cgcggcgccc
      541 ccgcttctcc gcaacccccc gccccgcgcc cggactcgcc ccgcgccacc aagatggtca
      601 tccagaaaga gaagaagagc tgcgggcagg tggttgagga gtggaaggag ttcgtgtgga
      661 acccgaggac gcaccagttt atgggccgca ccgggaccag ctgggccttt atcctcctct
      721 tctacctcgt tttttatggg ttcctcaccg ccatgttcac cctcaccatg tgggtgatgc
      781 tgcagactgt ctccgaccat acccccaagt accaggaccg actggccaca ccgggcttga
      841 tgattcgccc caagactgag aaccttgatg tcattgtcaa tgtcagtgac actgaaagct
      901 gggaccagca tgttcagaag ctcaacaagt tcttggagcc ttacaacgac tctatccaag
      961 cccaaaagaa tgatgtctgc cgccctggac gctattacga acagccagat aatggagtcc
     1021 tcaactaccc caaacgtgcc tgccaattca accggaccca gctgggcaac tgctccggca
     1081 ttggggactc cacccactat ggttacagca ctgggcagcc ctgtgtcttc atcaagatga
     1141 accgggtcat caacttctat gcaggagcaa accagagcat gaatgttacc tgtgctggga
     1201 agcgagatga agatgctgag aatctcggca acttcgtcat gttccccgcc aacggcaaca
     1261 tcgacctcat gtacttcccc tactatggca aaaagttcca cgtgaactac acacagcccc
     1321 tggtggctgt gaagttcctg aatgtgaccc ccaacgtgga ggtgaatgta gaatgtcgca
     1381 tcaacgccgc caacatcgcc acagacgatg agcgagacaa gttcgccggc cgcgtggcct
     1441 tcaaactccg catcaacaaa acctgaggcc ccttcctccc accccatctc tctcctgtgg
     1501 atgctcctgg aatgtccctg accctgcctg atccctccct cacccacccc aaaggtattt
     1561 ttgataacag agctatgact tgtctgagcc tcacatcctt ttccttgact tctcaaccca
     1621 gcctgaagtc cattgcggtt ccgtcactcg cctttcccac caacttctcc caacctcaga
     1681 tcagtcagac agggagctgg gctaagatgg ccacggagga gttaggagcc tttctagttc
     1741 tggtttagct gtgagagcta tccactctcc tgcctgcata tcccctgaga gttataggaa
     1801 gtgcccactg acccacccac ccacctacac cccccgccac acacacacac aaacgtgcac
     1861 acgcgtctca tttgacccct ttgcttccag agatgaatgt ggcactccct ccttccattc
     1921 ctaagctctg gccaccgtcc cttgatctct catactttct ccctgtctac acagtcgcca
     1981 tcttggtgac tttgaattta tctggctcct gggcaggtct tctcctcctc tccatcccta
     2041 ttccctcctc tgaaatgcac ccctttgtaa ttgaggacaa ggtggttctg tggccttttc
     2101 cctctttgct ggcacgttct gcttctcacc ctctggtgac tctgtgagct gggaaatgag
     2161 ggactggaag tgaggcctgt gttgaccctt cctgaaaatc ctctagcagc ccccgacttc
     2221 agcagtttct ttctttgttt ttttgagatg gagtttcgct cttgttgccc aggctggagt
     2281 gcaatggtgc aatctcagct cactgcaact tccgcatccc aggttcaagc gattctcccg
     2341 cctcaggttc ccgagtagct gggactacag gcatgtgcca ccatgcccgg ctaatttctt
     2401 tctttctttt tttttttttt tgcatttttt agtagagatg ggggtttctc cttgttggtc
     2461 aggctggtct cgaactcccg acctcaggtg atccacctgc ctcggcctcc caaagtgttg
     2521 ggattacagg cgtgagccac cgcgcccggc cttcagtttc ttcctaggcc gttctgtcac
     2581 ccaaatagct gctacccaga ggggcggggt tgacctaggc tgaatatcca ctttgttttt
     2641 atggatggct cccttccccc attcgccttc ccagaatatc cttcaagttc cacttcccag
     2701 ggagctctgg gggaggggcg gccattctgg ctccgtcccc agtggccacc ttggaaacat
     2761 cggctggctt tgggactatt ccacctcctt cccctgagcc cagatctgcc cccaccatcc
     2821 tttctctggc ttcttttagc aagttatcaa ctaatcacta actccttcct tttcctctgc
     2881 atgccagcct gaaaattcca aatctagcct ctgaatgtct tggctccatc tcttcagacc
     2941 cctttgcctt taaaaaaaaa acaaaaacaa aaacaaaaaa acccataatg cccacagaat
     3001 gtcaaatgag gggcctcctg cctcctgctc tgaatattct gtagctgtag aggcatttta
     3061 accctttgtc ctccagcatc ccttcacttc ctcatcctct ctaacctcct ttttcttttt
     3121 ttaatgctgc agcctccaca ctccacccac aggtggaccc ttcccttttt ctctagctgg
     3181 atctgtgttt cttcccttcg ggcccccatg ttttcctgca cccgccctac catggtctct
     3241 ctctgcagtt atttaatgcc tgtgtcagat ctactgtaaa aagaggatta agtaaaataa
     3301 aatgagagca attatatata taaatatata tcatacacag a
//
