LOCUS       NM_001677               2216 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ATPase Na+/K+ transporting subunit beta 1 (ATP1B1),
            mRNA.
ACCESSION   NM_001677
VERSION     NM_001677.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2216)
  AUTHORS   Chakraborty,M., Jandhyam,H., Basak,S.K., Das,S. and Alone,D.P.
  TITLE     Intergenic variants, rs1200114 and rs1200108 are genetically
            associated along with a decreased ATP1B1 expression in Fuchs
            Endothelial Corneal Dystrophy
  JOURNAL   Exp Eye Res 228, 109403 (2023)
   PUBMED   36736852
  REMARK    GeneRIF: Intergenic variants, rs1200114 and rs1200108 are
            genetically associated along with a decreased ATP1B1 expression in
            Fuchs Endothelial Corneal Dystrophy.
REFERENCE   2  (bases 1 to 2216)
  AUTHORS   Guo,Y., Zhang,Y., Yan,R., Huang,B., Ye,F., Wu,L., Chi,X., Shi,Y.
            and Zhou,Q.
  TITLE     Cryo-EM structures of recombinant human sodium-potassium pump
            determined in three different states
  JOURNAL   Nat Commun 13 (1), 3957 (2022)
   PUBMED   35803952
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2216)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2216)
  AUTHORS   Kryvenko,V., Wessendorf,M., Tello,K., Herold,S., Morty,R.E.,
            Seeger,W. and Vadasz,I.
  TITLE     Hypercapnia Induces Inositol-Requiring Enzyme 1alpha-Driven
            Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase
            beta-Subunit
  JOURNAL   Am J Respir Cell Mol Biol 65 (6), 615-629 (2021)
   PUBMED   34192507
  REMARK    GeneRIF: Hypercapnia Induces Inositol-Requiring Enzyme
            1alpha-Driven Endoplasmic Reticulum-associated Degradation of the
            Na,K-ATPase beta-Subunit.
REFERENCE   5  (bases 1 to 2216)
  AUTHORS   Cao,W., Guo,Y., Cheng,Z., Xu,G., Zuo,Q., Nie,L., Huang,Y., Liu,S.
            and Zhu,Y.
  TITLE     Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by
            the Ubiquitination of TRAF3 and TRAF6
  JOURNAL   J Immunol 206 (11), 2668-2681 (2021)
   PUBMED   34011520
  REMARK    GeneRIF: Inducible ATP1B1 Upregulates Antiviral Innate Immune
            Responses by the Ubiquitination of TRAF3 and TRAF6.
REFERENCE   6  (bases 1 to 2216)
  AUTHORS   Lingrel,J.B., Orlowski,J., Shull,M.M. and Price,E.M.
  TITLE     Molecular genetics of Na,K-ATPase
  JOURNAL   Prog Nucleic Acid Res Mol Biol 38, 37-89 (1990)
   PUBMED   2158121
  REMARK    Review article
REFERENCE   7  (bases 1 to 2216)
  AUTHORS   Ushkaryov,Yu.A., Monastyrskaya,G.S., Broude,N.E., Nikiforova,N.N.,
            Bessarab,D.A., Orlova,M.Yu., Petrukhin,K.E., Modyanov,N.N. and
            Sverdlov,E.D.
  TITLE     Human Na+,K+-ATPase genes. Beta-subunit gene family contains at
            least one gene and one pseudogene
  JOURNAL   FEBS Lett 257 (2), 439-442 (1989)
   PUBMED   2555225
REFERENCE   8  (bases 1 to 2216)
  AUTHORS   Lane,L.K., Shull,M.M., Whitmer,K.R. and Lingrel,J.B.
  TITLE     Characterization of two genes for the human Na,K-ATPase beta
            subunit
  JOURNAL   Genomics 5 (3), 445-453 (1989)
   PUBMED   2559024
REFERENCE   9  (bases 1 to 2216)
  AUTHORS   Martin-Vasallo,P., Dackowski,W., Emanuel,J.R. and Levenson,R.
  TITLE     Identification of a putative isoform of the Na,K-ATPase beta
            subunit. Primary structure and tissue-specific expression
  JOURNAL   J Biol Chem 264 (8), 4613-4618 (1989)
   PUBMED   2538450
REFERENCE   10 (bases 1 to 2216)
  AUTHORS   Yang-Feng,T.L., Schneider,J.W., Lindgren,V., Shull,M.M., Benz,E.J.
            Jr., Lingrel,J.B. and Francke,U.
  TITLE     Chromosomal localization of human Na+, K+-ATPase alpha- and
            beta-subunit genes
  JOURNAL   Genomics 2 (2), 128-138 (1988)
   PUBMED   2842249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031726.23, BQ934151.1,
            BC000006.2, CD722755.1, BM762099.1, AA514770.1, U16799.1 and
            BE223067.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001677.3.
            
            Summary: The protein encoded by this gene belongs to the family of
            Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily
            of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein
            responsible for establishing and maintaining the electrochemical
            gradients of Na and K ions across the plasma membrane. These
            gradients are essential for osmoregulation, for sodium-coupled
            transport of a variety of organic and inorganic molecules, and for
            electrical excitability of nerve and muscle. This enzyme is
            composed of two subunits, a large catalytic subunit (alpha) and a
            smaller glycoprotein subunit (beta). The beta subunit regulates,
            through assembly of alpha/beta heterodimers, the number of sodium
            pumps transported to the plasma membrane. The glycoprotein subunit
            of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a
            beta 1 subunit. Alternatively spliced transcript variants encoding
            different isoforms have been described, but their biological
            validity is not known. [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.2385.1,
                                           SRR11853558.2027.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367815.9/ ENSP00000356789.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL031726.23        66438-66456
            20-54               BQ934151.1         205-239
            55-1261             BC000006.2         1-1207
            1262-1512           CD722755.1         35-285
            1513-1537           BM762099.1         66-90
            1538-2018           AA514770.1         1-481
            2019-2196           U16799.1           1280-1457
            2197-2216           BE223067.1         16-35               c
FEATURES             Location/Qualifiers
     source          1..2216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..2216
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /note="ATPase Na+/K+ transporting subunit beta 1"
                     /db_xref="GeneID:481"
                     /db_xref="HGNC:HGNC:804"
                     /db_xref="MIM:182330"
     exon            1..237
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1052
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /EC_number="3.6.1.3"
                     /note="sodium/potassium-transporting ATPase beta-1 chain;
                     sodium/potassium-dependent ATPase beta-1 subunit; Na,
                     K-ATPase beta-1 polypeptide; ATPase, Na+/K+ transporting,
                     beta 1 polypeptide; adenosinetriphosphatase; Beta
                     1-subunit of Na(+),K(+)-ATPase; sodium pump subunit
                     beta-1; sodium-potassium ATPase subunit beta 1
                     (non-catalytic)"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-1"
                     /protein_id="NP_001668.1"
                     /db_xref="CCDS:CCDS1276.1"
                     /db_xref="GeneID:481"
                     /db_xref="HGNC:HGNC:804"
                     /db_xref="MIM:182330"
                     /translation="MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYG
                     CLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYV
                     LNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCS
                     GLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRD
                     EDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIEC
                     KAYGENIGYSEKDRFQGRFDVKIEVKS"
     exon            238..366
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            367..522
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            523..707
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            708..788
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            789..2216
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2199..2204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /note="hexamer: AATAAA"
     polyA_site      2216
                     /gene="ATP1B1"
                     /gene_synonym="ATP1B"
                     /note="major polyA site"
ORIGIN      
        1 actccgagag ccgcagcggc agcggcgcgt cctgcctgca gagagccagg ccggagaagc
       61 cgagcggcgc agaggacgcc agggcgcgcg ccgcagccac ccaccctccg gaccgcggca
      121 gctgctgacc cgccatcgcc atggcccgcg ggaaagccaa ggaggagggc agctggaaga
      181 aattcatctg gaactcagag aagaaggagt ttctgggcag gaccggtggc agttggttta
      241 agatccttct attctacgta atattttatg gctgcctggc tggcatcttc atcggaacca
      301 tccaagtgat gctgctcacc atcagtgaat ttaagcccac atatcaggac cgagtggccc
      361 cgccaggatt aacacagatt cctcagatcc agaagactga aatttccttt cgtcctaatg
      421 atcccaagag ctatgaggca tatgtactga acatagttag gttcctggaa aagtacaaag
      481 attcagccca gagggatgac atgatttttg aagattgtgg cgatgtgccc agtgaaccga
      541 aagaacgagg agactttaat catgaacgag gagagcgaaa ggtctgcaga ttcaagcttg
      601 aatggctggg aaattgctct ggattaaatg atgaaactta tggctacaaa gagggcaaac
      661 cgtgcattat tataaagctc aaccgagttc taggcttcaa acctaagcct cccaagaatg
      721 agtccttgga gacttaccca gtgatgaagt ataacccaaa tgtccttccc gttcagtgca
      781 ctggcaagcg agatgaagat aaggataaag ttggaaatgt ggagtatttt ggactgggca
      841 actcccctgg ttttcctctg cagtattatc cgtactatgg caaactcctg cagcccaaat
      901 acctgcagcc cctgctggcc gtacagttca ccaatcttac catggacact gaaattcgca
      961 tagagtgtaa ggcgtacggt gagaacattg ggtacagtga gaaagaccgt tttcagggac
     1021 gttttgatgt aaaaattgaa gttaagagct gatcacaagc acaaatcttt cccactagcc
     1081 atttaataag ttaaaaaaag atacaaaaac aaaaacctac tagtcttgaa caaactgtca
     1141 tacgtatggg acctacactt aatctatatg ctttacacta gctttctgca tttaataggt
     1201 tagaatgtaa attaaagtgt agcaatagca acaaaatatt tattctactg taaatgacaa
     1261 aagaaaaaga aaaattgagc cttgggacgt gcccattttt actgtaaatt atgattccgt
     1321 aactgacttg tagtaagcag tgtttctggc ccctaagtat tgctgccttg tgtattttat
     1381 ttagtgtaca gtactacagg tgcatactct ggtcattttt caagccatgt tttattgtat
     1441 ctgttttcta ctttatgtga gcaaggtttg ctgtccaagg tgtaaatatt caacgggaat
     1501 aaaactggca tggtaatttt tttttttttt ttttttttgt tttttggctc tttcaaaggt
     1561 aatggcccat cgatgagcat ttttaacata ctccatagtc ttttcctgtg gtgttaggtc
     1621 tttattttta tttttttcct gggggctggg gtgggggttt gtcatggggg aactgccctt
     1681 taaattttaa gtgacactac agaaaaacac aaaaaggtga tgggttgtgt tatgcttgta
     1741 ttgaatgctg tcttgacatc tcttgccttg tcctccggta tgttctaaag ctgtgtctga
     1801 gatctggatc tgcccatcac tttggctagt gacagggcta attaatttgc tttatacatt
     1861 ttcttttact ttcctttttt cctttctgga ggcatcacat gctggtgctg tgtctttatg
     1921 aatgttttaa ccattttcat ggtggaagaa ttttatattt atgcagttgt acaattttat
     1981 ttttttctgc aagaaaaagt gtaatgtatg aaataaacca aagtcacttg tttgaaaata
     2041 aatctttatt ttgaacttta taaaaagcaa tgcagtaccc catagactgg tgttaaatgt
     2101 tgtctacagt gcaaaatcca tgttctaaca tatgtaataa ttgccaggag tacagtgctc
     2161 ttgttgatct tgtattcagt caggttaaaa caacggacaa taaaagaatg aacaca
//
