LOCUS       NM_000702               5435 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ATPase Na+/K+ transporting subunit alpha 2 (ATP1A2),
            mRNA.
ACCESSION   NM_000702
VERSION     NM_000702.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5435)
  AUTHORS   Cordoba,N.M., Lince-Rivera,I., Gomez,J.L.R., Rubboli,G. and De la
            Rosa,S.O.
  TITLE     ATP1A2-related epileptic encephalopathy and movement disorder:
            Clinical features of three novel patients
  JOURNAL   Epileptic Disord 26 (3), 332-340 (2024)
   PUBMED   38512072
  REMARK    GeneRIF: ATP1A2-related epileptic encephalopathy and movement
            disorder: Clinical features of three novel patients.
REFERENCE   2  (bases 1 to 5435)
  AUTHORS   Dai,L., Ding,C., Tian,X., Liu,M., Ma,Y., Chen,C., Ren,X. and Li,H.
  TITLE     The clinical spectrum associated with ATP1A2 variants in Chinese
            pediatric patients
  JOURNAL   Brain Dev 45 (8), 422-431 (2023)
   PUBMED   37142513
  REMARK    GeneRIF: The clinical spectrum associated with ATP1A2 variants in
            Chinese pediatric patients.
REFERENCE   3  (bases 1 to 5435)
  AUTHORS   Oda,I., Danno,D., Saigoh,K., Wolf,J., Kawashita,N., Hirano,M.,
            Samukawa,M., Kitamura,S., Kikui,S., Takeshima,T., Mitsui,Y.,
            Kusunoki,S. and Nagai,Y.
  TITLE     Hemiplegic migraine type 2 with new mutation of the ATP1A2 gene in
            Japanese cases
  JOURNAL   Neurosci Res 180, 83-89 (2022)
   PUBMED   35257835
  REMARK    GeneRIF: Hemiplegic migraine type 2 with new mutation of the ATP1A2
            gene in Japanese cases.
REFERENCE   4  (bases 1 to 5435)
  AUTHORS   Kubota,T., Nabatame,S., Sato,R., Hama,M., Nishiike,U.,
            Mochizuki,H., Takahashi,M.P. and Takeshima,T.
  TITLE     Hemiplegic migraine type 2 caused by a novel variant within the
            P-type ATPase motif in ATP1A2 concomitant with a CACNA1A variant
  JOURNAL   Brain Dev 43 (9), 952-957 (2021)
   PUBMED   34092402
  REMARK    GeneRIF: Hemiplegic migraine type 2 caused by a novel variant
            within the P-type ATPase motif in ATP1A2 concomitant with a CACNA1A
            variant.
REFERENCE   5  (bases 1 to 5435)
  AUTHORS   Li,Y., Tang,W., Kang,L., Kong,S., Dong,Z., Zhao,D., Liu,R. and
            Yu,S.
  TITLE     Functional correlation of ATP1A2 mutations with phenotypic
            spectrum: from pure hemiplegic migraine to its variant forms
  JOURNAL   J Headache Pain 22 (1), 92 (2021)
   PUBMED   34384358
  REMARK    GeneRIF: Functional correlation of ATP1A2 mutations with phenotypic
            spectrum: from pure hemiplegic migraine to its variant forms.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5435)
  AUTHORS   Jen,J.C.
  TITLE     Familial Hemiplegic Migraine
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301562
REFERENCE   7  (bases 1 to 5435)
  AUTHORS   Lingrel,J.B., Orlowski,J., Shull,M.M. and Price,E.M.
  TITLE     Molecular genetics of Na,K-ATPase
  JOURNAL   Prog Nucleic Acid Res Mol Biol 38, 37-89 (1990)
   PUBMED   2158121
  REMARK    Review article
REFERENCE   8  (bases 1 to 5435)
  AUTHORS   Shull,M.M., Pugh,D.G. and Lingrel,J.B.
  TITLE     Characterization of the human Na,K-ATPase alpha 2 gene and
            identification of intragenic restriction fragment length
            polymorphisms
  JOURNAL   J Biol Chem 264 (29), 17532-17543 (1989)
   PUBMED   2477373
REFERENCE   9  (bases 1 to 5435)
  AUTHORS   Sverdlov,E.D., Bessarab,D.A., Malyshev,I.V., Petrukhin,K.E.,
            Smirnov,Yu.V., Ushkaryov,Yu.A., Monastyrskaya,G.S., Broude,N.E. and
            Modyanov,N.N.
  TITLE     Family of human Na+,K+-ATPase genes. Structure of the putative
            regulatory region of the alpha+-gene
  JOURNAL   FEBS Lett 244 (2), 481-483 (1989)
   PUBMED   2537767
REFERENCE   10 (bases 1 to 5435)
  AUTHORS   Yang-Feng,T.L., Schneider,J.W., Lindgren,V., Shull,M.M., Benz,E.J.
            Jr., Lingrel,J.B. and Francke,U.
  TITLE     Chromosomal localization of human Na+, K+-ATPase alpha- and
            beta-subunit genes
  JOURNAL   Genomics 2 (2), 128-138 (1988)
   PUBMED   2842249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA221602.1, BC052271.1,
            EB386326.1 and BC013680.1.
            
            On May 17, 2019 this sequence version replaced NM_000702.3.
            
            Summary: The protein encoded by this gene belongs to the family of
            P-type cation transport ATPases, and to the subfamily of Na+/K+
            -ATPases. Na+/K+ -ATPase is an integral membrane protein
            responsible for establishing and maintaining the electrochemical
            gradients of Na and K ions across the plasma membrane. These
            gradients are essential for osmoregulation, for sodium-coupled
            transport of a variety of organic and inorganic molecules, and for
            electrical excitability of nerve and muscle. This enzyme is
            composed of two subunits, a large catalytic subunit (alpha) and a
            smaller glycoprotein subunit (beta). The catalytic subunit of
            Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an
            alpha 2 subunit. Mutations in this gene result in familial basilar
            or hemiplegic migraines, and in a rare syndrome known as
            alternating hemiplegia of childhood. [provided by RefSeq, Oct
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047533.1, AK314296.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361216.8/ ENSP00000354490.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA221602.1         30-49
            21-4376             BC052271.1         1-4356
            4377-4800           EB386326.1         116-539
            4801-5435           BC013680.1         147-781
FEATURES             Location/Qualifiers
     source          1..5435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..5435
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /note="ATPase Na+/K+ transporting subunit alpha 2"
                     /db_xref="GeneID:477"
                     /db_xref="HGNC:HGNC:800"
                     /db_xref="MIM:182340"
     exon            1..115
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..3166
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /EC_number="7.2.2.13"
                     /note="sodium/potassium-transporting ATPase alpha-2 chain;
                     Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+
                     ATPase, alpha-B polypeptide; sodium pump subunit alpha-2;
                     sodium/potassium-transporting ATPase subunit alpha-2;
                     Na(+)/K(+) ATPase alpha-2 subunit; sodium-potassium ATPase
                     catalytic subunit alpha-2; ATPase Na+/K+ transporting
                     alpha 2 polypeptide"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-2 precursor"
                     /protein_id="NP_000693.1"
                     /db_xref="CCDS:CCDS1196.1"
                     /db_xref="GeneID:477"
                     /db_xref="HGNC:HGNC:800"
                     /db_xref="MIM:182340"
                     /translation="MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKL
                     SLDELGRKYQVDLSKGLTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILL
                     WIGAILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFK
                     NMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTG
                     ESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLE
                     VGRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGL
                     LATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFD
                     NQIHEADTTEDQSGATFDKRSPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDAS
                     ESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSIHEREDSPQSHVLVMKGAP
                     ERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGF
                     KFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI
                     AKGVGIISEGNETVEDIAARLNIPMSQVNPREAKACVVHGSDLKDMTSEQLDEILKNH
                     TEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSK
                     QAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLP
                     LGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDKLVNERLISMAYGQIGM
                     IQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTYEQRKVVEFT
                     CHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMG
                     VALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY"
     exon            116..220
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            221..280
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..484
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..598
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..733
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            734..851
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1120
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1319
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1429
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1564
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1754
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1930
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2067
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2218
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2387
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2542
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2666
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2812
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2943
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3045
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3137
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..5435
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5166..5171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /note="hexamer: AATAAA"
     polyA_site      5191
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /note="major polyA site"
     polyA_site      5403
                     /gene="ATP1A2"
                     /gene_synonym="DEE98; FARIMPD; FHM2; MHP2"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtctgc cagggtctcc gactgtccca gacgggctgg tgtgggcttg ggatcctcct
       61 ggtgacctct cccgctaagg tccctcagcc actctgcccc aagatgggcc gtggggctgg
      121 ccgtgagtac tcacctgccg ccaccacggc agagaatggg ggcggcaaga agaaacagaa
      181 ggagaaggaa ctggatgagc tgaagaagga ggtggcaatg gatgaccaca agctgtcctt
      241 ggatgagctg ggccgcaaat accaagtgga cctgtccaag ggcctcacca accagcgggc
      301 tcaggacgtt ctggctcgag atgggcccaa cgccctcaca ccacctccca caacccctga
      361 gtgggtcaag ttctgccgtc agcttttcgg ggggttctcc atcctgctgt ggattggggc
      421 tatcctctgc ttcctggcct acggcatcca ggctgccatg gaggatgaac catccaacga
      481 caatctatat ctgggtgtgg tgctggcagc tgtggtcatt gtcactggct gcttctccta
      541 ctaccaggag gccaagagct ccaagatcat ggattccttc aagaacatgg tacctcagca
      601 agcccttgtg atccgggagg gagagaagat gcagatcaac gcagaggaag tggtggtggg
      661 agacctggtg gaggtgaagg gtggagaccg cgtccctgct gacctccgga tcatctcttc
      721 tcatggctgt aaggtggata actcatcctt aacaggagag tcggagcccc agacccgctc
      781 ccccgagttc acccatgaga accccctgga gacccgcaat atctgtttct tctccaccaa
      841 ctgtgttgaa ggcactgcca ggggcattgt gattgccaca ggagaccgga cggtgatggg
      901 ccgcatagct actctcgcct caggcctgga ggttgggcgg acacccatag caatggagat
      961 tgaacacttc atccagctga tcacaggggt cgctgtattc ctgggggtct ccttcttcgt
     1021 gctctccctc atcctgggct acagctggct ggaggcagtc atcttcctca tcggcatcat
     1081 agtggccaac gtgcctgagg ggcttctggc cactgtcact gtgtgcctga ccctgacagc
     1141 caagcgcatg gcacggaaga actgcctggt gaagaacctg gaggcggtgg agacgctggg
     1201 ctccacgtcc accatctgct cggacaagac gggcaccctc acccagaacc gcatgaccgt
     1261 cgcccacatg tggttcgaca accaaatcca tgaggctgac accaccgaag atcagtctgg
     1321 ggccactttt gacaaacgat cccctacgtg gacggccctg tctcgaattg ctggtctctg
     1381 caaccgcgcc gtcttcaagg caggacagga gaacatctcc gtgtctaagc gggacacagc
     1441 tggtgatgcc tctgagtcag ctctgctcaa gtgcattgag ctctcctgtg gctcagtgag
     1501 gaaaatgaga gacagaaacc ccaaggtggc agagattcct ttcaactcta ccaacaagta
     1561 ccagctgtct atccacgagc gagaagacag cccccagagc cacgtgctgg tgatgaaggg
     1621 ggccccagag cgcattctgg accggtgctc caccatcctg gtgcagggca aggagatccc
     1681 gctcgacaag gagatgcaag atgcctttca aaatgcctac atggagctgg ggggacttgg
     1741 ggagcgtgtg ctgggattct gtcaactgaa tctgccatct ggaaagtttc ctcggggctt
     1801 caaattcgac acggatgagc tgaactttcc cacggagaag ctttgctttg tggggctcat
     1861 gtctatgatt gaccctcccc gggctgctgt gccagatgct gtgggcaagt gccgaagcgc
     1921 aggcatcaag gtgatcatgg taaccgggga tcaccctatc acagccaagg ccattgccaa
     1981 aggcgtgggc atcatatcag agggtaacga gactgtggag gacattgcag cccggctcaa
     2041 cattcccatg agtcaagtca accccagaga agccaaggca tgcgtggtgc acggctctga
     2101 cctgaaggac atgacatcgg agcagctcga tgagatcctc aagaaccaca cagagatcgt
     2161 ctttgctcga acgtctcccc agcagaagct catcattgtg gagggatgtc agaggcaggg
     2221 agccattgtg gccgtgacgg gtgacggggt gaacgactcc cctgcattga agaaggctga
     2281 cattggcatt gccatgggca tctctggctc tgacgtctct aagcaggcag ccgacatgat
     2341 cctgctggat gacaactttg cctccatcgt cacgggggtg gaggagggcc gcctgatctt
     2401 tgacaacttg aagaaatcca tcgcctacac cctgaccagc aacatccccg agatcacccc
     2461 cttcctgctg ttcatcattg ccaacatccc cctacctctg ggcactgtga ccatcctttg
     2521 cattgacctg ggcacagata tggtccctgc catctccttg gcctatgagg cagctgagag
     2581 tgatatcatg aagcggcagc cacgaaactc ccagacggac aagctggtga atgagaggct
     2641 catcagcatg gcctacggac agatcgggat gatccaggca ctgggtggct tcttcaccta
     2701 ctttgtgatc ctggcagaga acggtttcct gccatcacgg ctactgggaa tccgcctcga
     2761 ctgggatgac cggaccatga atgatctgga ggacagctat ggacaggagt ggacctatga
     2821 gcagcggaag gtggtggagt tcacgtgcca cacggcattc tttgccagca tcgtggtggt
     2881 gcagtgggct gacctcatca tctgcaagac ccgccgcaac tcagtcttcc agcagggcat
     2941 gaagaacaag atcctgattt ttgggctcct ggaggagacg gcgttggctg cctttctctc
     3001 ttactgccca ggcatgggtg tagccctccg catgtacccg ctcaaagtca cctggtggtt
     3061 ctgcgccttc ccctacagcc tcctcatctt catctatgat gaggtccgaa agctcatcct
     3121 gcggcggtat cctggtggct gggtggagaa ggagacatac tactgacccc attggaagaa
     3181 gaaccaggca tggaaagatg gggagctctg gaggtgttgt ggggatggtg atggagaggg
     3241 atggaaataa cgggtggcat tgggtggcaa catttgggga gagataatga ggcaactcag
     3301 caggctaagt tgcggggtat ataaattggg gtgatgaccc catagaccta actgtgaaca
     3361 atcagattag acactatgtg ttagagtccc cccgaccaga tccttttcca tcccactcca
     3421 ctatgttgtc tattttttct gaggaattaa gggttacccc accctgccca ctcccatccc
     3481 ttcaacccca cttcctactg taatagatca gcatccaaaa gcaggaaccc atctaaacca
     3541 gaaggaagcc ctctcagatc accccagcct cactccattt cccacttcca cccccgttag
     3601 cttcctgcag gactctatcc ctggcttccc cttcagacct tgcaatcaca aaaggttctt
     3661 ctggtgagtg caagagcctg agactggaaa aggtggactt gtctcccagt cgaggctggt
     3721 aagggacctt cagggagagc tgggcagaca ggtgggagat ggaggtaggg ctggctggag
     3781 gaaggaaaca acaaaggaag tgaggtagtg ccaatgacag gacatttgac atgagtctcc
     3841 agatagatgt cgtggactcc agctctacgt cccacatttt agaatacccc accagcagaa
     3901 caaactcaga tctcatcagg gtagcagcag aggcaggacc agaaggcaat caagagcttc
     3961 cagaaatgcc acacttgtgt gccacagagt tccccgctga cccttggtta ggggtcctct
     4021 tagtccacaa ggtccggatg tcactcatgt acttaataac acttcacctt ctgtaatact
     4081 aagtcctcag agctccatgc tgttctgaaa gggatggcca caagttcttt cccagcctct
     4141 tccattccct ttcttttcat gcccatcccg atgaacctgc atcattcccc gacactgcca
     4201 agccaaccct ggaaaaggag ttcgctggcc attggctaga atcagggtgg agaagttccc
     4261 tgaaccttcc tgtctcccag ggacatgtat gcttccaggg acaagcttag gtcatgaaca
     4321 tggtcagaac ctttggacaa gaggaaaaat actaagagat ttgctttttc tgggtgcggt
     4381 ggctcatgcc tgtaatccca gcactttggg aggccgaggc aggtggatca tgaggtcagg
     4441 agttcgaggc gagcctggcc aacatggtga aaccctgtct ctactaaaag tacaaaaaat
     4501 tagccagtca tggtggcaca cgcctgtaat ctcagctact caggaggctg aggcaggaga
     4561 attgcttgaa cctgtgagga agaggttgca gtgagctgag atcgtgccat tacactccag
     4621 cctgggcgaa agggtgagac tccatctcaa aaaaaaaaaa aatgatttgc ttttgacgtc
     4681 ttaggtggca gggctgttcc ctccaggcaa atgcccttca aaccgacgat cattgtgccc
     4741 acttaccctg ggctggagag ttggtttcag gttcctacag gagatagctt tctttccctt
     4801 actccctatc taacactttt gctctgcagg cagccttgcc cattctctaa gcctggctta
     4861 gaaggcactg ggaatgtcct gtagagagag acctagatag gtcatgcaag tgagaaagac
     4921 atctgaggaa aatggaagac ctaaggcaga caggaaggaa gcacaaaaga caagcattgg
     4981 gtcagaccca taaaccacct cccaaaggct gtcatttcat tgcactggaa ttttgcttta
     5041 tcagaagcaa ggaagtaagg gagtcattgc cttgggcctg ggaatctaag tgggagacaa
     5101 tattaatttg gatccgatta attggagatt actaactgtg gacaaaagtt tatctttgca
     5161 caatcaataa aaatggcatt tttttagtaa attaagagca taaacaatat tgctagaggt
     5221 ggcatgttta gtctaccaaa aacaatactt ttcaggcact ttagaaatat ccttttagaa
     5281 gcagcgagtg catgggctaa ttatcatcaa tctttatgta tttgttaaag aaacatctac
     5341 aggatcttta ttggtgacct tttgtaagac attagtttga ggtactacct atgtacttga
     5401 aaataataaa gtggcatttc tttatgaaaa aaaaa
//
