LOCUS       NM_198505               3938 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ATPase 13A5 (ATP13A5), mRNA.
ACCESSION   NM_198505
VERSION     NM_198505.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3938)
  AUTHORS   Sorensen,D.M., Holemans,T., van Veen,S., Martin,S., Arslan,T.,
            Haagendahl,I.W., Holen,H.W., Hamouda,N.N., Eggermont,J.,
            Palmgren,M. and Vangheluwe,P.
  TITLE     Parkinson disease related ATP13A2 evolved early in animal evolution
  JOURNAL   PLoS One 13 (3), e0193228 (2018)
   PUBMED   29505581
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3938)
  AUTHORS   Palmgren,M.G. and Nissen,P.
  TITLE     P-type ATPases
  JOURNAL   Annu Rev Biophys 40, 243-266 (2011)
   PUBMED   21351879
  REMARK    Review article
REFERENCE   3  (bases 1 to 3938)
  AUTHORS   Sorensen,D.M., Buch-Pedersen,M.J. and Palmgren,M.G.
  TITLE     Structural divergence between the two subgroups of P5 ATPases
  JOURNAL   Biochim Biophys Acta 1797 (6-7), 846-855 (2010)
   PUBMED   20416272
REFERENCE   4  (bases 1 to 3938)
  AUTHORS   Moller,A.B., Asp,T., Holm,P.B. and Palmgren,M.G.
  TITLE     Phylogenetic analysis of P5 P-type ATPases, a eukaryotic lineage of
            secretory pathway pumps
  JOURNAL   Mol Phylogenet Evol 46 (2), 619-634 (2008)
   PUBMED   18155930
REFERENCE   5  (bases 1 to 3938)
  AUTHORS   Kwasnicka-Crawford,D.A., Carson,A.R., Roberts,W., Summers,A.M.,
            Rehnstrom,K., Jarvela,I. and Scherer,S.W.
  TITLE     Characterization of a novel cation transporter ATPase gene
            (ATP13A4) interrupted by 3q25-q29 inversion in an individual with
            language delay
  JOURNAL   Genomics 86 (2), 182-194 (2005)
   PUBMED   15925480
REFERENCE   6  (bases 1 to 3938)
  AUTHORS   Schultheis,P.J., Hagen,T.T., O'Toole,K.K., Tachibana,A.,
            Burke,C.R., McGill,D.L., Okunade,G.W. and Shull,G.E.
  TITLE     Characterization of the P5 subfamily of P-type transport ATPases in
            mice
  JOURNAL   Biochem Biophys Res Commun 323 (3), 731-738 (2004)
   PUBMED   15381061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105057.7.
            
            On May 17, 2019 this sequence version replaced NM_198505.3.
            
            Summary: This gene encodes a member of the P5 subfamily of P-type
            transport ATPases. P-type ATPases form a large superfamily of
            cation and lipid pumps that transport inorganic cations and other
            substrates across cell membranes. P5 ATPases are localized to
            membranes of the endoplasmic reticulum (ER) and serve many
            important functions including transport of cargo proteins to the
            Golgi, glycosylation and cell wall biosynthesis, control of protein
            insertion orientation, 3-hydroxy-3-methylglutaryl-CoA reductase
            (HMGR) degradation, and sensitivity to unfolded protein response
            (UPR) activators. The encoded protein is organized into three
            cytoplasmic domains (A, P, and N) and two membrane-embedded domains
            (T and S). The N-domain binds ATP and serves as a built-in protein
            kinase, which phosphorylates the P-domain. The A-domain is an
            intrinsic protein phosphatase, which dephosphorylates the P-domain
            once during each catalytic cycle. [provided by RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY823163.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342358.9/ ENSP00000341942.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC105057.7         34793-34883
            92-265              AC105057.7         49266-49439
            266-412             AC105057.7         50164-50310
            413-483             AC105057.7         50909-50979
            484-564             AC105057.7         51085-51165
            565-634             AC105057.7         59350-59419
            635-769             AC105057.7         62345-62479
            770-842             AC105057.7         68471-68543
            843-971             AC105057.7         69491-69619
            972-1142            AC105057.7         78447-78617
            1143-1300           AC105057.7         79639-79796
            1301-1489           AC105057.7         82235-82423
            1490-1551           AC105057.7         86489-86550
            1552-1702           AC105057.7         88532-88682
            1703-1786           AC105057.7         90972-91055
            1787-1943           AC105057.7         91709-91865
            1944-2061           AC105057.7         94438-94555
            2062-2186           AC105057.7         98450-98574
            2187-2347           AC105057.7         99353-99513
            2348-2473           AC105057.7         101605-101730
            2474-2553           AC105057.7         102829-102908
            2554-2596           AC105057.7         106177-106219
            2597-2706           AC105057.7         107878-107987
            2707-2803           AC105057.7         112239-112335
            2804-2876           AC105057.7         114343-114415
            2877-3051           AC105057.7         123487-123661
            3052-3254           AC105057.7         128430-128632
            3255-3343           AC105057.7         134092-134180
            3344-3424           AC105057.7         136716-136796
            3425-3938           AC105057.7         138244-138757
FEATURES             Location/Qualifiers
     source          1..3938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..3938
                     /gene="ATP13A5"
                     /note="ATPase 13A5"
                     /db_xref="GeneID:344905"
                     /db_xref="HGNC:HGNC:31789"
                     /db_xref="MIM:619119"
     exon            1..91
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..3685
                     /gene="ATP13A5"
                     /EC_number="3.6.3.-"
                     /note="P5-ATPase; ATPase type 13A5"
                     /codon_start=1
                     /product="probable cation-transporting ATPase 13A5"
                     /protein_id="NP_940907.2"
                     /db_xref="CCDS:CCDS33914.1"
                     /db_xref="GeneID:344905"
                     /db_xref="HGNC:HGNC:31789"
                     /db_xref="MIM:619119"
                     /translation="MEENSKKDHRALLNQGEEDELEVFGYRDHNVRKAFCLVASVLTC
                     GGLLLVFYWRPQWRVWANCIPCPLQEADTVLLRTTDEFQRYMRKKVFCLYLSTLKFPV
                     SKKWEESLVADRHSVINQALIKPELKLRCMEVQKIRYVWNDLEKRFQKVGLLEDSNSC
                     SDIHQTFGLGLTSEEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLW
                     LSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKLHNLVEDHNKVQVTIIVKDKGLEEL
                     ESRLLVPGDILILPGKFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQMENTMPW
                     KCHSLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNF
                     KLYSDAFKFIVFLACLGVMGFFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAAL
                     TIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVPTADNC
                     FQEAHSFASGQAVPWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEDCIVD
                     SCKFGTSVSNIIKPGPKASKSPVEAIITLCQFPFSSSLQRMSVIAQLAGENHFHVYMK
                     GAPEMVARFCRSETVPKNFPQELRSYTVQGFRVIALAHKTLKMGNLSEVEHLAREKVE
                     SELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGS
                     QVIIVEADEPEEFVPASVTWQLVENQETGPGKKEIYMHTGNSSTPRGEGGSCYHFAMS
                     GKSYQVIFQHFNSLLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCG
                     ALKAAHAGISLSEQEASVASPFTSKTTNIQCVPHLIREGRAALVSSFGVFKYLTMYGI
                     IQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLTMSSTHAYPKLAPYRPAGQLLSPP
                     LLLSIFLNSCFSCIVQISAFLYVKQQPWYCEVYQYSECFLANQSNFSTNVSLERNWTG
                     NATLIPGSILSFETTTLWPITTINYITVAFIFSKGKPFRKPIYTNYIFSFLLLAALGL
                     TIFILFSDFQVIYRGMELIPTITSWRVLILVVALTQFCVAFFVEDSILQNHELWLLIK
                     REFGFYSKSQYRTWQKKLAEDSTWPPINRTDYSGDGKNGFYINGGYESHEQIPKRKLK
                     LGGQPTEQHFWARL"
     exon            92..265
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            266..412
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            413..483
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            484..564
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            565..634
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            635..769
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            770..842
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            843..971
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1142
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1300
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1489
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1551
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1702
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1786
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1943
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2061
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2186
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2347
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2473
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2553
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2596
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2706
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2803
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2876
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3051
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3254
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3343
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3424
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3938
                     /gene="ATP13A5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3912..3917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP13A5"
                     /note="hexamer: AATAAA"
     polyA_site      3938
                     /gene="ATP13A5"
                     /note="major polyA site"
ORIGIN      
        1 agaagagatc ctcgccggtt gagttcagat ggaagagaac agtaagaagg accatcgggc
       61 tttgctcaac cagggagagg aggatgaact ggaggtgttt ggttaccggg accacaatgt
      121 acggaaagcc ttctgccttg tcgcatccgt gctgacctgt gggggccttc tgctggtgtt
      181 ctactggaga ccccagtgga gagtgtgggc caactgcatc ccatgcccct tgcaagaagc
      241 agacactgtt ttgctgagga caacagacga atttcaaaga tatatgagga agaaggtatt
      301 ctgcctctac ttatccacac tgaagtttcc tgtaagcaag aagtgggaag aatccctggt
      361 ggctgaccgc cactctgtca taaaccaagc cttaataaag ccagaattaa aactgcggtg
      421 catggaagtg cagaaaatca ggtatgtttg gaacgacctg gagaagcggt ttcagaaagt
      481 tgggttgcta gaagacagca attcctgctc tgacatccat cagacatttg gattgggtct
      541 gaccagtgaa gagcaagagg tcagaagatt agtgtgtggg cccaacgcca ttgaggttga
      601 aatccaaccc atatggaagc tgcttgttaa acaggtttta aatccattct atgtgttcca
      661 agccttcacc ctaactttgt ggctgtctca aggttacata gaatactctg tggccatcat
      721 cattttgact gttatctcca ttgtcttaag tgtgtatgat ttgcgacagc aatcagttaa
      781 gctgcataac ctcgtggagg accacaacaa agtccaggtt acaatcattg taaaagacaa
      841 aggtttggag gagctggaat cccgtctctt ggttcccgga gacattctta ttcttccagg
      901 aaaattttca ttgccatgtg atgctgtttt gattgatgga agctgcgtgg tgaatgaagg
      961 catgcttaca ggagaaagta tacctgttac aaagacacca ttgccccaga tggagaacac
     1021 tatgccttgg aaatgtcaca gtttggagga ttataggaaa cacgtccttt tctgtggaac
     1081 agaagttatc caggtcaagc cctctgggca ggggcctgta cgagcagtcg ttttgcaaac
     1141 aggttacaat acagccaaag gggacttagt gagatccatc ctgtaccccc ggcctctgaa
     1201 cttcaaacta tacagcgatg ccttcaagtt catcgtgttc ctggcctgcc ttggtgtcat
     1261 gggttttttc tatgccctag gggtatatat gtaccatgga gttcctccaa aagatactgt
     1321 gaccatggcc ctgatcctcc tcaccgtgac tgtccctcca gtgctgccag ctgccctgac
     1381 cataggcaac gtgtatgctc agaagagact gaagaaaaag aaaatcttct gtatctcccc
     1441 acagagaatc aacatgtgtg ggcaaataaa cctcgtgtgc tttgacaaaa ctggcactct
     1501 cactgaagat gggctggacc tctgggggac tgtccctact gctgacaact gcttccagga
     1561 agcccacagc tttgcctcag gccaggctgt gccatggagc ccactgtgtg cggccatggc
     1621 cagctgccac tctctgatcc ttctcaatgg gaccatccag ggagaccctc tggacctcaa
     1681 aatgtttgag ggcactgcct ggaaaatgga agattgcatt gtagactcct gcaaatttgg
     1741 gacgtcagtt tcaaacatca taaaaccagg accaaaagcc agtaagagtc cagtggaagc
     1801 catcatcacc ttgtgccagt ttccattttc ctcgagcctg cagaggatgt ccgtgatcgc
     1861 tcagctagct ggggagaatc atttccatgt ctacatgaaa ggtgccccag aaatggtggc
     1921 caggttctgc agatctgaaa cagtgcccaa gaatttccca caggaactga ggagttacac
     1981 ggtgcaaggc ttccgtgtca ttgctcttgc ccacaaaacc ttaaagatgg ggaatctttc
     2041 agaagtcgag cacttagcca gagaaaaagt ggagtcagag ttaacatttc tgggacttct
     2101 catcatggag aatcgcttga aaaaagaaac caaactggtc ttgaaggaac tgagtgaggc
     2161 ccgtatcagg actgtgatga ttacaggtga taaccttcaa acggccatta ctgttgcaaa
     2221 gaattctgaa atgatccctc caggcagcca agtgatcatt gttgaggccg atgaaccaga
     2281 agaatttgtt cctgcctctg tgacctggca gctggtggag aaccaagaga ctggacctgg
     2341 gaagaaagaa atctacatgc atactggaaa cagttcaacc cctcgtgggg aaggaggaag
     2401 ctgttaccat tttgcaatga gtgggaaatc ataccaagtg atatttcagc atttcaacag
     2461 cttgcttcca aaaattctgg tgaatggaac agtttttgca agaatgtctc ctgggcagaa
     2521 atcaagcctt attgaagaat ttcagaaatt aaattattat gtgggcatgt gtggagatgg
     2581 agctaacgac tgtggggctt tgaaagcggc tcatgcaggc atttcattat cagagcagga
     2641 agcatctgtg gcatcccctt ttacctctaa aacaaccaac atccagtgtg tgcctcatct
     2701 catcagagaa ggccgagctg ctctggtttc atcctttgga gtatttaaat acttgaccat
     2761 gtacggcata atccagttta tcagtgcatt actgctctat tggcaactac aactctttgg
     2821 aaattaccag tatctcatgc aagatgtagc cattactttg atggtctgtt taacaatgag
     2881 ttcaactcat gcctacccaa agctggctcc atatagacca gcaggacagc tcctttctcc
     2941 ccctttactg ctttcaatat ttttgaattc ctgtttctcc tgcattgtgc agatcagtgc
     3001 atttctctat gtgaagcagc agccttggta ttgtgaggtc taccaataca gtgagtgttt
     3061 tctggccaac caaagtaatt tttcaacaaa tgtgagtttg gaaagaaact ggactggaaa
     3121 tgcaactctg attcctggtt caattttaag ttttgagacc accacactgt ggcccatcac
     3181 caccatcaac tatatcacag tagcattcat cttttctaag ggaaagccat ttcgaaaacc
     3241 catctataca aactatatat tttcatttct gctgctagct gccttgggcc tcacaatttt
     3301 cattctgttt tctgactttc aagttatata ccgtggaatg gagttgatcc caaccataac
     3361 atcgtggagg gttttaattt tggtggtagc cctcacccaa ttctgtgtgg ctttctttgt
     3421 agaggattcc atccttcaaa atcatgaact ctggctgttg atcaaaagag aatttggatt
     3481 ctactctaaa agtcaatata ggacttggca aaagaagcta gcagaagact caacctggcc
     3541 tcccataaac aggacagatt attcaggtga tggcaaaaat ggattctaca tcaacggagg
     3601 ctatgaaagc catgaacaga ttccaaaaag aaaactcaaa ttgggaggcc aacccacaga
     3661 acagcatttc tgggccaggc tgtaatcaga attgtcgtcg tacatgctca acagcattgc
     3721 ttttttcccc aaaattaaca cattgtggag aagtgatgat actctcccct tacctttcct
     3781 ctctccattc aagcattcaa agtatatttt caatgaatta aaccttgcag caagggacct
     3841 tagataggct tattctgact gtatgcttta ccaatgagag aaaaaaatgc atttcctgta
     3901 tcatcctttt caataaactg tattcatttt gcatagca
//
