LOCUS       NM_001367549            7538 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens ATPase 13A3 (ATP13A3), transcript variant 2, mRNA.
ACCESSION   NM_001367549 XM_011513120
VERSION     NM_001367549.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7538)
  AUTHORS   Liu,B., Azfar,M., Legchenko,E., West,J.A., Martin,S., Van den
            Haute,C., Baekelandt,V., Wharton,J., Howard,L., Wilkins,M.R.,
            Vangheluwe,P., Morrell,N.W. and Upton,P.D.
  TITLE     ATP13A3 variants promote pulmonary arterial hypertension by
            disrupting polyamine transport
  JOURNAL   Cardiovasc Res 120 (7), 756-768 (2024)
   PUBMED   38626311
  REMARK    GeneRIF: ATP13A3 variants promote pulmonary arterial hypertension
            by disrupting polyamine transport.
REFERENCE   2  (bases 1 to 7538)
  AUTHORS   Hamouda,N.N., Van den Haute,C., Vanhoutte,R., Sannerud,R.,
            Azfar,M., Mayer,R., Cortes Calabuig,A., Swinnen,J.V., Agostinis,P.,
            Baekelandt,V., Annaert,W., Impens,F., Verhelst,S.H.L.,
            Eggermont,J., Martin,S. and Vangheluwe,P.
  TITLE     ATP13A3 is a major component of the enigmatic mammalian polyamine
            transport system
  JOURNAL   J Biol Chem 296, 100182 (2021)
   PUBMED   33310703
REFERENCE   3  (bases 1 to 7538)
  AUTHORS   Lek,S.M., Li,K., Tan,Q.X., Shannon,N.B., Ng,W.H., Hendrikson,J.,
            Tan,J.W.S., Lim,H.J., Chen,Y., Koh,K.K.N., Skanthakumar,T.,
            Kwang,X.L., Chong,F.T., Leong,H.S., Tay,G., Putri,N.E., Lim,T.K.H.,
            Hwang,J.S.G., Ang,M.K., Tan,D.S.W., Tan,N.C., Tan,H.K., Kon,O.L.,
            Soo,K.C., Iyer,N.G. and Ong,C.J.
  TITLE     Pairing a prognostic target with potential therapeutic strategy for
            head and neck cancer
  JOURNAL   Oral Oncol 111, 105035 (2020)
   PUBMED   33091845
  REMARK    GeneRIF: Pairing a prognostic target with potential therapeutic
            strategy for head and neck cancer.
REFERENCE   4  (bases 1 to 7538)
  AUTHORS   Barozzi,C., Galletti,M., Tomasi,L., De Fanti,S., Palazzini,M.,
            Manes,A., Sazzini,M. and Galie,N.
  TITLE     A Combined Targeted and Whole Exome Sequencing Approach Identified
            Novel Candidate Genes Involved in Heritable Pulmonary Arterial
            Hypertension
  JOURNAL   Sci Rep 9 (1), 753 (2019)
   PUBMED   30679663
  REMARK    GeneRIF: In addition to EIF2AK4, which has been already suggested
            to be associated with pulmonary veno-occlusive disease, we
            identified the novel candidate genes ATP13A3, CD248, EFCAB4B,
            involved in lung vascular remodeling that represent reliable
            drivers contributing to the disease according to their biological
            functions/inheritance patterns
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7538)
  AUTHORS   Graf,S., Haimel,M., Bleda,M., Hadinnapola,C., Southgate,L., Li,W.,
            Hodgson,J., Liu,B., Salmon,R.M., Southwood,M., Machado,R.D.,
            Martin,J.M., Treacy,C.M., Yates,K., Daugherty,L.C., Shamardina,O.,
            Whitehorn,D., Holden,S., Aldred,M., Bogaard,H.J., Church,C.,
            Coghlan,G., Condliffe,R., Corris,P.A., Danesino,C., Eyries,M.,
            Gall,H., Ghio,S., Ghofrani,H.A., Gibbs,J.S.R., Girerd,B.,
            Houweling,A.C., Howard,L., Humbert,M., Kiely,D.G., Kovacs,G.,
            MacKenzie Ross,R.V., Moledina,S., Montani,D., Newnham,M.,
            Olschewski,A., Olschewski,H., Peacock,A.J., Pepke-Zaba,J.,
            Prokopenko,I., Rhodes,C.J., Scelsi,L., Seeger,W., Soubrier,F.,
            Stein,D.F., Suntharalingam,J., Swietlik,E.M., Toshner,M.R., van
            Heel,D.A., Vonk Noordegraaf,A., Waisfisz,Q., Wharton,J., Wort,S.J.,
            Ouwehand,W.H., Soranzo,N., Lawrie,A., Upton,P.D., Wilkins,M.R.,
            Trembath,R.C. and Morrell,N.W.
  TITLE     Identification of rare sequence variation underlying heritable
            pulmonary arterial hypertension
  JOURNAL   Nat Commun 9 (1), 1416 (2018)
   PUBMED   29650961
  REMARK    GeneRIF: Case-control analyses reveal significant
            overrepresentation of rare variants in ATP13A3, AQP1 and SOX17, and
            provide independent validation of a critical role for GDF2 in
            heritable pulmonary arterial hypertension.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7538)
  AUTHORS   Sorensen,D.M., Holemans,T., van Veen,S., Martin,S., Arslan,T.,
            Haagendahl,I.W., Holen,H.W., Hamouda,N.N., Eggermont,J.,
            Palmgren,M. and Vangheluwe,P.
  TITLE     Parkinson disease related ATP13A2 evolved early in animal evolution
  JOURNAL   PLoS One 13 (3), e0193228 (2018)
   PUBMED   29505581
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7538)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
REFERENCE   8  (bases 1 to 7538)
  AUTHORS   Habtemichael,N. and Kovacs,G.
  TITLE     Cloning the AFURS1 gene which is up-regulated in senescent human
            parenchymal kidney cells
  JOURNAL   Gene 283 (1-2), 271-275 (2002)
   PUBMED   11867234
REFERENCE   9  (bases 1 to 7538)
  AUTHORS   Wick,M., Burger,C., Brusselbach,S., Lucibello,F.C. and Muller,R.
  TITLE     Identification of serum-inducible genes: different patterns of gene
            regulation during G0-->S and G1-->S progression
  JOURNAL   J Cell Sci 107 (Pt 1), 227-239 (1994)
   PUBMED   8175911
  REMARK    Erratum:[J Cell Sci. 1994 Mar;107 ( Pt 3):preceding table of
            contents.. PMID: 8006057]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108676.8 and AC125362.6.
            
            On Dec 6, 2018 this sequence version replaced XM_011513120.2.
            
            Summary: ATP13A3 is a member of the P-type ATPase family of
            proteins that transport a variety of cations across membranes.
            Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM
            300011).[supplied by OMIM, Aug 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000645319.2/ ENSP00000494937.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               AC108676.8         28995-29431
            438-479             AC108676.8         30162-30203
            480-576             AC108676.8         53761-53857
            577-750             AC108676.8         55166-55339
            751-933             AC108676.8         56026-56208
            934-1004            AC108676.8         56456-56526
            1005-1085           AC108676.8         58823-58903
            1086-1155           AC108676.8         60035-60104
            1156-1290           AC108676.8         61605-61739
            1291-1363           AC108676.8         62219-62291
            1364-1495           AC108676.8         65721-65852
            1496-1675           AC108676.8         67361-67540
            1676-1833           AC108676.8         67988-68145
            1834-2022           AC108676.8         68882-69070
            2023-2084           AC108676.8         71211-71272
            2085-2235           AC108676.8         74536-74686
            2236-2352           AC108676.8         77025-77141
            2353-2370           AC108676.8         78424-78441
            2371-2524           AC108676.8         78533-78686
            2525-2645           AC108676.8         78782-78902
            2646-2770           AC108676.8         82101-82225
            2771-2946           AC108676.8         84105-84280
            2947-3069           AC108676.8         84771-84893
            3070-3149           AC108676.8         84975-85054
            3150-3192           AC108676.8         85682-85724
            3193-3302           AC108676.8         85816-85925
            3303-3399           AC108676.8         86223-86319
            3400-3472           AC108676.8         87080-87152
            3473-3650           AC125362.6         91296-91473         c
            3651-3838           AC125362.6         89563-89750         c
            3839-3927           AC125362.6         84100-84188         c
            3928-4008           AC125362.6         77980-78060         c
            4009-4098           AC125362.6         76420-76509         c
            4099-7538           AC125362.6         66898-70337         c
FEATURES             Location/Qualifiers
     source          1..7538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..7538
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /note="ATPase 13A3"
                     /db_xref="GeneID:79572"
                     /db_xref="HGNC:HGNC:24113"
                     /db_xref="MIM:610232"
     exon            1..437
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            438..479
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            480..576
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..4296
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /EC_number="7.6.2.16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable cation-transporting ATPase 13A3; ATPase family
                     homolog up-regulated in senescence cells 1; ATPase type
                     13A3; putrescine transporting ATPase;
                     polyamine-transporting ATPase 13A3"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A3 isoform 2"
                     /protein_id="NP_001354478.1"
                     /db_xref="CCDS:CCDS93438.1"
                     /db_xref="GeneID:79572"
                     /db_xref="HGNC:HGNC:24113"
                     /db_xref="MIM:610232"
                     /translation="MDREERKTINQGQEDEMEIYGYNLSRWKLAIVSLGVICSGGFLL
                     LLLYWMPEWRVKATCVRAAIKDCEVVLLRTTDEFKMWFCAKIRVLSLETYPVSSPKSM
                     SNKLSNGHAVCLIENPTEENRHRISKYSQTESQQIRYFTHHSVKYFWNDTIHNFDFLK
                     GLDEGVSCTSIYEKHSAGLTKGMHAYRKLLYGVNEIAVKVPSVFKLLIKEVLNPFYIF
                     QLFSVILWSTDEYYYYALAIVVMSIVSIVSSLYSIRKQYVMLHDMVATHSTVRVSVCR
                     VNEEIEEIFSTDLVPGDVMVIPLNGTIMPCDAVLINGTCIVNESMLTGESVPVTKTNL
                     PNPSVDVKGIGDELYNPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTGFSTSKGQL
                     VRSILYPKPTDFKLYRDAYLFLLCLVAVAGIGFIYTIINSILNEVQVGVIIIESLDII
                     TITVPPALPAAMTAGIVYAQRRLKKIGIFCISPQRINICGQLNLVCFDKTGTLTEDGL
                     DLWGIQRVENARFLSPEENVCNEMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFE
                     AIGWILEEATEEETALHNRIMPTVVRPPKQLLPESTPAGNQEMELFELPATYEIGIVR
                     QFPFSSALQRMSVVARVLGDRKMDAYMKGAPEAIAGLCKPETVPVDFQNVLEDFTKQG
                     FRVIALAHRKLESKLTWHKVQNISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKA
                     NIRTVMVTGDSMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHYADSLTQC
                     SHPSAIDPEAIPVKLVHDSLEDLQMTRYHFAMNGKSFSVILEHFQDLVPKLMLHGTVF
                     ARMAPDQKTQLIEALQNVDYFVGMCGDGANDCGALKRAHGGISLSELEASVASPFTSK
                     TPSISCVPNLIREGRAALITSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFID
                     LAIILVVVFTMSLNPAWKELVAQRPPSGLISGALLFSVLSQIIICIGFQSLGFFWVKQ
                     QPWYEVWHPKSDACNTTGSGFWNSSHVDNETELDEHNIQNYENTTVFFISSFQYLIVA
                     IAFSKGKPFRQPCYKNYFFVFSVIFLYIFILFIMLYPVASVDQVLQIVCVPYQWRVTM
                     LIIVLVNAFVSITVENFFLDMVLWKVVFNRDKQGEYRFSTTQPPQESVDRWGKCCLPW
                     ALGCRKKTPKAKYMYLAQELLVDPEWPPKPQTTTEAKALVKENGSCQIITIT"
     exon            577..750
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            751..933
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1004
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1085
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1155
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1290
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1363
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1495
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1675
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1833
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2022
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2084
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2235
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2352
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2370
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2524
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2645
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2770
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2946
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3069
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3149
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3192
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3302
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3399
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3472
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3650
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3838
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3927
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4008
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4098
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..7538
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7516..7521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /note="hexamer: AATAAA"
     polyA_site      7538
                     /gene="ATP13A3"
                     /gene_synonym="AFURS1; PPH5"
                     /note="major polyA site"
ORIGIN      
        1 agtcctgagc ccgcgcgcgc tcccccgcct gcctgccggc tctccccgca gcgtgatcgg
       61 gcgccgccgc ggaggggagg ggggttctct acgtcgctgg cggcgggggg gccgtttcgg
      121 agtgcagacc gcccccctcc cctgcccacc tcccgccgcc ctcccttgtt ctcgccctgc
      181 cggctgcacg ccgccgccgc gggcgcggag gaggaggaga gcgcggacgt cccagggccg
      241 gcccggcccc gccgcggcgc ctccttccct caccctgagc cgcagcgcgc ggcgccggcc
      301 gagggcgatg gggctgggct gaggcgaggc ggcggcggcg acagcggcgg ccgggtcccc
      361 cgcggtccct ggggctggtc cggccgcgag ggaggccgcg gaggaggcgg cgcggcggcg
      421 gccagtgagc ggccccgatc tgacagacat ccctgaatct tggtgtttgg acataggagt
      481 gatcttccat tgtttgaagc actggacctt taatccactg taggtatgga cagggaagaa
      541 aggaagacca tcaatcaggg tcaagaagat gaaatggaga tttatggtta caatttgagt
      601 cgctggaagc ttgccatagt ttctttagga gtgatttgct ctggtgggtt tctcctcctc
      661 ctcctctatt ggatgcctga gtggcgggtg aaagcgacct gtgtcagagc tgcaattaaa
      721 gactgtgaag tagtgctgct gaggactact gatgaattca aaatgtggtt ttgtgcaaaa
      781 attcgcgttc tttctttgga aacttaccca gtttcaagtc caaaatctat gtctaataag
      841 ctttcaaatg gccatgcagt ttgtttaatt gagaatccca ctgaagaaaa taggcacagg
      901 atcagtaaat attcacagac tgaatcacaa cagattcgtt atttcaccca ccatagtgta
      961 aaatatttct ggaatgatac cattcacaat tttgatttct taaagggact ggatgaaggt
     1021 gtttcttgta cgtcaattta tgaaaagcat agtgcaggac tgacaaaggg gatgcatgcc
     1081 tacagaaaac tgctttatgg agtaaatgaa attgctgtaa aagtgccttc tgtttttaag
     1141 cttctaatta aagaggttct caacccattt tacattttcc agctgttcag tgttatactg
     1201 tggagcactg atgaatacta ttactatgct ctagctattg tggttatgtc catagtatca
     1261 atcgtaagct cactatattc cattagaaag caatatgtta tgttgcatga catggtggca
     1321 actcatagta ccgtaagagt ttcagtttgt agagtaaatg aagaaataga agaaatcttt
     1381 tctaccgacc ttgtgccagg agatgtcatg gtcattccat taaatgggac aataatgcct
     1441 tgtgatgctg tgcttattaa tggtacctgc attgtaaacg aaagcatgtt aacaggagaa
     1501 agtgttccag tgacaaagac taatttgcca aatccttcag tggatgtgaa aggaatagga
     1561 gatgaattat ataatccaga aacacataaa cgacatactt tgttttgtgg gacaactgtt
     1621 attcagactc gtttctacac tggagaactc gtcaaagcca tagttgttag aacaggattt
     1681 agtacttcca aaggacagct tgttcgttcc atattgtatc ccaaaccaac tgattttaaa
     1741 ctctacagag atgcctactt gtttctacta tgtcttgtgg cagttgctgg cattgggttt
     1801 atctacacta ttattaatag cattttaaat gaggtacaag ttggggtcat aattatcgag
     1861 tctcttgata ttatcacaat tactgtgccc cctgcacttc ctgctgcaat gactgctggt
     1921 attgtgtatg ctcagagaag actgaaaaaa atcggtattt tctgtatcag tcctcaaaga
     1981 ataaatattt gtggacagct caatcttgtt tgctttgaca agactggaac tctaactgaa
     2041 gatggtttag atctttgggg gattcaacga gtggaaaatg cacgatttct ttcaccagaa
     2101 gaaaatgtgt gcaatgagat gttggtaaaa tcccagtttg ttgcttgtat ggctacttgt
     2161 cattcactta caaaaattga aggagtgctc tctggtgatc cacttgatct gaaaatgttt
     2221 gaggctattg gatggattct ggaagaagca actgaagaag aaacagcact tcataatcga
     2281 attatgccca cagtggttcg tcctcccaaa caactgcttc ctgaatctac ccctgcagga
     2341 aaccaagaaa tggagctgtt tgaacttcca gctacttatg agataggaat tgttcgccag
     2401 ttcccatttt cttctgcttt gcaacgtatg agtgtggttg ccagggtgct gggggatagg
     2461 aaaatggacg cctacatgaa aggagcgccc gaggccattg ccggtctctg taaacctgaa
     2521 acagttcctg tcgattttca aaacgttttg gaagacttca ctaaacaggg cttccgtgtg
     2581 attgctcttg cacacagaaa attggagtca aaactgacat ggcataaagt acagaatatt
     2641 agcagagatg caattgagaa caacatggat tttatgggat taattataat gcagaacaaa
     2701 ttaaagcaag aaacccctgc agtacttgaa gatttgcata aagccaacat tcgcaccgtc
     2761 atggtcacag gtgacagtat gttgactgct gtctctgtgg ccagagattg tggaatgatt
     2821 ctacctcagg ataaagtgat tattgctgaa gcattacctc caaaggatgg gaaagttgcc
     2881 aaaataaatt ggcattatgc agactccctc acgcagtgca gtcatccatc agcaattgac
     2941 ccagaggcta ttccggttaa attggtccat gatagcttag aggatcttca aatgactcgt
     3001 tatcattttg caatgaatgg aaaatcattc tcagtgatac tggagcattt tcaagacctt
     3061 gttcctaagt tgatgttgca tggcaccgtg tttgcccgta tggcacctga tcagaagaca
     3121 cagttgatag aagcattgca aaatgttgat tattttgttg ggatgtgtgg tgatggcgca
     3181 aatgattgtg gtgctttgaa gagggcacac ggaggcattt ccttatcgga gctcgaagct
     3241 tcagtggcat ctccctttac ctctaagact cctagtattt cctgtgtgcc aaaccttatc
     3301 agggaaggcc gtgctgcttt aataacttcc ttctgtgtgt ttaaattcat ggcattgtac
     3361 agcattatcc agtacttcag tgttactctg ctgtattcta tcttaagtaa cctaggagac
     3421 ttccagtttc tcttcattga tctggcaatc attttggtag tggtatttac aatgagttta
     3481 aatcctgcct ggaaagaact tgtggcacaa agaccacctt cgggtcttat atctggggcc
     3541 cttctcttct ccgttttgtc tcagattatc atctgcattg gatttcaatc tttgggtttt
     3601 ttttgggtca aacagcaacc ttggtatgaa gtgtggcatc caaaatcaga tgcttgtaat
     3661 acaacaggaa gcgggttttg gaattcttca cacgtagaca atgaaaccga acttgatgaa
     3721 cataatatac aaaattatga aaataccaca gtgtttttta tttccagttt tcagtacctc
     3781 atagtggcaa ttgccttttc aaaaggaaaa cccttcaggc aaccttgcta caaaaattat
     3841 ttttttgttt tttctgtgat ttttttatat atttttatat tattcatcat gttgtatcca
     3901 gttgcctctg ttgaccaggt tcttcagata gtgtgtgtac catatcagtg gcgtgtaact
     3961 atgctcatca ttgttcttgt caatgccttt gtgtctatca cagtggagaa cttcttcctt
     4021 gacatggtcc tttggaaagt tgtgttcaac cgagacaaac aaggagagta tcggttcagc
     4081 accacacagc caccgcagga gtcagtggat cggtggggaa aatgctgctt accctgggcc
     4141 ctgggctgta gaaagaagac accaaaggca aagtacatgt atctggcgca ggagctcttg
     4201 gttgatccag aatggccacc aaaacctcag acaaccacag aagctaaagc tttagttaag
     4261 gagaatggat catgtcaaat catcaccata acatagcagt gaatcagtct cagtggtatt
     4321 gctgatagca gtattcagga atatgtgatt ttaggagttt ctgatcctgt gtgtcagaat
     4381 ggcactagtt cagtttatgt cccttctgat atagtagctt atttgacagc tttgctcttc
     4441 cttaaaataa aaacagaaaa atatatcgtc ctaacagtta aattaacaat caatccataa
     4501 agtcctatat cttcattcag caacccaaat attacataca tttccagaat tttcttgatt
     4561 gttactttca gtgatattct ttatattggg tacaggagaa gtttggtgtt tggtaggttt
     4621 ttcaacatta gtttttgaga ctagtttacc tcttcacatt tatgctcaca accctcttgt
     4681 tagaaaagtc tgtgtttata tacaggctgt aagtttgtga ttgataaaaa gaagatgagt
     4741 gttaattagc ctccagtgaa aatatactga aagcctgttt tcatttgatt ccaatgtttc
     4801 ttccaaagaa ttctgtataa acatatgcca attccctatg atggtctaga gttaggaatg
     4861 agtgtttatg gtgttgctta tagaacaact caggtaatct ccatttctgg ttttatattt
     4921 tctgtacaaa ctgcctgggt tttatttttc taatcagcaa ggtgcttcac tgccttcttg
     4981 agacgcctct caaagctctt aaatggctcc tgtgctatgt gtggtgttgg cagtctaatt
     5041 tgcttctgtt aaatgttgta gaaccttttt cactaggaaa taagattcat ttctttcggc
     5101 agtagatgta gattcatctt ttaacgtttc ttcaaatttg tttctgtcag gctttgtgtt
     5161 attttaaatg gttttttaaa attttcttct atgttttcaa ttacctaaag acataggata
     5221 atagtttttt ttaagttaga attttacctc ataaaatttt ttgaggtttg atgtatgtct
     5281 ctgtcttatc aataatgagg cttaaaaaat actggatttg aatggctgcc gttttttcaa
     5341 agcaatatga atttgatgag tttgttttat gccattaggt ggcgccagag gtcagaacat
     5401 gtctattttg aattggatcg ttacaaatga gcatatttga tgcggaaatt tctgggagaa
     5461 aaaaaattga ggaaataaag ttaaaaaatt gacattcatt gagccaaaag agatgtggag
     5521 aaacattttt cacctttctg tttggcctga ttaacattta aattcttgcc aaaattaagg
     5581 taacttttaa aaaacacctt ttataggtgg atccagcagt ctggcaacgc ccacagttac
     5641 cacaacacag aaaactgatc gtgctataaa atggacgcta aactatgaaa acagtgtgac
     5701 attgttctct gttcttccag agccagtaac atgcttgctc gtgctttcta cttctagctg
     5761 atcattcttt tcccaacata tatttacaaa tttaccaaat tttacctaga attttaggac
     5821 caaatggttc tcactcttta tgctgcaaag acctggatga tgtttggtaa ctatagaaaa
     5881 atagaaatta cactcaggat cactgttact gctattgcca ctgatgattc ctgcaaaaat
     5941 ataatcgaag ttttccatca aatgtataat atgctattaa tacacattag atgataacag
     6001 ttgttccatg aatgattcta tgaagctatg catcttagac ctcttgagct gtgaattagc
     6061 actattttct atagttactt attctctgga tcattttata atttccatat taatttcaaa
     6121 tatgctcgtg ttattcttca gtgatttcca caattgtgca ttttattctt tggtttaagt
     6181 actgaagcat ataatgaaag taattgctaa gtagcagctt aaaaattcaa ttatccgatt
     6241 gtatttaaca tctttaagag catgatcata aagagctatt tttgacaccc cccccccact
     6301 tttttaacat ttagagttag taagggtttt atatctcttc tgtccatatt gttttcaaag
     6361 gaatgaggtg tttaggtggc tggaaaagca tttgtaggaa gttagatttg aatatagaca
     6421 aggtgggtta ttcacgttga gaatgttatt tgaagaatgc ctgtgaagcc aggtgtgggt
     6481 tctactcagt gccatagata gactgagtct tctctcgtag gttaccatta catagtaatt
     6541 ttgattctga atttcacatt aaattatttg agtttataca gacctaaatt ttaaaatctg
     6601 tacatatatt attttgatgt attaagatga atattgctga tttaaatttt atttatgcac
     6661 atacttaaag gacagaaatg tctgggaaag taattgttaa ataatgatat gtaacttttt
     6721 aactttttaa ataaataaca agatttttaa tgtgtgtctc cctcagggtt gtttaaagtt
     6781 ttttttctcc ctcaagtata aatagtggta actatatgtt ttgtatcttc tagcaccaac
     6841 tgctgtaaag caatgctgca aataatgctt gaatacaagt ggctaagcca acaacagaat
     6901 aaatactttt atagtagttt tataatcctg aaattcgaaa gctttcccaa ttgcacttgc
     6961 atctaaacaa aactgttgca gtttttactc tatttatttt gttccccatg tttatgaaag
     7021 tcctgcacag tttcaaaggc atggtaaata atatatcaat gtttatgtag tctgttacag
     7081 aaacagctat agataacatt atccagtgaa gagcaaaatt caagctttag aaaatattca
     7141 tgcatgcaat tttgacatat ctaaaaatag gtttttgtat atttatggtg ggaggtggtt
     7201 gggaactttt aacaaaatgg ggtgttaatt tttgtacagt ctgtgggcat ttacacattt
     7261 ttaatgtatt aaaatttggt aattatgtgt acattaaatt aataaaagtt acttctagtt
     7321 atgatttgtg aattccctaa gaccttggat ttttttaagt aactttatat cagaaatgat
     7381 actgcatctt tatattttta aaattgtatt gctgctcaag aatggtaccc tcttgtcaaa
     7441 aaggcataca ttcataattg tacattcagc attgtaaata atcttatgaa accttttttg
     7501 attgaagcta ttcaaaataa aaattttaat gaatgaaa
//
