LOCUS       NM_022089               3996 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ATPase cation transporting 13A2 (ATP13A2), transcript
            variant 1, mRNA.
ACCESSION   NM_022089
VERSION     NM_022089.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3996)
  AUTHORS   Zhang,F., Wu,Z., Yu,B., Ning,Z., Lu,Z., Li,L., Long,F., Hu,Q.,
            Zhong,C., Zhang,Y. and Lin,C.
  TITLE     ATP13A2 activates the pentose phosphate pathway to promote
            colorectal cancer growth though TFEB-PGD axis
  JOURNAL   Clin Transl Med 13 (5), e1272 (2023)
   PUBMED   37243374
  REMARK    GeneRIF: ATP13A2 activates the pentose phosphate pathway to promote
            colorectal cancer growth though TFEB-PGD axis.
REFERENCE   2  (bases 1 to 3996)
  AUTHORS   Fujii,T., Nagamori,S., Wiriyasermkul,P., Zheng,S., Yago,A.,
            Shimizu,T., Tabuchi,Y., Okumura,T., Fujii,T., Takeshima,H. and
            Sakai,H.
  TITLE     Parkinson's disease-associated ATP13A2/PARK9 functions as a
            lysosomal H+,K+-ATPase
  JOURNAL   Nat Commun 14 (1), 2174 (2023)
   PUBMED   37080960
  REMARK    GeneRIF: Parkinson's disease-associated ATP13A2/PARK9 functions as
            a lysosomal H[+],K[+]-ATPase.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3996)
  AUTHORS   Hatori,Y., Kanda,Y., Nonaka,S., Nakanishi,H. and Kitazawa,T.
  TITLE     ATP13A2 modifies mitochondrial localization of overexpressed TOM20
            to autolysosomal pathway
  JOURNAL   PLoS One 17 (11), e0276823 (2022)
   PUBMED   36445873
  REMARK    GeneRIF: ATP13A2 modifies mitochondrial localization of
            overexpressed TOM20 to autolysosomal pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3996)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
REFERENCE   5  (bases 1 to 3996)
  AUTHORS   Schultheis,P.J., Hagen,T.T., O'Toole,K.K., Tachibana,A.,
            Burke,C.R., McGill,D.L., Okunade,G.W. and Shull,G.E.
  TITLE     Characterization of the P5 subfamily of P-type transport ATPases in
            mice
  JOURNAL   Biochem Biophys Res Commun 323 (3), 731-738 (2004)
   PUBMED   15381061
REFERENCE   6  (bases 1 to 3996)
  AUTHORS   Hampshire,D.J., Roberts,E., Crow,Y., Bond,J., Mubaidin,A.,
            Wriekat,A.L., Al-Din,A. and Woods,C.G.
  TITLE     Kufor-Rakeb syndrome, pallido-pyramidal degeneration with
            supranuclear upgaze paresis and dementia, maps to 1p36
  JOURNAL   J Med Genet 38 (10), 680-682 (2001)
   PUBMED   11584046
REFERENCE   7  (bases 1 to 3996)
  AUTHORS   Gregory,A. and Hayflick,S.
  TITLE     Neurodegeneration with Brain Iron Accumulation Disorders Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23447832
REFERENCE   8  (bases 1 to 3996)
  AUTHORS   Mole,S.E. and Williams,R.E.
  TITLE     Neuronal Ceroid-Lipofuscinoses - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301601
REFERENCE   9  (bases 1 to 3996)
  AUTHORS   Cook Shukla,L., Schulze,J., Farlow,J., Pankratz,N.D., Wojcieszek,J.
            and Foroud,T.
  TITLE     Parkinson Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301402
REFERENCE   10 (bases 1 to 3996)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY024349.1, AL354615.1 and
            BC030267.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022089.3.
            
            Summary: This gene encodes a member of the P5 subfamily of ATPases
            which transports inorganic cations as well as other substrates.
            Mutations in this gene are associated with Kufor-Rakeb syndrome
            (KRS), also referred to as Parkinson disease 9. Multiple transcript
            variants encoding different isoforms have been found for this
            gene.[provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). The transcript
            contains an upstream ORF that could encode a 103aa protein and may
            modulate translation from the downstream ORF encoding isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL354615.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326735.13/ ENSP00000327214.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               HY024349.1         45-200
            157-3733            AL354615.1         1-3577
            3734-3996           BC030267.1         3419-3681
FEATURES             Location/Qualifiers
     source          1..3996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..3996
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:23400"
                     /db_xref="HGNC:HGNC:30213"
                     /db_xref="MIM:610513"
     exon            1..200
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..3733
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /EC_number="7.2.2.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 1"
                     /protein_id="NP_071372.1"
                     /db_xref="CCDS:CCDS175.1"
                     /db_xref="GeneID:23400"
                     /db_xref="HGNC:HGNC:30213"
                     /db_xref="MIM:610513"
                     /translation="MSADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSP
                     WRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQL
                     FTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQK
                     RVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKAIYGP
                     NVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLY
                     KTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALV
                     AGECMVNESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQARAYVGPHVL
                     AVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRN
                     RVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQ
                     LVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQD
                     TPVGDPMDLKMVESTGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSV
                     LHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTA
                     AGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALR
                     RTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPT
                     AVNGVKDPDQAASYTVEPDPRSRHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAP
                     EQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIE
                     CVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITT
                     TVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFV
                     PLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTNVPFLVALALL
                     SSVLVGLVLVPGLLQGPLALRNITDTGFKLLLLGLVTLNFVGAFMLESVLDQCLPACL
                     RRLRPKRASKKRFKQLERELAEQPWPPLPAGPLR"
     exon            201..295
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            296..478
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            479..537
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            538..667
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            668..747
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            748..825
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            826..895
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1030
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1097
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1229
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1385
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1496
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1543
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1732
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1939
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2035
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2195
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2316
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2441
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2602
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2719
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2799
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2952
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3049
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3273
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3425
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3595
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3996
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3972..3977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /note="hexamer: AATAAA"
     polyA_site      3996
                     /gene="ATP13A2"
                     /gene_synonym="CLN12; HSA9947; KRPPD; PARK9; SPG78"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcggag ccgcgccgag cctggtggcc caggtgcccc gcccgcgtca gccctgctcc
       61 agccccgcgc tagcccagcg cccctcgccc cgggccgtcc ggaccgcgcc cccgcccagg
      121 gccttgcgca cgccggggcc caggccgagg gccgcagcgc cggggccggc gatgagcgcg
      181 aggagccggc atgagcgcag acagcagccc tctcgtgggc agcacgccca ccggttatgg
      241 gaccctgacg atagggacat caatagatcc cctcagctcc tcagtttcat ccgtgaggct
      301 cagcggctac tgtggcagtc catggagggt catcggctat cacgtcgtgg tctggatgat
      361 ggctgggatc cctttgctgc tcttccgttg gaagcccctg tggggggtgc ggctgcggct
      421 ccggccctgc aacctggccc acgccgaaac actcgttatc gaaataagag acaaagagga
      481 tagttcctgg cagctcttca ctgtccaggt gcagactgag gccatcggcg agggcagcct
      541 ggagccgtcc ccacagtccc aggcagagga tggccggagc caggcggcag ttggggcggt
      601 accagagggt gcctggaagg atacggccca gctccacaag agcgaggagg cggtgagtgt
      661 cggacagaag cgggtgctgc ggtattacct cttccagggc cagcgctata tctggatcga
      721 gacccagcaa gccttctacc aggtcagcct cctggaccat ggccgctctt gtgacgacgt
      781 ccaccgctcc cgccatggcc tcagcctcca ggaccaaatg gtgaggaagg ccatttacgg
      841 ccccaacgtg atcagcatac cggtcaagtc ctacccccag ctgctggtgg acgaggcact
      901 gaacccctac tatgggttcc aggccttcag catcgcgctg tggctggctg accactacta
      961 ctggtacgcc ctgtgcatct tcctcatttc ctccatctcc atctgcctgt cgctgtacaa
     1021 gaccagaaag caaagccaga ctctaaggga catggtcaag ttgtccatgc gggtgtgcgt
     1081 gtgccggcca gggggagagg aagagtgggt ggactccagt gagctagtgc ccggagactg
     1141 cctggtgctg ccccaggagg gtgggctgat gccctgtgat gccgccctgg tggccggcga
     1201 gtgcatggtg aatgagagct ctctgacagg agagagcatt ccagtgctga agacggcact
     1261 gccggagggg ctggggccct actgtgcaga gacacaccgg cggcacacac tcttctgcgg
     1321 gaccctcatc ttgcaggccc gggcctatgt gggaccgcac gtcctggcag tggtgacccg
     1381 cacagggttc tgcacggcaa aagggggcct ggtgagctcc atcttgcacc cccggcccat
     1441 caacttcaag ttctataaac acagcatgaa gtttgtggct gccctctctg tcctggctct
     1501 cctcggcacc atctacagca tcttcatcct ctaccgaaac cgggtgcctc tgaatgagat
     1561 tgtaatccgg gctctcgacc tggtgaccgt ggtggtgcca cctgccctgc ctgctgccat
     1621 gactgtgtgc acgctctacg cccagagccg actgcggaga cagggcattt tctgcatcca
     1681 cccactgcgc atcaacctgg ggggcaagct gcagctggtg tgtttcgaca agacgggcac
     1741 cctcactgag gacggcttag acgtgatggg ggtggtgccc ctgaaggggc aggcattcct
     1801 gcccctggtc ccagagcctc gccgcctgcc tgtggggccc ctgctccgag cactggccac
     1861 ctgccatgcc ctcagccggc tccaggacac ccccgtgggc gaccccatgg acttgaagat
     1921 ggtggagtct actggctggg tcctggagga agagccggct gcagactcag catttgggac
     1981 ccaggtcttg gcagtgatga gacccccact ttgggagccc cagctgcagg caatggagga
     2041 gcccccggtg ccagtcagcg tcctccaccg cttccccttc tcttcggctc tgcagcgcat
     2101 gagtgtggtg gtggcgtggc caggggccac tcagcccgag gcctacgtca aaggctcccc
     2161 ggagctggtg gcagggctct gcaaccccga gacagtgccc accgacttcg cccagatgct
     2221 gcagagctat acagctgctg gctaccgtgt cgtggccctg gccagcaagc cactgcccac
     2281 tgtgcccagc ctggaggcag cccagcaact gacgagggac actgtggaag gagacctgag
     2341 cctcctgggg ctgctggtca tgaggaacct actgaagccg cagacaacgc cagttatcca
     2401 ggctctgcga aggacccgca tccgcgccgt catggtgaca ggggacaacc tgcagacagc
     2461 ggtgactgtg gcccggggct gtggcatggt ggccccccag gagcatctga tcatcgtcca
     2521 cgccacccac cctgagcggg gtcagcctgc ctctctcgag ttcctgccga tggagtcccc
     2581 cacagccgtg aatggcgtta aggatcctga ccaggctgca agctacaccg tggagccaga
     2641 cccccgatcc aggcacctgg ccctcagcgg gcccaccttt ggtatcattg tgaagcactt
     2701 ccccaagctg ctgcccaagg tcctggtcca gggcactgtc tttgcccgca tggcccctga
     2761 gcagaagaca gagctggtgt gcgagctaca gaagcttcag tactgcgtgg gcatgtgcgg
     2821 agacggcgcc aatgactgtg gggccctgaa ggcggctgat gtcggcatct cgctgtccca
     2881 ggcagaagcc tcagtggtct cacccttcac ctcgagcatg gccagtattg agtgcgtgcc
     2941 catggtcatc agggaggggc gctgttccct tgacacttcg ttcagcgtct tcaagtacat
     3001 ggctctgtac agcctgaccc agttcatctc cgtcctgatc ctctacacga tcaacaccaa
     3061 cctgggtgac ctgcagttcc tggccatcga cctggtcatc accaccacag tggcagtgct
     3121 catgagccgc acggggccag cgctggtcct gggacgggtg cggccaccgg gggcgctgct
     3181 cagcgtgccc gtgctcagca gcctgctgct gcagatggtc ctggtgaccg gcgtgcagct
     3241 agggggctac ttcctgaccc tggcccagcc atggttcgtg cctctgaaca ggacagtggc
     3301 cgcaccagac aacctgccca actacgagaa caccgtggtc ttctctctgt ccagcttcca
     3361 gtacctcatc ctggctgcag ccgtgtccaa gggggcgccc ttccgccggc cgctctacac
     3421 caatgtgccc ttcctggtgg ccctggcgct cctgagctcc gtcctggtgg gccttgtcct
     3481 ggtccccggc ctcctgcagg ggccgctggc gctgaggaac atcactgaca ccggcttcaa
     3541 gctgctgctg ctgggtctgg tcaccctcaa cttcgtgggg gccttcatgc tggagagcgt
     3601 gctagaccag tgcctccccg cctgcctgcg ccgcctccgg cccaagcggg cctccaagaa
     3661 gcgcttcaag cagctggaac gagagctggc cgagcagccc tggccgccgc tgcccgccgg
     3721 ccccctgagg tagtgcaggc ccacgggcac cccagacact ggaactccct gcctctgagc
     3781 caccaactgg acccctctcc agcaacacca ccgccaccac ctcccacatc cctgaggttg
     3841 gcgactgtct acactcctcc cccgagacca cccccaccct ggggaagcgt tgactactgt
     3901 cccctacctt ggaccatccc gcgtaggggt ggcagccccc agctcccctc agtgctgctg
     3961 tcagtgtagc aaataaagtc atgatatttt cctggc
//
